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Select item 102611901.

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes

Katherine Fodder, Megha Murthy, Patrizia Rizzu, Christina E. Toomey, Rahat Hasan, Jack Humphrey, Towfique Raj, Katie Lunnon, Jonathan Mill, Peter Heutink, Tammaryn Lashley, Conceição Bettencourt

Acta Neuropathol. 2023; 146(1): 77–95. Published online 2023 May 7. doi: 10.1007/s00401-023-02583-z

PMCID:: PMC10261190

Abstract Article PDF–5.5M

Select item 75191092.

OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex

Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn

Sci Rep. 2020; 10: 15725. Published online 2020 Sep 24. doi: 10.1038/s41598-020-72791-0

PMCID:: PMC7519109

Abstract Article PDF–2.3M

Select item 3345143.

HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts.

I Raineri, H P Senn

Nucleic Acids Res. 1992 Dec 11; 20(23): 6261–6266. doi: 10.1093/nar/20.23.6261

PMCID:: PMC334514

Summary Page Browse PDF–1.2M

Select item 109076234.

OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway

Mingxin Ci, Gaichao Zhao, Chongyang Li, Ruochen Liu, Xiaosong Hu, Jun Pan, Yang Shen, Guanghui Zhang, Yongsen Li, Li Zhang, Ping Liang, Hongjuan Cui

Cell Death Dis. 2024 Mar; 15(3): 179. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06569-x

PMCID:: PMC10907623

Abstract Article PDF–5.3M

Select item 68190065.

OTUD4 is a phospho-activated K63 deubiquitinase that regulates MyD88-dependent signaling

Yu Zhao, Miranda C. Mudge, Jennifer M. Soll, Rachel B. Rodrigues, Andrea K. Byrum, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Steven P. Gygi, Brian T. Edelson, Nima Mosammaparast

Mol Cell. Author manuscript; available in PMC 2019 Oct 29.

Published in final edited form as: Mol Cell. 2018 Feb 1; 69(3): 505–516.e5. doi: 10.1016/j.molcel.2018.01.009

PMCID:: PMC6819006

Abstract Article PDF–3.6M

Select item 37380656.

Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination

David H. Margolin, Maria Kousi, Yee-Ming Chan, Elaine T. Lim, Jeremy D. Schmahmann, Marios Hadjivassiliou, Janet E. Hall, Ibrahim Adam, Andrew Dwyer, Lacey Plummer, Stephanie V. Aldrin, Julia O’Rourke, Andrew Kirby, Kasper Lage, Aubrey Milunsky, Jeff M. Milunsky, Jennifer Chan, E. Tessa Hedley-Whyte, Mark J. Daly, Nicholas Katsanis, Stephanie B. Seminara

N Engl J Med. Author manuscript; available in PMC 2013 Nov 23.

Published in final edited form as: N Engl J Med. 2013 May 23; 368(21): 1992–2003. Published online 2013 May 8. doi: 10.1056/NEJMoa1215993

PMCID:: PMC3738065

Abstract Article PDF–3.4M

Select item 82929097.

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu

Adv Sci (Weinh) 2021 Jul; 8(14): 2004846. Published online 2021 Jun 1. doi: 10.1002/advs.202004846

PMCID:: PMC8292909

Abstract Article PDF–4.0M

Select item 28360338.

Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6

Shu Li, Hao Zheng, Ai-Ping Mao, Bo Zhong, Ying Li, Yu Liu, Yan Gao, Yong Ran, Po Tien, Hong-Bing Shu

J Biol Chem. 2010 Feb 12; 285(7): 4291–4297. Published online 2009 Dec 7. doi: 10.1074/jbc.M109.074971

PMCID:: PMC2836033

Abstract Article PDF–3.3M

Select item 46545799.

Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family

Marcell Louis, Kay Hofmann, Meike Broemer

PLoS One. 2015; 10(11): e0143227. Published online 2015 Nov 20. doi: 10.1371/journal.pone.0143227

PMCID:: PMC4654579

Abstract Article PDF–2.8M

Select item 967769110.

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao

J Exp Clin Cancer Res. 2022; 41: 328. Published online 2022 Nov 21. doi: 10.1186/s13046-022-02533-9

PMCID:: PMC9677691

Abstract Article PDF–20M

Select item 660664911.

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang

Nat Commun. 2019; 10: 2914. Published online 2019 Jul 2. doi: 10.1038/s41467-019-10824-7

PMCID:: PMC6606649

Abstract Article PDF–4.7M

Select item 631827312.

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

Tianzi Liuyu, Keying Yu, Liya Ye, Zhidong Zhang, Man Zhang, Yujie Ren, Zeng Cai, Qiyun Zhu, Dandan Lin, Bo Zhong

Cell Res. 2019 Jan; 29(1): 67–79. Published online 2018 Nov 8. doi: 10.1038/s41422-018-0107-6

PMCID:: PMC6318273

Abstract Article PDF–2.9M

Select item 694334613.

USP37 is a SNAI1 deubiquitinase

Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma

Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.

PMCID:: PMC6943346

Abstract Article PDF–1.2M

Select item 444076914.

TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation

Hannah Greenfeld, Kaoru Takasaki, Michael J. Walsh, Ina Ersing, Katharina Bernhardt, Yijie Ma, Bishi Fu, Camille W. Ashbaugh, Jackson Cabo, Sarah B. Mollo, Hufeng Zhou, Shitao Li, Benjamin E. Gewurz

PLoS Pathog. 2015 May; 11(5): e1004890. Published online 2015 May 21. doi: 10.1371/journal.ppat.1004890

PMCID:: PMC4440769

Abstract Article PDF–5.7M

Select item 370520815.

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Tycho E.T. Mevissen, Manuela K. Hospenthal, Paul P. Geurink, Paul R. Elliott, Masato Akutsu, Nadia Arnaudo, Reggy Ekkebus, Yogesh Kulathu, Tobias Wauer, Farid El Oualid, Stefan M.V. Freund, Huib Ovaa, David Komander

Cell. 2013 Jul 3; 154(1): 169–184. doi: 10.1016/j.cell.2013.05.046

PMCID:: PMC3705208

Abstract Article

Select item 447540216.

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase

Yu Zhao, Mona C Majid, Jennifer M Soll, Joshua R Brickner, Sebastian Dango, Nima Mosammaparast

EMBO J. 2015 Jun 12; 34(12): 1687–1703. Published online 2015 May 5. doi: 10.15252/embj.201490497

PMCID:: PMC4475402

Abstract Article PDF–2.2M

Select item 500055217.

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

Wendy Béguelin, Matt Teater, Micah D. Gearhart, María Teresa Calvo Fernández, Rebecca L. Goldstein, Mariano G. Cárdenas, Katerina Hatzi, Monica Rosen, Hao Shen, Connie M. Corcoran, Michelle Y. Hamline, Randy D. Gascoyne, Ross L. Levine, Omar Abdel-Wahab, Jonathan D. Licht, Rita Shaknovich, Olivier Elemento, Vivian J. Bardwell, Ari M. Melnick

Cancer Cell. Author manuscript; available in PMC 2017 Aug 8.

Published in final edited form as: Cancer Cell. 2016 Aug 8; 30(2): 197–213. doi: 10.1016/j.ccell.2016.07.006

PMCID:: PMC5000552

Abstract Article PDF–4.1M

Select item 720609918.

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53

Chen Hu, Mu Zhang, Niko Moses, Cong-li Hu, Lisa Polin, Wei Chen, Hyejeong Jang, Joshua Heyza, Agnes Malysa, Joseph A. Caruso, Shengyan Xiang, Steve Patrick, Paul Stemmer, Zhenkun Lou, Wenlong Bai, Chuangui Wang, Gerold Bepler, Xiaohong Mary Zhang

Cell Death Dis. 2020 May; 11(5): 328. Published online 2020 May 7. doi: 10.1038/s41419-020-2519-8

PMCID:: PMC7206099

Abstract Article PDF–2.1M

Select item 927116819.

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways

David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, Issam Ben-Sahra, Daniel R. Foltz, Jian Li, Marc L. Mendillo

Proc Natl Acad Sci U S A. 2022 Jul 5; 119(27): e2111262119. Published online 2022 Jul 1. doi: 10.1073/pnas.2111262119

PMCID:: PMC9271168

Abstract Article PDF–2.6M

Select item 589620220.

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

Dominika Kwasna, Syed Arif Abdul Rehman, Jayaprakash Natarajan, Stephen Matthews, Ross Madden, Virginia De Cesare, Simone Weidlich, Satpal Virdee, Ivan Ahel, Ian Gibbs-Seymour, Yogesh Kulathu

Mol Cell. 2018 Apr 5; 70(1): 150–164.e6. doi: 10.1016/j.molcel.2018.02.023

PMCID:: PMC5896202

Abstract Article

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