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Select item 107648511.

RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation

Kouki Hoshino, Seshiru Nakazawa, Takehiko Yokobori, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Kenichiro Araki, Norifumi Harimoto, Fuminori Tokunaga, Ken Shirabe

Sci Rep. 2024; 14: 346. Published online 2024 Jan 3. doi: 10.1038/s41598-023-50594-3

PMCID:: PMC10764851

Abstract Article PDF–8.0M

Select item 98016412.

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer

Huijie Yang, Min Xue, Peng Su, Yan Zhou, Xin Li, Zhongbo Li, Yan Xia, Chenmiao Zhang, Mingxi Fu, Xiuxia Zheng, Guosheng Luo, Tian Wei, Xinxing Wang, Yinlu Ding, Jian Zhu, Ting Zhuang

J Exp Clin Cancer Res. 2022; 41: 364. Published online 2022 Dec 29. doi: 10.1186/s13046-022-02576-y

PMCID:: PMC9801641

Abstract Article PDF–4.1M

Select item 64316123.

Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC

Hirotsugu Oda, David B. Beck, Hye Sun Kuehn, Natalia Sampaio Moura, Patrycja Hoffmann, Maria Ibarra, Jennifer Stoddard, Wanxia Li Tsai, Gustavo Gutierrez-Cruz, Massimo Gadina, Sergio D. Rosenzweig, Daniel L. Kastner, Luigi D. Notarangelo, Ivona Aksentijevich

Front Immunol. 2019; 10: 479. Published online 2019 Mar 18. doi: 10.3389/fimmu.2019.00479

PMCID:: PMC6431612

Abstract Article PDF–2.3M

Select item 49624164.

Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression

Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu, Hui Wang

BMC Cancer. 2016; 16: 538. Published online 2016 Jul 26. doi: 10.1186/s12885-016-2575-8

PMCID:: PMC4962416

Abstract Article PDF–866K

Select item 34638425.

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

Judith J Smit, Davide Monteferrario, Sylvie M Noordermeer, Willem J van Dijk, Bert A van der Reijden, Titia K Sixma

EMBO J. 2012 Oct 3; 31(19): 3833–3844. Published online 2012 Aug 3. doi: 10.1038/emboj.2012.217

PMCID:: PMC3463842

Abstract Article PDF–954K

Select item 93881216.

Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses

Mingqi Li, Ling Li, Sarah Asemota, David Kakhniashvili, Ramesh Narayanan, Xusheng Wang, Francesca-Fang Liao

Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2123097119. Published online 2022 Aug 8. doi: 10.1073/pnas.2123097119

PMCID:: PMC9388121

Abstract Article PDF–2.2M

Select item 93075107.

RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31

Xijun Chen, Qing Ye, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Xiaomin Wang

Cell Death Discov. 2022; 8: 334. Published online 2022 Jul 22. doi: 10.1038/s41420-022-01126-x

PMCID:: PMC9307510

Abstract Article PDF–6.1M

Select item 85958868.

A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages

Jun Young Park, Dongsoo Lee, Jang Jae Lee, Jungsoo Gim, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Sarang Kang, Ah Ra Do, Jinyeon Jo, Juhong Park, Kyungtaek Park, Donghe Li, Sanghun Lee, Hoowon Kim, Immanuel Dhanasingh, Suparna Ghosh, Seula Keum, Jee Hye Choi, Gyun Jee Song, Lee Sael, Sangmyung Rhee, Simon Lovestone, Eunae Kim, Seung Hwan Moon, Byeong C. Kim, SangYun Kim, Andrew J. Saykin, Kwangsik Nho, Sung Haeng Lee, Lindsay A. Farrer, Gyungah R. Jun, Sungho Won, Kun Ho Lee, for the Alzheimer’s Disease Neuroimaging Initiative

Transl Psychiatry. 2021; 11: 590. Published online 2021 Nov 16. doi: 10.1038/s41398-021-01680-5

PMCID:: PMC8595886

Abstract Article PDF–1.8M

Select item 80242859.

Taraxasterol acetate targets RNF31 to inhibit RNF31/p53 axis-driven cell proliferation in colorectal cancer

Chao-Tao Tang, Jing Yang, Zi-De Liu, Youxiang Chen, Chunyan Zeng

Cell Death Discov. 2021; 7: 66. Published online 2021 Apr 6. doi: 10.1038/s41420-021-00449-5

PMCID:: PMC8024285

Abstract Article PDF–6.3M

Select item 631150510.

Ring finger protein 31–mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function

Fuxiang Zhu, Gang Yi, Xu Liu, Fangming Zhu, Anna Zhao, Aiting Wang, Ruihong Zhu, Zuojia Chen, Binbin Zhao, Sijie Fang, Xiao Yu, Ruirong Lin, Rui Liang, Dan Li, Wenyi Zhao, Zizhen Zhang, Wenzhi Guo, Shuijun Zhang, Shengfang Ge, Xianqun Fan, Gang Zhao, Bin Li

J Biol Chem. 2018 Dec 28; 293(52): 20099–20111. Published online 2018 Nov 2. doi: 10.1074/jbc.RA118.005802

PMCID:: PMC6311505

Abstract Article PDF–2.8M

Select item 584483211.

Biophysical and Biological Evaluation of Optimized Stapled Peptide Inhibitors of the Linear Ubiquitin Chain Assembly Complex (LUBAC)

Francisco Aguilar-Alonso, Amanda L. Whiting, Ye Joon Kim, Federico Bernal

Bioorg Med Chem. Author manuscript; available in PMC 2019 Mar 15.

Published in final edited form as: Bioorg Med Chem. 2018 Mar 15; 26(6): 1179–1188. Published online 2017 Dec 5. doi: 10.1016/j.bmc.2017.11.047

PMCID:: PMC5844832

Abstract Article PDF–1.7M

Select item 483387312.

RING finger protein 31 promotes p53 degradation in breast cancer cells

J Zhu, C Zhao, T Zhuang, P Jonsson, I Sinha, C Williams, S Strömblad, K Dahlman-Wright

Oncogene. 2016 Apr 14; 35(15): 1955–1964. Published online 2015 Jul 6. doi: 10.1038/onc.2015.260

PMCID:: PMC4833873

Abstract Article PDF–3.1M

Select item 465947613.

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

James Bowman, Mary A. Rodgers, Mude Shi, Rina Amatya, Bruce Hostager, Kazuhiro Iwai, Shou-Jiang Gao, Jae U. Jung

mBio. 2015 Nov-Dec; 6(6): e01777-15. Published online 2015 Nov 17. doi: 10.1128/mBio.01777-15

PMCID:: PMC4659476

Abstract Article PDF–2.0M

Select item 445113714.

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

Bertrand Boisson, Emmanuel Laplantine, Kerry Dobbs, Aurélie Cobat, Nadine Tarantino, Melissa Hazen, Hart G.W. Lidov, Gregory Hopkins, Likun Du, Aziz Belkadi, Maya Chrabieh, Yuval Itan, Capucine Picard, Jean-Christophe Fournet, Hermann Eibel, Erdyni Tsitsikov, Sung-Yun Pai, Laurent Abel, Waleed Al-Herz, Jean-Laurent Casanova, Alain Israel, Luigi D. Notarangelo

J Exp Med. 2015 Jun 1; 212(6): 939–951. doi: 10.1084/jem.20141130

PMCID:: PMC4451137

Abstract Article PDF–2.3M

Select item 414130415.

The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation

J Zhu, C Zhao, A Kharman-Biz, T Zhuang, P Jonsson, N Liang, C Williams, C-Y Lin, Y Qiao, K Zendehdel, S Strömblad, E Treuter, K Dahlman-Wright

Oncogene. 2014 Aug 21; 33(34): 4340–4351. Published online 2014 Jan 20. doi: 10.1038/onc.2013.573

Correction in:: Oncogene. 2019; 38(2): 299–300.

PMCID:: PMC4141304

Abstract Article PDF–3.1M

Select item 381476716.

Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

Judith J. Smit, Willem J. van Dijk, Dris El Atmioui, Remco Merkx, Huib Ovaa, Titia K. Sixma

J Biol Chem. 2013 Nov 1; 288(44): 31728–31737. Published online 2013 Sep 12. doi: 10.1074/jbc.M113.495846

PMCID:: PMC3814767

Abstract Article PDF–1.8M

Select item 330288117.

Knockdown of SF-1 and RNF31 Affects Components of Steroidogenesis, TGFβ, and Wnt/β-catenin Signaling in Adrenocortical Carcinoma Cells

Anna Ehrlund, Philip Jonsson, Lise-Lotte Vedin, Cecilia Williams, Jan-Åke Gustafsson, Eckardt Treuter

PLoS One. 2012; 7(3): e32080. Published online 2012 Mar 9. doi: 10.1371/journal.pone.0032080

PMCID:: PMC3302881

Abstract Article PDF–1.1M

Select item 953336918.

Identification and molecular analysis of RNF31 Q622H germline polymorphism

Seshiru Nakazawa, Ryo Mamiya, Reika Kawabata-Iwakawa, Daisuke Oikawa, Kyoichi Kaira, Fuminori Tokunaga, Sumihito Nobusawa, Yusuke Sato, Atsushi Sasaki, Toshiki Yajima, Ken Shirabe

Oncol Lett. 2022 Nov; 24(5): 394. Published online 2022 Sep 21. doi: 10.3892/ol.2022.13514

PMCID:: PMC9533369

Abstract Article PDF–3.1M

Select item 929400019.

Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain

Simin Rahighi, Mamta Iyer, Hamid Oveisi, Sammy Nasser, Vincent Duong

Sci Rep. 2022; 12: 12241. Published online 2022 Jul 18. doi: 10.1038/s41598-022-16193-4

PMCID:: PMC9294000

Abstract Article PDF–3.7M

Select item 777359520.

Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB

An Thys, Kilian Trillet, Sara Rosińska, Audrey Gayraud, Tiphaine Douanne, Yannic Danger, Clotilde C.N. Renaud, Luc Antigny, Régis Lavigne, Charles Pineau, Emmanuelle Com, Franck Vérité, Julie Gavard, Nicolas Bidère

iScience. 2021 Jan 22; 24(1): 101939. Published online 2020 Dec 13. doi: 10.1016/j.isci.2020.101939

PMCID:: PMC7773595

Abstract Article PDF–14M

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