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Select item 111053011.

Structural insights into the function of Elongator

Udit Dalwadi, Calvin K. Yip

Cell Mol Life Sci. 2018 May; 75(9): 1613–1622. Published online 2018 Jan 13. doi: 10.1007/s00018-018-2747-6

PMCID:: PMC11105301

Abstract Article PDF–2.5M

Select item 32444512.

hElp3 Directly Modulates the Expression of HSP70 Gene in HeLa Cells via HAT Activity

Fen Li, Jixian Ma, Yu Ma, Yanyan Hu, Shujuan Tian, Richard E. White, Guichun Han

PLoS One. 2011; 6(12): e29303. Published online 2011 Dec 21. doi: 10.1371/journal.pone.0029303

PMCID:: PMC3244451

Abstract Article PDF–372K

Select item 59688443.

Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT

Yi Xu, Wei Zhou, Yuan Ji, Jian Shen, Xiaxia Zhu, Huijun Yu, Jingchun Guo, Zhi Pang, Wenxiang Wei

Int J Biol Sci. 2018; 14(5): 518–530. Published online 2018 Apr 5. doi: 10.7150/ijbs.23511

PMCID:: PMC5968844

Abstract Article PDF–3.6M

Select item 50682354.

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

Sylvain Delaunay, Francesca Rapino, Lars Tharun, Zhaoli Zhou, Lukas Heukamp, Martin Termathe, Kateryna Shostak, Iva Klevernic, Alexandra Florin, Hadrien Desmecht, Christophe J. Desmet, Laurent Nguyen, Sebastian A. Leidel, Anne E. Willis, Reinhard Büttner, Alain Chariot, Pierre Close

J Exp Med. 2016 Oct 17; 213(11): 2503–2523. doi: 10.1084/jem.20160397

PMCID:: PMC5068235

Abstract Article PDF–4.0M

Select item 61595325.

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Andre Bento-Abreu, Gunilla Jager, Bart Swinnen, Laura Rué, Stijn Hendrickx, Ashley Jones, Kim A Staats, Ines Taes, Caroline Eykens, Annelies Nonneman, Rik Nuyts, Mieke Timmers, Lara Silva, Alain Chariot, Laurent Nguyen, John Ravits, Robin Lemmens, Deirdre Cabooter, Ludo Van Den Bosch, Philip Van Damme, Ammar Al-Chalabi, Anders Bystrom, Wim Robberecht

Hum Mol Genet. 2018 Apr 1; 27(7): 1276–1289. Published online 2018 Feb 3. doi: 10.1093/hmg/ddy043

PMCID:: PMC6159532

Abstract Article PDF–977K

Select item 26388036.

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

Claire L. Simpson, Robin Lemmens, Katarzyna Miskiewicz, Wendy J. Broom, Valerie K. Hansen, Paul W.J. van Vught, John E. Landers, Peter Sapp, Ludo Van Den Bosch, Joanne Knight, Benjamin M. Neale, Martin R. Turner, Jan H. Veldink, Roel A. Ophoff, Vineeta B. Tripathi, Ana Beleza, Meera N. Shah, Petroula Proitsi, Annelies Van Hoecke, Peter Carmeliet, H. Robert Horvitz, P. Nigel Leigh, Christopher E. Shaw, Leonard H. van den Berg, Pak C. Sham, John F. Powell, Patrik Verstreken, Robert H. Brown, Jr, Wim Robberecht, Ammar Al-Chalabi

Hum Mol Genet. 2009 Feb 1; 18(3): 472–481. Published online 2008 Nov 7. doi: 10.1093/hmg/ddn375

PMCID:: PMC2638803

Abstract Article PDF–518K

Select item 50882027.

The Many Faces of Elongator in Neurodevelopment and Disease

Marija Kojic, Brandon Wainwright

Front Mol Neurosci. 2016; 9: 115. Published online 2016 Nov 1. doi: 10.3389/fnmol.2016.00115

PMCID:: PMC5088202

Abstract Article PDF–1.5M

Select item 41941218.

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress

Yi-Ping Wang, Li-Sha Zhou, Yu-Zheng Zhao, Shi-Wen Wang, Lei-Lei Chen, Li-Xia Liu, Zhi-Qiang Ling, Fu-Jun Hu, Yi-Ping Sun, Jing-Ye Zhang, Chen Yang, Yi Yang, Yue Xiong, Kun-Liang Guan, Dan Ye

EMBO J. 2014 Jun 17; 33(12): 1304–1320. Published online 2014 Apr 25. doi: 10.1002/embj.201387224

PMCID:: PMC4194121

Abstract Article PDF–1.8M

Select item 71809869.

The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila

Neetu Singh, Meridith T. Lorbeck, Ashley Zervos, John Zimmerman, Felice Elefant

J Neurochem. Author manuscript; available in PMC 2020 Apr 24.

Published in final edited form as: J Neurochem. 2010 Oct; 115(2): 493–504. Published online 2010 Aug 24. doi: 10.1111/j.1471-4159.2010.06892.x

PMCID:: PMC7180986

Abstract Article PDF–881K

Select item 1001836510.

Cryo-EM structure of the fully assembled Elongator complex

Marcin Jaciuk, David Scherf, Karol Kaszuba, Monika Gaik, Alexander Rau, Anna Kościelniak, Rościsław Krutyhołowa, Michał Rawski, Paulina Indyka, Andrea Graziadei, Andrzej Chramiec-Głąbik, Anna Biela, Dominika Dobosz, Ting-Yu Lin, Nour-el-Hana Abbassi, Alexander Hammermeister, Juri Rappsilber, Jan Kosinski, Raffael Schaffrath, Sebastian Glatt

Nucleic Acids Res. 2023 Mar 21; 51(5): 2011–2032. Published online 2023 Jan 9. doi: 10.1093/nar/gkac1232

PMCID:: PMC10018365

Abstract Article PDF–12M

Select item 455379511.

Dimerization of elongator protein 1 is essential for Elongator complex assembly

Huisha Xu, Zhijie Lin, Fengzhi Li, Wentao Diao, Chunming Dong, Hao Zhou, Xingqiao Xie, Zheng Wang, Yuequan Shen, Jiafu Long

Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34): 10697–10702. Published online 2015 Aug 10. doi: 10.1073/pnas.1502597112

PMCID:: PMC4553795

Abstract Article PDF–1.2M

Select item 275791512.

The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

Qing Li, A. M. Fazly, Hui Zhou, Shengbing Huang, Zhiguo Zhang, Bruce Stillman

PLoS Genet. 2009 Oct; 5(10): e1000684. Published online 2009 Oct 16. doi: 10.1371/journal.pgen.1000684

PMCID:: PMC2757915

Abstract Article PDF–811K

Select item 12217413.

Human Elongator facilitates RNA polymerase II transcription through chromatin

Jae-Hyun Kim, William S. Lane, Danny Reinberg

Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3): 1241–1246. Published online 2002 Jan 29. doi: 10.1073/pnas.251672198

PMCID:: PMC122174

Abstract Article PDF–584K

Select item 54580814.

Histone modifications defining active genes persist after transcriptional and mitotic inactivation

Antigone Kouskouti, Iannis Talianidis

EMBO J. 2005 Jan 26; 24(2): 347–357. Published online 2004 Dec 16. doi: 10.1038/sj.emboj.7600516

PMCID:: PMC545808

Abstract Article PDF–448K

Select item 346332215.

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

Pierre Close, Magali Gillard, Aurélie Ladang, Zheshen Jiang, Jessica Papuga, Nicola Hawkes, Laurent Nguyen, Jean-Paul Chapelle, Fabrice Bouillenne, Jesper Svejstrup, Marianne Fillet, Alain Chariot

J Biol Chem. 2012 Sep 21; 287(39): 32535–32545. Published online 2012 Aug 1. doi: 10.1074/jbc.M112.402727

PMCID:: PMC3463322

Abstract Article PDF–4.0M

Select item 558468516.

Genetic interaction mapping in mammalian cells using CRISPR interference

Dan Du, Assen Roguev, David E Gordon, Meng Chen, Si-Han Chen, Michael Shales, John Paul Shen, Trey Ideker, Prashant Mali, Lei S Qi, Nevan J Krogan

Nat Methods. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Nat Methods. 2017 Jun; 14(6): 577–580. Published online 2017 May 8. doi: 10.1038/nmeth.4286

PMCID:: PMC5584685

Abstract Article PDF–540K

Select item 378499017.

Human CIA2A (FAM96A) and CIA2B (FAM96B) integrate maturation of different subsets of cytosolic-nuclear iron-sulfur proteins and iron homeostasis

Oliver Stehling, Judita Mascarenhas, Ajay A. Vashisht, Alex D. Sheftel, Brigitte Niggemeyer, Ralf Rösser, Antonio J. Pierik, James A. Wohlschlegel, Roland Lill

Cell Metab. Author manuscript; available in PMC 2014 Aug 6.

Published in final edited form as: Cell Metab. 2013 Aug 6; 18(2): 187–198. Published online 2013 Jul 25. doi: 10.1016/j.cmet.2013.06.015

Correction in:: Cell Metab. 2018 Jan 9; 27(1): 263.

PMCID:: PMC3784990

Abstract Article PDF–3.8M

Select item 509166818.

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Daniel C. Scott, David Y. Rhee, David M. Duda, Ian R. Kelsall, Jennifer L. Olszewski, Joao A. Paulo, Annemieke de Jong, Huib Ovaa, Arno F. Alpi, J. Wade Harper, Brenda A. Schulman

Cell. Author manuscript; available in PMC 2017 Aug 25.

Published in final edited form as: Cell. 2016 Aug 25; 166(5): 1198–1214.e24. doi: 10.1016/j.cell.2016.07.027

PMCID:: PMC5091668

Abstract Article PDF–4.2M

Select item 495798119.

The TIP60 complex is a conserved coactivator of HIF1A

Joel I. Perez-Perri, Veronica L. Dengler, K. Audrey Audetat, Ahwan Pandey, Elizabeth A. Bonner, Marjeta Urh, Jacqui Mendez, Danette L. Daniels, Pablo Wappner, Matthew D. Galbraith, Joaquín M. Espinosa

Cell Rep. Author manuscript; available in PMC 2016 Jul 22.

Published in final edited form as: Cell Rep. 2016 Jun 28; 16(1): 37–47. Published online 2016 Jun 16. doi: 10.1016/j.celrep.2016.05.082

PMCID:: PMC4957981

Abstract Article PDF–1.5M

Select item 342034020.

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

Oliver Stehling, Ajay A. Vashisht, Judita Mascarenhas, Zophonias O. Jonsson, Tanu Sharma, Daili J.A. Netz, Antonio J. Pierik, James A. Wohlschlegel, Roland Lill

Science. Author manuscript; available in PMC 2013 Jan 13.

Published in final edited form as: Science. 2012 Jul 13; 337(6091): 195–199. Published online 2012 Jun 7. doi: 10.1126/science.1219723

PMCID:: PMC3420340

Abstract Article PDF–1.8M

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PMC Links for Gene (Select 55140) (64)
PMC
elongator complex protein 3 isoform X1 [Homo sapiens]
elongator complex protein 3 isoform X1 [Homo sapiens]
gi|2462620018|ref|XP_054216724.1|

Protein
Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3), transcript va...
Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3), transcript variant 2, mRNA
gi|1675178308|ref|NM_001284220.2|

Nucleotide

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