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Select item 48950151.

Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese

Yuanfeng Li, Lanlan Si, Yun Zhai, Yanling Hu, Zhibin Hu, Jin-Xin Bei, Bobo Xie, Qian Ren, Pengbo Cao, Fei Yang, Qingfeng Song, Zhiyu Bao, Haitao Zhang, Yuqing Han, Zhifu Wang, Xi Chen, Xia Xia, Hongbo Yan, Rui Wang, Ying Zhang, Chengming Gao, Jinfeng Meng, Xinyi Tu, Xinqiang Liang, Ying Cui, Ying Liu, Xiaopan Wu, Zhuo Li, Huifen Wang, Zhaoxia Li, Bo Hu, Minghui He, Zhibo Gao, Xiaobing Xu, Hongzan Ji, Chaohui Yu, Yi Sun, Baocai Xing, Xiaobo Yang, Haiying Zhang, Aihua Tan, Chunlei Wu, Weihua Jia, Shengping Li, Yi-Xin Zeng, Hongbing Shen, Fuchu He, Zengnan Mo, Hongxing Zhang, Gangqiao Zhou

Nat Commun. 2016; 7: 11664. Published online 2016 May 31. doi: 10.1038/ncomms11664

PMCID:: PMC4895015

Abstract Article PDF–1.1M

Select item 51899422.

Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution

Jimmy Van den Eynden, Swaraj Basu, Erik Larsson

PLoS Genet. 2016 Dec; 12(12): e1006506. Published online 2016 Dec 27. doi: 10.1371/journal.pgen.1006506

PMCID:: PMC5189942

Abstract Article PDF–1.8M

Select item 79802243.

Structure of the catalytic core of the Integrator complex

Moritz M. Pfleiderer, Wojciech P. Galej

Mol Cell. 2021 Mar 18; 81(6): 1246–1259.e8. doi: 10.1016/j.molcel.2021.01.005

PMCID:: PMC7980224

Abstract Article

Select item 74275684.

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

Felipe Beckedorff, Ezra Blumenthal, Lucas Ferreira daSilva, Yuki Aoi, Pradeep Reddy Cingaram, Jingyin Yue, Anda Zhang, Sadat Dokaneheifard, Monica Guiselle Valencia, Gabriel Gaidosh, Ali Shilatifard, Ramin Shiekhattar

Cell Rep. Author manuscript; available in PMC 2020 Aug 14.

Published in final edited form as: Cell Rep. 2020 Jul 21; 32(3): 107917. doi: 10.1016/j.celrep.2020.107917

PMCID:: PMC7427568

Abstract Article PDF–2.8M

Select item 73475975.

INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Kevin Sabath, Melanie L. Stäubli, Sabrina Marti, Alexander Leitner, Murielle Moes, Stefanie Jonas

Nat Commun. 2020; 11: 3422. Published online 2020 Jul 9. doi: 10.1038/s41467-020-17232-2

PMCID:: PMC7347597

Abstract Article PDF–2.5M

Select item 33565606.

Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia

E Ellinghaus, M Stanulla, G Richter, D Ellinghaus, G te Kronnie, G Cario, G Cazzaniga, M Horstmann, R Panzer Grümayer, H Cavé, J Trka, O Cinek, A Teigler-Schlegel, A ElSharawy, R Häsler, A Nebel, B Meissner, T Bartram, F Lescai, C Franceschi, M Giordan, P Nürnberg, B Heinzow, M Zimmermann, S Schreiber, M Schrappe, A Franke

Leukemia. 2012 May; 26(5): 902–909. Published online 2011 Nov 11. doi: 10.1038/leu.2011.302

PMCID:: PMC3356560

Abstract Article PDF–456K

Select item 37719567.

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex

Jeanne N. Jodoin, Poojitha Sitaram, Todd R. Albrecht, Sarah B. May, Mohammad Shboul, Ethan Lee, Bruno Reversade, Eric J. Wagner, Laura A. Lee

Mol Biol Cell. 2013 Sep 15; 24(18): 2954–2965. doi: 10.1091/mbc.E13-05-0254

PMCID:: PMC3771956

Abstract Article PDF–2.0M

Select item 85678408.

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod J. Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph H.A. Vissers, Karolina Pavic, Ben P. Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, Isabella Y. Kong, Edwin D. Hawkins, Simon J. Hogg, Madison J. Kelly, Andrea Newbold, Kaylene J. Simpson, Otto Kauko, Kieran F. Harvey, Michael Ohlmeyer, Jukka Westermarck, Nathanael Gray, Alessandro Gardini, Ricky W. Johnstone

Cell. Author manuscript; available in PMC 2022 Jun 10.

Published in final edited form as: Cell. 2021 Jun 10; 184(12): 3143–3162.e32. Published online 2021 May 17. doi: 10.1016/j.cell.2021.04.022

PMCID:: PMC8567840

Abstract Article PDF–2.8M

Select item 24309189.

A RECQ5–RNA polymerase II association identified by targeted proteomic analysis of human chromatin

Ozan Aygün, Jesper Svejstrup, Yilun Liu

Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25): 8580–8584. Published online 2008 Jun 18. doi: 10.1073/pnas.0804424105

PMCID:: PMC2430918

Abstract Article PDF–696K

Select item 391760510.

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci

Daphna Weissglas-Volkov, Carlos A. Aguilar-Salinas, Elina Nikkola, Kerry A. Deere, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Linda Liliana Muñoz-Hernandez, Lizeth Gomez-Munguia, Maria Luisa Ordoñez-Sánchez, Prasad MV Linga Reddy, Aldons J. Lusis, Niina Matikainen, Marja-Riitta Taskinen, Laura Riba, Rita M. Cantor, Janet S. Sinsheimer, Teresa Tusie-Luna, Päivi Pajukanta

J Med Genet. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: J Med Genet. 2013 May; 50(5): 298–308. Published online 2013 Mar 15. doi: 10.1136/jmedgenet-2012-101461

PMCID:: PMC3917605

Abstract Article PDF–575K

Select item 282392211.

Streamlined analysis schema for high-throughput identification of endogenous protein complexes

Anna Malovannaya, Yehua Li, Yaroslava Bulynko, Sung Yun Jung, Yi Wang, Rainer B. Lanz, Bert W. O’Malley, Jun Qin

Proc Natl Acad Sci U S A. 2010 Feb 9; 107(6): 2431–2436. Published online 2010 Jan 22. doi: 10.1073/pnas.0912599106

Correction in:: Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13): 6118.

PMCID:: PMC2823922

Abstract Article PDF–566K

Select item 840561512.

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1

Hong Luo, Zhicheng Zhou, Shan Huang, Mengru Ma, Manyu Zhao, Lixu Tang, Yuan Quan, Yiming Zeng, Li Su, Jongchan Kim, Peijing Zhang

Cell Death Dis. 2021 Sep; 12(9): 820. Published online 2021 Aug 30. doi: 10.1038/s41419-021-04114-8

PMCID:: PMC8405615

Abstract Article PDF–3.5M

Select item 738231313.

MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

Gayoung Seo, Han Han, Rebecca Elizabeth Vargas, Bing Yang, Xu Li, Wenqi Wang

Cell Rep. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Cell Rep. 2020 Jul 7; 32(1): 107860. doi: 10.1016/j.celrep.2020.107860

PMCID:: PMC7382313

Abstract Article PDF–2.6M

Select item 546865014.

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

Ferdinand M. Huber, Sarah M. Greenblatt, Andrew M. Davenport, Concepcion Martinez, Ye Xu, Ly P. Vu, Stephen D. Nimer, André Hoelz

Proc Natl Acad Sci U S A. 2017 Jun 6; 114(23): 6016–6021. Published online 2017 May 22. doi: 10.1073/pnas.1700328114

PMCID:: PMC5468650

Abstract Article PDF–1.3M

Select item 892305715.

Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease

Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E. J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J. G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Cell. Author manuscript; available in PMC 2023 Mar 3.

Published in final edited form as: Cell. 2022 Mar 3; 185(5): 794–814.e30. Published online 2022 Feb 18. doi: 10.1016/j.cell.2022.01.021

PMCID:: PMC8923057

Abstract Article PDF–2.5M

Select item 889438016.

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd, Markus C. Wahl

Nat Commun. 2022; 13: 1132. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28754-2

PMCID:: PMC8894380

Abstract Article PDF–5.6M

Select item 734672617.

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

Kristina N. Schaefer, Mira I. Pronobis, Clara E. Williams, Shiping Zhang, Lauren Bauer, Dennis Goldfarb, Feng Yan, M. Ben Major, Mark Peifer

Mol Biol Cell. 2020 May 1; 31(10): 992–1014. doi: 10.1091/mbc.E19-11-0647

PMCID:: PMC7346726

Abstract Article PDF–5.5M

Select item 694204418.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 642009719.

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids

Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker, Benjamin M. Foster, Nhuong V. Nguyen, Tracey Beyer, Laura C. Cesa, Peter A. Faull, Saulius Lukauskas, Thomas Frimurer, J. Ross Chapman, Till Bartke, Anja Groth

Nat Cell Biol. Author manuscript; available in PMC 2019 Aug 25.

Published in final edited form as: Nat Cell Biol. 2019 Mar; 21(3): 311–318. Published online 2019 Feb 25. doi: 10.1038/s41556-019-0282-9

PMCID:: PMC6420097

Article PDF–1.7M

Select item 674682220.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

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