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Select item 105776381.

Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance

Irmina Garcia‐Carpio, Vincent Z Braun, Elias S Weiler, Marina Leone, Sergio Niñerola, Angel Barco, Luca L Fava, Andreas Villunger

EMBO J. 2023 Oct; 42(20): e113510. Published online 2023 Aug 2. doi: 10.15252/embj.2023113510

PMCID:: PMC10577638

Article PDF–4.5M

Select item 83850732.

Pathogenic variants in PIDD1 lead to an autosomal recessive neurodevelopmental disorder with pachygyria and psychiatric features

Maha S. Zaki, Andrea Accogli, Ghayda Mirzaa, Fatima Rahman, Hiba Mohammed, Gloria Liliana Porras-Hurtado, Stephanie Efthymiou, Shazia Maqbool, Anju Shukla, John B. Vincent, Abrar Hussain, Asif Mir, Christian Beetz, Anika Leubauer, Henry Houlden, Joseph G. Gleeson, Reza Maroofian

Eur J Hum Genet. 2021 Aug; 29(8): 1226–1234. Published online 2021 Jun 24. doi: 10.1038/s41431-021-00910-0

PMCID:: PMC8385073

Article PDF–3.0M

Select item 77910373.

Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability

Taimoor I. Sheikh, Nasim Vasli, Stephen Pastore, Kimia Kharizi, Ricardo Harripaul, Zohreh Fattahi, Shruti Pande, Farooq Naeem, Abrar Hussain, Asif Mir, Omar Islam, Katta Mohan Girisha, Muhammad Irfan, Muhammad Ayub, Christoph Schwarzer, Hossein Najmabadi, Anju Shukla, Valentina C. Sladky, Vincent Zoran Braun, Irmina Garcia-Carpio, Andreas Villunger, John B. Vincent

Transl Psychiatry. 2021; 11: 1. Published online 2021 Jan 5. doi: 10.1038/s41398-020-01158-w

PMCID:: PMC7791037

Article PDF–1.5M

Select item 31319914.

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90

A Tinel, M J Eckert, E Logette, S Lippens, S Janssens, B Jaccard, M Quadroni, J Tschopp

Cell Death Differ. 2011 Mar; 18(3): 506–515. Published online 2010 Oct 22. doi: 10.1038/cdd.2010.124

PMCID:: PMC3131991

Article PDF–748K

Select item 23601895.

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

G Bradley, S Tremblay, J Irish, C MacMillan, G Baker, P Gullane, S Benchimol

Br J Cancer. 2007 May 7; 96(9): 1425–1432. Published online 2007 Apr 17. doi: 10.1038/sj.bjc.6603745

PMCID:: PMC2360189

Article PDF–309K

Select item 23301816.

Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD

Hyun Ho Park, Hao Wu

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1; 63(Pt 3): 229–232. Published online 2007 Feb 23. doi: 10.1107/S1744309107007889

PMCID:: PMC2330181

Article PDF–247K

Select item 67765077.

Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder

Laura Pineda-Cirera, Anu Shivalikanjli, Judit Cabana-Domínguez, Ditte Demontis, Veera M. Rajagopal, Anders D. Børglum, Stephen V. Faraone, Bru Cormand, Noèlia Fernàndez-Castillo

Transl Psychiatry. 2019; 9: 242. Published online 2019 Oct 3. doi: 10.1038/s41398-019-0574-7

PMCID:: PMC6776507

Article PDF–1.4M

Select item 67120448.

PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC

Lili Ji, Rui Zhang, Jie Chen, Qun Xue, Nadeem Moghal, Ming-Sound Tsao

Sci Rep. 2019; 9: 12437. Published online 2019 Aug 27. doi: 10.1038/s41598-019-48763-4

PMCID:: PMC6712044

Article PDF–5.9M

Select item 50979459.

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

Nataliya Di Donato, Ying Y. Jean, A. Murat Maga, Briana D. Krewson, Alison B. Shupp, Maria I. Avrutsky, Achira Roy, Sarah Collins, Carissa Olds, Rebecca A. Willert, Agnieszka M. Czaja, Rachel Johnson, Jessi A. Stover, Steven Gottlieb, Deborah Bartholdi, Anita Rauch, Amy Goldstein, Victoria Boyd-Kyle, Kimberly A. Aldinger, Ghayda M. Mirzaa, Anke Nissen, Karlla W. Brigatti, Erik G. Puffenberger, Kathleen J. Millen, Kevin A. Strauss, William B. Dobyns, Carol M. Troy, Robert N. Jinks

Am J Hum Genet. 2016 Nov 3; 99(5): 1117–1129. Published online 2016 Oct 20. doi: 10.1016/j.ajhg.2016.09.010

PMCID:: PMC5097945

Article PDF–1.3M

Select item 461928810.

PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs

Sebastian Heikaus, Igor Pejin, Helmut Erich Gabbert, Uwe Ramp, Csaba Mahotka

Cell Oncol. 2010; 32(1-2): 29–42. Published online 2010 Feb 4. doi: 10.3233/CLO-2009-0492

PMCID:: PMC4619288

Abstract PDF–543K

Select item 445819311.

An Inhibitor of PIDDosome Formation

Ruth Thompson, Richa B. Shah, Peter H. Liu, Yogesh Gupta, Kiyohiro Ando, Aneel K. Aggarwal, Samuel Sidi

Mol Cell. Author manuscript; available in PMC 2016 Jun 4.

Published in final edited form as: Mol Cell. 2015 Jun 4; 58(5): 767–779. Published online 2015 Apr 30. doi: 10.1016/j.molcel.2015.03.034

PMCID:: PMC4458193

Article PDF–2.5M

Select item 285439712.

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

Trudy G. Oliver, Kim L. Mercer, Leanne C. Sayles, James R. Burke, Diana Mendus, Katherine S. Lovejoy, Mei-Hsin Cheng, Aravind Subramanian, David Mu, Scott Powers, Denise Crowley, Roderick T. Bronson, Charles A. Whittaker, Arjun Bhutkar, Stephen J. Lippard, Todd Golub, Juergen Thomale, Tyler Jacks, E. Alejandro Sweet-Cordero

Genes Dev. 2010 Apr 15; 24(8): 837–852. doi: 10.1101/gad.1897010

PMCID:: PMC2854397

Article PDF–1.8M

Select item 253886113.

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

Nicole Baptiste-Okoh, Anthony M. Barsotti, Carol Prives

Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6): 1937–1942. Published online 2008 Jan 31. doi: 10.1073/pnas.0711800105

PMCID:: PMC2538861

Article PDF–803K

Select item 582974714.

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

Yu-Fen Lin, Hung-Ying Shih, Zeng-Fu Shang, Ching-Te Kuo, Jiaming Guo, Chunying Du, Hsinyu Lee, Benjamin P C Chen

Nucleic Acids Res. 2018 Feb 28; 46(4): 1847–1859. Published online 2018 Jan 4. doi: 10.1093/nar/gkx1298

Correction in:: Nucleic Acids Res. 2023 Jun 9; 51(10): 5298–5299.

PMCID:: PMC5829747

Article PDF–8.1M

Select item 344462015.

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath Versus Prosurvival PIDDosome Signaling

Kiyohiro Ando, Jennifer L. Kernan, Peter H. Liu, Takaomi Sanda, Emmanuelle Logette, Jurg Tschopp, A. Thomas Look, Jianlong Wang, Lisa Bouchier-Hayes, Samuel Sidi

Mol Cell. Author manuscript; available in PMC 2013 Sep 14.

Published in final edited form as: Mol Cell. 2012 Sep 14; 47(5): 681–693. Published online 2012 Jul 30. doi: 10.1016/j.molcel.2012.06.024

PMCID:: PMC3444620

Article PDF–2.3M

Select item 178237716.

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway

Antoine Tinel, Sophie Janssens, Saskia Lippens, Solange Cuenin, Emmanuelle Logette, Bastienne Jaccard, Manfredo Quadroni, Jürg Tschopp

EMBO J. 2007 Jan 10; 26(1): 197–208. Published online 2006 Dec 7. doi: 10.1038/sj.emboj.7601473

PMCID:: PMC1782377

Article PDF–393K

Select item 345893017.

Cytoplasmic and Nuclear Anti-Apoptotic Roles of αB-Crystallin in Retinal Pigment Epithelial Cells

Woo Jin Jeong, Jee Hyun Rho, Young Geol Yoon, Seung Hee Yoo, Na Young Jeong, Won Yeol Ryu, Hee Bae Ahn, Woo Chan Park, Sae Heun Rho, Hee Seong Yoon, Yung Hyun Choi, Young Hyun Yoo

PLoS One. 2012; 7(9): e45754. Published online 2012 Sep 26. doi: 10.1371/journal.pone.0045754

PMCID:: PMC3458930

Article PDF–4.7M

Select item 298891218.

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J. Rice, Anthony C. Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser, Carol V. Robinson, Richard M. Siegel, Thomas Walz, Hao Wu

Nat Struct Mol Biol. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2010 Nov; 17(11): 1324–1329. Published online 2010 Oct 10. doi: 10.1038/nsmb.1920

PMCID:: PMC2988912

Article PDF–1.6M

Select item 546101519.

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

Kiyohiro Ando, Melissa J. Parsons, Richa B. Shah, Chloé I. Charendoff, Sheré L. Paris, Peter H. Liu, Sara R. Fassio, Brittany A. Rohrman, Ruth Thompson, Andrew Oberst, Samuel Sidi, Lisa Bouchier-Hayes

J Cell Biol. 2017 Jun 5; 216(6): 1795–1810. doi: 10.1083/jcb.201608095

PMCID:: PMC5461015

Article PDF–2.8M

Select item 316028320.

Caspase-2-mediated cleavage of Mdm2 creates p53-induced positive feedback loop

Trudy G. Oliver, Etienne Meylan, Gregory P. Chang, Wen Xue, James R. Burke, Timothy J. Humpton, Diana Hubbard, Arjun Bhutkar, Tyler Jacks

Mol Cell. Author manuscript; available in PMC 2012 Jan 8.

Published in final edited form as: Mol Cell. 2011 Jul 8; 43(1): 57–71. doi: 10.1016/j.molcel.2011.06.012

PMCID:: PMC3160283

Article PDF–1.5M

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