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Select item 91891291.

Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins

Thomas M. Leissing, Adam P. Hardy, Hokfung Chan, Yihua Wang, Anthony Tumber, Rasheduzzaman Chowdhury, Tianshu Feng, Mathew L. Coleman, Matthew E. Cockman, Holger B. Kramer, Georgina Berridge, Roman Fischer, Benedikt M. Kessler, Peter J. Ratcliffe, Xin Lu, Christopher J. Schofield

J Biol Chem. 2022 Jun; 298(6): 102020. Published online 2022 May 7. doi: 10.1016/j.jbc.2022.102020

PMCID:: PMC9189129

Abstract Article PDF–2.5M

Select item 51616132.

The facial triad in the α-ketoglutarate dependent oxygenase FIH: a role for sterics in linking substrate binding to O₂ activation

John A. Hangasky, Cornelius Y. Taabazuing, Cristina B. Martin, Scott J. Eron, Michael J. Knapp

J Inorg Biochem. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: J Inorg Biochem. 2017 Jan; 166: 26–33. Published online 2016 Oct 17. doi: 10.1016/j.jinorgbio.2016.10.007

PMCID:: PMC5161613

Abstract Article PDF–1.1M

Select item 42839353.

The Rate-Limiting Step of O₂ Activation in the α-Ketoglutarate Oxygenase Factor Inhibiting Hypoxia Inducible Factor

John A. Hangasky, Hasand Gandhi, Meaghan A. Valliere, Nathaniel E. Ostrom, Michael J. Knapp

Biochemistry. 2014 Dec 30; 53(51): 8077–8084. Published online 2014 Nov 25. doi: 10.1021/bi501246v

PMCID:: PMC4283935

Abstract Article PDF–960K

Select item 40595184.

Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting HIF (FIH-1)

John Hangasky, Evren Saban, Michael J. Knapp

Biochemistry. Author manuscript; available in PMC 2014 Jun 16.

Published in final edited form as: Biochemistry. 2013 Mar 5; 52(9): 1594–1602. Published online 2013 Feb 18. doi: 10.1021/bi3015482

PMCID:: PMC4059518

Abstract Article PDF–912K

Select item 34052665.

MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism

Han Peng, Robert B. Hamanaka, Julia Katsnelson, Liang-Liang Hao, Wending Yang, Navdeep S. Chandel, Robert M. Lavker

FASEB J. 2012 Aug; 26(8): 3140–3147. doi: 10.1096/fj.11-198515

PMCID:: PMC3405266

Abstract Article

Select item 32588536.

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

Kirsty S. Hewitson, Samantha L. Holmes, Dominic Ehrismann, Adam P. Hardy, Rasheduzzaman Chowdhury, Christopher J. Schofield, Michael A. McDonough

J Biol Chem. 2008 Sep 19; 283(38): 25971–25978. doi: 10.1074/jbc.M804999200

PMCID:: PMC3258853

Abstract Article PDF–525K

Select item 30819187.

Uncoupled O₂-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species

Evren Saban, Shannon C. Flagg, Michael J. Knapp

J Inorg Biochem. Author manuscript; available in PMC 2012 May 1.

Published in final edited form as: J Inorg Biochem. 2011 May; 105(5): 630–636. Published online 2011 Jan 21. doi: 10.1016/j.jinorgbio.2011.01.007

PMCID:: PMC3081918

Abstract Article PDF–1.2M

Select item 26498158.

Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

Matthew E. Cockman, James D. Webb, Holger B. Kramer, Benedikt M. Kessler, Peter J. Ratcliffe

Mol Cell Proteomics. 2009 Mar; 8(3): 535–546. doi: 10.1074/mcp.M800340-MCP200

PMCID:: PMC2649815

Abstract Article PDF–475K

Select item 22461929.

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

Ern Yu Tan, Leticia Campo, Cheng Han, Helen Turley, Francesco Pezzella, Kevin C Gatter, Adrian L Harris, Stephen B Fox

Breast Cancer Res. 2007; 9(6): R89. Published online 2007 Dec 20. doi: 10.1186/bcr1838

PMCID:: PMC2246192

Abstract Article PDF–1.0M

Select item 986956810.

Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation

Ning Li, Qianyin Zhou, Zhang Yi, Huan Zhang, Dai Zhou

Biol Res. 2023; 56: 4. Published online 2023 Jan 23. doi: 10.1186/s40659-023-00413-w

PMCID:: PMC9869568

Abstract Article PDF–7.6M

Select item 493530611.

Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1

Ke Liang, Xue-qin Ding, Chen Lin, Y James Kang

Exp Biol Med (Maywood) 2015 Nov; 240(11): 1446–1451. doi: 10.1177/1535370215570821

PMCID:: PMC4935306

Abstract Article PDF–430K

Select item 452813512.

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor

Hanna Tarhonskaya, Adam P. Hardy, Emily A. Howe, Nikita D. Loik, Holger B. Kramer, James S. O. McCullagh, Christopher J. Schofield, Emily Flashman

J Biol Chem. 2015 Aug 7; 290(32): 19726–19742. Published online 2015 Jun 25. doi: 10.1074/jbc.M115.653014

PMCID:: PMC4528135

Abstract Article PDF–1.9M

Select item 428467713.

Variants of the Low Oxygen Sensors EGLN1 and HIF-1AN Associated with Acute Mountain Sickness

Enhao Zhang, Jihang Zhang, Jun Jin, Jun Qin, Huijie Li, Lan Huang

Int J Mol Sci. 2014 Dec; 15(12): 21777–21787. Published online 2014 Nov 26. doi: 10.3390/ijms151221777

PMCID:: PMC4284677

Abstract Article PDF–793K

Select item 426398314.

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

Tomohiro Umezu, Hiroko Tadokoro, Kenko Azuma, Seiichiro Yoshizawa, Kazuma Ohyashiki, Junko H. Ohyashiki

Blood. 2014 Dec 11; 124(25): 3748–3757. Prepublished online 2014 Oct 15. doi: 10.1182/blood-2014-05-576116

PMCID:: PMC4263983

Abstract Article

Select item 402607415.

MicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1α (FIH-1)

Tao Chen, Li-Qing Yao, Qiang Shi, Zhong Ren, Le-Chi Ye, Jian-Min Xu, Ping-Hong Zhou, Yun-Shi Zhong

Cancer Biol Ther. 2014 May 1; 15(5): 516–523. Published online 2014 Feb 12. doi: 10.4161/cbt.28017

PMCID:: PMC4026074

Abstract Article PDF–2.4M

Select item 390047816.

The Role of Factor Inhibiting HIF (FIH-1) in Inhibiting HIF-1 Transcriptional Activity in Glioblastoma Multiforme

Enfeng Wang, Chunyang Zhang, Navatha Polavaram, Fengming Liu, Gang Wu, Mark A. Schroeder, Julie S. Lau, Debabrata Mukhopadhyay, Shi-Wen Jiang, Brian Patrick O'Neill, Kaustubh Datta, Jinping Li

PLoS One. 2014; 9(1): e86102. Published online 2014 Jan 23. doi: 10.1371/journal.pone.0086102