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Select item 48503131.

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site

Silke Kleinboelting, Lavoisier Ramos-Espiritu, Hannes Buck, Laureen Colis, Joop van den Heuvel, J. Fraser Glickman, Lonny R. Levin, Jochen Buck, Clemens Steegborn

J Biol Chem. 2016 Apr 29; 291(18): 9776–9784. Published online 2016 Mar 9. doi: 10.1074/jbc.M115.708255

PMCID:: PMC4850313

Abstract Article PDF–1.4M

Select item 38363112.

Pharmacological Distinction between Soluble and Transmembrane Adenylyl Cyclases

Jacob L. Bitterman, Lavoisier Ramos-Espiritu, Ana Diaz, Lonny R. Levin, Jochen Buck

J Pharmacol Exp Ther. 2013 Dec; 347(3): 589–598. Published online 2013 Dec. doi: 10.1124/jpet.113.208496

PMCID:: PMC3836311

Abstract Article PDF–711K

Select item 35615353.

Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells

Jan-Paul Flacke, Hanna Flacke, Avinash Appukuttan, Rein-Jüri Palisaar, Joachim Noldus, Brian D. Robinson, H. Peter Reusch, Jonathan H. Zippin, Yury Ladilov

J Biol Chem. 2013 Feb 1; 288(5): 3126–3135. Published online 2012 Dec 19. doi: 10.1074/jbc.M112.403279

PMCID:: PMC3561535

Abstract Article PDF–1.8M

Select item 34754524.

Identification of a haem domain in human soluble adenylate cyclase

Sabine Middelhaufe, Martina Leipelt, Lonny R. Levin, Jochen Buck, Clemens Steegborn

Biosci Rep. 2012 Oct 1; 32(Pt 5): 491–499. Prepublished online 2012 Jul 10. Published online 2012 Aug 8. doi: 10.1042/BSR20120051

PMCID:: PMC3475452

Abstract Article PDF–683K

Select item 30824395.

Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases

Jonathan H. Zippin, Paul A. Chadwick, Lonny R. Levin, Jochen Buck, Cynthia M. Magro

J Invest Dermatol. Author manuscript; available in PMC 2011 Apr 26.

Published in final edited form as: J Invest Dermatol. 2010 May; 130(5): 1279–1287. Published online 2010 Feb 4. doi: 10.1038/jid.2009.440

PMCID:: PMC3082439

Abstract Article PDF–1.8M

Select item 28226586.

Association of Adenylate Cyclase 10 (ADCY10) Polymorphisms and Bone Mineral Density in Healthy Adults

Shoji Ichikawa, Daniel L. Koller, Leah R. Curry, Dongbing Lai, Xiaoling Xuei, Howard J. Edenberg, Siu L. Hui, Munro Peacock, Tatiana Foroud, Michael J. Econs

Calcif Tissue Int. Author manuscript; available in PMC 2010 Feb 16.

Published in final edited form as: Calcif Tissue Int. 2009 Feb; 84(2): 97. Published online 2008 Dec 18. doi: 10.1007/s00223-008-9200-z

PMCID:: PMC2822658

Abstract Article PDF–96K

Select item 1968637.

Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa

Bijay S. Jaiswal, Marco Conti

Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19): 10676–10681. Published online 2003 Sep 4. doi: 10.1073/pnas.1831008100

PMCID:: PMC196863

Abstract Article PDF–408K

Select item 80587078.

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma

Xiao Zhang, Keke Yu, Lifang Ma, Zijun Qian, Xiaoting Tian, Yayou Miao, Yongjie Niu, Xin Xu, Susu Guo, Yueyue Yang, Zhixian Wang, Xiangfei Xue, Chuanjia Gu, Wentao Fang, Jiayuan Sun, Yongchun Yu, Jiayi Wang

Theranostics. 2021; 11(12): 5650–5674. Published online 2021 Mar 24. doi: 10.7150/thno.55482

PMCID:: PMC8058707

Abstract Article PDF–4.3M

Select item 65140059.

Soluble adenylyl cyclase links Ca²⁺ entry to Ca²⁺/cAMP-response element binding protein (CREB) activation in vascular smooth muscle

Tony Parker, Kai-Wen Wang, Declan Manning, Caroline Dart

Sci Rep. 2019; 9: 7317. Published online 2019 May 13. doi: 10.1038/s41598-019-43821-3

PMCID:: PMC6514005

Abstract Article PDF–2.9M

Select item 646889210.

Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Paola Tanzarella, Anna Ferretta, Simona Nicol Barile, Mariella Ancona, Domenico De Rasmo, Anna Signorile, Sergio Papa, Nazzareno Capitanio, Consiglia Pacelli, Tiziana Cocco

Cells. 2019 Mar; 8(3): 250. Published online 2019 Mar 15. doi: 10.3390/cells8030250

PMCID:: PMC6468892

Abstract Article PDF–3.9M

Select item 474682311.

Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function

Pedro Ivonnet, Hoshang Unwalla, Matthias Salathe, Gregory E. Conner

Respir Res. 2016; 17: 15. Published online 2016 Feb 8. doi: 10.1186/s12931-016-0329-4

PMCID:: PMC4746823

Abstract Article PDF–1.6M

Select item 395617912.

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

Silke Kleinboelting, Ana Diaz, Sebastien Moniot, Joop van den Heuvel, Michael Weyand, Lonny R. Levin, Jochen Buck, Clemens Steegborn

Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10): 3727–3732. Published online 2014 Feb 24. doi: 10.1073/pnas.1322778111

PMCID:: PMC3956179

Abstract Article PDF–1.4M

Select item 382917413.

CO₂/HCO₃⁻- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor

Jonathan H. Zippin, Yanqiu Chen, Susanne G. Straub, Kenneth C. Hess, Ana Diaz, Dana Lee, Patrick Tso, George G. Holz, Geoffrey W. G. Sharp, Lonny R. Levin, Jochen Buck

J Biol Chem. 2013 Nov 15; 288(46): 33283–33291. Published online 2013 Oct 7. doi: 10.1074/jbc.M113.510073

Correction in:: J Biol Chem. 2014 May 2; 289(18): 12679.

PMCID:: PMC3829174

Abstract Article PDF–1.7M

Select item 308246114.

The “Soluble” Adenylyl Cyclase in Sperm Mediates Multiple Signaling Events Required for Fertilization

Kenneth C. Hess, Brian H. Jones, Becky Marquez, Yanqiu Chen, Teri S. Ord, Margarita Kamenetsky, Catarina Miyamoto, Jonathan H. Zippin, Gregory S. Kopf, Susan S. Suarez, Lonny R. Levin, Carmen J. Williams, Jochen Buck, Stuart B. Moss

Dev Cell. Author manuscript; available in PMC 2011 Apr 26.

Published in final edited form as: Dev Cell. 2005 Aug; 9(2): 249–259. doi: 10.1016/j.devcel.2005.06.007

PMCID:: PMC3082461

Abstract Article PDF–839K

Select item 215436015.

Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP

Andreas Schmid, Zoltan Sutto, Marie-Christine Nlend, Gabor Horvath, Nathalie Schmid, Jochen Buck, Lonny R. Levin, Gregory E. Conner, Nevis Fregien, Matthias Salathe

J Gen Physiol. 2007 Jul; 130(1): 99–109. doi: 10.1085/jgp.200709784

PMCID:: PMC2154360

Abstract Article PDF–2.1M

Select item 1509616.

Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals

Jochen Buck, Meeghan L. Sinclair, Lissy Schapal, Martin J. Cann, Lonny R. Levin

Proc Natl Acad Sci U S A. 1999 Jan 5; 96(1): 79–84. doi: 10.1073/pnas.96.1.79

PMCID:: PMC15096

Abstract Article PDF–268K

Select item 330884717.

Regulation of Anterior Chamber Drainage by Bicarbonate-sensitive Soluble Adenylyl Cyclase in the Ciliary Body

Yong S. Lee, Martin Tresguerres, Kenneth Hess, Lihua Y. Marmorstein, Lonny R. Levin, Jochen Buck, Alan D. Marmorstein

J Biol Chem. 2011 Dec 2; 286(48): 41353–41358. Published online 2011 Oct 12. doi: 10.1074/jbc.M111.284679

PMCID:: PMC3308847

Abstract Article PDF–1.8M

Select item 278354418.

Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study

Georg B Ehret, Ashley A O'Connor, Alan Weder, Richard S Cooper, Aravinda Chakravarti

Eur J Hum Genet. 2009 Dec; 17(12): 1650–1657. Published online 2009 Jun 17. doi: 10.1038/ejhg.2009.94

PMCID:: PMC2783544

Abstract Article PDF–494K

Select item 572549419.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr

Nat Commun. 2017; 8: 2039. Published online 2017 Dec 11. doi: 10.1038/s41467-017-02146-3