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Select item 102760511.

TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway

Wenjie Wu, Jialuo Xu, Dan Gao, Zhenliang Xie, Wenjing Chen, Wenjing Li, Qiang Yuan, Lina Duan, Yuhan Zhang, Xiaoxiao Yang, Yingying Chen, Ziming Dong, Kangdong Liu, Yanan Jiang

Cell Death Dis. 2023 Jun; 14(6): 364. Published online 2023 Jun 16. doi: 10.1038/s41419-023-05883-0

PMCID:: PMC10276051

Abstract Article PDF–6.0M

Select item 95209222.

Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis

Liang Qiao, Jinling Ba, Jiping Xie, Ruiping Zhu, Yi Wan, Min Zhang, Zeyu Jin, Zicheng Guo, Jiaxuan Yu, Sijing Chen, Yongqiang Yao

World J Surg Oncol. 2022; 20: 316. Published online 2022 Sep 28. doi: 10.1186/s12957-022-02769-x

PMCID:: PMC9520922

Abstract Article PDF–1.3M

Select item 93559413.

PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer

Hanlin Ma, Gonghua Qi, Fang Han, Jiali Peng, Cunzhong Yuan, Beihua Kong

Exp Mol Med. 2022 Jul; 54(7): 999–1010. Published online 2022 Jul 20. doi: 10.1038/s12276-022-00809-w

PMCID:: PMC9355941

Abstract Article PDF–6.1M

Select item 91642634.

Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma

Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min Li

Oncol Rep. 2022 Jul; 48(1): 125. Published online 2022 May 19. doi: 10.3892/or.2022.8336

PMCID:: PMC9164263

Abstract Article PDF–6.3M

Select item 89737845.

Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway

Jieke Cui, Rong Guo, Yingjun Wang, Yue Song, Xuewen Song, Hongwen Li, Xiaoqin Song, Jiwei Li

Bioengineered. 2022; 13(2): 4428–4440. Published online 2022 Feb 9. doi: 10.1080/21655979.2022.2034584

PMCID:: PMC8973784

Abstract Article PDF–3.2M

Select item 86375636.

T‐LAK cell‐originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma

Pichaya Thanindratarn, Ran Wei, Dylan C. Dean, Arun Singh, Noah Federman, Scott D. Nelson, Francis J. Hornicek, Zhenfeng Duan

Mol Oncol. 2021 Dec; 15(12): 3721–3737. Published online 2021 Jun 29. doi: 10.1002/1878-0261.13039

Expression of Concern in:: Mol Oncol. 2024 Oct; 18(10): 2601.

PMCID:: PMC8637563

Abstract Article PDF–2.8M

Select item 76592437.

Overexpression of T‐LAK cell‐originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma

Di‐Cing Wei, Yi‐Chen Yeh, Jung‐Jyh Hung, Teh‐Ying Chou, Yu‐Chung Wu, Pei‐Jung Lu, Hui‐Chuan Cheng, Yu‐Lin Hsu, Yu‐Lun Kuo, Kuan‐Yu Chen, Jin‐Mei Lai

Cancer Sci. 2012 Apr; 103(4): 731–738. Published online 2012 Feb 3. doi: 10.1111/j.1349-7006.2011.02197.x

PMCID:: PMC7659243

Abstract Article PDF–505K

Select item 74620348.

Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells

Akinobu Ota, Ichiro Hanamura, Sivasundaram Karnan, Shingo Inaguma, Norio Takei, Vu Quang Lam, Shohei Mizuno, Jo Kanasugi, Md Wahiduzzaman, Md Lutfur Rahman, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Hiroshi Ikeda, Akiyoshi Takami, Yoshitaka Hosokawa

J Interferon Cytokine Res. August 2020; 40(8): 389–405. Published online 2020 Aug 14. doi: 10.1089/jir.2020.0111

PMCID:: PMC7462034

Abstract Article PDF–1.2M

Select item 73148049.

A novel loss-of-function mutation of PBK associated with human kidney stone disease

Choochai Nettuwakul, Nunghathai Sawasdee, Oranud Praditsap, Nanyawan Rungroj, Arnat Pasena, Thanyaporn Dechtawewat, Nipaporn Deejai, Suchai Sritippayawan, Santi Rojsatapong, Wipada Chaowagul, Pa-thai Yenchitsomanus

Sci Rep. 2020; 10: 10282. Published online 2020 Jun 24. doi: 10.1038/s41598-020-66936-4

PMCID:: PMC7314804

Abstract Article PDF–3.4M

Select item 693856810.

Targeting PDZ Binding Kinase Is Anti-tumorigenic in Novel Preclinical Models of ACC

Adwitiya Kar, Yu Zhang, Betelehem W. Yacob, Jordan Saeed, Kenneth D. Tompkins, Stacey M. Bagby, Todd M. Pitts, Hilary Somerset, Stephen Leong, Margaret E. Wierman, Katja Kiseljak-Vassiliades

Endocr Relat Cancer. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Endocr Relat Cancer. 2019 Oct; 26(10): 765–778. doi: 10.1530/ERC-19-0262

PMCID:: PMC6938568

Abstract Article PDF–2.2M

Select item 693773211.

TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu, Ziming Dong

BMC Cancer. 2019; 19: 1264. Published online 2019 Dec 30. doi: 10.1186/s12885-019-6453-z

Correction in:: BMC Cancer. 2020; 20: 43.

PMCID:: PMC6937732

Abstract Article PDF–7.7M

Select item 672585012.

PBK/TOPK, a Proliferating Neural Progenitor-Specific Mitogen-Activated Protein Kinase Kinase

J. D. Dougherty, A. D. R. Garcia, I. Nakano, M. Livingstone, B. Norris, R. Polakiewicz, E. M. Wexler, M. V. Sofroniew, H. I. Kornblum, D. H. Geschwind

J Neurosci. 2005 Nov 16; 25(46): 10773–10785. doi: 10.1523/JNEUROSCI.3207-05.2005

PMCID:: PMC6725850

Abstract Article PDF–1.6M

Select item 637938113.

PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

Hanlin Ma, Yingwei Li, Xiangxiang Wang, Huan Wu, Gonghua Qi, Rongrong Li, Ning Yang, Min Gao, Shi Yan, Cunzhong Yuan, Beihua Kong

Cell Death Dis. 2019 Mar; 10(3): 166. Published online 2019 Feb 18. doi: 10.1038/s41419-019-1415-6

PMCID:: PMC6379381

Abstract Article PDF–8.4M

Select item 617187614.

Cytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays

Tzu-Cheng Su, Chun-Yu Chen, Wen-Che Tsai, Hui-Ting Hsu, Hsu-Heng Yen, Wen-Wei Sung, Chih-Jung Chen

PLoS One. 2018; 13(10): e0204866. Published online 2018 Oct 4. doi: 10.1371/journal.pone.0204866

PMCID:: PMC6171876

Abstract Article PDF–11M

Select item 555868515.

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

Giacomo Pirovano, Thomas M Ashton, Katharine J Herbert, Richard J Bryant, Clare L Verrill, Lucia Cerundolo, Francesca M Buffa, Remko Prevo, Iona Harrap, Anderson J Ryan, Valentine Macaulay, William G McKenna, Geoff S Higgins

Br J Cancer. 2017 Aug 8; 117(4): 503–512. Published online 2017 Jul 4. doi: 10.1038/bjc.2017.197

PMCID:: PMC5558685

Abstract Article PDF–1.1M

Select item 552225416.

Role of TOPK in lipopolysaccharide-induced breast cancer cell migration and invasion

Min-Ah Seol, Jung-Hwan Park, Ji Heun Jeong, Jungmook Lyu, Seung Yun Han, Sang-Muk Oh

Oncotarget. 2017 Jun 20; 8(25): 40190–40203. Published online 2017 Feb 15. doi: 10.18632/oncotarget.15360

PMCID:: PMC5522254

Abstract Article PDF–24M

Select item 540519617.

The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis

Tatyana A. Zykova, Feng Zhu, Lei Wang, Haitao Li, Ruihua Bai, Do Young Lim, Ke Yao, Ann M. Bode, Zigang Dong

EBioMedicine. 2017 Apr; 18: 73–82. Published online 2017 Apr 6. doi: 10.1016/j.ebiom.2017.04.003

PMCID:: PMC5405196

Abstract Article PDF–2.5M

Select item 532318818.

Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase

Xinhua Song, Shutao Yin, Enxiang Zhang, Lihong Fan, Min Ye, Yong Zhang, Hongbo Hu

Oncotarget. 2016 Oct 4; 7(40): 65732–65743. Published online 2016 Aug 25. doi: 10.18632/oncotarget.11610

PMCID:: PMC5323188

Abstract Article PDF–8.2M

Select item 524398619.

Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

Takuma Ohashi, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Wataru Okajima, Taisuke Imamura, Jun Kiuchi, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Hitoshi Tsuda, Eigo Otsuji

Br J Cancer. 2017 Jan 17; 116(2): 218–226. Published online 2016 Nov 29. doi: 10.1038/bjc.2016.394

PMCID:: PMC5243986

Abstract Article PDF–1.3M

Select item 496438320.

PBK/TOPK Expression Predicts Prognosis in Oral Cancer

Chin-Fang Chang, Sung-Lang Chen, Wen-Wei Sung, Ming-Ju Hsieh, Hui-Ting Hsu, Li-Hsin Chen, Mu-Kuan Chen, Jiunn-Liang Ko, Chih-Jung Chen, Ming-Chih Chou

Int J Mol Sci. 2016 Jul; 17(7): 1007. Published online 2016 Jun 24. doi: 10.3390/ijms17071007