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Select item 90428561.

Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma

Eijiro Shimada, Yoshihiro Matsumoto, Makoto Nakagawa, Yosuke Susuki, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Keiichiro Iida, Akira Nabeshima, Kenichiro Yahiro, Atsushi Kimura, Takeshi Hirose, Masaya Kanahori, Ryunosuke Oyama, Yoshinao Oda, Yasuharu Nakashima

Br J Cancer. 2022 May 18; 126(9): 1289–1300. Published online 2022 Jan 11. doi: 10.1038/s41416-021-01695-1

PMCID:: PMC9042856

Abstract Article PDF–4.8M

Select item 81247752.

Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively

Khalida Perveen, Alex Quach, Andrew McPhee, Susan L. Prescott, Simon C. Barry, Charles S. Hii, Antonio Ferrante

Int J Mol Sci. 2021 May; 22(9): 4907. Published online 2021 May 5. doi: 10.3390/ijms22094907

PMCID:: PMC8124775

Abstract Article PDF–2.4M

Select item 72025323.

Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21^WAF1-PKCζ pathway in p16^INK4a-silenced cells

Yun Yeong Lee, Yeon Seung Choi, Do Wan Kim, Jae Youn Cheong, Kye Yong Song, Min Sook Ryu, In Kyoung Lim

Aging (Albany NY) 2020 Apr 30; 12(8): 6700–6732. Published online 2020 Apr 24. doi: 10.18632/aging.103029

PMCID:: PMC7202532

Abstract Article PDF–3.9M

Select item 66575014.

Activation of Atypical Protein Kinase C by Sphingosine 1-Phosphate Revealed by Atypical Protein Kinase C-Specific Activity Reporter

Taketoshi Kajimoto, Alisha D. Caliman, Irene S. Tobias, Taro Okada, Caila A. Pilo, An-Angela N. Van, J. Andrew McCammon, Shun-ichi Nakamura, Alexandra C. Newton

Sci Signal. Author manuscript; available in PMC 2019 Jul 25.

Published in final edited form as: Sci Signal. 2019 Jan 1; 12(562): eaat6662. Published online 2019 Jan 1. doi: 10.1126/scisignal.aat6662

PMCID:: PMC6657501

Abstract Article PDF–1.1M

Select item 62772235.

PKCζ Phosphorylates SIRT6 to Mediate Fatty Acid β-Oxidation in Colon Cancer Cells

Tian Gao, Meiting Li, Guanqun Mu, Tianyun Hou, Wei-Guo Zhu, Yang Yang

Neoplasia. 2019 Jan; 21(1): 61–73. Published online 2018 Nov 30. doi: 10.1016/j.neo.2018.11.008

PMCID:: PMC6277223

Abstract Article PDF–2.2M

Select item 58734236.

Protein kinase C zeta suppresses low‐ or high‐grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

Ravi Kiran Deevi, Arman Javadi, Jane McClements, Jekaterina Vohhodina, Kienan Savage, Maurice Bernard Loughrey, Emma Evergren, Frederick Charles Campbell

J Pathol. 2018 Apr; 244(4): 445–459. Published online 2018 Mar 9. doi: 10.1002/path.5035

PMCID:: PMC5873423

Abstract Article PDF–2.4M

Select item 54821997.

The role of PKCζ in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oil

Hani Harb, James Irvine, Manori Amarasekera, Charles S. Hii, Dörthe A. Kesper, YueFang Ma, Nina D’Vaz, Harald Renz, Daniel P. Potaczek, Susan L. Prescott, Antonio Ferrante

Biosci Rep. 2017 Apr 30; 37(2): BSR20160485. Prepublished online 2017 Feb 3. Published online 2017 Mar 27. doi: 10.1042/BSR20160485

PMCID:: PMC5482199

Abstract Article PDF–670K

Select item 46566788.

Protein kinase C/ζ (PRKCZ) Gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes

Yun-Feng Li, Hong-Xia Sun, Guo-Dong Wu, Wei-Nan Du, Jin Zuo, Yan Shen, Bo-Qin Qiang, Zhi-Jian Yao, Heng Wang, Wei Huang, Zhu Chen, Mo-Miao Xiong, Yan Meng, Fu-De Fang

World J Gastroenterol. 2003 Sep 15; 9(9): 2078–2082. Published online 2003 Sep 15. doi: 10.3748/wjg.v9.i9.2078

PMCID:: PMC4656678

Abstract Article PDF–116K

Select item 45875329.

PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population

Stella Aslibekyan, Hassan S. Dashti, Toshiko Tanaka, Jin Sha, Luigi Ferrucci, Degui Zhi, Stefania Bandinelli, Ingrid B. Borecki, Devin M. Absher, Donna K. Arnett, Jose M. Ordovas

Chronobiol Int. Author manuscript; available in PMC 2015 Sep 29.

Published in final edited form as: Chronobiol Int. 2014 Nov; 31(9): 1034–1040. Published online 2014 Jul 30. doi: 10.3109/07420528.2014.944266

PMCID:: PMC4587532

Abstract Article PDF–281K

Select item 457628810.

Effect of SNPs in protein kinase Cz gene on gene expression in the reporter gene detection system

Zhuo Liu, Hong-Xia Sun, Yong-Wei Zhang, Yun-Feng Li, Jin Zuo, Yan Meng, Fu-De Fang

World J Gastroenterol. 2004 Aug 15; 10(16): 2357–2360. Published online 2004 Aug 15. doi: 10.3748/wjg.v10.i16.2357

PMCID:: PMC4576288

Abstract Article PDF–90K

Select item 446469411.

Protein microarrays identify antibodies to protein kinase Cζ that are associated with a greater risk of allograft loss in pediatric renal transplant recipients

Scott M. Sutherland, Li Li, Tara K. Sigdel, Persis P. Wadia, David B. Miklos, Atul J. Butte, Minnie M. Sarwal

Kidney Int. Author manuscript; available in PMC 2015 Jun 13.

Published in final edited form as: Kidney Int. 2009 Dec; 76(12): 1277–1283. Published online 2009 Oct 7. doi: 10.1038/ki.2009.384

PMCID:: PMC4464694

Abstract Article PDF–714K

Select item 439701912.

Atypical Protein Kinase C Zeta: Potential Player in Cell Survival and Cell Migration of Ovarian Cancer

Kelly K. Y. Seto, Irene L. Andrulis

PLoS One. 2015; 10(4): e0123528. Published online 2015 Apr 14. doi: 10.1371/journal.pone.0123528

PMCID:: PMC4397019

Abstract Article PDF–1.3M

Select item 432029613.

PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity

S A Hartsink-Segers, J J Beaudoin, M W J Luijendijk, C Exalto, R Pieters, M L Den Boer

Leukemia. 2015 Feb; 29(2): 304–311. Prepublished online 2014 Jul 3. Published online 2014 Aug 1. doi: 10.1038/leu.2014.210

PMCID:: PMC4320296

Abstract Article PDF–1.6M

Select item 376684214.

Atypical PKCζ transduces electrophilic fatty acid signaling in pulmonary epithelial cells

Chang-Jiang Guo, Francisco J. Schopfer, Linda Gonzales, Ping Wang, Bruce A. Freeman, Andrew J. Gow

Nitric Oxide. Author manuscript; available in PMC 2013 Sep 9.

Published in final edited form as: Nitric Oxide. 2011 Oct 30; 25(3): 366–372. Published online 2011 Aug 19. doi: 10.1016/j.niox.2011.07.003

PMCID:: PMC3766842

Abstract Article PDF–594K

Select item 339496515.

Splice variant PRKC-ζ_-PrC is a novel biomarker of human prostate cancer

S Yao, S J Ireland, A Bee, C Beesley, S S Forootan, A Dodson, T Dickinson, P Gerard, L-Y Lian, J M Risk, P Smith, M I Malki, Y Ke, C S Cooper, C Gosden, C S Foster

Br J Cancer. 2012 Jul 10; 107(2): 388–399. Published online 2012 May 29. doi: 10.1038/bjc.2012.162

PMCID:: PMC3394965

Abstract Article PDF–848K

Select item 337603716.

Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications

Yeong-Shiau Pu, Chao-Yuan Huang, Jyue-Yu Chen, Wang-Yi Kang, Ying-Chu Lin, Yu-Shiang Shiu, Shu-Ju Chuang, Hong-Jeng Yu, Ming-Kuen Lai, Yu-Chieh Tsai, Wen-Jeng Wu, Tzyh-Chyuan Hour

J Biomed Sci. 2012; 19(1): 39. Published online 2012 Apr 5. doi: 10.1186/1423-0127-19-39

PMCID:: PMC3376037

Abstract Article PDF–988K

Select item 291964917.

Role of Protein Kinase Cζ in Thrombin-induced RhoA Activation and Interendothelial Gap Formation of Human Dermal Microvessel Endothelial Cell Monolayers

Richard D. Minshall, Emily E. Vandenbroucke, Michael Holinstat, Aaron T. Place, Chinnaswamy Tiruppathi, Stephen M. Vogel, Geerten P. van NieuwAmerongen, Dolly Mehta, Asrar B. Malik

Microvasc Res. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Microvasc Res. 2010 Sep; 80(2): 240–249. Published online 2010 Apr 24. doi: 10.1016/j.mvr.2010.04.007

PMCID:: PMC2919649

Abstract Article PDF–1.6M

Select item 284654618.

Relaxin Stimulates Multiple Signaling Pathways: Activation of cAMP, PI3K, and PKCζ in THP-1 Cells

Carmen W. Dessauer, Bao T. Nguyen

Ann N Y Acad Sci. Author manuscript; available in PMC 2010 Mar 29.

Published in final edited form as: Ann N Y Acad Sci. 2005 May; 1041: 272–279. doi: 10.1196/annals.1282.040

PMCID:: PMC2846546

Abstract Article PDF–110K

Select item 268289519.

The Carboxyl-terminal Domain of Atypical Protein Kinase Cζ Binds to Ceramide and Regulates Junction Formation in Epithelial Cells

Guanghu Wang, Kannan Krishnamurthy, Nagavedi S. Umapathy, Alexander D. Verin, Erhard Bieberich

J Biol Chem. 2009 May 22; 284(21): 14469–14475. doi: 10.1074/jbc.M808909200

PMCID:: PMC2682895

Abstract Article PDF–497K

Select item 257401020.

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection

Miguel Prudêncio, Cristina D. Rodrigues, Michael Hannus, Cécilie Martin, Eliana Real, Lígia A. Gonçalves, Céline Carret, Robert Dorkin, Ingo Röhl, Kerstin Jahn-Hoffmann, Adrian J. F. Luty, Robert Sauerwein, Christophe J. Echeverri, Maria M. Mota

PLoS Pathog. 2008 Nov; 4(11): e1000201. Published online 2008 Nov 7. doi: 10.1371/journal.ppat.1000201

PMCID:: PMC2574010

Abstract Article PDF–876K

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PMC Links for Gene (Select 5590) (157)
PMC
PRKCZ[gene] (173)
ClinVar
Homo sapiens F-box and WD repeat domain containing 10B (FBXW10B), transcript var...
Homo sapiens F-box and WD repeat domain containing 10B (FBXW10B), transcript variant 1, mRNA
gi|1780222562|ref|NM_006382.4|

Nucleotide
protein kinase C zeta type isoform X12 [Homo sapiens]
protein kinase C zeta type isoform X12 [Homo sapiens]
gi|2462511454|ref|XP_054193669.1|

Protein
TRIM6 tripartite motif containing 6 [Homo sapiens]
TRIM6 tripartite motif containing 6 [Homo sapiens]
Gene ID:117854

Gene

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