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Select item 108021411.

Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis

Yuhao Wan, Yue Zhao, Minghui Cao, Jingyi Wang, Sheila V. Tran, Zhixuan Song, Brent W. Hsueh, Shizhen Emily Wang

Cancer Res Commun. 2024 Jan; 4(1): 170–181. Published online 2024 Jan 22. doi: 10.1158/2767-9764.CRC-23-0316

PMCID:: PMC10802141

Abstract Article PDF–8.5M

Select item 91163572.

MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome

Ke-Qin Gong, Carmen Mikacenic, Matthew E. Long, Charles W. Frevert, Timothy P. Birkland, Jean Charron, Sina A. Gharib, Anne M. Manicone

Am J Respir Cell Mol Biol. 2022 May 1; 66(5): 555–563. Published online 2022 Feb 14. doi: 10.1165/rcmb.2021-0252OC

PMCID:: PMC9116357

Abstract Article PDF–1.2M

Select item 49085863.

Interaction of tRNA with MEK2 in pancreatic cancer cells

Xiaoyun Wang, Christina R. Chow, Kazumi Ebine, Jiyoung Lee, Marsha R. Rosner, Tao Pan, Hidayatullah G. Munshi

Sci Rep. 2016; 6: 28260. Published online 2016 Jun 15. doi: 10.1038/srep28260

PMCID:: PMC4908586

Abstract Article PDF–1.2M

Select item 44808714.

Deletion of MAP2K2/MEK2: A novel mechanism for a RASopathy?

Małgorzata J.M. Nowaczyk, Brandi A. Thompson, Susan Zeesman, Ute Moog, Pedro A. Sanchez-Lara, Pilar L. Magoulas, Rena E. Falk, Julie Hoover Fong, Denise A.S. Batista, Shivarajan M. Amudhavalli, Sue M. White, Gail E. Graham, Katherine A. Rauen

Clin Genet. Author manuscript; available in PMC 2015 Jun 25.

Published in final edited form as: Clin Genet. 2014 Feb; 85(2): 138–146. Published online 2013 Apr 2. doi: 10.1111/cge.12116

PMCID:: PMC4480871

Abstract Article PDF–485K

Select item 30418225.

MEK2 Is Sufficient but Not Necessary for Proliferation and Anchorage-Independent Growth of SK-MEL-28 Melanoma Cells

Chih-Shia Lee, Karl J. Dykema, Danielle M. Hawkins, David M. Cherba, Craig P. Webb, Kyle A. Furge, Nicholas S. Duesbery

PLoS One. 2011; 6(2): e17165. Published online 2011 Feb 18. doi: 10.1371/journal.pone.0017165

PMCID:: PMC3041822

Abstract Article PDF–903K

Select item 16066076.

Activation of Mitogen-Activated Protein Kinases by Lysophosphatidylcholine-Induced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells

Nobuo Watanabe, Jaroslaw W. Zmijewski, Wakako Takabe, Makiko Umezu-Goto, Claire Le Goffe, Azusa Sekine, Aimee Landar, Akira Watanabe, Junken Aoki, Hiroyuki Arai, Tatsuhiko Kodama, Michael P. Murphy, Raman Kalyanaraman, Victor M. Darley-Usmar, Noriko Noguchi

Am J Pathol. 2006 May; 168(5): 1737–1748. doi: 10.2353/ajpath.2006.050648

PMCID:: PMC1606607

Abstract Article PDF–4.8M

Select item 208247.

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

Shih Khoo, Melanie H. Cobb

Proc Natl Acad Sci U S A. 1997 May 27; 94(11): 5599–5604. doi: 10.1073/pnas.94.11.5599

PMCID:: PMC20824

Abstract Article PDF–451K

Select item 87708288.

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma

Ting Ye, Jie-Ying Zhang, Xin-Yi Liu, Yu-Han Zhou, Si-Yue Yuan, Meng-Mei Yang, Wen-Zhuan Xie, Chan Gao, Yao-Xu Chen, Meng-Li Huang, Cheng-Zhi Ye, Jing Chen

Front Immunol. 2021; 12: 785526. Published online 2022 Jan 6. doi: 10.3389/fimmu.2021.785526

PMCID:: PMC8770828

Abstract Article PDF–2.8M

Select item 60813829.

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

Merav Ordan, Chiara Pallara, Galia Maik-Rachline, Tamar Hanoch, Francesco Luigi Gervasio, Fabian Glaser, Juan Fernandez-Recio, Rony Seger

Sci Rep. 2018; 8: 11830. Published online 2018 Aug 7. doi: 10.1038/s41598-018-30202-5

PMCID:: PMC6081382

Abstract Article PDF–4.8M

Select item 592475310.

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth

Wenjuan Li, Kaisa Cui, Edward V Prochownik, Youjun Li

Cell Death Dis. 2018 May; 9(5): 482. Published online 2018 Apr 30. doi: 10.1038/s41419-018-0523-z

PMCID:: PMC5924753

Abstract Article PDF–1.3M

Select item 561868211.

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation

Ding'an Zhou, Zhongshu Kuang, Xing Zeng, Ke Wang, Jiangshu Ma, Huangchao Luo, Mei Chen, Yan Li, Jiawei Zeng, Shu Li, Fujun Luan, Yong He, Hongying Dai, Beizhong Liu, Hui Li, Lin He, Qinghe Xing

J Cell Mol Med. 2017 Oct; 21(10): 2465–2480. Published online 2017 Apr 6. doi: 10.1111/jcmm.13168

PMCID:: PMC5618682

Abstract Article PDF–5.5M

Select item 480803712.

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells

Kelly Airiau, Valérie Prouzet-Mauléon, Benoit Rousseau, Arnaud Pigneux, Marie Jeanneteau, Manon Giraudon, Kaoutar Allou, Pierre Dubus, Francis Belloc, François-Xavier Mahon

Oncotarget. 2016 Jan 5; 7(1): 845–859. Published online 2015 Nov 27. doi: 10.18632/oncotarget.6417

PMCID:: PMC4808037

Abstract Article PDF–7.8M

Select item 469513313.

Cisplatin inhibits MEK1/2

Tetsu Yamamoto, Igor F. Tsigelny, Andreas W. Götz, Stephen B. Howell

Oncotarget. 2015 Sep 15; 6(27): 23510–23522. Published online 2015 Jun 20. doi: 10.18632/oncotarget.4355

PMCID:: PMC4695133

Abstract Article PDF–2.9M

Select item 454065914.

ERK1/2 can feedback-regulate cellular MEK1/2 levels

Seung-Keun Hong, Pui-Kei Wu, Mansi Karkhanis, Jong-In Park

Cell Signal. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Cell Signal. 2015 Oct; 27(10): 1939–1948. Published online 2015 Jul 9. doi: 10.1016/j.cellsig.2015.07.003

PMCID:: PMC4540659

Abstract Article PDF–1.1M

Select item 426194915.

Analysis of mRNA Profiles after MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity

Stephan Gysin, Jesse Paquette, Martin McMahon

Mol Cancer Res. Author manuscript; available in PMC 2014 Dec 10.

Published in final edited form as: Mol Cancer Res. 2012 Dec; 10(12): 1607–1619. Published online 2012 Jul 25. doi: 10.1158/1541-7786.MCR-12-0188

Correction in:: volume 11 on page 686

PMCID:: PMC4261949

Abstract Article PDF–2.7M

Select item 418066616.

Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: Transmission through four generations

Katherine A. Rauen, William E. Tidyman, Anne L. Estep, Srirangan Sampath, Henry M. Peltier, Sherri J. Bale, Yves Lacassie

Am J Med Genet A. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Am J Med Genet A. 2010 Apr; 0(4): 807–814. doi: 10.1002/ajmg.a.33342

PMCID:: PMC4180666

Abstract Article PDF–633K

Select item 410928617.

Activity of the MEK Inhibitor Trametinib (GSK1120212) in Advanced Melanoma in a Phase I, Dose-escalation Trial

Gerald S Falchook, Karl D Lewis, Jeffrey R Infante, Michael S Gordon, Nicholas J Vogelzang, Douglas J DeMarini, Peng Sun, Christopher Moy, Stephen A. Szabo, Lori T Roadcap, Vijay G R Peddareddigari, Peter F Lebowitz, Ngocdiep T Le, Howard A Burris, III, Wells A Messersmith, Peter J O'Dwyer, Kevin B. Kim, Keith Flaherty, Johanna C. Bendell, Rene Gonzalez, Razelle Kurzrock, Leslie A Fecher

Lancet Oncol. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Lancet Oncol. 2012 Aug; 13(8): 782–789. Published online 2012 Jul 16. doi: 10.1016/S1470-2045(12)70269-3

PMCID:: PMC4109286

Abstract Article PDF–546K

Select item 368149218.

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2

Takayuki Yoshida, Junya Kakegawa, Takayuki Yamaguchi, Yoshiji Hantani, Nobuyuki Okajima, Toshiyuki Sakai, Yoshihiro Watanabe, Motonao Nakamura

Oncotarget. 2012 Dec; 3(12): 1533–1545. Published online 2012 Dec 1. doi: 10.18632/oncotarget.747

PMCID:: PMC3681492

Abstract Article PDF–1.8M

Select item 346652319.

MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2

Chunmei Piao, Cha-Kyung Youn, Min Jin, Sang Pil Yoon, In-Youb Chang, Jung Hee Lee, Ho Jin You

Cell Cycle. 2012 Sep 1; 11(17): 3237–3249. doi: 10.4161/cc.21591

PMCID:: PMC3466523

Abstract Article PDF–2.1M

Select item 301750220.

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo

S. Grewal, D.M. Molina, L. Bardwell

Cell Signal. Author manuscript; available in PMC 2011 Jan 7.

Published in final edited form as: Cell Signal. 2006 Jan; 18(1): 123–134. Published online 2005 Jun 24. doi: 10.1016/j.cellsig.2005.04.001

PMCID:: PMC3017502

Abstract Article PDF–2.1M

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