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Items: 1 to 20 of 85

1.
Prosaposin, tumor‐secreted protein, promotes pancreatic cancer progression by decreasing tumor‐infiltrating lymphocytes
Yoji Miyahara, Shigetsugu Takano, Kazuyuki Sogawa, Satoshi Tomizawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masayuki Ohtsuka
Cancer Sci. 2022 Aug; 113(8): 2548–2559. Published online 2022 Jun 9. doi: 10.1111/cas.15444
PMCID:
PMC9357616
AbstractArticlePDF–21M
2.
Glucosylsphingosine but not Saposin C, is the target antigen in Gaucher disease-associated gammopathy
Shiny Nair, Noffar Bar, Mina L. Xu, Madhav Dhodapkar, Pramod K Mistry
Mol Genet Metab. Author manuscript; available in PMC 2021 Jun 24.
Published in final edited form as: Mol Genet Metab. 2020 Apr; 129(4): 286–291. Published online 2020 Feb 5. doi: 10.1016/j.ymgme.2020.01.009
PMCID:
PMC8223251
AbstractArticlePDF–1.6M
3.
Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth
Yihong Wu, Linlin Sun, Weiying Zou, Jiejie Xu, Haiou Liu, Wenzhong Wang, Xiaojing Yun, Jianxin Gu
Cancer Sci. 2012 Oct; 103(10): 1820–1825. Published online 2012 Aug 10. doi: 10.1111/j.1349-7006.2012.02374.x
PMCID:
PMC7659326
AbstractArticlePDF–425K
4.
Sequencing of the GBA co-activator, Saposin C, in Parkinson disease
Bouchra Ouled Amar Bencheikh, Etienne Leveille, Jennifer A. Ruskey, Dan Spiegelman, Christopher Liong, Edward A. Fon, Guy A. Rouleau, Yves Dauvilliers, Nicolas Dupre, Roy N. Alcalay, Ziv Gan-Or
Neurobiol Aging. Author manuscript; available in PMC 2019 Dec 1.
Published in final edited form as: Neurobiol Aging. 2018 Dec; 72: 187.e1–187.e3. Published online 2018 Jul 2. doi: 10.1016/j.neurobiolaging.2018.06.034
PMCID:
PMC6215722
AbstractArticlePDF–317K
5.
Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer
Azlena Ali, Laura Creevey, Yuan Hao, Damian McCartan, Peadar O’Gaora, Arnold Hill, Leonie Young, Marie McIlroy
Breast Cancer Res. 2015; 17(1): 123. Published online 2015 Sep 4. doi: 10.1186/s13058-015-0636-6
PMCID:
PMC4560928
AbstractArticlePDF–3.0M
6.
Prosaposin Deficiency and Saposin B Deficiency (Activator-Deficient Metachromatic Leukodystrophy): Report on Two Patients Detected by Analysis of Urinary Sphingolipids and Carrying Novel PSAP Gene Mutations
Ladislav Kuchař, Jana Ledvinová, Martin Hřebíček, Helena Myšková, Lenka Dvořáková, Linda Berná, Petr Chrastina, Befekadu Asfaw, Milan Elleder, Margret Petermöller, Heidi Mayrhofer, Martin Staudt, Ingeborg Krägeloh-Mann, Barbara C Paton, Klaus Harzer
Am J Med Genet A. 2009 Apr; 149A(4): 613–621. Published online 2009 Mar 6. doi: 10.1002/ajmg.a.32712
PMCID:
PMC3437469
AbstractArticlePDF–298K
7.
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion
Siyi Hu, Nathalie Delorme, Zhenzhen Liu, Tao Liu, Cruz Velasco-Gonzalez, Jone Garai, Ashok Pullikuth, Shahriar Koochekpour
Mol Cancer. 2010; 9: 30. Published online 2010 Feb 4. doi: 10.1186/1476-4598-9-30
PMCID:
PMC2825248
AbstractArticlePDF–8.2M
8.
Crystal structures of saposins A and C
Victoria E. Ahn, Paul Leyko, Jean-René Alattia, Lu Chen, Gilbert G. Privé
Protein Sci. 2006 Aug; 15(8): 1849–1857. doi: 10.1110/ps.062256606
PMCID:
PMC2242594
AbstractArticlePDF–627K
9.
Analysis of a splice-site mutation in the sap-precursor gene of a patient with metachromatic leukodystrophy.
M. Henseler, A. Klein, M. Reber, M. T. Vanier, P. Landrieu, K. Sandhoff
Am J Hum Genet. 1996 Jan; 58(1): 65–74.
PMCID:
PMC1914953
SummaryPage BrowsePDF–2.4M
10.
Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
Aya Shibamiya, Lars Muhl, Susanne Tannert-Otto, Klaus T. Preissner, Sandip M. Kanse
Biochem J. 2007 May 15; 404(Pt 1): 45–50. Prepublished online 2007 Feb 14. Published online 2007 Apr 26. doi: 10.1042/BJ20070166
PMCID:
PMC1868837
AbstractArticlePDF–456K
11.
Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells
Tae-Jin Lee, Oliver Sartor, Ronald B Luftig, Shahriar Koochekpour
Mol Cancer. 2004; 3: 31. Published online 2004 Nov 17. doi: 10.1186/1476-4598-3-31
PMCID:
PMC535542
AbstractArticlePDF–1.0M
12.
Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor.
N N Dewji, D A Wenger, J S O'Brien
Proc Natl Acad Sci U S A. 1987 Dec; 84(23): 8652–8656. doi: 10.1073/pnas.84.23.8652
PMCID:
PMC299604
SummaryPage BrowsePDF–802K
13.
Saposin A: second cerebrosidase activator protein.
S Morimoto, B M Martin, Y Yamamoto, K A Kretz, J S O'Brien, Y Kishimoto
Proc Natl Acad Sci U S A. 1989 May; 86(9): 3389–3393. doi: 10.1073/pnas.86.9.3389
PMCID:
PMC287138
SummaryPage BrowsePDF–1.1M
14.
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Victoria E. Ahn, Kym F. Faull, Julian P. Whitelegge, Arvan L. Fluharty, Gilbert G. Privé
Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1): 38–43. Published online 2002 Dec 23. doi: 10.1073/pnas.0136947100
PMCID:
PMC140876
AbstractArticlePDF–532K
15.
Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect.
K A Kretz, G S Carson, S Morimoto, Y Kishimoto, A L Fluharty, J S O'Brien
Proc Natl Acad Sci U S A. 1990 Apr; 87(7): 2541–2544. doi: 10.1073/pnas.87.7.2541
PMCID:
PMC53725
SummaryPage BrowsePDF–857K
16.
Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease
Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E Serrano, Thomas G Beach, Douglas G Walker
J Neuropathol Exp Neurol. 2021 Aug; 80(8): 741–753. Published online 2021 Aug 10. doi: 10.1093/jnen/nlab056
PMCID:
PMC8433593
AbstractArticlePDF–1.1M
17.
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology
Anarmaa Mendsaikhan, Ikuo Tooyama, Jean-Pierre Bellier, Geidy E. Serrano, Lucia I. Sue, Lih-Fen Lue, Thomas G. Beach, Douglas G. Walker
Acta Neuropathol Commun. 2019; 7: 215. Published online 2019 Dec 21. doi: 10.1186/s40478-019-0862-8
PMCID:
PMC6925443
AbstractArticlePDF–14M
18.
Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway
Yang Jiang, Jinpeng Zhou, Peng Luo, Huiling Gao, Yanju Ma, Yin-Sheng Chen, Long Li, Dan Zou, Ye Zhang, Zhitao Jing
EBioMedicine. 2018 Nov; 37: 78–90. Published online 2018 Oct 29. doi: 10.1016/j.ebiom.2018.10.053
PMCID:
PMC6286187
AbstractArticlePDF–4.9M
19.
Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics
Nandini A. Sahasrabuddhe, Mustafa A. Barbhuiya, Shushruta Bhunia, Tejaswini Subbannayya, Harsha Gowda, Jayshree Advani, Braj R. Shrivastav, Sanjay Navani, Pamela Leal, Juan Carlos Roa, Raghothama Chaerkady, Sanjeev Gupta, Aditi Chatterjee, Akhilesh Pandey, Pramod K. Tiwari
Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Dec 30.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Apr 18; 446(4): 863–869. Published online 2014 Mar 20. doi: 10.1016/j.bbrc.2014.03.017
PMCID:
PMC4696041
AbstractArticlePDF–604K
20.
Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure
Jia-Li Cai, Ling-Bin Sun, Zhi-Zhun Guo, Xiao-Ming Jiang, Guan-Chao Zheng, Hui-Ling Qiu, Ai-Guo Sha, Chong-Gang Wang, Jian-Zhi Ren, Zheng-Hong Zuo
Int J Clin Exp Pathol. 2015; 8(3): 2436–2448. Published online 2015 Mar 1.
PMCID:
PMC4440059
AbstractArticlePDF–1.5M

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