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Select item 94510601.

Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection

Mengqiong Xu, Sisi Xia, Mei Wang, Xiaolian Liu, Xin Li, Weijie Chen, Yaohao Wang, Hongjian Li, Chuan Xia, Jun Chen, Jianguo Wu

PLoS Pathog. 2022 Sep; 18(9): e1010794. Published online 2022 Sep 7. doi: 10.1371/journal.ppat.1010794

PMCID:: PMC9451060

Abstract Article PDF–3.6M

Select item 74155222.

Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukemia and promotes survival through Mcl-1

Francis R LeBlanc, Jennifer M Pearson, Su-Fern Tan, HeeJin Cheon, Jeffrey C. Xing, Wendy Dunton, David J Feith, Thomas P Loughran, Jr

Br J Haematol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Br J Haematol. 2020 Aug; 190(3): 405–417. Published online 2020 Mar 2. doi: 10.1111/bjh.16530

PMCID:: PMC7415522

Abstract Article PDF–1.5M

Select item 69381293.

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis

Pascale Blais-Lecours, Sofien Laouafa, Christian Arias-Reyes, Webster L. Santos, Vincent Joseph, Janette K. Burgess, Andrew J. Halayko, Jorge Soliz, David Marsolais

Am J Respir Cell Mol Biol. 2020 Jan; 62(1): 35–42. doi: 10.1165/rcmb.2018-0397OC

PMCID:: PMC6938129

Abstract Article PDF–895K

Select item 56904254.

RNAi screen reveals a role of SPHK2 in dengue virus–mediated apoptosis in hepatic cell lines

Atthapan Morchang, Regina Ching Hua Lee, Pa-thai Yenchitsomanus, Gopinathan Pillai Sreekanth, Sansanee Noisakran, Justin Jang Hann Chu, Thawornchai Limjindaporn

PLoS One. 2017; 12(11): e0188121. Published online 2017 Nov 16. doi: 10.1371/journal.pone.0188121

PMCID:: PMC5690425

Abstract Article PDF–6.3M

Select item 55036365.

Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination

Wen-Na Shi, Shu-Xiang Cui, Zhi-Yu Song, Shu-Qing Wang, Shi-Yue Sun, Xin-Feng Yu, Ye Li, Yu-Hang Zhang, Zu-Hua Gao, Xian-Jun Qu

Oncotarget. 2017 Jun 13; 8(24): 39605–39617. Published online 2017 Apr 18. doi: 10.18632/oncotarget.17174

PMCID:: PMC5503636

Abstract Article PDF–4.9M

Select item 53231236.

An oncogenic role for sphingosine kinase 2

Heidi A. Neubauer, Duyen H. Pham, Julia R. Zebol, Paul A.B. Moretti, Amanda L. Peterson, Tamara M. Leclercq, Huasheng Chan, Jason A. Powell, Melissa R. Pitman, Michael S. Samuel, Claudine S. Bonder, Darren J. Creek, Briony L. Gliddon, Stuart M. Pitson

Oncotarget. 2016 Oct 4; 7(40): 64886–64899. Published online 2016 Aug 30. doi: 10.18632/oncotarget.11714

PMCID:: PMC5323123

Abstract Article PDF–3.9M

Select item 45599037.

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

Cai Xun, Min-Bin Chen, Li Qi, Zhang Tie-Ning, Xue Peng, Li Ning, Chen Zhi-Xiao, Wang Li-Wei

J Exp Clin Cancer Res. 2015; 34(1): 94. Published online 2015 Sep 4. doi: 10.1186/s13046-015-0205-y

PMCID:: PMC4559903

Abstract Article PDF–878K

Select item 40921558.

Sphingosine Kinase-2 Maintains Viral Latency and Survival for KSHV-Infected Endothelial Cells

Lu Dai, Karlie Plaisance-Bonstaff, Christina Voelkel-Johnson, Charles D. Smith, Besim Ogretmen, Zhiqiang Qin, Chris Parsons

PLoS One. 2014; 9(7): e102314. Published online 2014 Jul 10. doi: 10.1371/journal.pone.0102314

PMCID:: PMC4092155

Abstract Article PDF–1.0M

Select item 39184949.

Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma

Zhiqiang Qin, Lu Dai, Jimena Trillo-Tinoco, Can Senkal, Wenxue Wang, Tom Reske, Karlie Bonstaff, Luis Del Valle, Paulo Rodriguez, Erik Flemington, Christina Voelkel-Johnson, Charles D. Smith, Besim Ogretmen, Chris Parsons

Mol Cancer Ther. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Mol Cancer Ther. 2014 Jan; 13(1): 154–164. Published online 2013 Oct 18. doi: 10.1158/1535-7163.MCT-13-0466

PMCID:: PMC3918494

Abstract Article PDF–2.7M

Select item 336824810.

Targeting Sphingosine-1-Phosphate in Hematologic Malignancies

Christina E. Stevenson, Kazuaki Takabe, Masayuki Nagahashi, Sheldon Milstien, Sarah Spiegel

Anticancer Agents Med Chem. Author manuscript; available in PMC 2012 Jun 6.

Published in final edited form as: Anticancer Agents Med Chem. 2011 Nov; 11(9): 794–798. doi: 10.2174/187152011797655122

PMCID:: PMC3368248

Abstract Article PDF–287K

Select item 314827311.

(R)-FTY720 METHYL ETHER IS A SPECIFIC SPHINGOSINE KINASE 2 INHIBITOR: EFFECT ON SPHINGOSINE KINASE 2 EXPRESSION IN HEK 293 CELLS AND ACTIN REARRANGEMENT AND SURVIVAL OF MCF-7 BREAST CANCER CELLS

Keng Gat Lim, Chaode Sun, Robert Bittman, Nigel J. Pyne, Susan Pyne

Cell Signal. Author manuscript; available in PMC 2012 Oct 1.

Published in final edited form as: Cell Signal. 2011 Oct; 23(10): 1590–1595. Published online 2011 May 18. doi: 10.1016/j.cellsig.2011.05.010

PMCID:: PMC3148273

Abstract Article PDF–1.8M

Select item 311957012.

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

Andrew J. Kennedy, Thomas P. Mathews, Yugesh Kharel, Saundra D. Field, Morgan L. Moyer, James E. East, Joseph D. Houck, Kevin R. Lynch, Timothy L. Macdonald

J Med Chem. Author manuscript; available in PMC 2012 May 26.

Published in final edited form as: J Med Chem. 2011 May 26; 54(10): 3524–3548. Published online 2011 May 2. doi: 10.1021/jm2001053

PMCID:: PMC3119570

Abstract Article PDF–2.4M

Select item 308497113.

Targeting NFκB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

James W Antoon, Martin D White, Evelyn M Slaughter, Jennifer L Driver, Hafez S Khalili, Steven Elliott, Charles D Smith, Matthew E Burow, Barbara S Beckman

Cancer Biol Ther. 2011 Apr 1; 11(7): 678–689. Published online 2011 Apr 1. doi: 10.4161/cbt.11.7.14903

PMCID:: PMC3084971

Abstract Article PDF–8.1M

Select item 998915314.

Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes

Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xia

Exp Biol Med (Maywood) 2023 Jan; 248(1): 44–51. Published online 2022 Nov 20. doi: 10.1177/15353702221131886

PMCID:: PMC9989153

Abstract Article PDF–1.7M

Select item 939477115.

Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury

Dengpiao Xie, Gaizun Hu, Chaoling Chen, Fereshteh Ahmadinejad, Weili Wang, Pin-Lan Li, David A. Gewirtz, Ningjun Li

Am J Physiol Renal Physiol. 2022 Sep 1; 323(3): F322–F334. Published online 2022 Jul 13. doi: 10.1152/ajprenal.00229.2021

PMCID:: PMC9394771

Abstract Article

Select item 829262916.

Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy

Hongliang Wang, Bing Zhao, Erbao Bian, Gang Zong, Jie He, Yuyang Wang, Chunchun Ma, Jinghai Wan

Front Cell Neurosci. 2021; 15: 660354. Published online 2021 Jul 7. doi: 10.3389/fncel.2021.660354

PMCID:: PMC8292629

Abstract Article PDF–5.2M

Select item 784473017.

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

Geqiong Xiao, Qiong Wang, Bo Li, Xiaohui Wu, Hui Liao, Yili Ren, Ning Ai

Oncol Res. 2018; 26(8): 1183–1189. Published online 2018 Sep 14. doi: 10.3727/096504018X15151495109394

PMCID:: PMC7844730

Abstract Article PDF–14M

Select item 741133418.

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhang

Mol Med Rep. 2020 Sep; 22(3): 2573–2582. Published online 2020 Jul 9. doi: 10.3892/mmr.2020.11313

PMCID:: PMC7411334

Abstract Article PDF–1.2M

Select item 668242619.

The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease

Eric K. Kwong, Runping Liu, Derrick Zhao, Xiaojiaoyang Li, Weiwei Zhu, Xuan Wang, Emily C. Gurley, Guanhua Lai, Jimin Liu, Phillip B. Hylemon, Huiping Zhou

Dig Liver Dis. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Dig Liver Dis. 2019 Aug; 51(8): 1154–1163. Published online 2019 Apr 16. doi: 10.1016/j.dld.2019.03.020