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Select item 90459811.

PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer

Jing Li, Wei-min Kong

J Immunol Res. 2022; 2022: 4510462. Published online 2022 Apr 20. doi: 10.1155/2022/4510462

PMCID:: PMC9045981

Abstract Article PDF–3.8M

Select item 85822462.

PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer

Dongxu Qiu, Jian Hu, Jiao Hu, Anze Yu, Belaydi Othmane, Tongchen He, Jian Ding, Xu Cheng, Wenbiao Ren, Xiyan Tan, Qiaoyan Yu, Jinbo Chen, Xiongbing Zu

Front Immunol. 2021; 12: 705086. Published online 2021 Oct 28. doi: 10.3389/fimmu.2021.705086

PMCID:: PMC8582246

Abstract Article PDF–61M

Select item 75651923.

PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer

Shashwat Sharad, Albert Dobi, Shiv Srivastava, Alagarsamy Srinivasan, Hua Li

Biomolecules. 2020 Sep; 10(9): 1221. Published online 2020 Aug 22. doi: 10.3390/biom10091221

PMCID:: PMC7565192

Abstract Article PDF–2.4M

Select item 65289434.

2‐(2‐nitrobenzylidene) indolin‐3‐one compound inhibits transmembrane prostate androgen‐induced protein (TMEPAI) expression and cancer cell proliferation

Yuyin Li, Jianjun Wang, Ning Song, Feihong Zeng, Miaomiao Zhao, Ali Wang, Yue Chen, Lei Jing, Peng Yu, Aipo Diao

Cell Prolif. 2018 Oct; 51(5): e12469. Published online 2018 Aug 2. doi: 10.1111/cpr.12469

PMCID:: PMC6528943

Abstract Article PDF–1.2M

Select item 64844145.

PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer

Lei Zhang, Xue Wang, Chong Lai, Honghe Zhang, Maode Lai

J Cell Mol Med. 2019 May; 23(5): 3603–3615. Published online 2019 Mar 19. doi: 10.1111/jcmm.14261

PMCID:: PMC6484414

Abstract Article PDF–1.5M

Select item 62757126.

High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Yoshifumi S. Hirokawa, Akimitsu Takagi, Katsunori Uchida, Yuji Kozuka, Misao Yoneda, Masatoshi Watanabe, Taizo Shiraishi

Cell Mol Biol Lett. 2007 Sep; 12(3): 370–377. Published online 2007 Feb 23. doi: 10.2478/s11658-007-0009-y

PMCID:: PMC6275712

Summary PDF–608K

Select item 48826517.

Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene

Naoko Nakano, Mitsuyasu Kato, Susumu Itoh

J Biochem. 2016 Jan; 159(1): 27–30. Published online 2015 Nov 20. doi: 10.1093/jb/mvv117

PMCID:: PMC4882651

Abstract Article PDF–238K

Select item 43179358.

TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells

Thanh Thao Vo Nguyen, Yukihide Watanabe, Aya Shiba, Masayuki Noguchi, Susumu Itoh, Mitsuyasu Kato

Cancer Sci. 2014 Mar; 105(3): 334–341. Published online 2014 Feb 18. doi: 10.1111/cas.12355

PMCID:: PMC4317935

Abstract Article PDF–1.7M

Select item 40651889.

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer

Shashwat Sharad, Lakshmi Ravindranath, Michael C Haffner, Hua Li, Wusheng Yan, Isabell A Sesterhenn, Yongmei Chen, Amina Ali, Alagarsamy Srinivasan, David G McLeod, Srinivasan Yegnasubramanian, Shiv Srivastava, Albert Dobi, Gyorgy Petrovics

Epigenetics. 2014 Jun 1; 9(6): 918–927. Published online 2014 Apr 2. doi: 10.4161/epi.28710

PMCID:: PMC4065188

Abstract Article PDF–2.1M

Select item 291295310.

TGF-β-Inducible Gene TMEPAI Converts TGF-β from a Tumor Suppressor to a Tumor Promoter in Breast Cancer

Prajjal K. Singha, I-Tien Yeh, Manjeri A. Venkatachalam, Pothana Saikumar

Cancer Res. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: Cancer Res. 2010 Aug 1; 70(15): 6377–6383. Published online 2010 Jul 7. doi: 10.1158/0008-5472.CAN-10-1180

PMCID:: PMC2912953

Abstract Article PDF–2.5M

Select item 1087815311.

METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway

Hao Yu, Juntao Zhuang, Zijian Zhou, Qiang Song, Jiancheng Lv, Xiao Yang, Haiwei Yang, Qiang Lu

Int J Biol Sci. 2024; 20(4): 1471–1491. Published online 2024 Feb 4. doi: 10.7150/ijbs.86719

PMCID:: PMC10878153

Abstract Article PDF–9.0M

Select item 649682612.

Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation

Yuyin Li, Ailong Guo, Yajuan Feng, Yueying Zhang, Jianjun Wang, Lifang Jing, Yali Yan, Lei Jing, Zhenxing Liu, Long Ma, Aipo Diao

Cell Prolif. 2016 Dec; 49(6): 710–719. Published online 2016 Sep 14. doi: 10.1111/cpr.12292

PMCID:: PMC6496826

Abstract Article PDF–916K

Select item 850811613.

PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells

Md. Anwarul Haque, Mohammed Abdelaziz, Meidi Utami Puteri, Thanh Thao Vo Nguyen, Kosei Kudo, Yukihide Watanabe, Mitsuyasu Kato

Cancers (Basel) 2021 Oct; 13(19): 4934. Published online 2021 Sep 30. doi: 10.3390/cancers13194934

PMCID:: PMC8508116

Abstract Article PDF–7.4M

Select item 831246814.

Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression

Yan Zhang, Huayun Zhu, Ning Sun, Xiaomei Zhang, Geyu Liang, Jiali Zhu, Lei Xia, Yingying Kou, Jianwei Lu

Aging (Albany NY) 2021 Jul 15; 13(13): 17830–17846. Published online 2021 Jul 13. doi: 10.18632/aging.203286

PMCID:: PMC8312468

Abstract Article PDF–1.7M

Select item 591246815.

The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor

Yanyun Du, Yan Liu, Yujia Xu, Jiaxiang Juan, Zubin Zhang, Zhuan Xu, Biyin Cao, Qi Wang, Yuanying Zeng, Xinliang Mao

J Biol Chem. 2018 Apr 20; 293(16): 5847–5859. Published online 2018 Feb 21. doi: 10.1074/jbc.RA117.000972

PMCID:: PMC5912468

Abstract Article PDF–3.3M

Select item 257089416.

A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells

Hongyun Li, Linda L. Xu, Katsuaki Masuda, Eliza Raymundo, David G. McLeod, Albert Dobi, Shiv Srivastava

J Biol Chem. 2008 Oct 24; 283(43): 28988–28995. doi: 10.1074/jbc.M710528200

PMCID:: PMC2570894

Abstract Article PDF–470K

Select item 455814117.

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN

Hua Li, Ahmed A. Mohamed, Shashwat Sharad, Elizabeth Umeda, Yingjie Song, Denise Young, Gyorgy Petrovics, David G. McLeod, Isabell A. Sesterhenn, Taduru Sreenath, Albert Dobi, Shiv Srivastava

Oncotarget. 2015 Jun 20; 6(17): 15137–15149. Published online 2015 Mar 30. doi: 10.18632/oncotarget.3526

PMCID:: PMC4558141

Abstract Article PDF–5.9M

Select item 531698918.

Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking

Shenheng Luo, Lei Jing, Tian Zhao, Yuyin Li, Zhenxing Liu, Aipo Diao

Sci Rep. 2017; 7: 42668. Published online 2017 Feb 20. doi: 10.1038/srep42668

PMCID:: PMC5316989

Abstract Article PDF–1.7M

Select item 400745819.

C18 ORF1, a Novel Negative Regulator of Transforming Growth Factor-β Signaling

Naoko Nakano, Kota Maeyama, Nobuo Sakata, Fumiko Itoh, Ryosuke Akatsu, Miki Nakata, Yuki Katsu, Souichi Ikeno, Yoko Togawa, Thanh Thao Vo Nguyen, Yukihide Watanabe, Mitsuyasu Kato, Susumu Itoh

J Biol Chem. 2014 May 2; 289(18): 12680–12692. Published online 2014 Mar 13. doi: 10.1074/jbc.M114.558981

PMCID:: PMC4007458

Abstract Article PDF–2.2M

Select item 698940320.

PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1

Jianxiong Ji, Kaikai Ding, Tao Luo, Ran Xu, Xin Zhang, Bin Huang, Anjing Chen, Di Zhang, Hrvoje Miletic, Rolf Bjerkvig, Frits Thorsen, Jian Wang, Xingang Li

Oncogene. 2020; 39(5): 1125–1139. Published online 2019 Oct 11. doi: 10.1038/s41388-019-1050-9