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Select item 43292191.

Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

Jia-hong Wang, Wei Wei, Zhi-xing Guo, Ming Shi, Rong-ping Guo

J Transl Med. 2015; 13: 41. Published online 2015 Feb 1. doi: 10.1186/s12967-015-0396-1

PMCID:: PMC4329219

Abstract Article PDF–3.5M

Select item 88030892.

Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling

Weiwei An, Le A Luong, Neil P Bowden, Mei Yang, Wei Wu, Xinmiao Zhou, Chenxin Liu, Kaiyuan Niu, Jun Luo, Cheng Zhang, Xiaolei Sun, Robin Poston, Li Zhang, Paul C Evans, Qingzhong Xiao

Cardiovasc Res. 2022 Feb; 118(2): 638–653. Published online 2021 Feb 18. doi: 10.1093/cvr/cvab056

PMCID:: PMC8803089

Abstract Article PDF–2.2M

Select item 81496563.

OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation

Jianing Tang, Zeyu Wu, Zelin Tian, Wei Chen, Gaosong Wu

Cell Death Dis. 2021 Jun; 12(6): 534. Published online 2021 May 25. doi: 10.1038/s41419-021-03785-7

PMCID:: PMC8149656

Abstract Article PDF–3.1M

Select item 77837594.

Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R

Xiaowei Chen, Zhaofei Pang, Yu Wang, Linhai Zhu, Jichang Liu, Jiajun Du

Am J Cancer Res. 2020; 10(12): 4342–4356. Published online 2020 Dec 1.

PMCID:: PMC7783759

Abstract Article PDF–2.1M

Select item 56369745.

Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma

Jia-hong Wang, Xiao-ping Zhong, Yong-fa Zhang, Xiao-liang Wu, Shao-hua Li, Pei-en Jian, Yi-hong Ling, Ming Shi, Min-shan Chen, Wei Wei, Rong-ping Guo

Cell Death Dis. 2017 Sep; 8(9): e3043. Published online 2017 Sep 7. doi: 10.1038/cddis.2017.428

PMCID:: PMC5636974

Abstract Article PDF–3.0M

Select item 96467336.

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway

Shiyu Chen, Kun Cai, Dijie Zheng, Yanqing Liu, Lin Li, Zhiwei He, Chengyi Sun, Chao Yu

Cell Death Dis. 2022 Nov; 13(11): 945. Published online 2022 Nov 9. doi: 10.1038/s41419-022-05379-3

PMCID:: PMC9646733

Abstract Article PDF–9.0M

Select item 76678627.

OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3

Boxiang Zhang, Chengcheng Yang, Rui Wang, Jie Wu, Yunfeng Zhang, Dapeng Liu, Xin Sun, Xiang Li, Hong Ren, Sida Qin

J Exp Clin Cancer Res. 2020; 39: 244. Published online 2020 Nov 16. doi: 10.1186/s13046-020-01751-3

PMCID:: PMC7667862

Abstract Article PDF–4.8M

Select item 70395508.

Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding

Julia Mader, Jessica Huber, Florian Bonn, Volker Dötsch, Vladimir V. Rogov, Anja Bremm

J Biol Chem. 2020 Feb 21; 295(8): 2160–2174. Published online 2020 Jan 14. doi: 10.1074/jbc.RA119.010315

PMCID:: PMC7039550

Abstract Article PDF–2.1M

Select item 68687889.

Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway

Shan Lei, Zhiwei He, Tengxiang Chen, Xingjun Guo, Zhirui Zeng, Yiyi Shen, Jianxin Jiang

J Exp Clin Cancer Res. 2019; 38: 470. Published online 2019 Nov 20. doi: 10.1186/s13046-019-1388-4

PMCID:: PMC6868788

Abstract Article PDF–6.4M

Select item 529563210.

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Tycho E.T. Mevissen, Yogesh Kulathu, Monique P.C. Mulder, Paul P. Geurink, Sarah L. Maslen, Malte Gersch, Paul R. Elliott, John E. Burke, Bianca D.M. van Tol, Masato Akutsu, Farid El Oualid, Masato Kawasaki, Stefan M.V. Freund, Huib Ovaa, David Komander

Nature. Author manuscript; available in PMC 2017 Apr 20.

Published in final edited form as: Nature. 2016 Oct 20; 538(7625): 402–405. Published online 2016 Oct 12. doi: 10.1038/nature19836

PMCID:: PMC5295632

Abstract Article PDF–6.5M

Select item 454104411.

Cezanne regulates E2F1-dependent HIF2α expression

Sonia Moniz, Daniel Bandarra, John Biddlestone, Kirsteen J. Campbell, David Komander, Anja Bremm, Sonia Rocha

J Cell Sci. 2015 Aug 15; 128(16): 3082–3093. doi: 10.1242/jcs.168864

PMCID:: PMC4541044

Abstract Article

Select item 426492912.

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

Anja Bremm, Sonia Moniz, Julia Mader, Sonia Rocha, David Komander

EMBO Rep. 2014 Dec; 15(12): 1268–1277. Published online 2014 Oct 29. doi: 10.15252/embr.201438850

PMCID:: PMC4264929

Abstract Article PDF–823K

Select item 332644113.

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

Fresia Pareja, Daniela Aleida Ferraro, Chanan Rubin, Hadas Cohen-Dvashi, Fan Zhang, Sebastian Aulmann, Nir Ben-Chetrit, Gur Pines, Roy Navon, Nicola Crosetto, Wolfgang Köstler, Silvia Carvalho, Sara Lavi, Fernando Schmitt, Ivan Dikic, Zohar Yakhini, Peter Sinn, Gordon B. Mills, Yosef Yarden

Oncogene. Author manuscript; available in PMC 2013 Apr 25.

Published in final edited form as: Oncogene. 2012 Oct 25; 31(43): 4599–4608. Published online 2011 Dec 19. doi: 10.1038/onc.2011.587

PMCID:: PMC3326441

Abstract Article PDF–2.6M

Select item 1038708414.

The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2

Kunjan Harit, Rituparna Bhattacharjee, Kai Matuschewski, Jennifer Becker, Ulrich Kalinke, Dirk Schlüter, Gopala Nishanth

Cell Death Dis. 2023 Jul; 14(7): 480. Published online 2023 Jul 29. doi: 10.1038/s41419-023-06014-5

PMCID:: PMC10387084

Abstract Article PDF–3.8M

Select item 943344315.

Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc

Yunhua Peng, Jing Liu, Zhen Wang, Chunping Cui, Tiantian Zhang, Shuangxi Zhang, Peipei Gao, Zhanwu Hou, Huadong Liu, Jianping Guo, Jinfang Zhang, Yurong Wen, Wenyi Wei, Lingqiang Zhang, Jiankang Liu, Jiangang Long

Cell Death Differ. 2022 Sep; 29(9): 1730–1743. Published online 2022 Feb 25. doi: 10.1038/s41418-022-00960-x

Correction in:: Cell Death Differ. 2023 Jan; 30(1): 224–225.

PMCID:: PMC9433443

Abstract Article PDF–6.8M

Select item 761106516.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination

Le A. Luong, Maria Fragiadaki, Jennifer Smith, Joseph Boyle, Jens Lutz, Jonathan L. E. Dean, Sarah Harten, Margaret Ashcroft, Sarah Walmsley, Dorian O. Haskard, Patrick H. Maxwell, Henning Walczak, Charles Pusey, Paul C. Evans

Circ Res. Author manuscript; available in PMC 2021 Jun 23.

Published in final edited form as: Circ Res. 2013 Jun 7; 112(12): 1583–91. Published online 2013 Apr 5. doi: 10.1161/CIRCRESAHA.111.300119