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Select item 77368471.

Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma

Yanyan Gu, Benjamin G. Barwick, Mala Shanmugam, Craig C. Hofmeister, Jonathan Kaufman, Ajay Nooka, Vikas Gupta, Madhav Dhodapkar, Lawrence H. Boise, Sagar Lonial

Blood Cancer J. 2020 Dec; 10(12): 125. Published online 2020 Dec 14. doi: 10.1038/s41408-020-00393-0

PMCID:: PMC7736847

Abstract Article PDF–1.4M

Select item 47597792.

Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma

Xiaodong Feng, Yuchen Jiang, Liang Xie, Lu Jiang, Jing Li, Chongkui Sun, Hao Xu, Ruinan Wang, Min Zhou, Yu Zhou, Hongxia Dan, Zhiyong Wang, Ning Ji, Peng Deng, Ga Liao, Ning Geng, Yun Wang, Dunfang Zhang, Yunfeng Lin, Ling Ye, Xinhua Liang, Longjiang Li, Gang Luo, Mingye Feng, Juan Fang, Xin Zeng, Zhi Wang, Qianming Chen

J Exp Clin Cancer Res. 2016; 35: 35. Published online 2016 Feb 19. doi: 10.1186/s13046-016-0309-z

PMCID:: PMC4759779

Abstract Article PDF–2.3M

Select item 37522123.

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

David Sánchez-Martín, Jorge Martínez-Torrecuadrada, Tambet Teesalu, Kazuki N. Sugahara, Ana Alvarez-Cienfuegos, Pilar Ximénez-Embún, Rodrigo Fernández-Periáñez, M. Teresa Martín, Irene Molina-Privado, Isabel Ruppen-Cañás, Ana Blanco-Toribio, Marta Cañamero, Ángel M. Cuesta, Marta Compte, Leonor Kremer, Carmen Bellas, Vanesa Alonso-Camino, Irene Guijarro-Muñoz, Laura Sanz, Erkki Ruoslahti, Luis Alvarez-Vallina

Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34): 13791–13796. Published online 2013 Aug 5. doi: 10.1073/pnas.1300013110

PMCID:: PMC3752212

Abstract Article PDF–985K

Select item 21435844.

The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer.

S. C. Johnston, F. G. Whitby, C. Realini, M. Rechsteiner, C. P. Hill

Protein Sci. 1997 Nov; 6(11): 2469–2473. doi: 10.1002/pro.5560061123

PMCID:: PMC2143584

Summary PDF–488K

Select item 35621865.

Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S (PA28) Regulator during Early Antiviral Response Mediated by IFNβ in Mouse Pancreatic β-Cells

Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S. Salvatori, Aaron Baldwin, Jill Schriewer, R. Mark L Buller, John A. Corbett, Dorota Skowyra

PLoS One. 2013; 8(2): e52408. Published online 2013 Feb 1. doi: 10.1371/journal.pone.0052408

Expression of Concern in:: PLoS One. 2020; 15(2): e0229516.

PMCID:: PMC3562186

Abstract Article PDF–1.1M

Select item 77086356.

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux

Nat Commun. 2020; 11: 6140. Published online 2020 Dec 1. doi: 10.1038/s41467-020-19934-z

PMCID:: PMC7708635

Abstract Article PDF–8.9M

Select item 12195367.

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes.

K B Hendil, S Khan, K Tanaka

Biochem J. 1998 Jun 15; 332(Pt 3): 749–754. doi: 10.1042/bj3320749

PMCID:: PMC1219536

Summary PDF–384K

Select item 21850778.

Dynamic Association of Proteasomal Machinery with the Centrosome

W. Christian Wigley, Rosalind P. Fabunmi, Min Goo Lee, Christopher R. Marino, Shmuel Muallem, George N. DeMartino, Philip J. Thomas

J Cell Biol. 1999 May 3; 145(3): 481–490. doi: 10.1083/jcb.145.3.481

PMCID:: PMC2185077

Abstract Article PDF–511K

Select item 27047579.

Human Immunodeficiency Virus Type 1 Gag p24 Alters the Composition of Immunoproteasomes and Affects Antigen Presentation

Nicholas J. Steers, Kristina K. Peachman, Sasha R. McClain, Carl R. Alving, Mangala Rao

J Virol. 2009 Jul; 83(14): 7049–7061. Published online 2009 Apr 29. doi: 10.1128/JVI.00327-09

PMCID:: PMC2704757

Abstract Article PDF–2.6M

Select item 393763710.

Inherent Asymmetry in the 26S Proteasome Is Defined by the Ubiquitin Receptor RPN13

Dikla Berko, Ora Herkon, Ilana Braunstein, Elada Isakov, Yael David, Tamar Ziv, Ami Navon, Ariel Stanhill

J Biol Chem. 2014 Feb 28; 289(9): 5609–5618. Published online 2014 Jan 15. doi: 10.1074/jbc.M113.509380

PMCID:: PMC3937637

Abstract Article PDF–1.8M

Select item 650373811.

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

Daniele Corridoni, Seiji Shiraishi, Thomas Chapman, Tessa Steevels, Daniele Muraro, Marie-Laëtitia Thézénas, Gennaro Prota, Ji-Li Chen, Uzi Gileadi, Nicola Ternette, Vincenzo Cerundolo, Alison Simmons

Front Immunol. 2019; 10: 958. Published online 2019 Apr 30. doi: 10.3389/fimmu.2019.00958

PMCID:: PMC6503738

Abstract Article PDF–13M

Select item 528283412.

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice

Siv Vingill, David Brockelt, Camille Lancelin, Lars Tatenhorst, Guergana Dontcheva, Christian Preisinger, Nicola Schwedhelm‐Domeyer, Sabitha Joseph, Miso Mitkovski, Sandra Goebbels, Klaus‐Armin Nave, Jörg B Schulz, Till Marquardt, Paul Lingor, Judith Stegmüller

EMBO J. 2016 Sep 15; 35(18): 2008–2025. Published online 2016 Aug 6. doi: 10.15252/embj.201593585

PMCID:: PMC5282834

Abstract Article PDF–3.1M

Select item 15402513.

Comprehensive Investigation of the Molecular Defect in vif-Deficient Human Immunodeficiency Virus Type 1 Virions

Nathan C. Gaddis, Elena Chertova, Ann M. Sheehy, Louis E. Henderson, Michael H. Malim

J Virol. 2003 May; 77(10): 5810–5820. doi: 10.1128/JVI.77.10.5810-5820.2003

PMCID:: PMC154025

Abstract Article PDF–1.2M

Select item 11060814.

An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein

Navid Madani, David Kabat

J Virol. 1998 Dec; 72(12): 10251–10255. doi: 10.1128/jvi.72.12.10251-10255.1998

PMCID:: PMC110608

Abstract Article PDF–1.3M

Select item 135096615.

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Hui Zhang, Bin Yang, Roger J. Pomerantz, Chune Zhang, Shyamala C. Arunachalam, Ling Gao

Nature. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: Nature. 2003 Jul 3; 424(6944): 94–98. Published online 2003 May 28. doi: 10.1038/nature01707

PMCID:: PMC1350966

Abstract Article PDF–355K

Select item 22935816.

The Human Immunodeficiency Virus Type 1 Vif Protein Reduces Intracellular Expression and Inhibits Packaging of APOBEC3G (CEM15), a Cellular Inhibitor of Virus Infectivity

Sandra Kao, Mohammad A. Khan, Eri Miyagi, Ron Plishka, Alicia Buckler-White, Klaus Strebel

J Virol. 2003 Nov; 77(21): 11398–11407. doi: 10.1128/JVI.77.21.11398-11407.2003

PMCID:: PMC229358

Abstract Article PDF–1.0M

Select item 743098317.

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes

Won Hoon Choi, Yejin Yun, Seoyoung Park, Jun Hyoung Jeon, Jeeyoung Lee, Jung Hoon Lee, Su-A Yang, Nak-Kyoon Kim, Chan Hoon Jung, Yong Tae Kwon, Dohyun Han, Sang Min Lim, Min Jae Lee

Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19190–19200. Published online 2020 Jul 28. doi: 10.1073/pnas.1920327117

PMCID:: PMC7430983

Abstract Article PDF–2.2M

Select item 562506018.

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Xiaorong Wang, Ilan E. Chemmama, Clinton Yu, Alexander Huszagh, Yue Xu, Rosa Viner, Sarah A. Block, Peter Cimermancic, Scott D. Rychnovsky, Yihong Ye, Andrej Sali, Lan Huang

J Biol Chem. 2017 Sep 29; 292(39): 16310–16320. Published online 2017 Aug 15. doi: 10.1074/jbc.M117.803619

PMCID:: PMC5625060

Abstract Article PDF–2.5M

Select item 893369919.

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem. 2022 Apr; 298(4): 101750. Published online 2022 Feb 23. doi: 10.1016/j.jbc.2022.101750

PMCID:: PMC8933699

Abstract Article PDF–1.6M

Select item 863597320.

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

eLife. 2021; 10: e72798. Published online 2021 Nov 11. doi: 10.7554/eLife.72798

PMCID:: PMC8635973

Abstract Article PDF–10M

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