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Select item 79830061.

Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia

Adrien Georges, Juliette Albuisson, Takiy Berrandou, Délia Dupré, Aurélien Lorthioir, Valentina D’Escamard, Antonio F Di Narzo, Daniella Kadian-Dodov, Jeffrey W Olin, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz, Patrick Bruneval, Anna A Baranowska, Tom R Webb, Stephen E Hamby, Nilesh J Samani, David Adlam, Natalia Fendrikova-Mahlay, Stanley Hazen, Yu Wang, Min-Lee Yang, Kristina Hunker, Nicolas Combaret, Pascal Motreff, Antoine Chédid, Béatrice Fiquet, Pierre-François Plouin, Elie Mousseaux, Arshid Azarine, Laurence Amar, Michel Azizi, Heather L Gornik, Santhi K Ganesh, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji

Cardiovasc Res. 2021 Apr 1; 117(4): 1154–1165. Published online 2020 Jun 12. doi: 10.1093/cvr/cvaa161

PMCID:: PMC7983006

Abstract Article PDF–1.4M

Select item 40417222.

High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function

Anke Bill, Elizabeth M. Rosethorne, Toby C. Kent, Lindsay Fawcett, Lynn Burchell, Michiel T. van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P. Orth, Nicole A. Renaud, Steven J. Charlton, Martin Gosling, L. Alex Gaither, Paul J. Groot-Kormelink

PLoS One. 2014; 9(6): e97973. Published online 2014 Jun 2. doi: 10.1371/journal.pone.0097973

PMCID:: PMC4041722

Abstract Article PDF–935K

Select item 30622673.

Maternal Levels of Prostacyclin, Thromboxane, ICAM, and VCAM in Normal and Preeclamptic Pregnancies

David F. Lewis, Bernard J. Canzoneri, Yang Gu, Shuang Zhao, Yuping Wang

Am J Reprod Immunol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Am J Reprod Immunol. 2010 Dec; 64(6): 376–383. doi: 10.1111/j.1600-0897.2010.00861.x

PMCID:: PMC3062267

Abstract Article PDF–354K

Select item 30467324.

A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor

Feng Ni, Shui-Ping So, Vanessa Cervantes, Ke-He Ruan

FEBS J. Author manuscript; available in PMC 2011 Mar 1.

Published in final edited form as: FEBS J. 2008 Jan; 275(1): 128–137. Published online 2007 Nov 27. doi: 10.1111/j.1742-4658.2007.06183.x

PMCID:: PMC3046732

Abstract Article PDF–823K

Select item 30449635.

Comprehensive Biochemical Analysis of Rare Prostacyclin Receptor Variants: STUDY OF ASSOCIATION OF SIGNALING WITH CORONARY ARTERY OBSTRUCTION

Jeremiah Stitham, Eric Arehart, Larkin Elderon, Scott R. Gleim, Karen Douville, Zsolt Kasza, Kristina Fetalvero, Todd MacKenzie, John Robb, Kathleen A. Martin, John Hwa

J Biol Chem. 2011 Mar 4; 286(9): 7060–7069. Published online 2010 Dec 28. doi: 10.1074/jbc.M110.124933

PMCID:: PMC3044963

Abstract Article PDF–1.9M

Select item 27936856.

Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation, potential implications for COX-2 inhibition

Eric Arehart, Jeremiah Stitham, Folkert W. Asselbergs, Karen Douville, Todd MacKenzie, Kristina M. Fetalvero, Scott Gleim, Zsolt Kasza, Yamini Rao, Laurie Martel, Sharon Segel, John Robb, Aaron Kaplan, Michael Simons, Richard J. Powell, Jason H. Moore, Eric B. Rimm, Kathleen A. Martin, John Hwa

Circ Res. Author manuscript; available in PMC 2009 Dec 15.

Published in final edited form as: Circ Res. 2008 Apr 25; 102(8): 986–993. Published online 2008 Mar 6. doi: 10.1161/CIRCRESAHA.107.165936

PMCID:: PMC2793685

Abstract Article PDF–1.6M

Select item 26949907.

Temporal expression and signalling of prostacyclin receptor in the human endometrium across the menstrual cycle

S Battersby, H O D Critchley, A J de Brum-Fernandes, H N Jabbour

Reproduction. Author manuscript; available in PMC 2009 Jun 11.

Published in final edited form as: Reproduction. 2004 Jan; 127(1): 79–86. doi: 10.1530/rep.1.00038

PMCID:: PMC2694990

Abstract Article PDF–1.4M

Select item 20508268.

New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues

J Stitham, E Arehart, S R Gleim, N Li, K Douville, J Hwa

Br J Pharmacol. 2007 Oct; 152(4): 513–522. Published online 2007 Aug 20. doi: 10.1038/sj.bjp.0707413

PMCID:: PMC2050826

Abstract Article PDF–293K

Select item 20167899.

Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR)

Jeremiah Stitham, Eric J. Arehart, Scott Gleim, Karen L. Douville, Todd MacKenzie, John Hwa

Gene. Author manuscript; available in PMC 2008 Jul 1.

Published in final edited form as: Gene. 2007 Jul 1; 396(1): 180–187. Published online 2007 Apr 1. doi: 10.1016/j.gene.2007.03.016

PMCID:: PMC2016789

Abstract Article PDF–980K

Select item 768507410.

Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner

Takahiro Osawa, Noritaka Ohga, Yasuhiro Hida, Kazuko Kitayama, Kosuke Akiyama, Yuichiro Onodera, Manabu Fujie, Nobuo Shinohara, Masanobu Shindoh, Katsuya Nonomura, Kyoko Hida

Cancer Sci. 2012 Jun; 103(6): 1038–1044. Published online 2012 Apr 17. doi: 10.1111/j.1349-7006.2012.02261.x

PMCID:: PMC7685074

Abstract Article PDF–510K

Select item 536373211.

Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels

Tongrong He, Anantha Vijay R Santhanam, Tong Lu, Livius V d'Uscio, Zvonimir S Katusic

J Cereb Blood Flow Metab. 2017 Jan; 37(1): 106–122. Published online 2015 Nov 20. doi: 10.1177/0271678X15618977

PMCID:: PMC5363732

Abstract Article PDF–1.0M

Select item 335379812.

Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel

Meera Sridharan, Elizabeth A. Bowles, Jennifer P. Richards, Medina Krantic, Katie L. Davis, Kristine A. Dietrich, Alan H. Stephenson, Mary L. Ellsworth, Randy S. Sprague

Am J Physiol Heart Circ Physiol. 2012 Feb 1; 302(3): H553–H559. Published online 2011 Dec 9. doi: 10.1152/ajpheart.00998.2011

PMCID:: PMC3353798

Abstract Article

Select item 292446013.

Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease

Salam Ibrahim, Mazell Tetruashvily, Alex J Frey, Stephen J Wilson, Jeremiah Stitham, John Hwa, Emer M Smyth

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9): 1802–1809. Published online 2010 Jun 3. doi: 10.1161/ATVBAHA.110.208900

PMCID:: PMC2924460

Abstract Article PDF–1.4M

Select item 268097614.

Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase

Martina B. O'Keeffe, Helen M. Reid, B. Therese Kinsella

Biochim Biophys Acta. 2008 Oct; 1783(10): 1914–1928. doi: 10.1016/j.bbamcr.2008.04.010

PMCID:: PMC2680976

Abstract Article

Select item 113478015.

The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor

Sarah J. O'Meara, B. Therese Kinsella

Biochem J. 2005 Feb 15; 386(Pt 1): 177–189. Prepublished online 2004 Oct 6. Published online 2005 Feb 8. doi: 10.1042/BJ20041290

PMCID:: PMC1134780

Abstract Article PDF–547K

Select item 364646816.

Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif

Alexander J. Frey, Salam Ibrahim, Scott Gleim, John Hwa, Emer M. Smyth

J Lipid Res. 2013 Jun; 54(6): 1678–1690. doi: 10.1194/jlr.M036673

PMCID:: PMC3646468

Abstract Article PDF–1.3M

Select item 353336317.

Heterodimerization with the Prostacyclin Receptor Triggers Thromboxane Receptor Relocation to Lipid Rafts

Salam Ibrahim, Ann McCartney, Nune Markosyan, Emer M Smyth

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1): 60–66. Published online 2012 Nov 15. doi: 10.1161/ATVBAHA.112.300536

PMCID:: PMC3533363

Abstract Article PDF–704K

Select item 314554318.

Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis

Elizebeth C. Turner, Eamon P. Mulvaney, Helen M. Reid, B. Therese Kinsella

Mol Biol Cell. 2011 Aug 1; 22(15): 2664–2679. doi: 10.1091/mbc.E11-04-0374

PMCID:: PMC3145543

Abstract Article PDF–4.1M

Select item 300125819.

Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension

Emilia Falcetti, Susan M. Hall, Peter G. Phillips, Jigisha Patel, Nicholas W. Morrell, Sheila G. Haworth, Lucie H. Clapp

Am J Respir Crit Care Med. 2010 Nov 1; 182(9): 1161–1170. Published online 2010 Jul 9. doi: 10.1164/rccm.201001-0011OC

PMCID:: PMC3001258

Abstract Article PDF–1.7M

Select item 131790720.

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

Muriel Nobles, Amy Benians, Andrew Tinker

Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51): 18706–18711. Published online 2005 Dec 13. doi: 10.1073/pnas.0504778102

PMCID:: PMC1317907

Abstract Article PDF–736K

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