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Select item 92623751.

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

Ryan J. Boyd, Tien L. Olson, James D. Zook, Derek Stein, Manuel Aceves, Wan‐Hsin Lin, Felicia M. Craciunescu, Debra T. Hansen, Panos Z. Anastasiadis, Abhishek Singharoy, Petra Fromme

FASEB J. 2022 Jul; 36(7): e22378. Published online 2022 May 31. doi: 10.1096/fj.202101808RR

PMCID:: PMC9262375

Abstract Article PDF–1.9M

Select item 37281512.

Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease

Hyeon Jin Kim, Young Bin Hong, Jin-Mo Park, Yu-Ri Choi, Ye Jin Kim, Bo Ram Yoon, Heasoo Koo, Jeong Hyun Yoo, Sang Beom Kim, Minhwa Park, Ki Wha Chung, Byung-Ok Choi

Orphanet J Rare Dis. 2013; 8: 104. Published online 2013 Jul 12. doi: 10.1186/1750-1172-8-104

PMCID:: PMC3728151

Abstract Article PDF–2.9M

Select item 19509133.

The Nuclear Factor κB–Activator Gene PLEKHG5 Is Mutated in a Form of Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

Isabelle Maystadt, René Rezsöhazy, Martine Barkats, Sandra Duque, Pascal Vannuffel, Sophie Remacle, Barbara Lambert, Mustapha Najimi, Etienne Sokal, Arnold Munnich, Louis Viollet, Christine Verellen-Dumoulin

Am J Hum Genet. 2007 Jul; 81(1): 67–76. Published online 2007 May 16. doi: 10.1086/518900

PMCID:: PMC1950913

Abstract Article PDF–598K

Select item 77368424.

PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells

Kaya Elisa Witte, Carsten Slotta, Melanie Lütkemeyer, Angelika Kitke, Roland Coras, Matthias Simon, Christian Kaltschmidt, Barbara Kaltschmidt

Sci Rep. 2020; 10: 21858. Published online 2020 Dec 14. doi: 10.1038/s41598-020-77958-3

PMCID:: PMC7736842

Abstract Article PDF–11M

Select item 63078885.

The RhoGEF protein Plekhg5 regulates apical constriction of bottle cells during gastrulation

Ivan K. Popov, Heather J. Ray, Paul Skoglund, Ray Keller, Chenbei Chang

Development. 2018 Dec 15; 145(24): dev168922. Published online 2018 Dec 12. doi: 10.1242/dev.168922

PMCID:: PMC6307888

Abstract Article

Select item 39834076.

PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot–Marie–Tooth disease

Hamid Azzedine, Petra Zavadakova, Violaine Planté-Bordeneuve, Maria Vaz Pato, Nuno Pinto, Luca Bartesaghi, Jennifer Zenker, Olivier Poirot, Nathalie Bernard-Marissal, Estelle Arnaud Gouttenoire, Romain Cartoni, Alexandra Title, Giulia Venturini, Jean-Jacques Médard, Edward Makowski, Ludger Schöls, Kristl G. Claeys, Claudia Stendel, Andreas Roos, Joachim Weis, Odile Dubourg, José Leal Loureiro, Giovanni Stevanin, Gérard Said, Anthony Amato, Jay Baraban, Eric LeGuern, Jan Senderek, Carlo Rivolta, Roman Chrast

Hum Mol Genet. 2013 Oct 15; 22(20): 4224–4232. Published online 2013 Jun 17. doi: 10.1093/hmg/ddt274

PMCID:: PMC3983407

Abstract Article PDF–1.2M

Select item 38895437.

The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration

Justus C. Dachsel, Siu P. Ngok, Laura J. Lewis-Tuffin, Antonis Kourtidis, Rory Geyer, Lauren Johnston, Ryan Feathers, Panos Z. Anastasiadis

Mol Cell Biol. 2013 Dec; 33(24): 4909–4918. doi: 10.1128/MCB.00565-13

PMCID:: PMC3889543

Abstract Article PDF–3.8M

Select item 35851038.

Phosphorylation-mediated 14-3-3 Protein Binding Regulates the Function of the Rho-specific Guanine Nucleotide Exchange Factor (RhoGEF) Syx

Siu P. Ngok, Rory Geyer, Antonis Kourtidis, Peter Storz, Panos Z. Anastasiadis

J Biol Chem. 2013 Mar 1; 288(9): 6640–6650. Published online 2013 Jan 18. doi: 10.1074/jbc.M112.432682

PMCID:: PMC3585103

Abstract Article PDF–3.6M

Select item 34423769.

The GTPase-deficient Rnd Proteins Are Stabilized by Their Effectors

Liuh Ling Goh, Ed Manser

J Biol Chem. 2012 Sep 7; 287(37): 31311–31320. Published online 2012 Jul 17. doi: 10.1074/jbc.M111.327056

PMCID:: PMC3442376

Abstract Article PDF–2.2M

Select item 292829910.

The RhoA GEF Syx Is a Target of Rnd3 and Regulated via a Raf1-Like Ubiquitin-Related Domain

Liuh Ling Goh, Ed Manser

PLoS One. 2010; 5(8): e12409. Published online 2010 Aug 25. doi: 10.1371/journal.pone.0012409

PMCID:: PMC2928299

Abstract Article PDF–1.6M

Select item 270144911.

Common variants at ten loci influence myocardial repolarization: the QTGEN consortium

Christopher Newton-Cheh, Mark Eijgelsheim, Kenneth Rice, Paul I. W. de Bakker, Xiaoyan Yin, Karol Estrada, Joshua Bis, Kristin Marciante, Fernando Rivadeneira, Peter A. Noseworthy, Nona Sotoodehnia, Nicholas L. Smith, Jerome I. Rotter, Jan A. Kors, Jacqueline C.M. Witteman, Albert Hofman, Susan R. Heckbert, Christopher J. O’Donnell, Andre G. Uitterlinden, Bruce M. Psaty, Thomas Lumley, Martin G. Larson, Bruno H.Ch. Stricker

Nat Genet. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Nat Genet. 2009 Apr; 41(4): 399–406. Published online 2009 Mar 22. doi: 10.1038/ng.364

PMCID:: PMC2701449

Abstract Article PDF–804K

Select item 321081212.

Biochemical and Computational Analysis Of LNX1 Interacting Proteins

Cheryl D. Wolting, Emily K. Griffiths, Renu Sarao, Brittany C. Prevost, Leanne E. Wybenga-Groot, C. Jane McGlade

PLoS One. 2011; 6(11): e26248. Published online 2011 Nov 8. doi: 10.1371/journal.pone.0026248

PMCID:: PMC3210812

Abstract Article PDF–1.5M

Select item 675758313.

Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

Anthony W. Harrington, Ju Young Kim, Sung Ok Yoon

J Neurosci. 2002 Jan 1; 22(1): 156–166. doi: 10.1523/JNEUROSCI.22-01-00156.2002

PMCID:: PMC6757583

Abstract Article PDF–582K

Select item 292822414.

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity

HD Hosgood, III, L Zhang, M Shen, SI Berndt, R Vermeulen, G Li, S Yin, M Yeager, J Yuenger, N Rothman, S Chanock, M Smith, Q Lan

Occup Environ Med. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Occup Environ Med. 2009 Dec; 66(12): 848–853. Published online 2009 Sep 22. doi: 10.1136/oem.2008.044024

PMCID:: PMC2928224

Abstract Article PDF–321K

Select item 683185115.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

Mohamed Taha Moutaoufik, Ramy Malty, Shahreen Amin, Qingzhou Zhang, Sadhna Phanse, Alla Gagarinova, Mara Zilocchi, Larissa Hoell, Zoran Minic, Maria Gagarinova, Hiroyuki Aoki, Jocelyn Stockwell, Matthew Jessulat, Florian Goebels, Kirsten Broderick, Nichollas E. Scott, James Vlasblom, Gabriel Musso, Bhanu Prasad, Eleonora Lamantea, Barbara Garavaglia, Alex Rajput, Kei Murayama, Yasushi Okazaki, Leonard J. Foster, Gary D. Bader, Francisco S. Cayabyab, Mohan Babu

iScience. 2019 Sep 27; 19: 1114–1132. Published online 2019 Sep 4. doi: 10.1016/j.isci.2019.08.057

PMCID:: PMC6831851

Abstract Article PDF–9.8M

Select item 563060016.

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D’Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell

Nat Commun. 2017; 8: 797. Published online 2017 Oct 6. doi: 10.1038/s41467-017-00842-8

PMCID:: PMC5630600

Abstract Article PDF–2.3M

Select item 926261417.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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