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Select item 103739841.

Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines

Wuhan Zhou, Jiafei Chen, Jingui Wang

Aging (Albany NY) 2023 Jul 15; 15(13): 6545–6576. Published online 2023 Jul 13. doi: 10.18632/aging.204869

PMCID:: PMC10373984

Article PDF–10M

Select item 94410072.

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher

Mol Oncol. 2022 Sep; 16(17): 3082–3106. Published online 2022 Apr 30. doi: 10.1002/1878-0261.13217

PMCID:: PMC9441007

Article PDF–13M

Select item 57101393.

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Anna E. Mazzucco, Agata Smogorzewska, Chanhee Kang, Ji Luo, Michael R. Schlabach, Qikai Xu, Rupesh Patel, Stephen J. Elledge

Genes Dev. 2017 Oct 1; 31(19): 1933–1938. doi: 10.1101/gad.304857.117

Correction in:: Genes Dev. 2017 Nov 15; 31(22): 2310.

PMCID:: PMC5710139

Article PDF–3.0M

Select item 49354444.

Ubiquitin-specific protease 28 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity by regulating MYC expression

Zengwu Wang, Qimin Song, Jian Xue, Yumei Zhao, Shiqiang Qin

Exp Biol Med (Maywood) 2016 Feb; 241(3): 255–264. Published online 2015 Jul 23. doi: 10.1177/1535370215595468

PMCID:: PMC4935444

Article PDF–1.5M

Select item 109485585.

USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells

Janardhan Keshav Karapurkar, Jencia Carminha Colaco, Bharathi Suresh, Apoorvi Tyagi, Sang Hyeon Woo, Won-Jun Jo, Nare Ko, Vijai Singh, Seok-Ho Hong, Seung Jun Oh, Kye-Seong Kim, Suresh Ramakrishna

Cell Mol Life Sci. 2024; 81(1): 145. Published online 2024 Mar 18. doi: 10.1007/s00018-024-05187-2

PMCID:: PMC10948558

Article PDF–10M

Select item 104046176.

The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells

Junjun Li, Jin Peng, Lingzhi Wu, Xiang Shen, Xinghua Zhen, Yimao Zhang, Huailu Ma, Yongfeng Xu, Qunli Xiong, Qing Zhu, Pumin Zhang

J Biol Chem. 2023 Jul; 299(7): 104856. Published online 2023 May 23. doi: 10.1016/j.jbc.2023.104856

PMCID:: PMC10404617

Article PDF–2.9M

Select item 87332647.

The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells

Jiewei Wang, Yiping Dong, Huailu Ma, Lingzhi Wu, Xinghua Zhen, Lichun Tang, Jianping Jin, Suxia Han, Pumin Zhang, Jin Peng

J Biol Chem. 2022 Jan; 298(1): 101443. Published online 2021 Nov 22. doi: 10.1016/j.jbc.2021.101443

PMCID:: PMC8733264

Article PDF–2.8M

Select item 84789458.

USP28 facilitates pancreatic cancer progression through activation of Wnt/β-catenin pathway via stabilising FOXM1

Leifeng Chen, Zheng Xu, Qing Li, Qian Feng, Cihua Zheng, Yunyan Du, Rongfa Yuan, Xiaogang Peng

Cell Death Dis. 2021 Oct; 12(10): 887. Published online 2021 Sep 28. doi: 10.1038/s41419-021-04163-z

PMCID:: PMC8478945

Article PDF–6.5M

Select item 79143549.

Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28

Bing Chen, Yuting Sang, Xiaojin Song, Dong Zhang, Lijuan Wang, Wenjing Zhao, Yiran Liang, Ning Zhang, Qifeng Yang

Theranostics. 2021; 11(8): 3932–3947. Published online 2021 Feb 6. doi: 10.7150/thno.53412

PMCID:: PMC7914354

Article PDF–4.9M

Select item 748836510.

Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Zhenzhen Liu, Taoqian Zhao, Zhonghua Li, Kai Sun, Yundong Fu, Ting Cheng, Jimin Guo, Bin Yu, Xiaojing Shi, Hongmin Liu

Acta Pharm Sin B. 2020 Aug; 10(8): 1476–1491. Published online 2019 Dec 16. doi: 10.1016/j.apsb.2019.12.008

PMCID:: PMC7488365

Article PDF–4.6M

Select item 713696411.

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher

EMBO Mol Med. 2020 Apr 7; 12(4): e11101. Published online 2020 Mar 4. doi: 10.15252/emmm.201911101

PMCID:: PMC7136964

Article PDF–4.0M

Select item 706081012.

Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint through cleavage of USP28

Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, Dagmar Kulms

Mol Cell. Author manuscript; available in PMC 2021 Mar 5.

Published in final edited form as: Mol Cell. 2020 Mar 5; 77(5): 970–984.e7. Published online 2020 Jan 22. doi: 10.1016/j.molcel.2019.12.023

PMCID:: PMC7060810

Article PDF–2.7M

Select item 678901413.

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Nadia Gul, Joakim Karlsson, Carolina Tängemo, Sanna Linsefors, Samuel Tuyizere, Rosie Perkins, Chandu Ala, Zhiyuan Zou, Erik Larsson, Martin O. Bergö, Per Lindahl

Sci Rep. 2019; 9: 14667. Published online 2019 Oct 11. doi: 10.1038/s41598-019-51205-w

PMCID:: PMC6789014

Article PDF–1.4M

Select item 639665614.

Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer

Pengling Li, Ziming Huang, Jipeng Wang, Wei Chen, Jianan Huang

Onco Targets Ther. 2019; 12: 1603–1611. Published online 2019 Feb 26. doi: 10.2147/OTT.S194917

PMCID:: PMC6396656

Article PDF–1.5M

Select item 602851915.

Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies

Azad Saei, Marta Palafox, Touati Benoukraf, Nishi Kumari, Patrick William Jaynes, Prasanna Vasudevan Iyengar, Eva Muñoz-Couselo, Paolo Nuciforo, Javier Cortés, Christopher Nötzel, Nesaretnam Barr Kumarakulasinghe, John Lalith Charles Richard, Zul Fazreen Bin Adam Isa, Brendan Pang, Marta Guzman, Zhou Siqin, Henry Yang, Wai Leong Tam, Violeta Serra, Pieter Johan Adam Eichhorn

J Exp Med. 2018 Jul 2; 215(7): 1913–1928. doi: 10.1084/jem.20171960