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Items: 1 to 20 of 92

1.
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng
Cell Death Dis. 2023 Oct; 14(10): 682. Published online 2023 Oct 16. doi: 10.1038/s41419-023-06200-5
PMCID:
PMC10579265
AbstractArticlePDF–8.8M
2.
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
Xianglai Xu, Ying Wang, Xinyu Hu, Yanjun Zhu, Jiajun Wang, Jianming Guo
Neoplasia. 2023 Sep; 43: 100919. Published online 2023 Jul 28. doi: 10.1016/j.neo.2023.100919
PMCID:
PMC10404727
AbstractArticlePDF–10M
3.
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Emily J. Kay, Karla Paterson, Carla Riera-Domingo, David Sumpton, J. Henry M. Däbritz, Saverio Tardito, Claudia Boldrini, Juan R. Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J. Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J. Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Massimiliano Mazzone, Karen Blyth, Michele Zagnoni, Sara Zanivan
Nat Metab. 2022; 4(6): 693–710. Published online 2022 Jun 27. doi: 10.1038/s42255-022-00582-0
Correction in:
Nat Metab. 2022; 4(8): 1084.
PMCID:
PMC9236907
AbstractArticlePDF–10M
4.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
Rebecca L. Westbrook, Esther Bridges, Jennie Roberts, Cristina Escribano-Gonzalez, Katherine L. Eales, Lisa A. Vettore, Paul D. Walker, Elias Vera-Siguenza, Himani Rana, Federica Cuozzo, Kattri-Liis Eskla, Hans Vellama, Abeer Shaaban, Colin Nixon, Hendrik Luuk, Gareth G. Lavery, David J. Hodson, Adrian L. Harris, Daniel A. Tennant
Cell Rep. 2022 Feb 1; 38(5): 110320. Published online 2022 Feb 1. doi: 10.1016/j.celrep.2022.110320
PMCID:
PMC8822494
AbstractArticle
5.
Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1
Emily M. Christensen, Sagar M. Patel, David A. Korasick, Ashley C. Campbell, Kurt L. Krause, Donald F. Becker, John J. Tanner
J Biol Chem. 2017 Apr 28; 292(17): 7233–7243. Published online 2017 Mar 3. doi: 10.1074/jbc.M117.780288
PMCID:
PMC5409489
AbstractArticlePDF–2.5M
6.
Effect of R119G Mutation on Human P5CR1 Dynamic Property and Enzymatic Activity
Linhua Li, Yujia Ye, Peng Sang, Yirui Yin, Wei Hu, Jing Wang, Chao Zhang, Deyun Li, Wen Wan, Rui Li, Longjun Li, Linling Ma, Yuehui Xie, Zhaohui Meng
Biomed Res Int. 2017; 2017: 4184106. Published online 2017 Jan 18. doi: 10.1155/2017/4184106
PMCID:
PMC5286483
AbstractArticlePDF–1.2M
7.
Mutation in Pyrroline-5-Carboxylate Reductase 1 Gene in Families with Cutis Laxa Type 2
Duane L. Guernsey, Haiyan Jiang, Susan C. Evans, Meghan Ferguson, Makoto Matsuoka, Mathew Nightingale, Andrea L. Rideout, Sylvie Provost, Karen Bedard, Andrew Orr, Marie-Pierre Dubé, Mark Ludman, Mark E. Samuels
Am J Hum Genet. 2009 Jul 10; 85(1): 120–129. doi: 10.1016/j.ajhg.2009.06.008
PMCID:
PMC2706970
AbstractArticlePDF–1.2M
8.
Pyrroline-5-carboxylate reductase in human erythrocytes.
G C Yeh, S C Harris, J M Phang
J Clin Invest. 1981 Apr; 67(4): 1042–1046. doi: 10.1172/JCI110115
PMCID:
PMC370662
SummaryPage BrowsePDF–762K
9.
MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1)
Zhiqun Li, Xiaoliu Zhou, Jiajun Huang, Zhencai Xu, Chengliang Xing, Junwei Yang, Xuejun Zhou
Bioengineered. 2021; 12(2): 9766–9778. Published online 2021 Dec 2. doi: 10.1080/21655979.2021.1995102
PMCID:
PMC8810012
AbstractArticlePDF–3.3M
10.
Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma
Yanzhen Xu, Wenpu Zuo, Xiao Wang, Qinle Zhang, Xiang Gan, Ning Tan, Wenxian Jia, Jiayi Liu, Zhouquan Li, Bo Zhou, Dong Zhao, Zhibin Xie, Yanjun Tan, Shengfeng Zheng, Chengwu Liu, Hongtao Li, Zhijian Chen, Xiaoli Yang, Zhaoquan Huang
Int J Biol Sci. 2021; 17(9): 2223–2239. Published online 2021 Jun 1. doi: 10.7150/ijbs.58026
PMCID:
PMC8241733
AbstractArticlePDF–2.7M
11.
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis
Un Yung Choi, Jae Jin Lee, Angela Park, Wei Zhu, Hye-Ra Lee, Youn Jung Choi, Ji-Seung Yoo, Claire Yu, Pinghui Feng, Shou-Jiang Gao, Shaochen Chen, Hyungjin Eoh, Jae U. Jung
Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 8083–8093. Published online 2020 Mar 25. doi: 10.1073/pnas.1918607117
PMCID:
PMC7149499
AbstractArticlePDF–1.8M
12.
Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations
Davor Lessel, Ayse Bilge Ozel, Susan E. Campbell, Abdelkrim Saadi, Martin F. Arlt, Keisha Melodi McSweeney, Vasilica Plaiasu, Katalin Szakszon, Anna Szőllős, Cristina Rusu, Armando J. Rojas, Jaime Lopez-Valdez, Holger Thiele, Peter Nürnberg, Deborah A. Nickerson, Michael J. Bamshad, Jun Z. Li, Christian Kubisch, Thomas W. Glover, Leslie B. Gordon
Hum Genet. Author manuscript; available in PMC 2019 Jul 24.
Published in final edited form as: Hum Genet. 2018 Dec; 137(11-12): 921–939. Published online 2018 Nov 19. doi: 10.1007/s00439-018-1957-1
PMCID:
PMC6652186
AbstractArticlePDF–645K
13.
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Cell Rep. 2018 Mar 20; 22(12): 3107–3114. Published online 2018 Mar 20. doi: 10.1016/j.celrep.2018.02.084
PMCID:
PMC5883319
AbstractArticle
14.
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia
Ke Zheng, Nannan Sha, Guofang Hou, Zhuyun Leng, Qin Zhao, Li Zhang, Lingnan He, Meidong Xu, Yuhui Jiang, Tao Chen
Nat Commun. 2023; 14: 6117. Published online 2023 Sep 30. doi: 10.1038/s41467-023-41658-z
PMCID:
PMC10542766
AbstractArticlePDF–2.1M
15.
SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3
Zhuo Li, Jian Liu, Huifeng Fu, Yuanwei Li, Qiang Liu, Wei Song, Mingqiang Zeng
Aging (Albany NY) 2022 Oct 15; 14(19): 8032–8045. Published online 2022 Oct 11. doi: 10.18632/aging.204333
PMCID:
PMC9596220
AbstractArticlePDF–1.4M
16.
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression
Wei Song, Ke Yang, Jianjun Luo, Zhiyong Gao, Yunliang Gao
Aging (Albany NY) 2021 Feb 15; 13(3): 3909–3925. Published online 2021 Jan 10. doi: 10.18632/aging.202359
PMCID:
PMC7906198
AbstractArticlePDF–1.7M
17.
PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer
Juhua Zhuang, Yanan Song, Ying Ye, Saifei He, Xing Ma, Miao Zhang, Jing Ni, Jiening Wang, Wei Xia
J Transl Med. 2019; 17: 343. Published online 2019 Oct 16. doi: 10.1186/s12967-019-2091-0
PMCID:
PMC6796468
AbstractArticlePDF–7.2M
18.
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production
Yosuke Togashi, Tokuzo Arao, Hiroaki Kato, Kazuko Matsumoto, Masato Terashima, Hidetoshi Hayashi, Marco A de Velasco, Yoshihiko Fujita, Hideharu Kimura, Takushi Yasuda, Hitoshi Shiozaki, Kazuto Nishio
Oncotarget. 2014 May; 5(10): 2962–2973. Published online 2013 Dec 30. doi: 10.18632/oncotarget.1561
PMCID:
PMC4102783
AbstractArticlePDF–1.3M
19.
PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress
Mei-Ling Kuo, Mabel Bin-Er Lee, Michelle Tang, Willem den Besten, Shuya Hu, Michael J. Sweredoski, Sonja Hess, Chih-Ming Chou, Chun A. Changou, Mingming Su, Wei Jia, Leila Su, Yun Yen
Sci Rep. 2016; 6: 18846. Published online 2016 Jan 6. doi: 10.1038/srep18846
PMCID:
PMC4702135
AbstractArticlePDF–1.7M
20.
Functional Specialization in Proline Biosynthesis of Melanoma
Jessica De Ingeniis, Boris Ratnikov, Adam D. Richardson, David A. Scott, Pedro Aza-Blanc, Surya K. De, Marat Kazanov, Maurizio Pellecchia, Ze'ev Ronai, Andrei L. Osterman, Jeffrey W. Smith
PLoS One. 2012; 7(9): e45190. Published online 2012 Sep 14. doi: 10.1371/journal.pone.0045190
PMCID:
PMC3443215
AbstractArticlePDF–591K

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