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Select item 107674301.

RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome

Jingjing Zheng, Longyun Peng, Ruofei Cheng, Zhiyan Li, Jianjie Xie, Erwen Huang, Jianding Cheng, Qianhao Zhao

Mol Genet Genomic Med. 2024 Jan; 12(1): e2290. Published online 2023 Oct 3. doi: 10.1002/mgg3.2290

PMCID:: PMC10767430

Article PDF–8.9M

Select item 102848402.

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues

Saeideh Nakhaei-Rad, Fereshteh Haghighi, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Karolin Kleemann, Anne Schänzer, Andrea Borchardt, Andreas Hahn, Sebastian Kötter, Denny Schanze, Ruchika Anand, Florian Funk, Annette Vera Kronenbitter, Jürgen Scheller, Roland P. Piekorz, Andreas S. Reichert, Marianne Volleth, Matthew J. Wolf, Ion Cristian Cirstea, Bruce D. Gelb, Marco Tartaglia, Joachim P. Schmitt, Martina Krüger, Ingo Kutschka, Lukas Cyganek, Martin Zenker, George Kensah, Mohammad R. Ahmadian

Commun Biol. 2023; 6: 657. Published online 2023 Jun 21. doi: 10.1038/s42003-023-05013-8

PMCID:: PMC10284840

Article PDF–5.2M

Select item 86335623.

The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus

Yunxiang Zang, Alem W. Kahsai, Natalia Pakharukova, Li-yin Huang, Robert J. Lefkowitz

J Biol Chem. 2021 Dec; 297(6): 101369. Published online 2021 Oct 30. doi: 10.1016/j.jbc.2021.101369

PMCID:: PMC8633562

Article PDF–1.1M

Select item 76592374.

Prognostic impact of Raf‐1 and p‐Raf‐1 expressions for poor survival rate in non‐small cell lung cancer

Zhi‐Xin Qiu, Lei Wang, Juan Han, Dan Liu, Wei Huang, Kiran Altaf, Xue‐Song Qiu, Muhammad A. Javed, Jing Zheng, Bo‐Jiang Chen, Wei‐Min Li

Cancer Sci. 2012 Oct; 103(10): 1774–1779. Published online 2012 Aug 8. doi: 10.1111/j.1349-7006.2012.02375.x

PMCID:: PMC7659237

Article PDF–653K

Select item 73849855.

Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles

Erik A. Williams, Nikunj Shah, Meagan Montesion, Radwa Sharaf, Dean C. Pavlick, Ethan S. Sokol, Brian M. Alexander, Jeff M. Venstrom, Julia A. Elvin, Jeffrey S. Ross, Julie Y. Tse, Mark C. Mochel

Mod Pathol. 2020; 33(8): 1466–1474. Published online 2020 Mar 2. doi: 10.1038/s41379-020-0510-7

PMCID:: PMC7384985

Article PDF–2.2M

Select item 67562266.

CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition

Amir Noeparast, Philippe Giron, Alfiah Noor, Rajendra Bahadur Shahi, Sylvia De Brakeleer, Carolien Eggermont, Hugo Vandenplas, Bram Boeckx, Diether Lambrechts, Jacques De Grève, Erik Teugels

Oncogene. 2019; 38(31): 5933–5941. Published online 2019 Jul 8. doi: 10.1038/s41388-019-0866-7

PMCID:: PMC6756226

Article PDF–1.2M

Select item 67096787.

iPSC-derived cardiomyocytes reveal aberrant ERK5 and MEK1/2 signaling concomitantly promote hypertrophic cardiomyopathy in RAF1-associated Noonan Syndrome

Fabrice Jaffré, Clint L. Miller, Anne Schänzer, Todd Evans, Amy E. Roberts, Andreas Hahn, Maria I. Kontaridis

Circulation. Author manuscript; available in PMC 2020 Jul 16.

Published in final edited form as: Circulation. 2019 Jul 16; 140(3): 207–224. Published online 2019 Jun 5. doi: 10.1161/CIRCULATIONAHA.118.037227

PMCID:: PMC6709678

Article PDF–1.4M

Select item 63550658.

Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response

Benjamin R. Nixon, Sara C. Sebag, Michael S. Glennon, Eric J. Hall, Emily S. Kounlavong, Michael L. Freeman, Jason R. Becker

FASEB J. 2019 Jan; 33(1): 1138–1150. Published online 2018 Aug 14. doi: 10.1096/fj.201800336R

PMCID:: PMC6355065

Article

Select item 51731599.

Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence

Jianyong Lei, Jinjing Zhong, Jingcheng Hao, Zhengni Liu, Peng Zhang, Lixue Wu, Lunan Yan, Jinqiang Zhu, Yong Zeng, Bo Li, Tianfu Wen, Wentao Wang

Oncotarget. 2016 Jul 5; 7(27): 42598–42607. Published online 2016 Mar 13. doi: 10.18632/oncotarget.3799

PMCID:: PMC5173159

Article PDF–1.2M

Select item 489763610.

CRAF R391W is a melanoma driver oncogene

Mohammad Atefi, Bjoern Titz, Jennifer Tsoi, Earl Avramis, Allison Le, Charles Ng, Anastasia Lomova, Amanda Lassen, Michael Friedman, Bartosz Chmielowski, Antoni Ribas, Thomas G. Graeber

Sci Rep. 2016; 6: 27454. Published online 2016 Jun 8. doi: 10.1038/srep27454

PMCID:: PMC4897636

Article PDF–1.4M

Select item 434888311.

Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence

Kai Zhang, Hao Chen, Bin Zhang, Jiajia Sun, Jian Lu, Kangwu Chen, Huilin Yang

Int J Clin Exp Pathol. 2015; 8(1): 608–614. Published online 2015 Jan 1.

PMCID:: PMC4348883

Article PDF–728K

Select item 405877012.

Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells

ALEXEY A. LEONTOVICH, SHUYA ZHANG, COSIMA QUATRARO, IANKO IANKOV, PIER FRANCESCO VEROUX, MARIO W. GAMBINO, AMY DEGNIM, JAMES McCUBREY, JAMES INGLE, EVANTHIA GALANIS, ANTONINO B. D'ASSORO

Int J Oncol. Author manuscript; available in PMC 2014 Jun 16.

Published in final edited form as: Int J Oncol. 2012 Jun; 40(6): 1858–1864. Published online 2012 Mar 19. doi: 10.3892/ijo.2012.1407

PMCID:: PMC4058770

Article PDF–974K

Select item 388546713.

Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine

Da-Ping Fan, Yi-Mei Zhang, Xiao-Chen Hu, Jing-Jing Li, Wei Zhang

Int J Clin Exp Pathol. 2014; 7(1): 134–143. Published online 2013 Dec 15.

PMCID:: PMC3885467

Article PDF–1.0M

Select item 382298314.

Raf-1 levels determine the migration rate of primary endometrial stromal cells of patients with endometriosis

Iveta Yotova, Ping Quan, Aulona Gaba, Nadja Leditznig, Petra Pateisky, Christine Kurz, Walter Tschugguel

J Cell Mol Med. 2012 Sep; 16(9): 2127–2139. Published online 2012 Aug 23. doi: 10.1111/j.1582-4934.2011.01520.x

PMCID:: PMC3822983

Article PDF–700K

Select item 378118015.

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

Linda S. Steelman, Stephen L. Abrams, John G. Shelton, William H. Chappell, Jörg Bäsecke, Franca Stivala, Marco Donia, Ferdinando Nicoletti, Massimo Libra, Alberto M. Martelli, James A. McCubrey

Cell Cycle. 2010 Apr 15; 9(8): 1629–1638. doi: 10.4161/cc.9.8.11487

PMCID:: PMC3781180

Article PDF–694K

Select item 374838916.

C-RAF mutations confer resistance to RAF inhibitors

Rajee Antony, Caroline M. Emery, Allison M. Sawyer, Levi A. Garraway

Cancer Res. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: Cancer Res. 2013 Aug 1; 73(15): 4840–4851. Published online 2013 Jun 4. doi: 10.1158/0008-5472.CAN-12-4089

PMCID:: PMC3748389

Article PDF–2.8M

Select item 323364417.

A MEK-independent role for CRAF in mitosis and tumor progression

Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Maria Fernanda Camargo, Sudarshan Anand, Aleksandra Franovic, Sara M. Weis, Sunil J. Advani, Eric A. Murphy, David A. Cheresh

Nat Med. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Nat Med. 2011 Dec; 17(12): 1641–1645. Published online 2011 Nov 13. doi: 10.1038/nm.2464

PMCID:: PMC3233644

Article PDF–1.3M

Select item 322694018.

Conditional Expression of Oncogenic C-RAF in Mouse Pulmonary Epithelial Cells Reveals Differential Tumorigenesis and Induction of Autophagy Leading to Tumor Regression

Fatih Ceteci, Jiajia Xu, Semra Ceteci, Emanuele Zanucco, Chitra Thakur, Ulf R Rapp

Neoplasia. 2011 Nov; 13(11): 1005–1018. doi: 10.1593/neo.11652

PMCID:: PMC3226940

Article PDF–24M

Select item 312862919.

Raf Family Kinases: Old Dogs Have Learned New Tricks

David Matallanas, Marc Birtwistle, David Romano, Armin Zebisch, Jens Rauch, Alexander von Kriegsheim, Walter Kolch

Genes Cancer. 2011 Mar; 2(3): 232–260. doi: 10.1177/1947601911407323

PMCID:: PMC3128629

Article PDF–739K

Select item 281441720.

Raf-1 Signaling Is Required for the Later Stages of 1,25-Dihydroxyvitamin D₃-Induced Differentiation of HL60 Cells But Is Not Mediated by the MEK/ERK Module

Xuening Wang, George P. Studzinski

J Cell Physiol. Author manuscript; available in PMC 2010 Feb 1.

Published in final edited form as: J Cell Physiol. 2006 Nov; 209(2): 253. doi: 10.1002/jcp.20731

PMCID:: PMC2814417

Article PDF–375K

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