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Select item 111599861.

Vacuolar H⁺‐ATPase inhibitors overcome Bcl‐xL‐mediated chemoresistance through restoration of a caspase‐independent apoptotic pathway

Yukiko Sasazawa, Yushi Futamura, Etsu Tashiro, Masaya Imoto

Cancer Sci. 2009 Aug; 100(8): 1460–1467. Published online 2009 Apr 21. doi: 10.1111/j.1349-7006.2009.01194.x

PMCID:: PMC11159986

Abstract Article PDF–2.0M

Select item 108819962.

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, Xiaohua Chen, Boyi Yu, Xiaogang Zhen, Jing Si, Chao Sun, Hong Zhang, Cuixia Di

Cell Death Dis. 2024 Feb; 15(2): 160. Published online 2024 Feb 21. doi: 10.1038/s41419-024-06507-x

PMCID:: PMC10881996

Abstract Article PDF–5.0M

Select item 108445233.

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen

Life Sci Alliance. 2024 Apr; 7(4): e202302353. Published online 2024 Feb 5. doi: 10.26508/lsa.202302353

PMCID:: PMC10844523

Abstract Article PDF–4.9M

Select item 103644354.

Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment

Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero, Donatella Del Bufalo

J Exp Clin Cancer Res. 2023; 42: 178. Published online 2023 Jul 24. doi: 10.1186/s13046-023-02735-9

PMCID:: PMC10364435

Abstract Article PDF–4.4M

Select item 102022815.

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis

Lyndsey N. Moore, Daniel L. Holmes, Anjali Sharma, Joselyn Landazuri Vinueza, Michael Lagunoff

PLoS Pathog. 2023 May; 19(5): e1011385. Published online 2023 May 10. doi: 10.1371/journal.ppat.1011385

PMCID:: PMC10202281

Abstract Article PDF–1.9M

Select item 96989576.

Bioinformatic Analysis of the BCL-xL/BCL2L1 Interactome in Patients with Pancreatic Cancer

Dimitrios E. Magouliotis, Anna P. Karamolegkou, Prokopis-Andreas Zotos, Evangelos Tatsios, Athina A. Samara, Dimitra Alexopoulou, Fani Koutsougianni, Nikos Sakellaridis, Dimitris Zacharoulis, Konstantinos Dimas

Medicina (Kaunas) 2022 Nov; 58(11): 1663. Published online 2022 Nov 17. doi: 10.3390/medicina58111663

PMCID:: PMC9698957

Abstract Article PDF–2.3M

Select item 89900117.

Bcl-xL acts as an inhibitor of IP₃R channels, thereby antagonizing Ca²⁺-driven apoptosis

Nicolas Rosa, Hristina Ivanova, Larry E. Wagner, 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule, Geert Bultynck

Cell Death Differ. 2022 Apr; 29(4): 788–805. Published online 2021 Nov 8. doi: 10.1038/s41418-021-00894-w

PMCID:: PMC8990011

Abstract Article PDF–4.2M

Select item 88837588.

In silico analysis highlighting the prevalence of BCL2L1 gene and its correlation to miRNA in human coronavirus (HCoV) genetic makeup

Agnik Haldar, Keerti K. Yadav, Suchitra Singh, Piyush K. Yadav, Ajay K. Singh

Infect Genet Evol. 2022 Apr; 99: 105260. Published online 2022 Feb 28. doi: 10.1016/j.meegid.2022.105260

PMCID:: PMC8883758

Abstract Article PDF–8.0M

Select item 88765209.

Roles and Regulation of BCL-xL in Hematological Malignancies

Mario Morales-Martínez, Mario I. Vega

Int J Mol Sci. 2022 Feb; 23(4): 2193. Published online 2022 Feb 16. doi: 10.3390/ijms23042193

PMCID:: PMC8876520

Abstract Article PDF–25M

Select item 849050710.

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann, Jean-Paul Borg, Sima Lev, Fabienne Lamballe, Flavio Maina

Theranostics. 2021; 11(19): 9180–9197. Published online 2021 Sep 3. doi: 10.7150/thno.60503

PMCID:: PMC8490507

Abstract Article PDF–4.1M

Select item 796717911.

Bcl-xL: A Focus on Melanoma Pathobiology

Anna Maria Lucianò, Ana B. Pérez-Oliva, Victoriano Mulero, Donatella Del Bufalo

Int J Mol Sci. 2021 Mar; 22(5): 2777. Published online 2021 Mar 9. doi: 10.3390/ijms22052777

PMCID:: PMC7967179

Abstract Article PDF–1.7M

Select item 792043412.

The Role of Bcl-xL Protein in Viral Infections

Zbigniew Wyżewski, Weronika Świtlik, Matylda Barbara Mielcarska, Karolina Paulina Gregorczyk-Zboroch

Int J Mol Sci. 2021 Feb; 22(4): 1956. Published online 2021 Feb 16. doi: 10.3390/ijms22041956

PMCID:: PMC7920434

Abstract Article PDF–569K

Select item 689878513.

A selective BCL-X_L PROTAC degrader achieves safe and potent antitumor activity

Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng, Daohong Zhou

Nat Med. Author manuscript; available in PMC 2020 Jun 2.

Published in final edited form as: Nat Med. 2019 Dec; 25(12): 1938–1947. Published online 2019 Dec 2. doi: 10.1038/s41591-019-0668-z

PMCID:: PMC6898785

Abstract Article PDF–3.9M

Select item 658934814.

Lipid-Modulation of Membrane Insertion and Refolding of the Apoptotic Inhibitor Bcl-xL

Victor Vasquez-Montes, Mauricio Vargas-Uribe, Nitin K. Pandey, Mykola V. Rodnin, Ralf Langen, Alexey S. Ladokhin

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2019 Jul-Aug; 1867(7-8): 691–700. Published online 2019 Apr 18. doi: 10.1016/j.bbapap.2019.04.006

PMCID:: PMC6589348

Abstract Article PDF–1.4M

Select item 621284715.

Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

Xiao-Lan Li, Guo-Hua Li, Juan Fu, Ya-Wen Fu, Lu Zhang, Wanqiu Chen, Cameron Arakaki, Jian-Ping Zhang, Wei Wen, Mei Zhao, Weisheng V Chen, Gary D Botimer, David Baylink, Leslie Aranda, Hannah Choi, Rachel Bechar, Prue Talbot, Chang-Kai Sun, Tao Cheng, Xiao-Bing Zhang

Nucleic Acids Res. 2018 Nov 2; 46(19): 10195–10215. Published online 2018 Sep 20. doi: 10.1093/nar/gky804