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Select item 109888721.

Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells

Juwon Lee, Suin Jang, Jihye Im, Youngjin Han, Soochi Kim, HyunA Jo, Wenyu Wang, Untack Cho, Se Ik Kim, Aeran Seol, Boyun Kim, Yong Sang Song

J Ovarian Res. 2024; 17: 73. Published online 2024 Apr 2. doi: 10.1186/s13048-024-01389-1

PMCID:: PMC10988872

Abstract Article PDF–5.6M

Select item 100954872.

Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis

Jiaping Chen, Yangwei Wang, Wangyang Meng, Rong Zhao, Wei Lin, Han Xiao, Yongde Liao

Int J Mol Sci. 2023 Apr; 24(7): 6826. Published online 2023 Apr 6. doi: 10.3390/ijms24076826

PMCID:: PMC10095487

Abstract Article PDF–15M

Select item 99500663.

SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer

Kangyu Wang, Shiwen Wang, Yue Zhang, Li Xie, Xingguo Song, Xianrang Song

Cell Death Differ. 2023 Feb; 30(2): 341–355. Published online 2022 Nov 14. doi: 10.1038/s41418-022-01087-9

PMCID:: PMC9950066

Abstract Article PDF–6.1M

Select item 96548814.

Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition

Catarina M. Morais, Ana M. Cardoso, Ana Rita D. Araújo, Ana Reis, Pedro Domingues, Maria Rosário M. Domingues, Maria C. Pedroso de Lima, Amália S. Jurado

Int J Mol Sci. 2022 Nov; 23(21): 13014. Published online 2022 Oct 27. doi: 10.3390/ijms232113014

PMCID:: PMC9654881

Abstract Article PDF–3.3M

Select item 92632485.

An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming

Hua-Hua Liu, Yang Xu, Cao-Jie Li, Shu-Jung Hsu, Xia-Hui Lin, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Xin-Rong Yang, Zheng-Gang Ren, Rong-Xin Chen

Mol Ther. 2022 Jul 6; 30(7): 2554–2567. Published online 2022 Mar 28. doi: 10.1016/j.ymthe.2022.03.015

PMCID:: PMC9263248

Abstract Article PDF–5.6M

Select item 92567836.

Elevated Stearoyl-CoA Desaturase 1 Activity is associated with Alcohol-associated Liver Disease

T.D. Klepp, M.E. Sloan, Soundarya Soundararajan, C.E. Ramsden, R. Cinar, M.L. Schwandt, N. Diazgranados, V. Vatsalya, V.A. Ramchandani

Alcohol. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Alcohol. 2022 Aug; 102: 51–57. Published online 2022 Apr 19. doi: 10.1016/j.alcohol.2022.04.001

PMCID:: PMC9256783

Abstract Article PDF–570K

Select item 91818257.

Molecular Mechanisms Underlying the Elevated Expression of a Potentially Type 2 Diabetes Mellitus Associated SCD1 Variant

Kinga Tibori, Gabriella Orosz, Veronika Zámbó, Péter Szelényi, Farkas Sarnyai, Viola Tamási, Zsolt Rónai, Judit Mátyási, Blanka Tóth, Miklós Csala, Éva Kereszturi

Int J Mol Sci. 2022 Jun; 23(11): 6221. Published online 2022 Jun 2. doi: 10.3390/ijms23116221

PMCID:: PMC9181825

Abstract Article PDF–1.9M

Select item 85332178.

Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study

Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry

Biomolecules. 2021 Oct; 11(10): 1435. Published online 2021 Sep 30. doi: 10.3390/biom11101435

PMCID:: PMC8533217

Abstract Article PDF–5.9M

Select item 78266079.

Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling

Yeongji Yu, Hyejin Kim, SeokGyeong Choi, JinSuh Yu, Joo Yeon Lee, Hani Lee, Sukjoon Yoon, Woo-Young Kim

Cells. 2021 Jan; 10(1): 106. Published online 2021 Jan 8. doi: 10.3390/cells10010106

PMCID:: PMC7826607

Abstract Article PDF–3.2M

Select item 765716210.

Decreasing stearoyl‐CoA desaturase‐1 expression inhibits β‐catenin signaling in breast cancer cells

Daniel Mauvoisin, Cyndia Charfi, Amine M Lounis, Eric Rassart, Catherine Mounier

Cancer Sci. 2013 Jan; 104(1): 36–42. Published online 2012 Nov 9. doi: 10.1111/cas.12032

PMCID:: PMC7657162

Abstract Article PDF–919K

Select item 765713711.

Positive feedback loop and synergistic effects between hypoxia‐inducible factor‐2α and stearoyl–CoA desaturase‐1 promote tumorigenesis in clear cell renal cell carcinoma

Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yiran Huang

Cancer Sci. 2013 Apr; 104(4): 416–422. Published online 2013 Mar 3. doi: 10.1111/cas.12108

PMCID:: PMC7657137

Abstract Article PDF–1.2M

Select item 728333712.

Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway

Yunhe Gao, Jiyang Li, Hongqing Xi, Jianxin Cui, Kecheng Zhang, Jiabing Zhang, Yanmei Zhang, Wei Xu, Wenquan Liang, Ziwei Zhuang, Pengpeng Wang, Zhi Qiao, Bo Wei, Lin Chen

Br J Cancer. 2020 Jun 9; 122(12): 1837–1847. Published online 2020 Apr 30. doi: 10.1038/s41416-020-0827-5

PMCID:: PMC7283337

Abstract Article PDF–4.8M

Select item 724346613.

The Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women

Stephanie T. Chung, Celeste KL Cravalho, Abby G Meyers, Amber B Courville, Shanna Yang, Nirupa Rachel Matthan, Lilian Mabundo, Maureen Sampson, Ronald Ouwerkerk, Ahmed M Gharib, Alice H Lichtenstein, Alan T Remaley, Anne E Sumner

Circ Res. Author manuscript; available in PMC 2021 Jan 3.

Published in final edited form as: Circ Res. 2020 Jan 3; 126(1): 94–108. Published online 2019 Oct 18. doi: 10.1161/CIRCRESAHA.119.315701

PMCID:: PMC7243466

Abstract Article PDF–1.0M

Select item 691471414.

Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages

Jan Korbecki, Izabela Gutowska, Marta Wiercioch, Agnieszka Łukomska, Maciej Tarnowski, Arleta Drozd, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka

Biol Trace Elem Res. 2020; 193(1): 152–161. Published online 2019 Mar 29. doi: 10.1007/s12011-019-01699-2

PMCID:: PMC6914714

Abstract Article PDF–679K

Select item 637821815.

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Chiyuan Piao, Xiaolu Cui, Bo Zhan, Jun Li, Zeliang Li, Zhenhua Li, Xiankui Liu, Jianbin Bi, Zhe Zhang, Chuize Kong

J Cell Mol Med. 2019 Mar; 23(3): 2064–2076. Published online 2018 Dec 27. doi: 10.1111/jcmm.14114

PMCID:: PMC6378218

Abstract Article PDF–2.8M

Select item 613307116.

Increased expression of the gene encoding stearoyl-CoA desaturase 1 in human bladder cancer

M. Presler, A. Wojtczyk-Miaskowska, B. Schlichtholz, A. Kaluzny, M. Matuszewski, A. Mika, T. Sledzinski, J. Swierczynski

Mol Cell Biochem. 2018; 447(1): 217–224. Published online 2018 Feb 2. doi: 10.1007/s11010-018-3306-z

PMCID:: PMC6133071

Abstract Article PDF–919K

Select item 612732717.

Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus

Kálmán Bódis, Sabine Kahl, Marie-Christine Simon, Zhou Zhou, Henrike Sell, Birgit Knebel, Andrea Tura, Klaus Strassburger, Volker Burkart, Karsten Müssig, Daniel Markgraf, Hadi Al-Hasani, Julia Szendroedi, Michael Roden, for the GDS Study Group

Nutr Diabetes. 2018; 8: 49. Published online 2018 Sep 7. doi: 10.1038/s41387-018-0054-9

PMCID:: PMC6127327

Abstract Article PDF–470K

Select item 583140418.

Transcriptomic profiling of curcumin treated human breast stem cells identifies a role for stearoyl coa-desaturase in breast cancer prevention

Justin A. Colacino, Sean P. McDermott, Maureen A. Sartor, Max S. Wicha, Laura S. Rozek

Breast Cancer Res Treat. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Breast Cancer Res Treat. 2016 Jul; 158(1): 29–41. Published online 2016 Jun 15. doi: 10.1007/s10549-016-3854-4

PMCID:: PMC5831404

Abstract Article PDF–843K

Select item 512998519.

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing He

Oncotarget. 2016 Jun 28; 7(26): 39970–39979. Published online 2016 May 19. doi: 10.18632/oncotarget.9461

PMCID:: PMC5129985

Abstract Article PDF–5.3M

Select item 511571120.

High Expression of Stearoyl-CoA Desaturase 1 Predicts Poor Prognosis in Patients with Clear-Cell Renal Cell Carcinoma

Jianfeng Wang, Yunze Xu, Liangsong Zhu, Yun Zou, Wen Kong, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Jin Zhang

PLoS One. 2016; 11(11): e0166231. Published online 2016 Nov 18. doi: 10.1371/journal.pone.0166231

PMCID:: PMC5115711

Abstract Article PDF–1.9M

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PMC Links for Gene (Select 6319) (149)
PMC
Homo sapiens stearoyl-CoA desaturase (SCD), mRNA
Homo sapiens stearoyl-CoA desaturase (SCD), mRNA
gi|1519313488|ref|NM_005063.5|

Nucleotide
Lentinus squarrosulus/Pleurotus sp. 'florida' fusant strain pfls 1q 18S ribosoma...
Lentinus squarrosulus/Pleurotus sp. 'florida' fusant strain pfls 1q 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1 and 5.8S ribosomal RNA gene, complete sequence; and internal transcribed spacer 2, partial sequence
gi|575669187|gb|KF150328.1|

Nucleotide

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