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Select item 107304701.

SCN4B inhibits the progression of lung adenocarcinoma and is associated with better prognosis

Minting Ma, Bin Guo, Hongwei Lu, Lei Hong

Clin Respir J. 2023 Dec; 17(12): 1233–1245. Published online 2023 Oct 12. doi: 10.1111/crj.13709

PMCID:: PMC10730470

Abstract Article PDF–6.5M

Select item 83047572.

The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells

Adélaïde Doray, Roxane Lemoine, Marc Severin, Stéphanie Chadet, Osbaldo Lopez-Charcas, Audrey Héraud, Christophe Baron, Pierre Besson, Arnaud Monteil, Stine Falsig Pedersen, Sébastien Roger

Cells. 2021 Jul; 10(7): 1624. Published online 2021 Jun 29. doi: 10.3390/cells10071624

PMCID:: PMC8304757

Abstract Article PDF–6.2M

Select item 68152213.

Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation

Hongbo Xiong, Qin Yang, Xiaoping Zhang, Pengxia Wang, Feifei Chen, Ying Liu, Pengyun Wang, Yuanyuan Zhao, Sisi Li, Yufeng Huang, Shanshan Chen, Xiaojing Wang, Hongfu Zhang, Dong Yu, Chencheng Tan, Cheng Fang, Yuan Huang, Gang Wu, Yanxia Wu, Xiang Cheng, Yuhua Liao, Rongfeng Zhang, Yanzong Yang, Tie Ke, Xiang Ren, Hui Li, Xin Tu, Yunlong Xia, Chengqi Xu, Qiuyun Chen, Qing K. Wang

Ann Hum Genet. Author manuscript; available in PMC 2019 Oct 26.

Published in final edited form as: Ann Hum Genet. 2019 Jul; 83(4): 239–248. Published online 2019 Mar 1. doi: 10.1111/ahg.12305

PMCID:: PMC6815221

Abstract Article PDF–715K

Select item 68125214.

Identification of rare variants in cardiac sodium channel β4‑subunit gene SCN4B associated with ventricular tachycardia

Qin Yang, Hongbo Xiong, Chengqi Xu, Yuan Huang, Xin Tu, Gang Wu, Fenfen Fu, Zhijie Wang, Longfei Wang, Yuanyuan Zhao, Sisi Li, Yufeng Huang, Chuchu Wang, Dan Wang, Yufeng Yao, Fan Wang, Yongbo Wang, Yu Xue, Pengyun Wang, Qiuyun Chen, Jielin Pu, Qing K. Wang

Mol Genet Genomics. Author manuscript; available in PMC 2019 Oct 24.

Published in final edited form as: Mol Genet Genomics. 2019 Aug; 294(4): 1059–1071. Published online 2019 Apr 17. doi: 10.1007/s00438-019-01567-7

PMCID:: PMC6812521

Abstract Article PDF–927K

Select item 62071855.

Slow Inactivation of the NaV1.4 Sodium Channel in Mammalian Cells Is Impeded by Co-Expression of the β1 Subunit

Jadon Webb, Fen-fen Wu, Stephen C. Cannon

Pflugers Arch. Author manuscript; available in PMC 2018 Oct 30.

Published in final edited form as: Pflugers Arch. 2009 Apr; 457(6): 1253–1263. Published online 2008 Oct 22. doi: 10.1007/s00424-008-0600-8

PMCID:: PMC6207185

Abstract Article PDF–1.0M

Select item 59337256.

Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer

Yanping Gong, Jing Yang, Wenshuang Wu, Feng Liu, Anping Su, Zhihui Li, Jingqiang Zhu, Tao Wei

PLoS One. 2018; 13(5): e0197007. Published online 2018 May 3. doi: 10.1371/journal.pone.0197007

PMCID:: PMC5933725

Abstract Article PDF–19M

Select item 51502247.

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

Emeline Bon, Virginie Driffort, Frédéric Gradek, Carlos Martinez-Caceres, Monique Anchelin, Pablo Pelegrin, Maria-Luisa Cayuela, Séverine Marionneau-Lambot, Thibauld Oullier, Roseline Guibon, Gaëlle Fromont, Jorge L. Gutierrez-Pajares, Isabelle Domingo, Eric Piver, Alain Moreau, Julien Burlaud-Gaillard, Philippe G. Frank, Stéphan Chevalier, Pierre Besson, Sébastien Roger

Nat Commun. 2016; 7: 13648. Published online 2016 Dec 5. doi: 10.1038/ncomms13648

PMCID:: PMC5150224

Abstract Article PDF–3.2M

Select item 44524648.

Transcriptome Organization for Chronic Alcohol Abuse in Human Brain

Sean P. Farris, Dhivya Arasappan, Scott Hunicke-Smith, R. Adron Harris, R. Dayne Mayfield

Mol Psychiatry. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mol Psychiatry. 2015 Nov; 20(11): 1438–1447. Published online 2014 Dec 2. doi: 10.1038/mp.2014.159

PMCID:: PMC4452464

Abstract Article PDF–762K

Select item 55552019.

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell–cell adhesion

Hideaki Shimizu, Asako Tosaki, Noboru Ohsawa, Yoshiko Ishizuka-Katsura, Shisako Shoji, Haruko Miyazaki, Fumitaka Oyama, Takaho Terada, Mikako Shirouzu, Shun-ichi Sekine, Nobuyuki Nukina, Shigeyuki Yokoyama

J Biol Chem. 2017 Aug 11; 292(32): 13428–13440. Published online 2017 Jun 27. doi: 10.1074/jbc.M117.786509

PMCID:: PMC5555201

Abstract Article PDF–2.9M

Select item 305554510.

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

Jonathan W Theile, Brian W Jarecki, Andrew D Piekarz, Theodore R Cummins

J Physiol. 2011 Feb 1; 589(Pt 3): 597–608. Published online 2010 Nov 29. doi: 10.1113/jphysiol.2010.200915

PMCID:: PMC3055545

Abstract Article PDF–514K

Select item 450467411.

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction

Reesha R. Patel, Cindy Barbosa, Yucheng Xiao, Theodore R. Cummins

PLoS One. 2015; 10(7): e0133485. Published online 2015 Jul 16. doi: 10.1371/journal.pone.0133485

PMCID:: PMC4504674

Abstract Article PDF–1.8M

Select item 387067912.

Crystallographic insights into sodium-channel modulation by the β4 subunit

John Gilchrist, Samir Das, Filip Van Petegem, Frank Bosmans

Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51): E5016–E5024. Published online 2013 Dec 2. doi: 10.1073/pnas.1314557110

PMCID:: PMC3870679

Abstract Article PDF–1.4M

Select item 342666113.

A voltage-gated sodium channel is essential for the positive selection of CD4⁺ T cells

Wan-Lin Lo, David L. Donermeyer, Paul M. Allen

Nat Immunol. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Nat Immunol. 2012 Sep; 13(9): 880–887. Published online 2012 Jul 29. doi: 10.1038/ni.2379

PMCID:: PMC3426661

Abstract Article PDF–1.0M

Select item 333254614.

SCN4B-Encoded Sodium Channel β4 Subunit in Congenital Long-QT Syndrome

Argelia Medeiros-Domingo, Toshihiko Kaku, David J. Tester, Pedro Iturralde-Torres, Ajit Itty, Bin Ye, Carmen Valdivia, Kazuo Ueda, Samuel Canizales-Quinteros, Maria Teresa Tusié-Luna, Jonathan C. Makielski, Michael J. Ackerman

Circulation. Author manuscript; available in PMC 2012 Apr 23.

Published in final edited form as: Circulation. 2007 Jul 10; 116(2): 134–142. Published online 2007 Jun 25. doi: 10.1161/CIRCULATIONAHA.106.659086

PMCID:: PMC3332546

Abstract Article PDF–2.5M

Select item 674076315.

Sodium Channel β4, a New Disulfide-Linked Auxiliary Subunit with Similarity to β2

Frank H. Yu, Ruth E. Westenbroek, Inmaculada Silos-Santiago, Kimberly A. McCormick, Deborah Lawson, Pei Ge, Holly Ferriera, Jeremiah Lilly, Peter S. DiStefano, William A. Catterall, Todd Scheuer, Rory Curtis

J Neurosci. 2003 Aug 20; 23(20): 7577–7585. doi: 10.1523/JNEUROSCI.23-20-07577.2003

PMCID:: PMC6740763

Abstract Article PDF–577K

Select item 290968016.

Sudden Infant Death Syndrome-Associated Mutations in the Sodium Channel Beta Subunits

Bi-Hua Tan, Kavitha N Pundi, David W Van Norstrand, Carmen R Valdivia, David J Tester, Argelia Medeiros-Domingo, Jonathan C. Makielski, Michael J. Ackerman

Heart Rhythm. Author manuscript; available in PMC 2011 Jun 1.

Published in final edited form as: Heart Rhythm. 2010 Jun; 7(6): 771–778. Published online 2010 Feb 1. doi: 10.1016/j.hrthm.2010.01.032

PMCID:: PMC2909680

Abstract Article PDF–1.9M

Select item 266724417.

Regulation of Persistent Na Current by Interactions between β Subunits of Voltage-Gated Na Channels

Teresa K. Aman, Tina M. Grieco-Calub, Chunling Chen, Raffaella Rusconi, Emily A. Slat, Lori L. Isom, Indira M. Raman

J Neurosci. 2009 Feb 18; 29(7): 2027–2042. doi: 10.1523/JNEUROSCI.4531-08.2009

PMCID:: PMC2667244

Abstract Article PDF–909K

Select item 272772518.

Mutations in Sodium Channel Beta1 and Beta2 Subunits Associated with Atrial Fibrillation

Hiroshi Watanabe, Dawood Darbar, Daniel W Kaiser, Kim Jiramongkolchai, Sameer Chopra, Brian S. Donahue, Prince J. Kannankeril, Dan M. Roden

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2009 Jun; 2(3): 268–275. Published online 2009 Mar 6. doi: 10.1161/CIRCEP.108.779181

PMCID:: PMC2727725

Abstract Article PDF–4.4M

Select item 135612919.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 716998320.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

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