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Select item 78397641.

Targeting stromal cell Syndecan‐2 reduces breast tumour growth, metastasis and limits immune evasion

Paul G. Loftus, Luke Watson, Laura M. Deedigan, Eva Camarillo‐Retamosa, Róisín M. Dwyer, Lisa O'Flynn, Senthilkumar Alagesan, Matthew Griffin, Timothy O'Brien, Michael J. Kerin, Stephen J. Elliman, Laura R. Barkley

Int J Cancer. 2021 Mar 1; 148(5): 1245–1259. Published online 2020 Dec 2. doi: 10.1002/ijc.33383

PMCID:: PMC7839764

Abstract Article PDF–2.1M

Select item 78095452.

Stool DNA test targeting methylated syndecan-2 (SDC2) as a noninvasive screening method for colorectal cancer

Wei-Chih Su, Wei-Yu Kao, Tsung-Kun Chang, Hsiang-Lin Tsai, Ching-Wen Huang, Yen-Cheng Chen, Ching-Chun Li, Yi-Chien Hsieh, Hsing-Jung Yeh, Chun-Chao Chang, Jaw-Yuan Wang

Biosci Rep. 2021 Jan 29; 41(1): BSR20201930. Published online 2021 Jan 14. doi: 10.1042/BSR20201930

PMCID:: PMC7809545

Abstract Article PDF–515K

Select item 76023313.

Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study

Jianping Wang, Side Liu, Hui Wang, Lei Zheng, Changchun Zhou, Guoxin Li, Rongkang Huang, Huaiming Wang, Chujun Li, Xinjuan Fan, Xinhui Fu, Xinying Wang, Hongliang Guo, Jie Guan, Yanlai Sun, Xilin Song, Zengjun Li, Dianbin Mu, Jujie Sun, Xianglin Liu, Yan Qi, Feng Niu, Chunhua Chen, Xiaolin Wu, Xianshu Wang, Xianrang Song, Hongzhi Zou

Clin Epigenetics. 2020; 12: 162. Published online 2020 Oct 30. doi: 10.1186/s13148-020-00954-x

PMCID:: PMC7602331

Abstract Article PDF–1.4M

Select item 65437474.

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness

Konstantin Tsoyi, Juan C. Osorio, Sarah G. Chu, Isis E. Fernandez, Sergio Poli De Frias, Lynette Sholl, Ye Cui, Carmen S. Tellez, Jill M. Siegfried, Steven A. Belinsky, Mark A. Perrella, Souheil El-Chemaly, Ivan O. Rosas

Am J Respir Cell Mol Biol. 2019 Jun; 60(6): 659–666. doi: 10.1165/rcmb.2018-0118OC

PMCID:: PMC6543747

Abstract Article PDF–1.2M

Select item 41426445.

Expression of human liver HSPGs on acute myeloid leukemia

Preeyanat Vongchan, Robert J. Linhardt

Clin Immunol. Author manuscript; available in PMC 2014 Aug 25.

Published in final edited form as: Clin Immunol. 2007 Feb; 122(2): 194–206. Published online 2006 Oct 10. doi: 10.1016/j.clim.2006.08.017

PMCID:: PMC4142644

Abstract Article PDF–2.6M

Select item 34826796.

Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface

Xavier Rovira-Clavé, Maria Angulo-Ibáñez, Oriol Noguer, Enric Espel, Manuel Reina

Immunology. 2012 Nov; 137(3): 214–225. Published online 2012 Oct 2. doi: 10.1111/j.1365-2567.2012.03626.x

PMCID:: PMC3482679

Abstract Article PDF–555K

Select item 33512837.

Reciprocal Regulation of Syndecan-2 and Notch Signaling in Vascular Smooth Muscle Cells

Ning Zhao, Hua Liu, Brenda Lilly

J Biol Chem. 2012 May 11; 287(20): 16111–16120. Published online 2012 Mar 21. doi: 10.1074/jbc.M111.322107

PMCID:: PMC3351283

Abstract Article PDF–1.6M

Select item 33504628.

Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype

Tiago De Oliveira, Ivane Abiatari, Susanne Raulefs, Danguole Sauliunaite, Mert Erkan, Bo Kong, Helmut Friess, Christoph W Michalski, Jörg Kleeff

Mol Cancer. 2012; 11: 19. Published online 2012 Apr 3. doi: 10.1186/1476-4598-11-19

PMCID:: PMC3350462

Abstract Article PDF–2.3M

Select item 21728039.

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

Xingbin Ai, Anh-Tri Do, Olga Lozynska, Marion Kusche-Gullberg, Ulf Lindahl, Charles P. Emerson, Jr.

J Cell Biol. 2003 Jul 21; 162(2): 341–351. doi: 10.1083/jcb.200212083

PMCID:: PMC2172803

Abstract Article PDF–425K

Select item 122387110.

Interleukin-8 binds to syndecan-2 on human endothelial cells.

Yvonne Halden, Angelika Rek, Werner Atzenhofer, Laszlo Szilak, Astrid Wabnig, Andreas J Kungl

Biochem J. 2004 Jan 15; 377(Pt 2): 533–538. doi: 10.1042/BJ20030729

PMCID:: PMC1223871

Summary PDF–115K

Select item 919001611.

Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression

DeannaLee M. Beauvais, Scott E. Nelson, Kristin M. Adams, Noah A. Stueven, Oisun Jung, Alan C. Rapraeger

J Biol Chem. 2022 Jun; 298(6): 102029. Published online 2022 May 13. doi: 10.1016/j.jbc.2022.102029

PMCID:: PMC9190016

Abstract Article PDF–2.8M

Select item 888682712.

The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer

Ruixue Lei, Yanteng Zhao, Kai Huang, Qian Wang, Kangkang Wan, Tingting Li, Haijun Yang, Xianping Lv

BMC Gastroenterol. 2022; 22: 88. Published online 2022 Feb 28. doi: 10.1186/s12876-022-02175-3

PMCID:: PMC8886827

Abstract Article PDF–2.6M

Select item 876688213.

Mesenchymal stromal cell‐derived syndecan‐2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation

Junwen Han, Yuanyuan Shi, Gareth Willis, Jewel Imani, Min‐Young Kwon, Gu Li, Ehab Ayaub, Sailaja Ghanta, Julie Ng, Narae Hwang, Konstantin Tsoyi, Souheil El‐Chemaly, Stella Kourembanas, S. Alex Mitsialis, Ivan O. Rosas, Xiaoli Liu, Mark A. Perrella

FEBS J. 2022 Jan; 289(2): 417–435. Published online 2021 Aug 15. doi: 10.1111/febs.16154

PMCID:: PMC8766882

Abstract Article PDF–2.3M

Select item 858397414.

Bacteroides fragilis Enterotoxin Upregulates Matrix Metalloproteinase-7 Expression through MAPK and AP-1 Activation in Intestinal Epithelial Cells, Leading to Syndecan-2 Release

Jong Ik Jeon, Keun Hwa Lee, Jung Mogg Kim

Int J Mol Sci. 2021 Nov; 22(21): 11817. Published online 2021 Oct 30. doi: 10.3390/ijms222111817

PMCID:: PMC8583974

Abstract Article PDF–2.0M

Select item 373933015.

Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer

Rodrigo Ledezma, Federico Cifuentes, Iván Gallegos, Juan Fullá, Enrique Ossandon, Enrique A Castellon, Héctor R Contreras

Asian J Androl. 2011 May; 13(3): 476–480. Published online 2011 Feb 14. doi: 10.1038/aja.2010.143

PMCID:: PMC3739330

Abstract Article PDF–541K

Select item 338372716.

Syndecan-1 Enhances Proliferation, Migration and Metastasis of HT-1080 Cells in Cooperation with Syndecan-2

Bálint Péterfia, Tibor Füle, Kornélia Baghy, Krisztina Szabadkai, Alexandra Fullár, Katalin Dobos, Fang Zong, Katalin Dobra, Péter Hollósi, András Jeney, Sándor Paku, Ilona Kovalszky

PLoS One. 2012; 7(6): e39474. Published online 2012 Jun 26. doi: 10.1371/journal.pone.0039474

PMCID:: PMC3383727

Abstract Article PDF–841K

Select item 330234017.

Entry of Human T-Cell Leukemia Virus Type 1 Is Augmented by Heparin Sulfate Proteoglycans Bearing Short Heparin-Like Structures

Atsushi Tanaka, Atsushi Jinno-Oue, Nobuaki Shimizu, Ariful Hoque, Takahisa Mori, Salequl Islam, Youko Nakatani, Masahiko Shinagawa, Hiroo Hoshino

J Virol. 2012 Mar; 86(6): 2959–2969. doi: 10.1128/JVI.05783-11

PMCID:: PMC3302340

Abstract Article PDF–1.9M

Select item 318301618.

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

James R. Whiteford, Xiaojie Xian, Claire Chaussade, Bart Vanhaesebroeck, Sussan Nourshargh, John R. Couchman

Mol Biol Cell. 2011 Oct 1; 22(19): 3609–3624. doi: 10.1091/mbc.E11-02-0099

PMCID:: PMC3183016

Abstract Article PDF–6.6M

Select item 313369919.

Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection

Sarolta Bacsa, Ghadah Karasneh, Sandor Dosa, Jian Liu, Tibor Valyi-Nagy, Deepak Shukla

J Gen Virol. 2011 Apr; 92(Pt 4): 733–743. doi: 10.1099/vir.0.027052-0

PMCID:: PMC3133699

Abstract Article PDF–584K

Select item 834708220.

Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain

Jisun Hwang, Bohee Jang, Ayoung Kim, Yejin Lee, Joonha Lee, Chungho Kim, Jinmahn Kim, Kyeong Min Moon, Kyuhyung Kim, Ram Wagle, Young-Han Song, Eok-Soo Oh

Int J Mol Sci. 2021 Aug; 22(15): 7918. Published online 2021 Jul 24. doi: 10.3390/ijms22157918