PMC Links for Gene (Select 64146) - PMC

Select item 62739751.

Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer

Jian Gao, Tao Wang, Shengzhi Qiu, Yasheng Zhu, Li Liang, Youguang Zheng

Molecules. 2016 Apr; 21(4): 396. Published online 2016 Mar 23. doi: 10.3390/molecules21040396

PMCID:: PMC6273975

Abstract Article PDF–1.2M

Select item 37220142.

Overexpression of peptide deformylase in breast, colon, and lung cancers

Harsharan Randhawa, Shireen Chikara, Drew Gehring, Tuba Yildirim, Jyotsana Menon, Katie M Reindl

BMC Cancer. 2013; 13: 321. Published online 2013 Jul 1. doi: 10.1186/1471-2407-13-321

PMCID:: PMC3722014

Abstract Article PDF–568K

Select item 27826313.

Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target

Sindy Escobar-Alvarez, Yehuda Goldgur, Guangli Yang, Ouathek Ouerfelli, Yueming Li, David A. Scheinberg

J Mol Biol. Author manuscript; available in PMC 2010 Apr 17.

Published in final edited form as: J Mol Biol. 2009 Apr 17; 387(5): 1211–1228. Published online 2009 Feb 21. doi: 10.1016/j.jmb.2009.02.032

PMCID:: PMC2782631

Abstract Article PDF–5.3M

Select item 39732384.

Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

A Sheth, S Escobar-Alvarez, J Gardner, L Ran, M L Heaney, D A Scheinberg

Cell Death Dis. 2014 Mar; 5(3): e1152. Published online 2014 Mar 27. doi: 10.1038/cddis.2014.112

PMCID:: PMC3973238

Abstract Article PDF–1.9M

Select item 5222565.

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Mona D. Lee, Yuhong She, Michael J. Soskis, Christopher P. Borella, Jeffrey R. Gardner, Paula A. Hayes, Benzon M. Dy, Mark L. Heaney, Mark R. Philips, William G. Bornmann, Francis M. Sirotnak, David A. Scheinberg

J Clin Invest. 2004 Oct 15; 114(8): 1107–1116. doi: 10.1172/JCI22269

PMCID:: PMC522256

Abstract Article PDF–652K

Select item 3057966.

Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

Carmela Giglione, Alexandre Serero, Michèle Pierre, Bertrand Boisson, Thierry Meinnel

EMBO J. 2000 Nov 1; 19(21): 5916–5929. doi: 10.1093/emboj/19.21.5916

PMCID:: PMC305796

Abstract Article PDF–1.7M

Select item 3785907.

A Missense Mutation (R565W) in Cirhin (FLJ14728) in North American Indian Childhood Cirrhosis

Pierre Chagnon, Jacques Michaud, Grant Mitchell, Jocelyne Mercier, Jean-François Marion, Eric Drouin, Andrée Rasquin-Weber, Thomas J. Hudson, Andrea Richter

Am J Hum Genet. 2002 Dec; 71(6): 1443–1449. Published online 2002 Nov 4. doi: 10.1086/344580

PMCID:: PMC378590

Abstract Article PDF–558K

Select item 27508918.

Polymorphisms in mitochondrial genes and prostate cancer risk

Liang Wang, Shannon K. McDonnell, Scott J. Hebbring, Julie M. Cunningham, Jennifer St Sauver, James R. Cerhan, Grazia Isaya, Daniel J. Schaid, Stephen N. Thibodeau

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 Dec; 17(12): 3558–3566. doi: 10.1158/1055-9965.EPI-08-0434

PMCID:: PMC2750891

Abstract Article PDF–608K

Select item 106277869.

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis

Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge

Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335

PMCID:: PMC10627786

Abstract Article PDF–5.2M

Select item 923162310.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 486917011.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Abstract Article PDF–2.0M

Select item 583915812.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 461721113.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011