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Select item 91900191.

Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

Renpeng Ji, Qianqian Shi, Yixin Cao, Jingyue Zhang, Cancan Zhao, Huanyu Zhao, Yasra Sayyed, Li Fu, Lu-Yuan Li

J Biol Chem. 2022 Jun; 298(6): 102033. Published online 2022 May 18. doi: 10.1016/j.jbc.2022.102033

PMCID:: PMC9190019

Abstract Article PDF–3.6M

Select item 82869692.

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

Shan Gao, Li-Song Zhang, Lei Wang, Nan-Nan Xiao, Hui Long, Yi-Lun Yin, Yu-Meng Yang, Zhen Xi, Lu-Yuan Li, Zhi-Song Zhang

Signal Transduct Target Ther. 2021; 6: 273. Published online 2021 Jul 19. doi: 10.1038/s41392-021-00597-1

PMCID:: PMC8286969

Article PDF–2.0M

Select item 61976183.

Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression

Jie Li, Tai-Ran Bai, Shan Gao, Zhuan Zhou, Xue-Mei Peng, Li-Song Zhang, Dao-Lei Dou, Zhi-Song Zhang, Lu-Yuan Li

EBioMedicine. 2018 Oct; 36: 229–240. Published online 2018 Sep 29. doi: 10.1016/j.ebiom.2018.09.038

PMCID:: PMC6197618

Abstract Article PDF–6.1M

Select item 34267534.

Human Rhomboid Family-1 (RHBDF1) Gene-Silencing Causes Apoptosis or Autophagy to Epithelial Cancer Cells and Inhibits Xenograft Tumor Growth

Zhenwen Yan, Huafei Zou, Fang Tian, Jennifer R. Grandis, A. James Mixson, Patrick Y. Lu, Lu-Yuan Li

Mol Cancer Ther. Author manuscript; available in PMC 2012 Aug 24.

Published in final edited form as: Mol Cancer Ther. 2008 Jun; 7(6): 1355–1364. Published online 2008 Jun 4. doi: 10.1158/1535-7163.MCT-08-0104

PMCID:: PMC3426753

Abstract Article PDF–1.7M

Select item 91082605.

Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

Taylor J. Louis, Ahmad Qasem, Saleh A. Naser

Front Immunol. 2022; 13: 887830. Published online 2022 May 2. doi: 10.3389/fimmu.2022.887830

PMCID:: PMC9108260

Abstract Article PDF–3.7M

Select item 69089406.

Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways

Qin Xu, Chuanben Chen, Bin Liu, Yibin Lin, Peng Zheng, Dongmei Zhou, Yunqing Xie, Ya Lin, Ciren Guo, Jing Liu, Li Li

Oncol Rep. 2020 Jan; 43(1): 41–54. Published online 2019 Oct 25. doi: 10.3892/or.2019.7389

PMCID:: PMC6908940

Abstract Article PDF–1011K

Select item 72024667.

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

Sathish K. Maney, David R. McIlwain, Robin Polz, Aleksandra A. Pandyra, Balamurugan Sundaram, Dorit Wolff, Kazuhito Ohishi, Thorsten Maretzky, Matthew A. Brooke, Astrid Evers, Ananda A. Jaguva Vasudevan, Nima Aghaeepour, Jürgen Scheller, Carsten Münk, Dieter Häussinger, Tak W. Mak, Garry P. Nolan, David P. Kelsell, Carl P. Blobel, Karl S. Lang, Philipp A. Lang

Sci Signal. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: Sci Signal. 2015 Nov 3; 8(401): ra109. Published online 2015 Nov 3. doi: 10.1126/scisignal.aac5356

PMCID:: PMC7202466

Abstract Article PDF–1.2M

Select item 26389658.

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

Huafei Zou, Sufi M. Thomas, Zhen-Wen Yan, Jennifer R. Grandis, Andreas Vogt, Lu-Yuan Li

FASEB J. 2009 Feb; 23(2): 425–432. doi: 10.1096/fj.08-112771

PMCID:: PMC2638965

Abstract Article

Select item 44798039.

iRhom1 regulates proteasome activity via PAC1/2 under ER stress

WonJae Lee, YoungDoo Kim, Jisu Park, SangMi Shim, Jieun Lee, Se-hoon Hong, Hye-Hyun Ahn, Huikyong Lee, Yong-Keun Jung

Sci Rep. 2015; 5: 11559. Published online 2015 Jun 25. doi: 10.1038/srep11559

PMCID:: PMC4479803

Abstract Article PDF–2.0M

Select item 604296310.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Heike Naegele, Danielle Clancy, Jana Brezinova, Tianyi Hu, Andrea Bileck, Christopher Gerner, Alfonso Bolado, Alex von Kriegsheim, Seamus J Martin, Florian Steinberg, Kvido Strisovsky, Colin Adrain

eLife. 2018; 7: e35032. Published online 2018 Jun 13. doi: 10.7554/eLife.35032

PMCID:: PMC6042963

Abstract Article PDF–7.7M

Select item 604296111.

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

Ulrike Künzel, Adam Graham Grieve, Yao Meng, Boris Sieber, Sally A Cowley, Matthew Freeman

eLife. 2018; 7: e35012. Published online 2018 Jun 13. doi: 10.7554/eLife.35012

PMCID:: PMC6042961

Abstract Article PDF–6.4M

Select item 314927712.

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

Markus Zettl, Colin Adrain, Kvido Strisovsky, Viorica Lastun, Matthew Freeman

Cell. 2011 Apr 1; 145(1): 79–91. doi: 10.1016/j.cell.2011.02.047

PMCID:: PMC3149277

Abstract Article

Select item 863966813.

TRIP12 Ubiquitination of Glucocerebrosidase Contributes to Neurodegeneration in Parkinson’s Disease

Bo Am Seo, Donghoon Kim, Heehong Hwang, Min Seong Kim, Shi-Xun Ma, Seung-Hwan Kwon, Sin Ho Kweon, Hu Wang, Je Min Yoo, Seulah Choi, Sang Ho Kwon, Sung-Ung Kang, Tae-In Kam, Kwangsoo Kim, Senthilkumar S Karuppagounder, Bong Gu Kang, Saebom Lee, Hyejin Park, Sangjune Kim, Wei Yan, Yong-Shi Li, Sheng-Han Kuo, Javier Redding-Ochoa, Olga Pletnikova, Juan C. Troncoso, Gabsang Lee, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Han Seok Ko

Neuron. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Neuron. 2021 Dec 1; 109(23): 3758–3774.e11. Published online 2021 Oct 12. doi: 10.1016/j.neuron.2021.09.031

PMCID:: PMC8639668

Abstract Article PDF–2.6M

Select item 910630314.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 1091686615.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 638658816.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 926261417.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 674682218.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 583915819.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 289646420.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

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