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Select item 34776861.

High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer

Yuan-fang Li, Dan-dan Wang, Bai-wei Zhao, Wei Wang, Chun-yu Huang, Yong-ming Chen, Yan Zheng, Rajiv Prasad Keshari, Jian-chuan Xia, Zhi-wei Zhou

Int J Biol Sci. 2012; 8(8): 1168–1177. Published online 2012 Oct 2. doi: 10.7150/ijbs.4778

PMCID:: PMC3477686

Abstract Article PDF–952K

Select item 29707442.

Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma

Yun-Han Lee, Jesper B. Andersen, Ho-Taek Song, Adam D. Judge, Daekwan Seo, Tsuyoshi Ishikawa, Jens U. Marquardt, Mitsuteru Kitade, Marian Durkin, Chiara Raggi, Hyun Goo Woo, Elizabeth A. Conner, Itzhak Avital, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson

Cancer Res. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Cancer Res. 2010 Nov 1; 70(21): 8264–8269. Published online 2010 Oct 19. doi: 10.1158/0008-5472.CAN-10-0749

PMCID:: PMC2970744

Abstract Article PDF–1.2M

Select item 100729653.

Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway

Benhuo Zhao, Jiaojiao Wu, Xiuli Cha, Guangtong Mao, Hengliang Shi, Sujuan Fei, Bei Miao

Anal Cell Pathol (Amst) 2023; 2023: 5617875. Published online 2023 Mar 28. doi: 10.1155/2023/5617875

PMCID:: PMC10072965

Abstract Article PDF–6.6M

Select item 58738784.

COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors

Yuanyuan Xie, Zhen Cao, Elissa W.P. Wong, Youxin Guan, Wenfu Ma, Jenny Q. Zhang, Edward G. Walczak, Devan Murphy, Leili Ran, Inna Sirota, Shangqian Wang, Shipra Shukla, Dong Gao, Simon R.V. Knott, Kenneth Chang, Justin Leu, John Wongvipat, Cristina R. Antonescu, Gregory Hannon, Ping Chi, Yu Chen

J Clin Invest. 2018 Apr 2; 128(4): 1442–1457. Published online 2018 Mar 5. doi: 10.1172/JCI94840

PMCID:: PMC5873878

Abstract Article PDF–8.3M

Select item 57574915.

Imaging and kinetics of the bimolecular complex formed by the tumor suppressor p53 with ubiquitin ligase COP1 as studied by atomic force microscopy and surface plasmon resonance

Ilaria Moscetti, Anna Rita Bizzarri, Salvatore Cannistraro

Int J Nanomedicine. 2018; 13: 251–259. Published online 2018 Jan 4. doi: 10.2147/IJN.S152214

PMCID:: PMC5757491

Abstract Article PDF–2.0M

Select item 46373166.

COP1 enhances ubiquitin-mediated degradation of p27^Kip1 to promote cancer cell growth

Hyun Ho Choi, Liem Phan, Ping-Chieh Chou, Chun-Hui Su, Sai-Ching J. Yeung, Jiun-Sheng Chen, Mong-Hong Lee

Oncotarget. 2015 Aug 14; 6(23): 19721–19734. Published online 2015 Apr 14. doi: 10.18632/oncotarget.3821

PMCID:: PMC4637316

Abstract Article PDF–6.3M

Select item 43813717.

COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer

Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang, Wenjian Wang

BMC Cancer. 2015; 15: 132. Published online 2015 Mar 15. doi: 10.1186/s12885-015-1151-y

PMCID:: PMC4381371

Abstract Article PDF–1.4M

Select item 36942478.

p28, A first in class peptide inhibitor of cop1 binding to p53

T Yamada, K Christov, A Shilkaitis, L Bratescu, A Green, S Santini, A R Bizzarri, S Cannistraro, T K D Gupta, C W Beattie

Br J Cancer. 2013 Jun 25; 108(12): 2495–2504. Published online 2013 Jun 4. doi: 10.1038/bjc.2013.266

PMCID:: PMC3694247

Abstract Article PDF–1.3M

Select item 33581209.

14-3-3σ exerts tumor suppressor activity mediated by regulation of COP1 stability

Chun-Hui Su, Ruiying Zhao, Fanmao Zhang, Changju Qu, Bo Chen, Yin-Hsun Feng, Liem Phan, Jian Chen, Hua Wang, Huamin Wang, Sai-Ching J. Yeung, Mong-Hong Lee

Cancer Res. Author manuscript; available in PMC 2012 May 22.

Published in final edited form as: Cancer Res. 2011 Feb 1; 71(3): 884–894. Published online 2010 Dec 6. doi: 10.1158/0008-5472.CAN-10-2518

PMCID:: PMC3358120

Abstract Article PDF–3.4M

Select item 984524110.

Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination

Jianjian Hu, Wenxue Jiang, Jiaqi Zuo, Dujuan Shi, Xiaoqi Chen, Xiao Yang, Wenhui Zhang, Lixin Ma, Zhu Liu, Qiong Xing

Commun Biol. 2023; 6: 59. Published online 2023 Jan 17. doi: 10.1038/s42003-023-04458-1

PMCID:: PMC9845241

Abstract Article PDF–3.3M

Select item 961814911.

A COP1-GATA2 axis suppresses AR signaling and prostate cancer

Tao Shen, Bingning Dong, Yanling Meng, David D. Moore, Feng Yang

Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43): e2205350119. Published online 2022 Oct 17. doi: 10.1073/pnas.2205350119

PMCID:: PMC9618149

Abstract Article PDF–2.2M

Select item 850326212.

RFWD2 Knockdown as a Blocker to Reverse the Oncogenic Role of TRIB2 in Lung Adenocarcinoma

Ruimin Hao, Jinxia Hu, Yuemei Liu, Dongmin Liang, Yan-Mei Li, Ranran Wang, Shucui Zhang, Pingyu Wang, You-Jie Li, Shuyang Xie

Front Oncol. 2021; 11: 733175. Published online 2021 Sep 27. doi: 10.3389/fonc.2021.733175

PMCID:: PMC8503262

Abstract Article PDF–5.7M

Select item 757886413.

EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Hyun Ho Choi, Shaomin Zou, Jian‐lin Wu, Huashe Wang, Liem Phan, Kai Li, Peng Zhang, Daici Chen, Qingxin Liu, Baifu Qin, Thu Anh Thai Nguyen, Sai‐Ching J. Yeung, Lekun Fang, Mong‐Hong Lee

Adv Sci (Weinh) 2020 Oct; 7(20): 2000681. Published online 2020 Sep 23. doi: 10.1002/advs.202000681

PMCID:: PMC7578864

Abstract Article PDF–5.0M

Select item 512767414.

MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression

Cecilia Dallavalle, Domenico Albino, Gianluca Civenni, Jessica Merulla, Paola Ostano, Maurizia Mello-Grand, Simona Rossi, Marco Losa, Gioacchino D’Ambrosio, Fausto Sessa, George N. Thalmann, Ramon Garcia-Escudero, Andrea Zitella, Giovanna Chiorino, Carlo V. Catapano, Giuseppina M. Carbone

J Clin Invest. 2016 Dec 1; 126(12): 4585–4602. Published online 2016 Nov 7. doi: 10.1172/JCI86505

PMCID:: PMC5127674

Abstract Article PDF–5.1M

Select item 485659015.

Structural Basis for Substrate Selectivity of the E3 Ligase COP1

Sacha Uljon, Xiang Xu, Izabela Durzynska, Sarah Stein, Guillaume Adelmant, Jarrod A. Marto, Warren S. Pear, Stephen C. Blacklow

Structure. Author manuscript; available in PMC 2017 May 3.

Published in final edited form as: Structure. 2016 May 3; 24(5): 687–696. Published online 2016 Mar 31. doi: 10.1016/j.str.2016.03.002

PMCID:: PMC4856590

Abstract Article PDF–2.2M

Select item 461318116.

Regulating the stability and localization of CDK inhibitor p27^Kip1 via CSN6-COP1 axis

Hyun Ho Choi, Sergei Guma, Lekun Fang, Liem Phan, Cristina Ivan, Keith Baggerly, Anil Sood, Mong-Hong Lee

Cell Cycle. 2015 Jul 18; 14(14): 2265–2273. Published online 2015 May 6. doi: 10.1080/15384101.2015.1046655

PMCID:: PMC4613181

Abstract Article PDF–789K

Select item 376988617.

COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

Jing Shao, Yong Teng, Ravi Padia, Sungguan Hong, Hyangsoon Noh, Xiayang Xie, Jeff S Mumm, Zheng Dong, Han-Fei Ding, John Cowell, Jaejik Kim, Jiahuai Han, Shuang Huang

Neoplasia. 2013 Sep; 15(9): 1075–1085. doi: 10.1593/neo.13966