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Select item 109441801.

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells

Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao, Rhiannon B. Werder, Shreya Mishra, Yihan Zhou, Wardatul Jannat Anamika, Taotao Lao, Hiroyuki Inuzuka, Yihan Zhang, Betty Pham, Tao Liu, Tiffany S. Tufenkjian, Bradley W. Richmond, Wenyi Wei, Hongmei Mou, Andrew A. Wilson, Ming Hu, Wei Chen, Xiaobo Zhou

eBioMedicine. 2024 Mar; 101: 105026. Published online 2024 Feb 27. doi: 10.1016/j.ebiom.2024.105026

PMCID:: PMC10944180

Abstract Article PDF–2.8M

Select item 97305852.

Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein

An-Li Jin, Lin Ding, Wen-Jing Yang, Te Liu, Wei Chen, Tong Li, Chun-Yan Zhang, Bai-Shen Pan, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang, Bei-Li Wang

BMC Gastroenterol. 2022; 22: 505. Published online 2022 Dec 8. doi: 10.1186/s12876-022-02594-2

PMCID:: PMC9730585

Abstract Article PDF–7.1M

Select item 78775603.

Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells

Peichao Li, Xiaoru Zhang, Anthony J Murphy, Max Costa, Xiaogang Zhao, Hong Sun

Carcinogenesis. 2021 Jan; 42(1): 136–147. Published online 2020 Jul 25. doi: 10.1093/carcin/bgaa085

PMCID:: PMC7877560

Abstract Article PDF–7.9M

Select item 67816014.

Evaluation Of HHIP Polymorphisms And Their Relationship With Chronic Obstructive Pulmonary Disease Phenotypes

Thiago Prudente Bártholo, Luis Cristovão Porto, Roberto Pozzan, Adriana Nascimento, Claudia Henrique Da Costa

Int J Chron Obstruct Pulmon Dis. 2019; 14: 2267–2272. Published online 2019 Oct 3. doi: 10.2147/COPD.S213519

PMCID:: PMC6781601

Abstract Article PDF–545K

Select item 62134975.

Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer

Woo Kyung Lee, Seul Gi Lee, Seung Hyuk Yim, Daham Kim, Hyunji Kim, Seonhyang Jeong, Sang Geun Jung, Young Suk Jo, Jandee Lee

Int J Mol Sci. 2018 Oct; 19(10): 2867. Published online 2018 Sep 21. doi: 10.3390/ijms19102867

PMCID:: PMC6213497

Abstract Article PDF–2.0M

Select item 55919656.

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Zili Zhang, Jian Wang, Zeguang Zheng, Xindong Chen, Xiansheng Zeng, Yi Zhang, Defu Li, Jiaze Shu, Kai Yang, Ning Lai, Lian Dong, Wenju Lu

Biomed Res Int. 2017; 2017: 2756726. Published online 2017 Aug 27. doi: 10.1155/2017/2756726

PMCID:: PMC5591965

Abstract Article PDF–678K

Select item 54842497.

Smoking status and gene susceptibility play important roles in the development of chronic obstructive pulmonary disease and lung function decline: A population-based prospective study

Junling Zhao, Miao Li, Jinkun Chen, Xiaomei Wu, Qin Ning, Jianping Zhao, Yongjian Xu, Jungang Xie, Jun Yu

Medicine (Baltimore) 2017 Jun; 96(25): e7283. Published online 2017 Jun 23. doi: 10.1097/MD.0000000000007283

PMCID:: PMC5484249

Abstract Article PDF–460K

Select item 50296938.

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

Erh-Hsuan Lin, Yu-Rung Kao, Chih-An Lin, Ting-Yu Kuo, Sheng-Ping Yang, Chiung-Fang Hsu, Teh-Ying Chou, Chao-Chi Ho, Cheng-Wen Wu

Oncotarget. 2016 Apr 26; 7(17): 24179–24193. Published online 2016 Mar 22. doi: 10.18632/oncotarget.8253

PMCID:: PMC5029693

Abstract Article PDF–7.2M

Select item 50124309.

Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples

Mehdi H. Shahi, Idoya Zazpe, Mohammad Afzal, Subrata Sinha, Robert B. Rebhun, Bárbara Meléndez, Juan A. Rey, Javier S. Castresana

Tumour Biol. Author manuscript; available in PMC 2016 Sep 6.

Published in final edited form as: Tumour Biol. 2015 Apr; 36(4): 2383–2391. Published online 2014 Nov 22. doi: 10.1007/s13277-014-2846-4

PMCID:: PMC5012430

Abstract Article PDF–1.0M

Select item 497784110.

Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b

Maria Karlou, Vassiliki Tzelepi, Sankar Maity, Nora M. Navone, Jun Yang, Anh Hoang, Jing-Fang Lu, Christopher J. Logothetis, Eleni Efstathiou

Prostate. Author manuscript; available in PMC 2016 Aug 9.

Published in final edited form as: Prostate. 2012 Nov; 72(15): 1638–1647. Published online 2012 Mar 27. doi: 10.1002/pros.22517

PMCID:: PMC4977841

Abstract Article PDF–1.2M

Select item 451047111.

Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples

Mehdi H. Shahi, Mohammad Afzal, Subrata Sinha, Charles G. Eberhart, Juan A. Rey, Xing Fan, Javier S. Castresana

J Neurooncol. Author manuscript; available in PMC 2015 Jul 22.

Published in final edited form as: J Neurooncol. 2011 Jun; 103(2): 287–296. Published online 2010 Sep 19. doi: 10.1007/s11060-010-0401-8

PMCID:: PMC4510471

Abstract Article PDF–2.1M

Select item 365982612.

Gene expression analysis uncovers novel Hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

Xiaobo Zhou, Weiliang Qiu, J. Fah. Sathirapongsasuti, Michael H. Cho, John D. Mancini, Taotao Lao, Derek M. Thibault, Gus Litonjua, Per S. Bakke, Amund Gulsvik, David A. Lomas, Terri H. Beaty, Craig P. Hersh, Christopher Anderson, Ute Geigenmuller, Benjamin A. Raby, Stephen I. Rennard, Mark A. Perrella, Augustine M.K. Choi, John Quackenbush, Edwin K. Silverman

Genomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Genomics. 2013 May; 101(5): 263–272. Published online 2013 Mar 1. doi: 10.1016/j.ygeno.2013.02.010

PMCID:: PMC3659826

Abstract Article PDF–1.5M

Select item 328412013.

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP

Xiaobo Zhou, Rebecca M. Baron, Megan Hardin, Michael H. Cho, Jan Zielinski, Iwona Hawrylkiewicz, Pawel Sliwinski, Craig P. Hersh, John D. Mancini, Ke Lu, Derek Thibault, Amy L. Donahue, Barbara J. Klanderman, Bernard Rosner, Benjamin A. Raby, Quan Lu, Adriana M. Geldart, Matthew D. Layne, Mark A. Perrella, Scott T. Weiss, Augustine M.K. Choi, Edwin K. Silverman

Hum Mol Genet. 2012 Mar 15; 21(6): 1325–1335. Published online 2011 Dec 2. doi: 10.1093/hmg/ddr569

PMCID:: PMC3284120

Abstract Article PDF–389K

Select item 310520214.

Importance of hedgehog interacting protein and other lung function genes in asthma

Xingnan Li, Timothy D. Howard, Wendy C. Moore, Elizabeth J. Ampleford, Huashi Li, William W. Busse, William J. Calhoun, Mario Castro, Kian Fan Chung, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, W. Gerald Teague, Sally E. Wenzel, Stephen P. Peters, Gregory A. Hawkins, Eugene R. Bleecker, Deborah A. Meyers

J Allergy Clin Immunol. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: J Allergy Clin Immunol. 2011 Jun; 127(6): 1457–1465. Published online 2011 Mar 12. doi: 10.1016/j.jaci.2011.01.056

PMCID:: PMC3105202

Abstract Article PDF–425K

Select item 866089515.

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold

Nat Commun. 2021; 12: 7171. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27475-2