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Select item 87387431.

ITSN1: a novel candidate gene involved in autosomal dominant neurodevelopmental disorder spectrum

Ange-Line Bruel, Antonio Vitobello, Isabelle Thiffault, Linda Manwaring, Marcia Willing, Pankaj B. Agrawal, Allan Bayat, Thomas M. Kitzler, Catherine A. Brownstein, Casie A. Genetti, Joseph Gonzalez-Heydrich, Parul Jayakar, Jacob W. Zyskind, Zehua Zhu, Clemence Vachet, Gena R. Wilson, Brianna Pruniski, Anne-Marie Goyette, Yannis Duffourd, Christel Thauvin-Robinet, Christophe Philippe, Laurence Faivre

Eur J Hum Genet. 2022 Jan; 30(1): 111–116. Published online 2021 Oct 28. doi: 10.1038/s41431-021-00985-9

PMCID:: PMC8738743

Abstract Article PDF–530K

Select item 85011012.

Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer

Huikun Zhang, Zhifang Guo, Xiaoli Liu, Yawen Zhao, Yongzi Chen, Ming Zhang, Li Fu, Feng Gu, Yongjie Ma

Cell Death Dis. 2021 Oct; 12(10): 922. Published online 2021 Oct 8. doi: 10.1038/s41419-021-04218-1

PMCID:: PMC8501101

Abstract Article PDF–8.9M

Select item 56565113.

Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice

Jamie Harris, Erika Herrero-Garcia, Angela Russo, Andre Kajdacsy-Balla, John P. O’Bryan, Bill Chiu

J Pediatr Hematol Oncol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Pediatr Hematol Oncol. 2017 Nov; 39(8): e413–e418. doi: 10.1097/MPH.0000000000000931

PMCID:: PMC5656511

Abstract Article PDF–861K

Select item 33398664.

Intersectin 1 contributes to phenotypes in vivo: implications for Down Syndrome

Michael P. Hunter, Marianela Nelson, Michael Kurzer, Xuerong Wang, Richard J. Kryscio, Elizabeth Head, Graziano Pinna, John P. O’Bryan

Neuroreport. Author manuscript; available in PMC 2012 Oct 26.

Published in final edited form as: Neuroreport. 2011 Oct 26; 22(15): 767–772. doi: 10.1097/WNR.0b013e32834ae348

PMCID:: PMC3339866

Abstract Article PDF–1.7M

Select item 33378845.

Intersectin 1 is required for neuroblastoma tumorigenesis

Angela Russo, John P. O'Bryan

Oncogene. Author manuscript; available in PMC 2013 May 15.

Published in final edited form as: Oncogene. 2012 Nov 15; 31(46): 4828–4834. Published online 2012 Jan 23. doi: 10.1038/onc.2011.643

PMCID:: PMC3337884

Abstract Article PDF–870K

Select item 30057876.

Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3-DH domain linker

Carsten Kintscher, Silvia Wuertenberger, Roy Eylenstein, Theresia Uhlendorf, Yvonne Groemping

Protein Sci. 2010 Nov; 19(11): 2164–2174. Published online 2010 Sep 14. doi: 10.1002/pro.500

PMCID:: PMC3005787

Abstract Article PDF–2.0M

Select item 2848017.

Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells

Sanda A. Predescu, Dan N. Predescu, Barbara K. Timblin, Radu V. Stan, Asrar B. Malik

Mol Biol Cell. 2003 Dec; 14(12): 4997–5010. doi: 10.1091/mbc.E03-01-0041

PMCID:: PMC284801

Abstract Article PDF–1.2M

Select item 95199028.

The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression

Chungen Lan, Huikun Zhang, Kezhen Wang, Xiaoli Liu, Yawen Zhao, Zhifang Guo, Ning Zhang, Yongxia Zhou, Manzhi Gao, Feng Gu, Yongjie Ma

Cell Death Dis. 2022 Sep; 13(9): 835. Published online 2022 Sep 28. doi: 10.1038/s41419-022-05238-1

PMCID:: PMC9519902

Abstract Article PDF–8.3M

Select item 79047289.

ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs

S. Pankivskyi, D. Pastré, E. Steiner, V. Joshi, A. Rynditch, L. Hamon

Cell Mol Life Sci. 2021 Feb; 78(4): 1745–1763. Published online 2020 Aug 11. doi: 10.1007/s00018-020-03610-y

PMCID:: PMC7904728

Abstract Article PDF–5.2M

Select item 658957710.

Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture

Christian Makhoul, Prajakta Gosavi, Regina Duffield, Bronwen Delbridge, Nicholas A. Williamson, Paul A. Gleeson

Mol Biol Cell. 2019 Feb 1; 30(3): 370–386. doi: 10.1091/mbc.E18-05-0313

PMCID:: PMC6589577

Abstract Article PDF–3.3M

Select item 654766911.

Alternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression

Ying Shao, Wei Chong, Xiaoli Liu, Yun Xu, Huikun Zhang, Qiao Xu, Zhifang Guo, Yawen Zhao, Ming Zhang, Yongjie Ma, Feng Gu

Cell Death Dis. 2019 Jun; 10(6): 431. Published online 2019 Jun 3. doi: 10.1038/s41419-019-1668-0

PMCID:: PMC6547669

Abstract Article PDF–3.6M

Select item 372366812.

Adaptor Proteins Intersectin 1 and 2 Bind Similar Proline-Rich Ligands but Are Differentially Recognized by SH2 Domain-Containing Proteins

Olga Novokhatska, Mykola Dergai, Liudmyla Tsyba, Inessa Skrypkina, Valeriy Filonenko, Jacques Moreau, Alla Rynditch

PLoS One. 2013; 8(7): e70546. Published online 2013 Jul 25. doi: 10.1371/journal.pone.0070546

PMCID:: PMC3723668

Abstract Article PDF–5.3M

Select item 307244313.

Regulation of dynamin-2 assembly–disassembly and function through the SH3A domain of intersectin-1s

Ivana Knezevic, Dan Predescu, Cristina Bardita, Minhua Wang, Tiffany Sharma, Barbara Keith, Radu Neamu, Asrar B Malik, Sanda Predescu

J Cell Mol Med. 2011 Nov; 15(11): 2364–2376. Published online 2011 Oct 24. doi: 10.1111/j.1582-4934.2010.01226.x

PMCID:: PMC3072443

Abstract Article PDF–1006K

Select item 153855514.

Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42

Magali Malacombe, Mara Ceridono, Valérie Calco, Sylvette Chasserot-Golaz, Peter S McPherson, Marie-France Bader, Stéphane Gasman

EMBO J. 2006 Aug 9; 25(15): 3494–3503. Published online 2006 Jul 27. doi: 10.1038/sj.emboj.7601247

PMCID:: PMC1538555

Abstract Article PDF–348K

Select item 30566715.

The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

Xin-Kang Tong, Natasha K. Hussain, Elaine de Heuvel, Alexei Kurakin, Elia Abi-Jaoude, Christopher C. Quinn, Michael F. Olson, Richard Marais, Danny Baranes, Brian K. Kay, Peter S. McPherson

EMBO J. 2000 Mar 15; 19(6): 1263–1271. doi: 10.1093/emboj/19.6.1263

PMCID:: PMC305667

Abstract Article PDF–427K

Select item 570977016.

Intersectin‐s interaction with DENND2B facilitates recycling of epidermal growth factor receptor

Maria S Ioannou, Gopinath Kulasekaran, Maryam Fotouhi, Justin J Morein, Chanshuai Han, Sarah Tse, Nadya Nossova, Tony Han, Erin Mannard, Peter S McPherson

EMBO Rep. 2017 Dec; 18(12): 2119–2130. Published online 2017 Oct 13. doi: 10.15252/embr.201744034

PMCID:: PMC5709770

Abstract Article PDF–1.3M

Select item 423700217.

De novo mutations in schizophrenia implicate synaptic networks

Menachem Fromer, Andrew J. Pocklington, David H. Kavanagh, Hywel J. Williams, Sarah Dwyer, Padhraig Gormley, Lyudmila Georgieva, Elliott Rees, Priit Palta, Douglas M. Ruderfer, Noa Carrera, Isla Humphreys, Jessica S. Johnson, Panos Roussos, Douglas D. Barker, Eric Banks, Vihra Milanova, Seth G. Grant, Eilis Hannon, Samuel A. Rose, Kimberly Chambert, Milind Mahajan, Edward M. Scolnick, Jennifer L. Moran, George Kirov, Aarno Palotie, Steven A. McCarroll, Peter Holmans, Pamela Sklar, Michael J. Owen, Shaun M. Purcell, Michael C. O’Donovan

Nature. Author manuscript; available in PMC 2014 Nov 19.

Published in final edited form as: Nature. 2014 Feb 13; 506(7487): 179–184. Published online 2014 Jan 22. doi: 10.1038/nature12929

PMCID:: PMC4237002

Abstract Article PDF–1.7M

Select item 605726918.

A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits

Leonardo Almeida-Souza, Rene A.W. Frank, Javier García-Nafría, Adeline Colussi, Nushan Gunawardana, Christopher M. Johnson, Minmin Yu, Gillian Howard, Byron Andrews, Yvonne Vallis, Harvey T. McMahon

Cell. 2018 Jul 12; 174(2): 325–337.e14. doi: 10.1016/j.cell.2018.05.020

PMCID:: PMC6057269

Abstract Article

Select item 117120719.

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.

A S Sengar, W Wang, J Bishay, S Cohen, S E Egan

EMBO J. 1999 Mar 1; 18(5): 1159–1171. doi: 10.1093/emboj/18.5.1159

PMCID:: PMC1171207

Summary PDF–1.1M

Select item 340841720.

The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis

Anjali Teckchandani, Erin E. Mulkearns, Timothy W. Randolph, Natalie Toida, Jonathan A. Cooper

Mol Biol Cell. 2012 Aug 1; 23(15): 2905–2916. doi: 10.1091/mbc.E11-12-1007

PMCID:: PMC3408417

Abstract Article PDF–3.8M

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