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Select item 67313521.

Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1

Norbert F. Ajeawung, Thi Tuyet Mai Nguyen, Linchao Lu, Thomas J. Kucharski, Justine Rousseau, Sirinart Molidperee, Joshua Atienza, Isabel Gamache, Weidong Jin, Sharon E. Plon, Brendan H. Lee, Jose G. Teodoro, Lisa L. Wang, Philippe M. Campeau

Am J Hum Genet. 2019 Sep 5; 105(3): 625–630. Published online 2019 Jul 11. doi: 10.1016/j.ajhg.2019.06.011

PMCID:: PMC6731352

Abstract Article PDF–1.0M

Select item 64270392.

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density

Erna V. Ivarsdottir, Stefania Benonisdottir, Gudmar Thorleifsson, Patrick Sulem, Asmundur Oddsson, Unnur Styrkarsdottir, Snaedis Kristmundsdottir, Gudny A. Arnadottir, Gudmundur Thorgeirsson, Ingileif Jonsdottir, Gunnar M. Zoega, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Fridbert Jonasson, Hilma Holm, Kari Stefansson

Nat Commun. 2019; 10: 1284. Published online 2019 Mar 20. doi: 10.1038/s41467-019-09304-9

PMCID:: PMC6427039

Abstract Article PDF–1.1M

Select item 63407783.

Posing the APC/C E3 ubiquitin ligase to orchestrate cell division

Edmond R. Watson, Nicholas G. Brown, Jan-Michael Peters, Holger Stark, Brenda A. Schulman

Trends Cell Biol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Trends Cell Biol. 2019 Feb; 29(2): 117–134. Published online 2018 Oct 25. doi: 10.1016/j.tcb.2018.09.007

PMCID:: PMC6340778

Abstract Article PDF–1.7M

Select item 24382994.

Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis

Takeo Fujita, Weijun Liu, Hiroyoshi Doihara, Yong Wan

Am J Pathol. 2008 Jul; 173(1): 217–228. doi: 10.2353/ajpath.2008.070957

PMCID:: PMC2438299

Abstract Article PDF–3.9M

Select item 93696485.

Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1

Guy Mann, Prasad Sulkshane, Pradeep Sadhu, Tamar Ziv, Michael H. Glickman, Ashraf Brik

Molecules. 2022 Aug; 27(15): 4867. Published online 2022 Jul 29. doi: 10.3390/molecules27154867

PMCID:: PMC9369648

Abstract Article PDF–5.3M

Select item 54549696.

New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer’s Disease

Tanja Fuchsberger, Ana Lloret, Jose Viña

Int J Mol Sci. 2017 May; 18(5): 1057. Published online 2017 May 14. doi: 10.3390/ijms18051057

PMCID:: PMC5454969

Abstract Article PDF–1.6M

Select item 53425677.

Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma

Lisa J. Crawford, Gordon Anderson, Cliona K. Johnston, Alexandra E. Irvine

Oncotarget. 2016 Oct 25; 7(43): 70481–70493. Published online 2016 Sep 15. doi: 10.18632/oncotarget.12026

PMCID:: PMC5342567

Abstract Article PDF–2.8M

Select item 44685078.

Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5

Alex E. Clark, Deborah H. Spector

J Virol. 2015 Jul; 89(13): 6928–6939. Prepublished online 2015 Apr 22. Published online 2015 Jun 3. doi: 10.1128/JVI.00403-15

PMCID:: PMC4468507

Abstract Article PDF–1.8M

Select item 36899579.

Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment

Zhuan Zhou, Chao Jing, Liyong Zhang, Fujita Takeo, Hyun Kim, Yi Huang, Zhihua Liu, Yong Wan

J Biol Chem. 2013 Jun 21; 288(25): 18134–18145. Published online 2013 May 1. doi: 10.1074/jbc.M113.456962

PMCID:: PMC3689957

Abstract Article PDF–3.7M

Select item 352906210.

Ubiquitylation of p53 by the APC/C inhibitor Trim39

Liguo Zhang, Nai-Jia Huang, Chen Chen, Wanli Tang, Sally Kornbluth

Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51): 20931–20936. Published online 2012 Dec 4. doi: 10.1073/pnas.1212047110

PMCID:: PMC3529062

Abstract Article PDF–703K

Select item 306918611.

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-β-TrCP, sequentially regulate glycolysis during the cell cycle

Slavica Tudzarova, Sergio L. Colombo, Kai Stoeber, Saul Carcamo, Gareth H. Williams, Salvador Moncada

Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13): 5278–5283. Published online 2011 Mar 14. doi: 10.1073/pnas.1102247108

PMCID:: PMC3069186

Abstract Article PDF–933K

Select item 14541712.

Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

Amit Zur, Michael Brandeis

EMBO J. 2001 Feb 15; 20(4): 792–801. doi: 10.1093/emboj/20.4.792

PMCID:: PMC145417

Abstract Article PDF–314K

Select item 362308913.

The Phosphatase-Transcription Activator EYA1 Is Targeted by Anaphase-Promoting Complex/Cdh1 for Degradation at M-to-G₁ Transition

Jianbo Sun, Zoi Karoulia, Elaine Y. M. Wong, Mohi Ahmed, Keiji Itoh, Pin-Xian Xu

Mol Cell Biol. 2013 Mar; 33(5): 927–936. doi: 10.1128/MCB.01516-12

PMCID:: PMC3623089

Abstract Article PDF–2.4M

Select item 310260014.

The emerging role of APC/C^Cdh1 in controlling differentiation, genomic stability and tumor suppression

Ralph Wäsch, Jonathan A. Robbins, Frederick R. Cross

Oncogene. Author manuscript; available in PMC 2011 May 26.

Published in final edited form as: Oncogene. 2010 Jan 7; 29(1): 1–10. Published online 2009 Oct 12. doi: 10.1038/onc.2009.325

PMCID:: PMC3102600

Abstract Article PDF–1.1M

Select item 308950715.

Regulation of the Action of Early Mitotic Inhibitor 1 on the Anaphase-promoting Complex/Cyclosome by Cyclin-dependent Kinases

Yakir Moshe, Ortal Bar-On, Dvora Ganoth, Avram Hershko

J Biol Chem. 2011 May 13; 286(19): 16647–16657. Published online 2011 Mar 16. doi: 10.1074/jbc.M111.223339

PMCID:: PMC3089507

Abstract Article PDF–2.5M

Select item 222437816.

Accumulation of Substrates of the Anaphase-Promoting Complex (APC) during Human Cytomegalovirus Infection Is Associated with the Phosphorylation of Cdh1 and the Dissociation and Relocalization of APC Subunits

Karen Tran, Jeffrey A. Mahr, Jiwon Choi, Jose G. Teodoro, Michael R. Green, Deborah H. Spector

J Virol. 2008 Jan; 82(1): 529–537. Published online 2007 Oct 17. doi: 10.1128/JVI.02010-07

PMCID:: PMC2224378

Abstract Article PDF–407K

Select item 8724317.

Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation

Yongke Zhang, Emma Lees

Mol Cell Biol. 2001 Aug; 21(15): 5190–5199. doi: 10.1128/MCB.21.15.5190-5199.2001

PMCID:: PMC87243

Abstract Article PDF–1.5M

Select item 805471218.

Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells

Meenu Maan, Neha Jaiswal Agrawal, Jaya Padmanabhan, Christelle Colin Leitzinger, Yainyrette Rivera-Rivera, Harold I. Saavedra, Srikumar P. Chellappan

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2021 Mar; 1868(3): 118929. Published online 2020 Dec 11. doi: 10.1016/j.bbamcr.2020.118929