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Select item 93720631.

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki

Nat Commun. 2022; 13: 4714. Published online 2022 Aug 11. doi: 10.1038/s41467-022-32442-6

PMCID:: PMC9372063

Abstract Article PDF–2.2M

Select item 89036232.

Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population

Lina Wang, Tantan Ma, Dongdong Qiao, Kaiyan Cui, Xiaojiao Bi, Chao Han, Limin Yang, Mengmeng Sun, Lanfen Liu

BMC Psychiatry. 2022; 22: 171. Published online 2022 Mar 8. doi: 10.1186/s12888-022-03799-1

PMCID:: PMC8903623

Abstract Article PDF–1.0M

Select item 86034233.

The Glutamate Transporter EAAT2 Is Transiently Expressed in Developing Human Cerebral White Matter

TARA M. DESILVA, HANNAH C. KINNEY, NATALIA S. BORENSTEIN, FELICIA L. TRACHTENBERG, NINA IRWIN, JOSEPH J. VOLPE, PAUL A. ROSENBERG

J Comp Neurol. Author manuscript; available in PMC 2021 Nov 19.

Published in final edited form as: J Comp Neurol. 2007 Apr 20; 501(6): 879–890. doi: 10.1002/cne.21289

PMCID:: PMC8603423

Abstract Article PDF–2.3M

Select item 84450784.

Endocytosis of the glutamate transporter 1 is regulated by Laforin and Malin: implications in Lafora Disease.

Eva Perez-Jimenez, Rosa Viana, Carmen Muñoz-Ballester, Carlos Vendrell-Tornero, Raquel Moll-Diaz, Maria Adelaida Garcia-Gimeno, Pascual Sanz

Glia. Author manuscript; available in PMC 2021 Sep 16.

Published in final edited form as: Glia. 2021 May; 69(5): 1170–1183. Published online 2020 Dec 23. doi: 10.1002/glia.23956

PMCID:: PMC8445078

Abstract Article PDF–1.7M

Select item 80959785.

Excitatory Amino Acid Transporter EAAT‐2 in Tangle‐bearing Neurons in Alzheimer's Disease

Dietmar Rudolf Thal

Brain Pathol. 2002 Oct; 12(4): 405–411. Published online 2006 Apr 5. doi: 10.1111/j.1750-3639.2002.tb00457.x

PMCID:: PMC8095978

Summary PDF–277K

Select item 76066706.

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates

Bettina Kolen, Daniel Kortzak, Arne Franzen, Christoph Fahlke

J Biol Chem. 2020 Oct 30; 295(44): 14936–14947. Published online 2020 Aug 20. doi: 10.1074/jbc.RA120.013704

PMCID:: PMC7606670

Abstract Article PDF–3.2M

Select item 71053067.

A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)

Kelly L. Damm-Ganamet, Marie-Laure Rives, Alan D. Wickenden, Heather M. McAllister, Taraneh Mirzadegan

J Biol Chem. 2020 Mar 27; 295(13): 4359–4366. Published online 2020 Feb 20. doi: 10.1074/jbc.AC119.011190

PMCID:: PMC7105306

Abstract Article PDF–1.2M

Select item 70804318.

Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China

Ting Gao, Jiong Wu, Ran Zheng, Yi Fang, Chong‐Yao Jin, Yang Ruan, Jin Cao, Jun Tian, Jia‐Li Pu, Bao‐Rong Zhang

CNS Neurosci Ther. 2020 Apr; 26(4): 448–452. Published online 2019 Nov 21. doi: 10.1111/cns.13272

PMCID:: PMC7080431

Abstract Article PDF–467K

Select item 68002109.

Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism

Andrew B. Stergachis, Jonai Pujol-Giménez, Gergely Gyimesi, Daniel Fuster, Giusppe Albano, Marina Troxler, Jonathan Picker, Paul A. Rosenberg, Ann Bergin, Jurriaan Peters, Christelle Moufawad El Achkar, Chellamani Harini, Shannon Manzi, Alexander Rotenberg, Matthias A. Hediger, Lance H. Rodan

Ann Neurol. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Ann Neurol. 2019 Jun; 85(6): 921–926. Published online 2019 Apr 26. doi: 10.1002/ana.25477

PMCID:: PMC6800210

Abstract Article PDF–1.2M

Select item 653328210.

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling

Marin Veldic, Vincent Millischer, John D. Port, Ada Man-Choi Ho, Yun-Fang Jia, Jennifer R. Geske, Joanna M. Biernacka, Lena Backlund, Susan L. McElroy, David J. Bond, J. Carlos Villaescusa, Michelle Skime, Doo-Sup Choi, Catharina Lavebratt, Martin Schalling, Mark A. Frye

Transl Psychiatry. 2019; 9: 149. Published online 2019 May 23. doi: 10.1038/s41398-019-0483-9

PMCID:: PMC6533282

Abstract Article PDF–1.3M

Select item 584024711.

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants

Shavanthi Rajatileka, David Odd, Matthew T. Robinson, Alexandra C. Spittle, Louis Dwomoh, Maggie Williams, David Harding, Miles Wagstaff, Marie Owen, Charlene Crosby, Jared Ching, Elek Molnár, Karen Luyt, Anikó Váradi

Mol Neurobiol. 2018; 55(3): 2013–2024. Published online 2017 Mar 7. doi: 10.1007/s12035-017-0462-1

PMCID:: PMC5840247

Abstract Article PDF–836K

Select item 578604512.

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

Eiji Kobayashi, Masako Nakano, Kenta Kubota, Nobuaki Himuro, Shougo Mizoguchi, Takako Chikenji, Miho Otani, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya

Sci Rep. 2018; 8: 1712. Published online 2018 Jan 26. doi: 10.1038/s41598-018-19442-7

PMCID:: PMC5786045

Abstract Article PDF–2.2M

Select item 550172913.

Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study

Jie Wang, Geoffrey C. Kelly, William J. Tate, Yong-Shi Li, Michelle Lee, Jesus Gutierrez, Elan D. Louis, Phyllis L. Faust, Sheng-Han Kuo

Parkinsonism Relat Disord. Author manuscript; available in PMC 2017 Jul 7.

Published in final edited form as: Parkinsonism Relat Disord. 2016 Nov; 32: 87–93. Published online 2016 Sep 6. doi: 10.1016/j.parkreldis.2016.09.003

PMCID:: PMC5501729

Abstract Article PDF–615K

Select item 507053914.

GLT-1: The elusive presynaptic glutamate transporter

Theresa S. Rimmele, Paul A. Rosenberg

Neurochem Int. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Neurochem Int. 2016 Sep; 98: 19–28. Published online 2016 Apr 26. doi: 10.1016/j.neuint.2016.04.010

PMCID:: PMC5070539

Abstract Article PDF–1.1M

Select item 504830015.

TM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle

Xiuliang Rong, Feng Tan, Xiaojuan Wu, Xiuping Zhang, Lingli Lu, Xiaoming Zou, Shaogang Qu

Sci Rep. 2016; 6: 34522. Published online 2016 Oct 4. doi: 10.1038/srep34522

PMCID:: PMC5048300

Abstract Article PDF–1.5M

Select item 468326816.

The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2

Alexandre Simonin, Nicolas Montalbetti, Gergely Gyimesi, Jonai Pujol-Giménez, Matthias A. Hediger

J Biol Chem. 2015 Dec 18; 290(51): 30464–30474. Published online 2015 Oct 19. doi: 10.1074/jbc.M115.689836

PMCID:: PMC4683268

Abstract Article PDF–2.9M

Select item 467326617.

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

Jared Ching, Stephanie Amiridis, Stanley S. Stylli, Andrew R. Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B. Luwor, Andrew P. Morokoff, Terence J. O'Brien, Andrew H. Kaye

Oncotarget. 2015 Aug 28; 6(25): 21301–21314. Published online 2015 Jun 3. doi: 10.18632/oncotarget.4019

PMCID:: PMC4673266

Abstract Article PDF–5.3M

Select item 438804018.

SLC1A2 rs3764087 does not associate with essential tremor

Jay P Ross, Sruti Rayaprolu, Cecily Q Bernales, Alexandra I Soto-Ortolaza, Jay van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Alex Rajput, Ali H Rajput, Michele L Rajput, Owen A Ross, Carles Vilariño-Güell

Neurobiol Aging. Author manuscript; available in PMC 2015 Apr 7.

Published in final edited form as: Neurobiol Aging. 2014 Apr; 35(4): 935.e9–935.10. Published online 2013 Oct 16. doi: 10.1016/j.neurobiolaging.2013.09.022