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Select item 43492401.

The Integrator complex controls the termination of transcription at diverse classes of gene targets

Jeffrey R Skaar, Andrea L Ferris, Xiaolin Wu, Anita Saraf, Kum Kum Khanna, Laurence Florens, Michael P Washburn, Stephen H Hughes, Michele Pagano

Cell Res. 2015 Mar; 25(3): 288–305. Published online 2015 Feb 13. doi: 10.1038/cr.2015.19

PMCID:: PMC4349240

Abstract Article PDF–1.8M

Select item 79489522.

Structural basis for multifunctional roles of human Ints3 C-terminal domain

Jian Li, Xinli Ma, Surajit Banerjee, Sankar Baruah, Nicholas J. Schnicker, Eunmiri Roh, Weiya Ma, Kangdong Liu, Ann M. Bode, Zigang Dong

J Biol Chem. 2021 Jan-Jun; 296: 100112. Published online 2020 Dec 3. doi: 10.1074/jbc.RA120.016393

PMCID:: PMC7948952

Abstract Article PDF–3.0M

Select item 57488373.

Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding

Venkatasubramanian Vidhyasagar, Yujiong He, Manhong Guo, Tanu Talwar, Ravi Shankar Singh, Manisha Yadav, George Katselis, Franco J. Vizeacoumar, Kiven E. Lukong, Yuliang Wu

Biochem J. 2018 Jan 15; 475(1): 45–60. Prepublished online 2017 Nov 17. Published online 2018 Jan 2. doi: 10.1042/BCJ20170351

PMCID:: PMC5748837

Abstract Article PDF–5.3M

Select item 43273874.

Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response

Seungchan Yang, Alexandre J. C. Quaresma, Jeffrey A. Nickerson, Karin M. Green, Scott A. Shaffer, Anthony N. Imbalzano, Lori A. Martin-Buley, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, Gary S. Stein

J Cell Sci. 2015 Feb 15; 128(4): 728–740. doi: 10.1242/jcs.160051

PMCID:: PMC4327387

Abstract Article

Select item 54330285.

hSSB1 associates with and promotes stability of the BLM helicase

Laura V. Croft, Nicholas W. Ashton, Nicolas Paquet, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard

BMC Mol Biol. 2017; 18: 13. Published online 2017 May 15. doi: 10.1186/s12867-017-0090-3

PMCID:: PMC5433028

Abstract Article PDF–2.2M

Select item 27620976.

INTS3 controls the hSSB1-mediated DNA damage response

Jeffrey R. Skaar, Derek J. Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P. Washburn, Kum Kum Khanna, Michele Pagano

J Cell Biol. 2009 Oct 5; 187(1): 25–32. doi: 10.1083/jcb.200907026

PMCID:: PMC2762097

Abstract Article PDF–3.6M

Select item 38202397.

A core hSSB1–INTS complex participates in the DNA damage response

Feng Zhang, Teng Ma, Xiaochun Yu

J Cell Sci. 2013 Nov 1; 126(21): 4850–4855. doi: 10.1242/jcs.132514

PMCID:: PMC3820239

Abstract Article

Select item 30894708.

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

Derek J. Richard, Liza Cubeddu, Aaron J. Urquhart, Amanda Bain, Emma Bolderson, Dinoop Menon, Malcolm F. White, Kum Kum Khanna

Nucleic Acids Res. 2011 May; 39(9): 3643–3651. Published online 2011 Jan 10. doi: 10.1093/nar/gkq1340

PMCID:: PMC3089470

Abstract Article PDF–3.9M

Select item 44464299.

RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

Ananya Kar, Manpreet Kaur, Tanushree Ghosh, Md. Muntaz Khan, Aparna Sharma, Ritu Shekhar, Akhil Varshney, Sandeep Saxena

Nucleic Acids Res. 2015 May 26; 43(10): 4962–4974. Published online 2015 Apr 27. doi: 10.1093/nar/gkv369

PMCID:: PMC4446429

Abstract Article PDF–9.4M

Select item 364159710.

Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres

Peili Gu, Wei Deng, Ming Lei, Sandy Chang

Cell Res. 2013 May; 23(5): 705–719. Published online 2013 Mar 5. doi: 10.1038/cr.2013.31

PMCID:: PMC3641597

Abstract Article PDF–1.4M

Select item 274912611.

hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response

Yongjiang Li, Emma Bolderson, Rakesh Kumar, Parameswary A. Muniandy, Yutong Xue, Derek J. Richard, Michael Seidman, Tej K. Pandita, Kum Kum Khanna, Weidong Wang

J Biol Chem. 2009 Aug 28; 284(35): 23525–23531. Published online 2009 Jul 14. doi: 10.1074/jbc.C109.039586

PMCID:: PMC2749126

Abstract Article PDF–1.3M

Select item 798022412.

Structure of the catalytic core of the Integrator complex

Moritz M. Pfleiderer, Wojciech P. Galej

Mol Cell. 2021 Mar 18; 81(6): 1246–1259.e8. doi: 10.1016/j.molcel.2021.01.005

PMCID:: PMC7980224

Abstract Article

Select item 742756813.

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

Felipe Beckedorff, Ezra Blumenthal, Lucas Ferreira daSilva, Yuki Aoi, Pradeep Reddy Cingaram, Jingyin Yue, Anda Zhang, Sadat Dokaneheifard, Monica Guiselle Valencia, Gabriel Gaidosh, Ali Shilatifard, Ramin Shiekhattar

Cell Rep. Author manuscript; available in PMC 2020 Aug 14.

Published in final edited form as: Cell Rep. 2020 Jul 21; 32(3): 107917. doi: 10.1016/j.celrep.2020.107917

PMCID:: PMC7427568

Abstract Article PDF–2.8M

Select item 734759714.

INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Kevin Sabath, Melanie L. Stäubli, Sabrina Marti, Alexander Leitner, Murielle Moes, Stefanie Jonas

Nat Commun. 2020; 11: 3422. Published online 2020 Jul 9. doi: 10.1038/s41467-020-17232-2

PMCID:: PMC7347597

Abstract Article PDF–2.5M

Select item 278159515.

Integrator3, a Partner of Single-stranded DNA-binding Protein 1, Participates in the DNA Damage Response

Feng Zhang, Jiaxue Wu, Xiaochun Yu

J Biol Chem. 2009 Oct 30; 284(44): 30408–30415. Published online 2009 Sep 15. doi: 10.1074/jbc.M109.039404

PMCID:: PMC2781595

Abstract Article PDF–3.1M

Select item 435749616.

A DNA Damage Response Screen Identifies RHINO: a 9-1-1 and TopBP1 interacting protein required for ATR signaling

Cecilia Cotta-Ramusino, E. Robert McDonald 3, 3rd, Kristen Hurov, Mathew E. Sowa, J. Wade Harper, Stephen J. Elledge

Science. Author manuscript; available in PMC 2015 Mar 12.

Published in final edited form as: Science. 2011 Jun 10; 332(6035): 1313–1317. doi: 10.1126/science.1203430

PMCID:: PMC4357496

Abstract Article PDF–816K

Select item 377195617.

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex

Jeanne N. Jodoin, Poojitha Sitaram, Todd R. Albrecht, Sarah B. May, Mohammad Shboul, Ethan Lee, Bruno Reversade, Eric J. Wagner, Laura A. Lee

Mol Biol Cell. 2013 Sep 15; 24(18): 2954–2965. doi: 10.1091/mbc.E13-05-0254

PMCID:: PMC3771956

Abstract Article PDF–2.0M

Select item 31107318.

Gene Expression Profiling in Human Fetal Liver and Identification of Tissue- and Developmental-Stage-Specific Genes through Compiled Expression Profiles and Efficient Cloning of Full-Length cDNAs

Yongtao Yu, Chenggang Zhang, Gangqiao Zhou, Songfeng Wu, Xianghu Qu, Handong Wei, Guichun Xing, Chunna Dong, Yun Zhai, Jinghong Wan, Shuguang Ouyang, Li Li, Shaowen Zhang, Kaixin Zhou, Yinan Zhang, Chutse Wu, Fuchu He

Genome Res. 2001 Aug; 11(8): 1392–1403. doi: 10.1101/gr.175501

PMCID:: PMC311073

Abstract Article PDF–142K

Select item 394758419.

Phosphoproteomics screen reveals Akt isoform-specific signals linking RNA processing to lung cancer

Ioannis Sanidas, Christos Polytarchou, Maria Hatziapostolou, Scott A. Ezell, Filippos Kottakis, Lan Hu, Ailan Guo, Jianxin Xie, Michael J. Comb, Dimitrios Iliopoulos, Philip N. Tsichlis

Mol Cell. Author manuscript; available in PMC 2015 Feb 20.

Published in final edited form as: Mol Cell. 2014 Feb 20; 53(4): 577–590. Published online 2014 Jan 23. doi: 10.1016/j.molcel.2013.12.018