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Select item 105677221.

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O’Mara, Alastair G. Stewart

Nat Commun. 2023; 14: 6374. Published online 2023 Oct 11. doi: 10.1038/s41467-023-42086-9

PMCID:: PMC10567722

Abstract Article PDF–3.9M

Select item 90262892.

The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region

Sweny de S. M. Fernandes, Luciana P. C. Leitão, Amanda de N. Cohen-Paes, Laura P. A. Gellen, Lucas F. Pastana, Darlen C. de Carvalho, Antônio A. C. Modesto, Ana C. A. da Costa, Alayde V. Wanderley, Carlos H. V. de Lima, Esdras E. B. Pereira, Marianne R. Fernandes, Rommel M. R. Burbano, Paulo P. de Assumpção, Sidney E. B. dos Santos, Ney P. C. dos Santos

Genes (Basel) 2022 Apr; 13(4): 610. Published online 2022 Mar 29. doi: 10.3390/genes13040610

PMCID:: PMC9026289

Abstract Article PDF–893K

Select item 88781593.

Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1

Ole Jensen, Lukas Gebauer, Jürgen Brockmöller, Christof Dücker

Int J Mol Sci. 2022 Feb; 23(4): 2007. Published online 2022 Feb 11. doi: 10.3390/ijms23042007

PMCID:: PMC8878159

Abstract Article PDF–7.0M

Select item 75969694.

Overexpression of OCT-1 gene is a biomarker of adverse prognosis for diffuse large B-cell lymphoma (DLBCL): data from a retrospective cohort of 77 Brazilian patients

Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa, Juliana Pereira

BMC Cancer. 2020; 20: 1041. Published online 2020 Oct 29. doi: 10.1186/s12885-020-07553-2

PMCID:: PMC7596969

Abstract Article PDF–1.3M

Select item 52335695.

Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children with Insulin Resistance

Wai Johnn Sam, Orsolya Roza, Yuen Yi Hon, Raul M. Alfaro, Karim A Calis, James C Reynolds, Jack A Yanovski

J Clin Pharmacol. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: J Clin Pharmacol. 2017 Feb; 57(2): 219–229. Published online 2016 Aug 23. doi: 10.1002/jcph.796

PMCID:: PMC5233569

Abstract Article PDF–669K

Select item 50646456.

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

T. Dujic, A. Causevic, T. Bego, M. Malenica, Z. Velija‐Asimi, E. R. Pearson, S. Semiz

Diabet Med. 2016 Apr; 33(4): 511–514. Published online 2015 Dec 24. doi: 10.1111/dme.13040

PMCID:: PMC5064645

Abstract Article PDF–61K

Select item 47516387.

Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment

Daniel Grimm, Jonas Lieb, Veronika Weyer, Johanna Vollmar, Felix Darstein, Anja Lautem, Maria Hoppe-Lotichius, Sandra Koch, Arno Schad, Jörn M. Schattenberg, Marcus A. Wörns, Arndt Weinmann, Peter R. Galle, Tim Zimmermann

BMC Cancer. 2016; 16: 94. Published online 2016 Feb 12. doi: 10.1186/s12885-016-2150-3

PMCID:: PMC4751638

Abstract Article PDF–613K

Select item 41280498.

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors

C Arimany-Nardi, E Errasti-Murugarren, G Minuesa, J Martinez-Picado, V Gorboulev, H Koepsell, M Pastor-Anglada

Br J Pharmacol. 2014 Aug; 171(16): 3868–3880. Published online 2014 Jul 25. doi: 10.1111/bph.12748

PMCID:: PMC4128049

Abstract Article PDF–1.0M

Select item 41166709.

OCT1 genetic variants influence the pharmacokinetics of morphine in children

Tsuyoshi Fukuda, Vidya Chidambaran, Tomoyuki Mizuno, Raja Venkatasubramanian, Pornswan Ngamprasertwong, Vanessa Olbrecht, Hope R Esslinger, Alexander A Vinks, Senthilkumar Sadhasivam

Pharmacogenomics. Author manuscript; available in PMC 2014 Jul 31.

Published in final edited form as: Pharmacogenomics. 2013 Jul; 14(10): 1141–1151. doi: 10.2217/pgs.13.94

PMCID:: PMC4116670

Abstract Article PDF–360K

Select item 401466310.

Common Drugs Inhibit Human Organic Cation Transporter 1 (OCT1)-Mediated Neurotransmitter Uptake

Kelli H. Boxberger, Bruno Hagenbuch, Jed N. Lampe

Drug Metab Dispos. 2014 Jun; 42(6): 990–995. Published online 2014 Jun. doi: 10.1124/dmd.113.055095

PMCID:: PMC4014663

Abstract Article PDF–263K

Select item 393230211.

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1)

Anne T. Nies, Elke Schaeffeler, Heiko van der Kuip, Ingolf Cascorbi, Oliver Bruhn, Michael Kneba, Christiane Pott, Ute Hofmann, Christopher Volk, Shuiying Hu, Sharyn D. Baker, Alex Sparreboom, Peter Ruth, Hermann Koepsell, Matthias Schwab

Clin Cancer Res. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: Clin Cancer Res. 2014 Feb 15; 20(4): 985–994. Published online 2013 Dec 18. doi: 10.1158/1078-0432.CCR-13-1999

PMCID:: PMC3932302

Abstract Article PDF–1.8M

Select item 349345512.

Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant

Jessica Maddox, Arvind Shakya, Samuel South, Dawne Shelton, Jared N. Andersen, Stephanie Chidester, Jinsuk Kang, Keith M. Gligorich, David A. Jones, Gerald J. Spangrude, Bryan E. Welm, Dean Tantin

PLoS Genet. 2012 Nov; 8(11): e1003048. Published online 2012 Nov 8. doi: 10.1371/journal.pgen.1003048

PMCID:: PMC3493455

Abstract Article PDF–1.9M

Select item 336665813.

Chronic phase chronic myeloid leukemia patients with low OCT-1 activity randomized to high-dose imatinib achieve better responses and have lower failure rates than those randomized to standard-dose imatinib

Deborah L. White, Jerald Radich, Simona Soverini, Verity A Saunders, Amity K. Frede, Phuong Dang, Daniela Cilloni, Peter Lin, Lidia Mongay, Richard Woodman, Paul Manley, Cassandra Slader, Dong Wook Kim, Fabrizio Pane, Giovanni Martinelli, Giuseppe Saglio, Timothy P. Hughes

Haematologica. 2012 Jun; 97(6): 907–914. doi: 10.3324/haematol.2011.056457

PMCID:: PMC3366658

Abstract Article PDF–902K

Select item 302981914.

OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users

Matthijs L. Becker, Loes E. Visser, Ron H. N. van Schaik, Albert Hofman, André G. Uitterlinden, Bruno H. Ch. Stricker

Neurogenetics. 2011; 12(1): 79–82. Published online 2010 Aug 1. doi: 10.1007/s10048-010-0254-5

PMCID:: PMC3029819

Abstract Article PDF–97K

Select item 268268915.

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

Kaixin Zhou, Louise A. Donnelly, Charlotte H. Kimber, Peter T. Donnan, Alex S.F. Doney, Graham Leese, Andrew T. Hattersley, Mark I. McCarthy, Andrew D. Morris, Colin N.A. Palmer, Ewan R. Pearson

Diabetes. 2009 Jun; 58(6): 1434–1439. Published online 2009 Mar 31. doi: 10.2337/db08-0896

PMCID:: PMC2682689

Abstract Article PDF–126K

Select item 256918016.

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia

Athina Giannoudis, Andrea Davies, Claire M. Lucas, Robert J. Harris, Munir Pirmohamed, Richard E. Clark

Blood. 2008 Oct 15; 112(8): 3348–3354. Prepublished online 2008 Jul 31. doi: 10.1182/blood-2007-10-116236

PMCID:: PMC2569180

Abstract Article

Select item 15629917.

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Yan Shu, Maya K. Leabman, Bo Feng, Lara M. Mangravite, Conrad C. Huang, Doug Stryke, Michiko Kawamoto, Susan J. Johns, Joseph DeYoung, Elaine Carlson, Thomas E. Ferrin, Ira Herskowitz, Kathleen M. Giacomini, Pharmacogenetics of Membrane Transporters Investigators

Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 5902–5907. Published online 2003 Apr 28. doi: 10.1073/pnas.0730858100

PMCID:: PMC156299

Abstract Article PDF–311K

Select item 913053818.

Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

Marleen J. Meyer, Pascale C.F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Jürgen Brockmöller, Barbara Zdrazil, Mladen V. Tzvetkov

J Biol Chem. 2022 Jun; 298(6): 101974. Published online 2022 Apr 22. doi: 10.1016/j.jbc.2022.101974

PMCID:: PMC9130538

Abstract Article PDF–4.4M

Select item 900551419.

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G. Lawrence, Renea A. Taylor, Gail P. Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue

Sci Rep. 2022; 12: 6094. Published online 2022 Apr 12. doi: 10.1038/s41598-022-10099-x

PMCID:: PMC9005514

Abstract Article PDF–3.5M

Select item 612345620.

Polymorphisms of SLCO1B1 rs4149056 and SLC22A1 rs2282143 are associated with responsiveness to acitretin in psoriasis patients

Wangqing Chen, Xu Zhang, Wei Zhang, Cong Peng, Wu Zhu, Xiang Chen

Sci Rep. 2018; 8: 13182. Published online 2018 Sep 4. doi: 10.1038/s41598-018-31352-2

PMCID:: PMC6123456

Abstract Article PDF–1.5M

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PMC Links for Gene (Select 6580) (70)
PMC
PREDICTED: Homo sapiens roundabout guidance receptor 1 (ROBO1), transcript varia...
PREDICTED: Homo sapiens roundabout guidance receptor 1 (ROBO1), transcript variant X6, mRNA
gi|2217345342|ref|XM_006713277.4|

Nucleotide
MULTISPECIES: AI-2E family transporter [Furfurilactobacillus]
MULTISPECIES: AI-2E family transporter [Furfurilactobacillus]
gi|1867850559|ref|WP_178942273.1|

Protein
PREDICTED: Homo sapiens ventral anterior homeobox 2 (VAX2), transcript variant X...
PREDICTED: Homo sapiens ventral anterior homeobox 2 (VAX2), transcript variant X1, mRNA
gi|2217326839|ref|XM_011532751.4|

Nucleotide
GRM6 glutamate metabotropic receptor 6 [Homo sapiens]
GRM6 glutamate metabotropic receptor 6 [Homo sapiens]
Gene ID:2916

Gene

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