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Items: 1 to 20 of 90

1.
A PKA Inhibitor Motif within SMOOTHENED Controls Hedgehog Signal Transduction
John T. Happ, Corvin D. Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B. Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S. Hedeen, Ju-Fen Zhu, Jacob L. Capener, Jan W. Bröckel, Lily Vu, C.C. King, Victor L. Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W. Herberg, Susan S. Taylor, Benjamin R. Myers
Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Apr 6.
Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 990–999. Published online 2022 Oct 6. doi: 10.1038/s41594-022-00838-z
PMCID:
PMC9696579
AbstractArticlePDF–4.9M
2.
SMO Regulates IGF1R levels and AKT Localization and Signaling
Nitin K Agarwal, Chae-Hwa Kim, Kranthi Kunkalla, Amineh Vaghefi, Sandra Sanchez, Samantha Manuel, Daniel Bilbao, Francisco Vega, Ralf Landgraf
Lab Invest. Author manuscript; available in PMC 2022 Jun 10.
Published in final edited form as: Lab Invest. 2022 Apr; 102(4): 401–410. Published online 2021 Dec 10. doi: 10.1038/s41374-021-00702-6
PMCID:
PMC8969180
AbstractArticlePDF–2.0M
3.
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity
Xujia Wu, Songhua Xiao, Maolei Zhang, Lixuan Yang, Jian Zhong, Bo Li, Fanying Li, Xin Xia, Xixi Li, Huangkai Zhou, Dawei Liu, Nunu Huang, Xuesong Yang, Feizhe Xiao, Nu Zhang
Genome Biol. 2021; 22: 33. Published online 2021 Jan 14. doi: 10.1186/s13059-020-02250-6
PMCID:
PMC7807754
AbstractArticlePDF–3.1M
4.
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Xiaofeng Qi, Lucas Friedberg, Ryan DeBose-Boyd, Tao Long, Xiaochun Li
Nat Chem Biol. Author manuscript; available in PMC 2021 Mar 14.
Published in final edited form as: Nat Chem Biol. 2020 Dec; 16(12): 1368–1375. Published online 2020 Sep 14. doi: 10.1038/s41589-020-0646-2
PMCID:
PMC7669734
AbstractArticlePDF–2.1M
5.
Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population
Augusto Monteiro de Souza, Otávio Sérgio Lopes, Andressa de Lima Liberato, Paulo Junior Ribeiro de Oliveira, Sylvia Satomi Takeno Herrero, Agnaldo Luiz do Nascimento, Carlos Alberto Longui, Ivan Rodrigues de Carvalho Filho, Leonardo Ferreira Soares, Renally Barbosa da Silva, Rommel Rodriguez Burbano, Plínio Delatorre, Eleonidas Moura Lima
Asian Pac J Cancer Prev. 2020; 21(1): 25–29. doi: 10.31557/APJCP.2020.21.1.25
PMCID:
PMC7294008
AbstractArticlePDF–269K
6.
Bi-allelic Variations of SMO in Humans Cause a Broad Spectrum of Developmental Anomalies Due to Abnormal Hedgehog Signaling
Thuy-Linh Le, Yunia Sribudiani, Xiaomin Dong, Céline Huber, Chelsea Kois, Geneviève Baujat, Christopher T. Gordon, Valerie Mayne, Louise Galmiche, Valérie Serre, Nicolas Goudin, Mohammed Zarhrate, Christine Bole-Feysot, Cécile Masson, Patrick Nitschké, Frans W. Verheijen, Lynn Pais, Anna Pelet, Simon Sadedin, John A. Pugh, Natasha Shur, Susan M. White, Salima El Chehadeh, John Christodoulou, Valérie Cormier-Daire, R.M.W. Hofstra, Stanislas Lyonnet, Tiong Yang Tan, Tania Attié-Bitach, Wilhelmina S. Kerstjens-Frederikse, Jeanne Amiel, Sophie Thomas
Am J Hum Genet. 2020 Jun 4; 106(6): 779–792. Published online 2020 May 14. doi: 10.1016/j.ajhg.2020.04.010
PMCID:
PMC7273534
AbstractArticlePDF–2.5M
7.
Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened
George Hedger, Heidi Koldsø, Matthieu Chavent, Christian Siebold, Rajat Rohatgi, Mark S.P. Sansom
Structure. 2019 Mar 5; 27(3): 549–559.e2. doi: 10.1016/j.str.2018.11.003
PMCID:
PMC6408332
AbstractArticlePDF–3.2M
8.
Gastrointestinal disorders in Curry–Jones syndrome: Clinical and molecular insights from an affected newborn
Kristen Wigby, Stephen R. F. Twigg, Ryan Broderick, Katherine P. Davenport, Andrew O. M. Wilkie, Stephen W. Bickler, Marilyn C. Jones
Am J Med Genet A. 2017 Jun; 173(6): 1586–1592. Published online 2017 Apr 6. doi: 10.1002/ajmg.a.38232
PMCID:
PMC5933242
AbstractArticlePDF–640K
9.
Genomic analysis of Smoothened inhibitor resistance in basal cell carcinoma
Hayley J. Sharpe, Gregoire Pau, Gerrit J. Dijkgraaf, Nicole Basset-Seguin, Zora Modrusan, Thomas Januario, Vickie Tsui, Alison B. Durham, Andrzej A. Dlugosz, Peter M. Haverty, Richard Bourgon, Jean Y. Tang, Kavita Y. Sarin, Luc Dirix, David C. Fisher, Charles M. Rudin, Howard Sofen, Michael R. Migden, Robert L. Yauch, Frederic J. de Sauvage
Cancer Cell. Author manuscript; available in PMC 2017 Nov 7.
Published in final edited form as: Cancer Cell. 2015 Mar 9; 27(3): 327–341. doi: 10.1016/j.ccell.2015.02.001
PMCID:
PMC5675004
AbstractArticlePDF–2.3M
10.
Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
Sabrina Pricl, Barbara Cortelazzi, Valentina Dal Col, Domenico Marson, Erik Laurini, Maurizio Fermeglia, Lisa Licitra, Silvana Pilotti, Paolo Bossi, Federica Perrone
Mol Oncol. 2015 Feb; 9(2): 389–397. Published online 2014 Sep 26. doi: 10.1016/j.molonc.2014.09.003
PMCID:
PMC5528667
AbstractArticlePDF–1.5M
11.
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu
Nat Commun. 2017; 8: 15383. Published online 2017 May 17. doi: 10.1038/ncomms15383
PMCID:
PMC5442369
AbstractArticlePDF–1.6M
12.
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch, Gerrit J. P. Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P. Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A. Callahan, Tracy Tang, J. Fernando Bazan, Zhengyan Kan, Somasekar Seshagiri, Christine L. Hann, Stephen E. Gould, Jennifer A. Low, Charles M. Rudin, Frederic J. de Sauvage
Science. Author manuscript; available in PMC 2017 Feb 15.
Published in final edited form as: Science. 2009 Oct 23; 326(5952): 572–574. Published online 2009 Sep 2. doi: 10.1126/science.1179386
PMCID:
PMC5310713
AbstractArticlePDF–503K
13.
Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis
Shang-ling Zhu, Jian-lin Huang, Wei-xiang Peng, Dan-chun Wu, Min-qi Luo, Qiu-xia Li, Zhao-xia Li, Xiao-xue Feng, Fang Liu, Ming-xia Wang, Wei-qian Chen, Nancy Olsen, Song Guo Zheng
Cell Mol Immunol. 2017 Feb; 14(2): 214–222. Published online 2015 Jul 20. doi: 10.1038/cmi.2015.67
PMCID:
PMC5301154
AbstractArticlePDF–2.0M
14.
Structural basis for Smoothened regulation by its extracellular domains
Eamon F.X. Byrne, Ria Sircar, Paul S. Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D. Tully, Laurel Mydock-McGrane, Douglas F. Covey, Robert P. Rambo, Mark S. P. Sansom, Simon Newstead, Rajat Rohatgi, Christian Siebold
Nature. Author manuscript; available in PMC 2017 Jan 28.
Published in final edited form as: Nature. 2016 Jul 28; 535(7613): 517–522. doi: 10.1038/nature18934
PMCID:
PMC4970916
AbstractArticlePDF–4.9M
15.
A Recurrent Mosaic Mutation in SMO, Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome
Stephen R.F. Twigg, Robert B. Hufnagel, Kerry A. Miller, Yan Zhou, Simon J. McGowan, John Taylor, Jude Craft, Jenny C. Taylor, Stephanie L. Santoro, Taosheng Huang, Robert J. Hopkin, Angela F. Brady, Jill Clayton-Smith, Carol L. Clericuzio, Dorothy K. Grange, Leopold Groesser, Christian Hafner, Denise Horn, I. Karen Temple, William B. Dobyns, Cynthia J. Curry, Marilyn C. Jones, Andrew O.M. Wilkie
Am J Hum Genet. 2016 Jun 2; 98(6): 1256–1265. Published online 2016 May 26. doi: 10.1016/j.ajhg.2016.04.007
PMCID:
PMC4908219
AbstractArticlePDF–1.3M
16.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma
Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Jiang R. Li, Geurim Kim, Melika Rezaee, Mina S. Ally, Jinah Kim, Catherine Yao, Anne Lynn S. Chang, Anthony E. Oro, Jean Y. Tang
Cancer Cell. Author manuscript; available in PMC 2016 Mar 9.
Published in final edited form as: Cancer Cell. 2015 Mar 9; 27(3): 342–353. doi: 10.1016/j.ccell.2015.02.002
PMCID:
PMC4357167
AbstractArticlePDF–2.3M
17.
SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological and Molecular Features
Tingting Li, Xiaoyun Liao, Paul Lochhead, Teppei Morikawa, Mai Yamauchi, Reiko Nishihara, Kentaro Inamura, Sun A Kim, Kosuke Mima, Yasutaka Sukawa, Aya Kuchiba, Yu Imamura, Yoshifumi Baba, Kaori Shima, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino, Zhi Rong Qian
Ann Surg Oncol. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Ann Surg Oncol. 2014 Dec; 21(13): 4164–4173. Published online 2014 Jul 15. doi: 10.1245/s10434-014-3888-y
PMCID:
PMC4221469
AbstractArticlePDF–952K
18.
Structural basis for Smoothened receptor modulation and chemoresistance to anti-cancer drugs
Chong Wang, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J. Hufeisen, Thomas J. Mangano, Dan J. Urban, Vsevolod Katritch, Vadim Cherezov, Marc G. Caron, Bryan L. Roth, Raymond C. Stevens
Nat Commun. Author manuscript; available in PMC 2015 Jul 10.
Published in final edited form as: Nat Commun. 2014; 5: 4355. Published online 2014 Jul 10. doi: 10.1038/ncomms5355
PMCID:
PMC4198951
AbstractArticlePDF–2.7M
19.
Structure of the human smoothened receptor 7TM bound to an antitumor agent
Chong Wang, Huixian Wu, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Wei Liu, Fai Yiu Siu, Bryan L. Roth, Vadim Cherezov, Raymond C. Stevens
Nature. Author manuscript; available in PMC 2014 May 16.
Published in final edited form as: Nature. 2013 May 16; 497(7449): 338–343. Published online 2013 May 1. doi: 10.1038/nature12167
PMCID:
PMC3657389
AbstractArticlePDF–1.9M
20.
Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
Shamik Das, Rajeev S. Samant, Lalita A. Shevde
J Biol Chem. 2013 Apr 26; 288(17): 11824–11833. Published online 2013 Mar 18. doi: 10.1074/jbc.M112.432302
PMCID:
PMC3636870
AbstractArticlePDF–2.3M

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