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Select item 110821511.

SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma

Rongrong Fu, Wenqing Xue, Jingjie Liang, Xinran Li, Juan Zheng, Lechen Wang, Min Zhang, Jing Meng

Cell Death Dis. 2024 May; 15(5): 325. Published online 2024 May 9. doi: 10.1038/s41419-024-06711-9

PMCID:: PMC11082151

Abstract Article PDF–7.3M

Select item 110507122.

Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1

Nicole Y. Farhat, Derek Alexander, Kyli McKee, James Iben, Jorge L. Rodriguez-Gil, Christopher A. Wassif, Niamh X. Cawley, William E. Balch, Forbes D. Porter

Int J Mol Sci. 2024 Apr; 25(8): 4217. Published online 2024 Apr 11. doi: 10.3390/ijms25084217

PMCID:: PMC11050712

Abstract Article PDF–1.8M

Select item 93854703.

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer

Carolin Eckhardt, Iuliu Sbiera, Markus Krebs, Silviu Sbiera, Martin Spahn, Burkhard Kneitz, Steven Joniau, Martin Fassnacht, Hubert Kübler, Isabel Weigand, Matthias Kroiss

Prostate Cancer Prostatic Dis. 2022; 25(3): 484–490. Published online 2021 Jul 29. doi: 10.1038/s41391-021-00431-3

PMCID:: PMC9385470

Abstract Article PDF–1.7M

Select item 93615494.

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He

BMC Med. 2022; 20: 292. Published online 2022 Aug 9. doi: 10.1186/s12916-022-02436-8

PMCID:: PMC9361549

Abstract Article PDF–11M

Select item 89988555.

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

Mario Löhr, Wolfgang Härtig, Almut Schulze, Matthias Kroiß, Silviu Sbiera, Constantin Lapa, Bianca Mages, Sabrina Strobel, Jennifer Elisabeth Hundt, Simone Bohnert, Stefan Kircher, Sudha Janaki-Raman, Camelia-Maria Monoranu

Int J Mol Sci. 2022 Apr; 23(7): 3726. Published online 2022 Mar 28. doi: 10.3390/ijms23073726

PMCID:: PMC8998855

Abstract Article PDF–4.5M

Select item 81521516.

Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu

BMC Cancer. 2021; 21: 615. Published online 2021 May 26. doi: 10.1186/s12885-021-08245-1

PMCID:: PMC8152151

Abstract Article PDF–1.4M

Select item 79035237.

Structure of Nevanimibe-bound Tetrameric Human Sterol O-acyltransferase 1

Tao Long, Yingyuan Sun, Abdirahman Hassan, Xiaofeng Qi, Xiaochun Li

Nature. Author manuscript; available in PMC 2021 Feb 24.

Published in final edited form as: Nature. 2020 May; 581(7808): 339–343. Published online 2020 May 13. doi: 10.1038/s41586-020-2295-8

PMCID:: PMC7903523

Abstract Article PDF–4.5M

Select item 74787398.

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

Tobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Yuan Hao, Claudia Tonelli, Tim D.D. Somerville, Astrid Deschênes, Pascal Belleau, Chang-il Hwang, Francisco J. Sánchez-Rivera, Hilary Cox, Erin Brosnan, Abhishek Doshi, Rebecca P. Lumia, Kimia Khaledi, Youngkyu Park, Lloyd C. Trotman, Scott W. Lowe, Alexander Krasnitz, Christopher R. Vakoc, David A. Tuveson

J Exp Med. 2020 Sep 7; 217(9): e20192389. Published online 2020 Jul 7. doi: 10.1084/jem.20192389

PMCID:: PMC7478739

Abstract Article PDF–6.5M

Select item 69806019.

Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study

Vijayalakshmi N. Ayyagari, Xinjia Wang, Paula L. Diaz-Sylvester, Kathleen Groesch, Laurent Brard

PLoS One. 2020; 15(1): e0228024. Published online 2020 Jan 24. doi: 10.1371/journal.pone.0228024

PMCID:: PMC6980601

Abstract Article PDF–4.4M

Select item 508786810.

Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death

Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi

J Lipid Res. 2016 Nov; 57(11): 2005–2014. Published online 2016 Oct 27. doi: 10.1194/jlr.M068775

PMCID:: PMC5087868

Abstract Article PDF–1.2M

Select item 406083211.

Acyl-Coenzyme A:cholesterol Acyltransferase 1: Significance of Single Nucleotide Polymorphism at Residue 526 and Role of Proline 347 near the Fifth Transmembrane Domain

Li-Hao Huang, Koji Nishi, Song Li, Thomas Ho, Ruhong Dong, Catherine C.Y. Chang, Ta-Yuan Chang

FEBS J. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: FEBS J. 2014 Apr; 281(7): 1773–1783. Published online 2014 Feb 24. doi: 10.1111/febs.12739

PMCID:: PMC4060832

Abstract Article PDF–2.3M

Select item 404065112.

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

K Yamanaka, Y Urano, W Takabe, Y Saito, N Noguchi

Cell Death Dis. 2014 Jan; 5(1): e990. Published online 2014 Jan 9. doi: 10.1038/cddis.2013.524

PMCID:: PMC4040651

Abstract Article PDF–1.1M

Select item 397535313.

Association between Single Nucleotide Polymorphism rs1044925 and the Risk of Coronary Artery Disease and Ischemic Stroke

Dong-Feng Wu, Rui-Xing Yin, Xiao-Li Cao, Wu-Xian Chen

Int J Mol Sci. 2014 Mar; 15(3): 3546–3559. Published online 2014 Feb 26. doi: 10.3390/ijms15033546

PMCID:: PMC3975353

Abstract Article PDF–116K

Select item 373156614.

Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene

Guang-Jing Hu, Jia Chen, Xiao-Nan Zhao, Jia-Jia Xu, Dong-Qing Guo, Ming Lu, Ming Zhu, Ying Xiong, Qin Li, Catherine CY Chang, Bao-Liang Song, Ta-Yuan Chang, Bo-Liang Li

Cell Res. 2013 Aug; 23(8): 1007–1024. Published online 2013 Jul 9. doi: 10.1038/cr.2013.86

PMCID:: PMC3731566

Abstract Article PDF–3.6M

Select item 327197215.

Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects

Dong-Feng Wu, Rui-Xing Yin, Lynn Htet Htet Aung, Qing Li, Ting-Ting Yan, Xiao-Na Zeng, Ke-Ke Huang, Ping Huang, Jin-Zhen Wu, Shang-Ling Pan

Lipids Health Dis. 2012; 11: 9. Published online 2012 Jan 13. doi: 10.1186/1476-511X-11-9

PMCID:: PMC3271972

Abstract Article PDF–245K

Select item 308679016.

The RNA secondary structures located at the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kD isoform

Jia Chen, Xiao-Nan Zhao, Li Yang, Guang-Jing Hu, Ming Lu, Ying Xiong, Xin-Ying Yang, Catherine C. Y. Chang, Bao-Liang Song, Ta-Yuan Chang, Bo-Liang Li

Cell Res. Author manuscript; available in PMC 2011 May 3.

Published in final edited form as: Cell Res. 2008 Sep; 18(9): 921–936. doi: 10.1038/cr.2008.66