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Select item 110114001.

Squalene Epoxidase: Its Regulations and Links with Cancers

Lin Zhang, Zheng Cao, Yuheng Hong, Haihua He, Leifeng Chen, Zhentao Yu, Yibo Gao

Int J Mol Sci. 2024 Apr; 25(7): 3874. Published online 2024 Mar 30. doi: 10.3390/ijms25073874

PMCID:: PMC11011400

Abstract Article PDF–3.7M

Select item 108757112.

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index

Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang

Clin Transl Med. 2024 Feb; 14(2): e1586. Published online 2024 Feb 19. doi: 10.1002/ctm2.1586

PMCID:: PMC10875711

Abstract Article PDF–20M

Select item 96273663.

Downregulated ferroptosis‐related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma

Lei Yao, Juanni Li, Xiaofang Zhang, Lei Zhou, Kuan Hu

CNS Neurosci Ther. 2022 Dec; 28(12): 2104–2115. Published online 2022 Aug 13. doi: 10.1111/cns.13945

PMCID:: PMC9627366

Abstract Article PDF–14M

Select item 92043194.

SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma

Weiqiang You, Jia Ke, Yufeng Chen, Zerong Cai, Ze-ping Huang, Peishan Hu, Xiaojian Wu

Front Immunol. 2022; 13: 864244. Published online 2022 May 26. doi: 10.3389/fimmu.2022.864244

PMCID:: PMC9204319

Abstract Article PDF–11M

Select item 85552095.

Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer

Wenqing Tang, Fangshi Xu, Meng Zhao, Shuqun Zhang

BMC Cancer. 2021; 21: 1160. Published online 2021 Oct 29. doi: 10.1186/s12885-021-08892-4

PMCID:: PMC8555209

Abstract Article PDF–6.1M

Select item 81667756.

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

Hudson W. Coates, Isabelle M. Capell-Hattam, Andrew J. Brown

J Biol Chem. 2021 Jan-Jun; 296: 100731. Published online 2021 Apr 30. doi: 10.1016/j.jbc.2021.100731

PMCID:: PMC8166775

Abstract Article PDF–3.5M

Select item 65271787.

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

Ngee Kiat Chua, Gene Hart-Smith, Andrew J. Brown

J Biol Chem. 2019 May 17; 294(20): 8134–8147. Published online 2019 Apr 2. doi: 10.1074/jbc.RA119.007798

PMCID:: PMC6527178

Abstract Article PDF–3.5M

Select item 63979188.

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling

Hong Ge, Yamei Zhao, Xinyan Shi, Zhen Tan, Xiaorui Chi, Man He, Guohui Jiang, Lixia Ji, Hongmei Li

Thorac Cancer. 2019 Mar; 10(3): 428–436. Published online 2019 Feb 7. doi: 10.1111/1759-7714.12944

PMCID:: PMC6397918

Abstract Article PDF–1.3M

Select item 63849279.

The shape of human squalene epoxidase expands the arsenal against cancer

Andrew J. Brown, Ngee Kiat Chua, Nieng Yan

Nat Commun. 2019; 10: 888. Published online 2019 Feb 21. doi: 10.1038/s41467-019-08866-y

PMCID:: PMC6384927

Abstract Article PDF–724K

Select item 472602510.

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

David N. Brown, Irene Caffa, Gabriella Cirmena, Daniela Piras, Anna Garuti, Maurizio Gallo, Saverio Alberti, Alessio Nencioni, Alberto Ballestrero, Gabriele Zoppoli

Sci Rep. 2016; 6: 19435. Published online 2016 Jan 18. doi: 10.1038/srep19435

PMCID:: PMC4726025

Abstract Article PDF–1.4M

Select item 464600611.

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

Vicky Howe, Ngee Kiat Chua, Julian Stevenson, Andrew J. Brown

J Biol Chem. 2015 Nov 13; 290(46): 27533–27544. Published online 2015 Oct 3. doi: 10.1074/jbc.M115.675181

PMCID:: PMC4646006

Abstract Article PDF–2.1M

Select item 252813712.

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease

M W Helms, D Kemming, H Pospisil, U Vogt, H Buerger, E Korsching, C Liedtke, C M Schlotter, A Wang, S Y Chan, B H Brandt

Br J Cancer. 2008 Sep 2; 99(5): 774–780. Published online 2008 Aug 12. doi: 10.1038/sj.bjc.6604556

PMCID:: PMC2528137

Abstract Article PDF–145K

Select item 1040358213.

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway

Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao

Cell Death Dis. 2023 Aug; 14(8): 497. Published online 2023 Aug 4. doi: 10.1038/s41419-023-05987-7

PMCID:: PMC10403582

Abstract Article PDF–8.1M

Select item 889870414.

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression

Huihong Jiang, Erjiang Tang, Ying Chen, Hailong Liu, Yun Zhao, Moubin Lin, Luwei He

Cancer Sci. 2022 Mar; 113(3): 971–985. Published online 2022 Jan 6. doi: 10.1111/cas.15248

PMCID:: PMC8898704

Abstract Article PDF–2.6M

Select item 837921415.

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze

Nat Commun. 2021; 12: 5066. Published online 2021 Aug 20. doi: 10.1038/s41467-021-25325-9

PMCID:: PMC8379214

Abstract Article PDF–3.0M

Select item 836064116.

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Luwei He, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao, Moubin Lin

Cancer Commun (Lond) 2021 Aug; 41(8): 726–746. Published online 2021 Jul 16. doi: 10.1002/cac2.12187

PMCID:: PMC8360641

Abstract Article PDF–4.4M

Select item 632703017.

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen

Nat Commun. 2019; 10: 97. Published online 2019 Jan 9. doi: 10.1038/s41467-018-07928-x