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Items: 1 to 20 of 28

1.
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
Nathan Appanna, Hylton Gibson, Elena Gangitano, Niall J Dempster, Karen Morris, Sherly George, Anastasia Arvaniti, Laura L Gathercole, Brian Keevil, Trevor M Penning, Karl-Heinz Storbeck, Jeremy W Tomlinson, Nikolaos Nikolaou
J Mol Endocrinol. 2021 Mar; 66(3): 181–194. Published online 2021 Jan 12. doi: 10.1530/JME-20-0160
PMCID:
PMC7965358
AbstractArticlePDF–3.3M
2.
先天性胆汁酸合成障碍2型一家系临床和遗传学分析:两个AKR1D1新突变的识别
程 映, 郭 丽, 邓 梅, 宋 元宗
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jul 25; 19(7): 734–740. Chinese. doi: 10.7499/j.issn.1008-8830.2017.07.002
PMCID:
PMC7389931
AbstractArticlePDF–2.8M
3.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
Nikolaos Nikolaou, Laura L. Gathercole, Lea Marchand, Sara Althari, Niall J. Dempster, Charlotte J. Green, Martijn van de Bunt, Catriona McNeil, Anastasia Arvaniti, Beverly A. Hughes, Bruno Sgromo, Richard S. Gillies, Hanns-Ulrich Marschall, Trevor M. Penning, John Ryan, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson
Metabolism. 2019 Oct; 99: 67–80. doi: 10.1016/j.metabol.2019.153947
PMCID:
PMC6744372
AbstractArticle
4.
Dysregulation of Δ4-3-oxosteroid 5β-reductase in Diabetic Patients: Implications and Mechanisms
Leila Valanejad, Mwlod Ghareeb, Stephanie Shiffka, Christina Nadolny, Yuan Chen, Liangran Guo, Ruchi Verma, Sangmin You, Fatemeh Akhlaghi, Ruitang Deng
Mol Cell Endocrinol. Author manuscript; available in PMC 2019 Jul 15.
Published in final edited form as: Mol Cell Endocrinol. 2018 Jul 15; 470: 127–141. Published online 2017 Oct 9. doi: 10.1016/j.mce.2017.10.005
PMCID:
PMC5891389
AbstractArticlePDF–923K
5.
In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency
Mo Chen, Yi Jin, Trevor M. Penning
Biochemistry. Author manuscript; available in PMC 2016 Oct 20.
Published in final edited form as: Biochemistry. 2015 Oct 20; 54(41): 6343–6351. Published online 2015 Oct 6. doi: 10.1021/acs.biochem.5b00816
PMCID:
PMC4696769
AbstractArticlePDF–986K
6.
The Rate-determining Steps of Aldo-keto Reductases (AKRs), a Study on Human Steroid 5β-Reductase (AKR1D1)
Mo Chen, Yi Jin, Trevor M. Penning
Chem Biol Interact. Author manuscript; available in PMC 2016 Jun 5.
Published in final edited form as: Chem Biol Interact. 2015 Jun 5; 234: 360–365. Published online 2014 Dec 11. doi: 10.1016/j.cbi.2014.12.004
PMCID:
PMC4414691
AbstractArticlePDF–910K
7.
Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis
Yi Jin, Mo Chen, Trevor M. Penning
Biochem J. Author manuscript; available in PMC 2015 Aug 15.
Published in final edited form as: Biochem J. 2014 Aug 15; 462(1): 163–171. doi: 10.1042/BJ20140220
PMCID:
PMC4163838
AbstractArticlePDF–961K
8.
Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s
Amarjit S. Chaudhry, Ranjit K. Thirumaran, Kazuto Yasuda, Xia Yang, Yiping Fan, Stephen C. Strom, Erin G. Schuetz
Drug Metab Dispos. 2013 Aug; 41(8): 1538–1547. Published online 2013 Aug. doi: 10.1124/dmd.113.051672
Correction in:
Drug Metab Dispos. 2014 May; 42(5): 917.
PMCID:
PMC4162005
AbstractArticlePDF–906K
9.
5β-Reduced Steroids and Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1)
Mo Chen, Trevor M. Penning
Steroids. Author manuscript; available in PMC 2015 May 1.
Published in final edited form as: Steroids. 2014 May; 83: 17–26. Published online 2014 Feb 8. doi: 10.1016/j.steroids.2014.01.013
PMCID:
PMC3971473
AbstractArticlePDF–2.6M
10.
Conversion of Human Steroid 5β-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING
Mo Chen, Jason E. Drury, David W. Christianson, Trevor M. Penning
J Biol Chem. 2012 May 11; 287(20): 16609–16622. Published online 2012 Mar 20. doi: 10.1074/jbc.M111.338780
PMCID:
PMC3351325
AbstractArticlePDF–2.6M
11.
The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function
Rebekka Mindnich, Jason E. Drury, Trevor M. Penning
Chem Biol Interact. Author manuscript; available in PMC 2012 May 30.
Published in final edited form as: Chem Biol Interact. 2011 May 30; 191(1-3): 250–254. Published online 2010 Dec 24. doi: 10.1016/j.cbi.2010.12.020
PMCID:
PMC3101292
AbstractArticlePDF–460K
12.
Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)
Mo Chen, Jason E. Drury, Trevor M. Penning
Steroids. Author manuscript; available in PMC 2012 Apr 1.
Published in final edited form as: Steroids. 2011 Apr; 76(5): 484–490. Published online 2011 Jan 19. doi: 10.1016/j.steroids.2011.01.003
PMCID:
PMC3056882
AbstractArticlePDF–584K
13.
Characterization of Disease-related 5β-Reductase (AKR1D1) Mutations Reveals Their Potential to Cause Bile Acid Deficiency
Jason E. Drury, Rebekka Mindnich, Trevor M. Penning
J Biol Chem. 2010 Aug 6; 285(32): 24529–24537. Published online 2010 Jun 3. doi: 10.1074/jbc.M110.127779
PMCID:
PMC2915689
AbstractArticlePDF–1.7M
14.
Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)
Luigi Di Costanzo, Jason E. Drury, David W. Christianson, Trevor M. Penning
Mol Cell Endocrinol. Author manuscript; available in PMC 2010 Mar 25.
Published in final edited form as: Mol Cell Endocrinol. 2009 Mar 25; 301(1-2): 191–198. Published online 2008 Sep 19. doi: 10.1016/j.mce.2008.09.013
PMCID:
PMC2675190
AbstractArticlePDF–3.3M
15.
Crystal Structure of Human Liver Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis
Luigi Di Costanzo, Jason E. Drury, Trevor M. Penning, David W. Christianson
J Biol Chem. 2008 Jun 13; 283(24): 16830–16839. doi: 10.1074/jbc.M801778200
PMCID:
PMC2423251
AbstractArticlePDF–942K
16.
Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
Pengfei Zhu, Ruo Feng, Xu Lu, Yuan Liao, Zhicheng Du, Wenlong Zhai, Kunlun Chen
Aging (Albany NY) 2021 Feb 15; 13(3): 4138–4156. Published online 2021 Jan 20. doi: 10.18632/aging.202380
PMCID:
PMC7906155
AbstractArticlePDF–2.3M
17.
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
Nikolaos Nikolaou, Laura L. Gathercole, Lucy Kirkwood, James E. Dunford, Beverly A. Hughes, Lorna C. Gilligan, Udo Oppermann, Trevor M. Penning, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson
J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2020 Jul 22.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 May; 189: 218–227. Published online 2019 Feb 12. doi: 10.1016/j.jsbmb.2019.02.002
PMCID:
PMC7375835
AbstractArticlePDF–1.1M
18.
A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease
Neil V Morgan, Jane L Hartley, Kenneth DR Setchell, Michael A Simpson, Rachel Brown, Louise Tee, Sian Kirkham, Shanaz Pasha, Richard C Trembath, Eamonn R Maher, Paul Gissen, Deirdre A Kelly
Orphanet J Rare Dis. 2013; 8: 74. Published online 2013 May 16. doi: 10.1186/1750-1172-8-74
PMCID:
PMC3659031
AbstractArticlePDF–344K
19.
Role of Aldo-Keto Reductase Family 1 (AKR1) Enzymes in Human Steroid Metabolism
Tea Lanišnik Rižner, Trevor M. Penning
Steroids. Author manuscript; available in PMC 2015 Jan 1.
Published in final edited form as: Steroids. 2014 Jan; 79: 10.1016/j.steroids.2013.10.012. Published online 2013 Nov 1. doi: 10.1016/j.steroids.2013.10.012
PMCID:
PMC3870468
AbstractArticlePDF–1.3M
20.
Genome-wide association of mood-incongruent psychotic bipolar disorder
F S Goes, M L Hamshere, F Seifuddin, M Pirooznia, P Belmonte-Mahon, R Breuer, T Schulze, M Nöthen, S Cichon, M Rietschel, P Holmans, P P Zandi, Bipolar Genome Study (BiGS), N Craddock, J B Potash
Transl Psychiatry. 2012 Oct; 2(10): e180. Published online 2012 Oct 23. doi: 10.1038/tp.2012.106
PMCID:
PMC3565814
AbstractArticlePDF–489K

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