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Select item 108789751.

Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells

Hanqin Li, Rebecca Bartke, Lei Zhao, Yogendra Verma, Anna Horacek, Alma Rechav Ben-Natan, Gabriella R. Pangilinan, Netravathi Krishnappa, Rasmus Nielsen, Dirk Hockemeyer

Nat Biomed Eng. 2024; 8(2): 165–176. Published online 2023 Jul 24. doi: 10.1038/s41551-023-01065-7

PMCID:: PMC10878975

Article PDF–7.0M

Select item 103988182.

Emergence of BRCA Reversion Mutations in Patients with Metastatic Castration-resistant Prostate Cancer After Treatment with Rucaparib

Andrea Loehr, Arif Hussain, Akash Patnaik, Alan H. Bryce, Daniel Castellano, Albert Font, Jeremy Shapiro, Jingsong Zhang, Brieuc Sautois, Nicholas J. Vogelzang, Gurkamal Chatta, Kevin Courtney, Andrea Harzstark, Francesco Ricci, Darrin Despain, Simon Watkins, Charmin King, Minh Nguyen, Andrew D. Simmons, Simon Chowdhury, Wassim Abida

Eur Urol. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Eur Urol. 2023 Mar; 83(3): 200–209. Published online 2022 Oct 13. doi: 10.1016/j.eururo.2022.09.010

PMCID:: PMC10398818

Article PDF–1.3M

Select item 103230793.

The pathogenic role of the BRCA2 c.7847C>T (p.Ser2616Phe) variant in breast and ovarian cancer predisposition

Kazuki Yamazawa, Kokichi Sugano, Kohji Tanakaya, Satomi Inoue, Haruka Murakami, Moeko Nakashima, Masataka Adachi, Shinya Oki, Takeshi Makabe, Hiroshi Yamashita, Arisa Ueki, Ayako Sasaoka, Ayako Nakashoji, Takayuki Kinoshita, Tatsuo Matsunaga, Masami Arai, Seigo Nakamura, Hiroaki Miyata, Masachika Ikegami, Hiroyuki Mano, Shinji Kohsaka, Akira Matsui

Cancer Sci. 2023 Jul; 114(7): 2993–3002. Published online 2023 Apr 17. doi: 10.1111/cas.15799

PMCID:: PMC10323079

Article PDF–5.7M

Select item 102286324.

Analysis of BRCA2 Copy Number Loss and Genomic Instability in Circulating Tumor Cells from Patients with Metastatic Castration-resistant Prostate Cancer

Ethan S. Barnett, Nikolaus Schultz, Konrad H. Stopsack, Ernest T. Lam, Andrea Arfe, Jerry Lee, Jimmy L. Zhao, Joseph D. Schonhoft, Emily A. Carbone, Niamh M. Keegan, Andreas Wibmer, Yipeng Wang, David B. Solit, Wassim Abida, Richard Wenstrup, Howard I. Scher

Eur Urol. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Eur Urol. 2023 Feb; 83(2): 112–120. Published online 2022 Sep 16. doi: 10.1016/j.eururo.2022.08.010

PMCID:: PMC10228632

Article PDF–926K

Select item 101838065.

BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo, Matteo Benelli, Loris De Cecco, Dario Romagnoli, Enrico Berrino, Claudia Orrù, Salvatore Ribisi, Daniel Moya-Rull, Cristina Migliore, Daniela Conticelli, Irene M. Maina, Elisabetta Puliga, Violeta Serra, Benedetta Pellegrino, Alba Llop-Guevara, Antonino Musolino, Salvatore Siena, Andrea Sartore-Bianchi, Michele Prisciandaro, Federica Morano, Maria Antista, Uberto Fumagalli, Giovanni De Manzoni, Maurizio Degiuli, Gian Luca Baiocchi, Marco F. Amisano, Alessandro Ferrero, Caterina Marchiò, Simona Corso, Silvia Giordano

Cancer Res. 2023 May 15; 83(10): 1699–1710. Published online 2023 May 2. doi: 10.1158/0008-5472.CAN-22-2620

PMCID:: PMC10183806

Article PDF–4.7M

Select item 96662156.

BRCA2 gene mutation in cancer

Chunbao Xie, Jiangrong Luo, Yangjun He, Lingxi Jiang, Ling Zhong, Yi Shi

Medicine (Baltimore) 2022 Nov 11; 101(45): e31705. Published online 2022 Nov 11. doi: 10.1097/MD.0000000000031705

PMCID:: PMC9666215

Article PDF–457K

Select item 96591167.

Characteristics of BRCA2 Mutated Prostate Cancer at Presentation

Hyunho Han, Cheol Keun Park, Nam Hoon Cho, Jongsoo Lee, Won Sik Jang, Won Sik Ham, Young Deuk Choi, Kang Su Cho

Int J Mol Sci. 2022 Nov; 23(21): 13426. Published online 2022 Nov 3. doi: 10.3390/ijms232113426

PMCID:: PMC9659116

Article PDF–1018K

Select item 93729108.

Templated insertions are associated specifically with BRCA2 deficiency and overall survival in advanced ovarian cancer

Grace Moore, Rahul Majumdar, Simon N. Powell, Atif J. Khan, Nils Weinhold, Shen Yin, Daniel S. Higginson

Mol Cancer Res. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Mol Cancer Res. 2022 Jul 6; 20(7): 1061–1070. doi: 10.1158/1541-7786.MCR-21-1012

PMCID:: PMC9372910

Article PDF–1.6M

Select item 91624589.

Divergent binding mode for a protozoan BRC repeat to RAD51

Teodors Pantelejevs, Marko Hyvönen

Biochem J. 2022 May 27; 479(10): 1031–1043. Prepublished online 2022 May 3. Published online 2022 May 23. doi: 10.1042/BCJ20220141

PMCID:: PMC9162458

Article PDF–3.5M

Select item 879959010.

Interpretation of BRCA2 Splicing Variants: A Case Series of Challenging Variant Interpretations and the Importance of Functional RNA Analysis

Paola Nix, Erin Mundt, Bradford Coffee, Elizabeth Goossen, Bryan M. Warf, Krystal Brown, Karla Bowles, Benjamin Roa

Fam Cancer. 2022; 21(1): 7–19. Published online 2021 Jan 20. doi: 10.1007/s10689-020-00224-y

PMCID:: PMC8799590

Article PDF–1.6M

Select item 839400111.

Guardians of the Genome: BRCA2 and Its Partners

Hang Phuong Le, Wolf-Dietrich Heyer, Jie Liu

Genes (Basel) 2021 Aug; 12(8): 1229. Published online 2021 Aug 10. doi: 10.3390/genes12081229

PMCID:: PMC8394001

Article PDF–1.9M

Select item 830770512.

Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses

Paul R. Andreassen, Joonbae Seo, Constanze Wiek, Helmut Hanenberg

Genes (Basel) 2021 Jul; 12(7): 1034. Published online 2021 Jul 2. doi: 10.3390/genes12071034

PMCID:: PMC8307705

Article PDF–571K

Select item 830180113.

Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events

Manon Julien, Rania Ghouil, Ambre Petitalot, Sandrine M. Caputo, Aura Carreira, Sophie Zinn-Justin

Biomolecules. 2021 Jul; 11(7): 1060. Published online 2021 Jul 20. doi: 10.3390/biom11071060

PMCID:: PMC8301801

Article PDF–3.2M

Select item 807879014.

Pathways and signatures of mutagenesis at targeted DNA nicks

Yinbo Zhang, Luther Davis, Nancy Maizels

PLoS Genet. 2021 Apr; 17(4): e1009329. Published online 2021 Apr 15. doi: 10.1371/journal.pgen.1009329

PMCID:: PMC8078790

Article PDF–2.0M

Select item 800849415.

Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance

Marcy E. Richardson, Chunling Hu, Kun Y. Lee, Holly LaDuca, Kelly Fulk, Kate M. Durda, Ashley M. Deckman, David E. Goldgar, Alvaro N.A. Monteiro, Rohan Gnanaolivu, Steven N. Hart, Eric C. Polley, Elizabeth Chao, Tina Pesaran, Fergus J. Couch

Am J Hum Genet. 2021 Mar 4; 108(3): 458–468. Published online 2021 Feb 19. doi: 10.1016/j.ajhg.2021.02.005

PMCID:: PMC8008494

Article PDF–1.1M

Select item 791116816.

Identification of Variants (rs11571707, rs144848, and rs11571769) in the BRCA2 Gene Associated with Hereditary Breast Cancer in Indigenous Populations of the Brazilian Amazon

Elizabeth Ayres Fragoso Dobbin, Jéssyca Amanda Gomes Medeiros, Marta Solange Camarinha Ramos Costa, Juliana Carla Gomes Rodrigues, João Farias Guerreiro, José Eduardo Kroll, Sandro José de Souza, Paulo Pimentel de Assumpção, Ândrea Ribeiro-dos-Santos, Sidney Emanuel Batista dos Santos, Rommel Mario Rodríguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos

Genes (Basel) 2021 Feb; 12(2): 142. Published online 2021 Jan 22. doi: 10.3390/genes12020142

PMCID:: PMC7911168

Article PDF–368K

Select item 790388817.

Treatment-emergent neuroendocrine prostate cancer with a germline BRCA2 mutation: identification of a candidate reversion mutation associated with platinum/PARP-inhibitor resistance

Deep Pandya, Myra Shah, Fuat Kaplan, Candice Martino, Gillian Levy, Mia Kazanjian, Stephen Batter, John Martignetti, Richard C. Frank

Cold Spring Harb Mol Case Stud. 2021 Feb; 7(1): a005801. doi: 10.1101/mcs.a005801

PMCID:: PMC7903888

Article PDF–5.3M

Select item 776831018.

The BRCA2 p.N372 H i.a.1342A>C Could Regulate the Sensitivity of Ovarian Cancer Cells to Platinum-Based Drugs

Zhen-Hua Du, Yu Xia, Qing Yang, Song Gao

Technol Cancer Res Treat. 2020; 19: 1533033820983289. Published online 2020 Dec 24. doi: 10.1177/1533033820983289

PMCID:: PMC7768310

Article PDF–759K

Select item 768635619.

Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status

Elinborg J. Olafsdottir, Ake Borg, Maj-Britt Jensen, Anne-Marie Gerdes, Anna L. V. Johansson, Rosa B. Barkardottir, Oskar T. Johannsson, Bent Ejlertsen, Ida Marie Heeholm Sønderstrup, Eivind Hovig, Anne-Vibeke Lænkholm, Thomas van Overeem Hansen, Gudridur H. Olafsdottir, Maria Rossing, Jon G. Jonasson, Stefan Sigurdsson, Niklas Loman, Martin P. Nilsson, Steven A. Narod, Laufey Tryggvadottir

Br J Cancer. 2020 Nov 24; 123(11): 1608–1615. Published online 2020 Sep 17. doi: 10.1038/s41416-020-01056-4

PMCID:: PMC7686356

Article PDF–682K

Select item 743849020.

Segregation analysis of the BRCA2 c.9227G>T variant in multiple families suggests a pathogenic role in breast and ovarian cancer predisposition

Simona Agata, Silvia Tognazzo, Elisa Alducci, Laura Matricardi, Lidia Moserle, Daniela Barana, Marco Montagna

Sci Rep. 2020; 10: 13987. Published online 2020 Aug 19. doi: 10.1038/s41598-020-70729-0

PMCID:: PMC7438490

Article PDF–982K

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