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Select item 67324911.

WNK4 limits distal calcium losses following acute furosemide treatment

Mohammed Z. Ferdaus, Brittany D. K. Gratreak, Lauren Miller, Jinge Si, James A. McCormick, Chao‐Ling Yang, David H. Ellison, Andrew S. Terker

Physiol Rep. 2019 Sep; 7(17): e14195. Published online 2019 Sep 8. doi: 10.14814/phy2.14195

PMCID:: PMC6732491

Abstract Article PDF–857K

Select item 64108022.

WNK4 kinase is a physiological intracellular chloride sensor

Jen-Chi Chen, Yi-Fen Lo, Ya-Wen Lin, Shih-Hua Lin, Chou-Long Huang, Chih-Jen Cheng

Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10): 4502–4507. Published online 2019 Feb 14. doi: 10.1073/pnas.1817220116

PMCID:: PMC6410802

Abstract Article PDF–1.2M

Select item 60784423.

C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity

Adrián Rafael Murillo-de-Ozores, Alejandro Rodríguez-Gama, Silvana Bazúa-Valenti, Karla Leyva-Ríos, Norma Vázquez, Diana Pacheco-Álvarez, Inti A. De La Rosa-Velázquez, Agnieszka Wengi, Kathryn L. Stone, Junhui Zhang, Johannes Loffing, Richard P. Lifton, Chao-Ling Yang, David H. Ellison, Gerardo Gamba, Maria Castañeda-Bueno

J Biol Chem. 2018 Aug 3; 293(31): 12209–12221. Published online 2018 Jun 19. doi: 10.1074/jbc.RA118.003037

PMCID:: PMC6078442

Abstract Article PDF–2.7M

Select item 54051614.

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice

Daiei Takahashi, Takayasu Mori, Eisei Sohara, Miyako Tanaka, Motoko Chiga, Yuichi Inoue, Naohiro Nomura, Moko Zeniya, Hiroki Ochi, Shu Takeda, Takayoshi Suganami, Tatemitsu Rai, Shinichi Uchida

EBioMedicine. 2017 Apr; 18: 118–127. Published online 2017 Mar 8. doi: 10.1016/j.ebiom.2017.03.011

PMCID:: PMC5405161

Abstract Article PDF–1.3M

Select item 48143755.

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

Andrew S. Terker, Chong Zhang, Kayla J. Erspamer, Gerardo Gamba, Chao-Ling Yang, David H. Ellison

Kidney Int. Author manuscript; available in PMC 2016 Jul 4.

Published in final edited form as: Kidney Int. 2016 Jan; 89(1): 127–134. Published online 2016 Jan 4. doi: 10.1038/ki.2015.289

PMCID:: PMC4814375

Abstract Article PDF–299K

Select item 33588186.

Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions

Tao Na, Guojin Wu, Ji-Bin Peng

Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Mar 9.

Published in final edited form as: Biochem Biophys Res Commun. 2012 Mar 9; 419(2): 293–298. Published online 2012 Feb 11. doi: 10.1016/j.bbrc.2012.02.013

PMCID:: PMC3358818

Abstract Article PDF–2.6M

Select item 27397147.

Characterization of the kinase activity of a WNK4 protein complex

Robert Ahlstrom, Alan S. L. Yu

Am J Physiol Renal Physiol. 2009 Sep; 297(3): F685–F692. Published online 2009 Jul 8. doi: 10.1152/ajprenal.00358.2009

PMCID:: PMC2739714

Abstract Article

Select item 5220378.

Paracellular Cl^- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension

Kristopher T. Kahle, Gordon G. MacGregor, Frederick H. Wilson, Alfred N. Van Hoek, Dennis Brown, Thomas Ardito, Michael Kashgarian, Gerhard Giebisch, Steven C. Hebert, Emile L. Boulpaep, Richard P. Lifton

Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41): 14877–14882. Published online 2004 Oct 1. doi: 10.1073/pnas.0406172101

PMCID:: PMC522037

Abstract Article PDF–526K

Select item 81748089.

Roles of WNK4 and SPAK in K⁺-mediated dephosphorylation of the NaCl cotransporter

Anindit Mukherjee, Chao-Ling Yang, James A. McCormick, Kevin Martz, Avika Sharma, David H. Ellison

Am J Physiol Renal Physiol. 2021 May 1; 320(5): F719–F733. Published online 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020

PMCID:: PMC8174808

Abstract Article

Select item 623073610.

With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo

Andrew S. Terker, Maria Castañeda-Bueno, Mohammed Z. Ferdaus, Ryan J. Cornelius, Kayla J. Erspamer, Xiao-Tong Su, Lauren N. Miller, James A. McCormick, Wen-Hui Wang, Gerardo Gamba, Chao-Ling Yang, David H. Ellison

Am J Physiol Renal Physiol. 2018 Oct 1; 315(4): F781–F790. Published online 2018 Feb 7. doi: 10.1152/ajprenal.00485.2017

PMCID:: PMC6230736

Abstract Article

Select item 603191111.

Differential roles of WNK4 in regulation of NCC in vivo

Yih-Sheng Yang, Jian Xie, Sung-Sen Yang, Shih-Hua Lin, Chou-Long Huang

Am J Physiol Renal Physiol. 2018 May 1; 314(5): F999–F1007. Published online 2018 Jan 31. doi: 10.1152/ajprenal.00177.2017

PMCID:: PMC6031911

Abstract Article

Select item 583204512.

The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4

María Chávez-Canales, Chong Zhang, Christelle Soukaseum, Erika Moreno, Diana Pacheco-Alvarez, Emmanuelle Vidal-Petiot, María Castañeda-Bueno, Norma Vázquez, Lorena Rojas-Vega, Nicholas P. Meermeier, Shaunessy Rogers, Xavier Jeunemaitre, Chao-Ling Yang, David H Ellison, Gerardo Gamba, Juliette Hadchouel

Hypertension. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Hypertension. 2014 Nov; 64(5): 1047–1053. Published online 2014 Aug 11. doi: 10.1161/HYPERTENSIONAHA.114.04036

PMCID:: PMC5832045

Abstract Article PDF–386K

Select item 421291313.

WNK4 is the major WNK positively regulating NCC in the mouse kidney

Daiei Takahashi, Takayasu Mori, Naohiro Nomura, Muhammad Zakir Hossain Khan, Yuya Araki, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida

Biosci Rep. 2014; 34(3): e00107. Prepublished online 2014 Mar 21. Published online 2014 May 9. doi: 10.1042/BSR20140047

PMCID:: PMC4212913

Abstract Article PDF–1.1M

Select item 405997114.

Modulation of NCC activity by low and high K⁺ intake: insights into the signaling pathways involved

María Castañeda-Bueno, Luz Graciela Cervantes-Perez, Lorena Rojas-Vega, Isidora Arroyo-Garza, Norma Vázquez, Erika Moreno, Gerardo Gamba

Am J Physiol Renal Physiol. 2014 Jun 15; 306(12): F1507–F1519. Published online 2014 Apr 23. doi: 10.1152/ajprenal.00255.2013

PMCID:: PMC4059971

Abstract Article

Select item 335663515.

Activation of the renal Na⁺:Cl⁻ cotransporter by angiotensin II is a WNK4-dependent process

María Castañeda-Bueno, Luz Graciela Cervantes-Pérez, Norma Vázquez, Norma Uribe, Sheila Kantesaria, Luciana Morla, Norma A. Bobadilla, Alain Doucet, Dario R. Alessi, Gerardo Gamba

Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7929–7934. Published online 2012 May 1. doi: 10.1073/pnas.1200947109

PMCID:: PMC3356635

Abstract Article PDF–1001K

Select item 335364316.

WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway

Bo Zhou, Dexuan Wang, Xiuyan Feng, Yiqian Zhang, Yanhui Wang, Jieqiu Zhuang, Xuemei Zhang, Guangping Chen, Eric Delpire, Dingying Gu, Hui Cai

Am J Physiol Renal Physiol. 2012 Mar 1; 302(5): F533–F539. Published online 2011 Nov 23. doi: 10.1152/ajprenal.00032.2011

PMCID:: PMC3353643

Abstract Article

Select item 180545517.

WNK4 regulates activity of the epithelial Na⁺ channel in vitro and in vivo

Aaron M. Ring, Sam X. Cheng, Qiang Leng, Kristopher T. Kahle, Jesse Rinehart, Maria D. Lalioti, Heather M. Volkman, Frederick H. Wilson, Steven C. Hebert, Richard P. Lifton

Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10): 4020–4024. Published online 2007 Feb 26. doi: 10.1073/pnas.0611727104

PMCID:: PMC1805455

Abstract Article PDF–442K

Select item 816357618.

WNKs are potassium-sensitive kinases

John M. Pleinis, Logan Norrell, Radha Akella, John M. Humphreys, Haixia He, Qifei Sun, Feng Zhang, Jason Sosa-Pagan, Daryl E. Morrison, Jeffrey N. Schellinger, Laurie K. Jackson, Elizabeth J. Goldsmith, Aylin R. Rodan

Am J Physiol Cell Physiol. 2021 May 1; 320(5): C703–C721. Published online 2021 Jan 13. doi: 10.1152/ajpcell.00456.2020