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Select item 92149841.

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis

Genxiang Rong, Tao Zhang, Yayun Xu, Zhenyu Zhang, Binjie Gui, Kongzu Hu, Jinling Zhang, Zhi Tang, Cailiang Shen

BMC Musculoskelet Disord. 2022; 23: 604. Published online 2022 Jun 22. doi: 10.1186/s12891-022-05567-4

PMCID:: PMC9214984

Abstract Article PDF–2.7M

Select item 87145532.

TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer

Quoc Thang Pham, Daiki Taniyama, Shintaro Akabane, Kenji Harada, Takashi Babasaki, Yohei Sekino, Tetsuraro Hayashi, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui

Cancer Rep (Hoboken) 2021 Dec; 4(6): e1417. Published online 2021 Jun 7. doi: 10.1002/cnr2.1417

PMCID:: PMC8714553

Abstract Article PDF–4.9M

Select item 80607933.

Tryptophan 2, 3-dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells

Yuemei Zhao, Fengxing Tao, Jiayu Jiang, Lina Chen, Jizao Du, Xiaoxiao Cheng, Qin He, Shouhui Zhong, Wei Chen, Xiaoli Wu, Rongying Ou, Yunsheng Xu, Kai-Fu Tang

Mol Med Rep. 2021 Jun; 23(6): 445. Published online 2021 Apr 12. doi: 10.3892/mmr.2021.12084

PMCID:: PMC8060793

Abstract Article PDF–2.0M

Select item 49855834.

Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function

Frank Elbers, Claudia Woite, Valentina Antoni, Sara Stein, Hiroshi Funakoshi, Toshikazu Nakamura, Gereon Schares, Walter Däubener, Silvia K. Eller

Mediators Inflamm. 2016; 2016: 1638916. Published online 2016 Aug 2. doi: 10.1155/2016/1638916

PMCID:: PMC4985583

Abstract Article PDF–1.3M

Select item 32378925.

Molecular basis for the substrate stereoselectivity in Tryptophan Dioxygenase

Luciana Capece, Ariel Lewis-Ballester, Marcelo A. Marti, Dario A. Estrin, Syun-Ru Yeh

Biochemistry. Author manuscript; available in PMC 2012 Dec 20.

Published in final edited form as: Biochemistry. 2011 Dec 20; 50(50): 10910–10918. Published online 2011 Nov 23. doi: 10.1021/bi201439m

PMCID:: PMC3237892

Abstract Article PDF–1.3M

Select item 87797176.

MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma

Yang Ai, Sang Luo, Ben Wang, Shuai Xiao, Yefu Wang

Molecules. 2022 Jan; 27(2): 443. Published online 2022 Jan 10. doi: 10.3390/molecules27020443

PMCID:: PMC8779717

Abstract Article PDF–2.9M

Select item 87002007.

Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism

Véronique Trézéguet, Hala Fatrouni, Aksam J. Merched

Cells. 2021 Dec; 10(12): 3469. Published online 2021 Dec 9. doi: 10.3390/cells10123469

PMCID:: PMC8700200

Abstract Article PDF–2.7M

Select item 76793278.

Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines

Sara Paccosi, Marta Cecchi, Angela Silvano, Sergio Fabbri, Astrid Parenti

J Cancer Res Clin Oncol. 2020; 146(12): 3155–3163. Published online 2020 Aug 10. doi: 10.1007/s00432-020-03351-2

PMCID:: PMC7679327

Abstract Article PDF–1.1M

Select item 69054089.

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

Soumya R. Mohapatra, Ahmed Sadik, Lars-Oliver Tykocinski, Jørn Dietze, Gernot Poschet, Ines Heiland, Christiane A. Opitz

Front Immunol. 2019; 10: 2762. Published online 2019 Dec 4. doi: 10.3389/fimmu.2019.02762

PMCID:: PMC6905408

Abstract Article PDF–994K

Select item 507183210.

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Ariel Lewis-Ballester, Farhad Forouhar, Sung-Mi Kim, Scott Lew, YongQiang Wang, Shay Karkashon, Jayaraman Seetharaman, Dipanwita Batabyal, Bing-Yu Chiang, Munif Hussain, Maria Almira Correia, Syun-Ru Yeh, Liang Tong

Sci Rep. 2016; 6: 35169. Published online 2016 Oct 20. doi: 10.1038/srep35169

PMCID:: PMC5071832

Abstract Article PDF–2.5M

Select item 499278511.

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

I-Chien Chen, Kuen-Haur Lee, Ying-Hua Hsu, Wei-Ran Wang, Chuan-Mu Chen, Ya-Wen Cheng

Dis Markers. 2016; 2016: 8169724. Published online 2016 Aug 8. doi: 10.1155/2016/8169724

PMCID:: PMC4992785

Abstract Article PDF–1.1M

Select item 453384412.

The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies

Luciana Capece, Ariel Lewis-Ballester, Dipanwita Batabyal, Natali Di Russo, Syun-Ru Yeh, Dario A. Estrin, Marcelo A. Marti

J Biol Inorg Chem. Author manuscript; available in PMC 2015 Aug 12.

Published in final edited form as: J Biol Inorg Chem. 2010 Aug; 15(6): 811–823. Published online 2010 Apr 2. doi: 10.1007/s00775-010-0646-x

PMCID:: PMC4533844

Abstract Article PDF–833K

Select item 363260913.

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

Wei Wu, Joseph A. Nicolazzo, Li Wen, Roger Chung, Roger Stankovic, Shisan S. Bao, Chai K. Lim, Bruce J. Brew, Karen M. Cullen, Gilles J. Guillemin

PLoS One. 2013; 8(4): e59749. Published online 2013 Apr 22. doi: 10.1371/journal.pone.0059749

PMCID:: PMC3632609

Abstract Article PDF–3.6M

Select item 328931914.

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte, Pierre Larrieu, Vincent Stroobant, Didier Colau, Eduard Dolušić, Raphaël Frédérick, Etienne De Plaen, Catherine Uyttenhove, Johan Wouters, Bernard Masereel, Benoît J. Van den Eynde

Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2497–2502. Published online 2012 Jan 30. doi: 10.1073/pnas.1113873109

PMCID:: PMC3289319

Abstract Article PDF–775K

Select item 321054615.

The Mechanism of Formation of N-Formylkynurenine by Heme Dioxygenases

Jaswir Basran, Igor Efimov, Nishma Chauhan, Sarah J. Thackray, James L. Krupa, Graham Eaton, Gerry A. Griffith, Christopher G. Mowat, Sandeep Handa, Emma Lloyd Raven

J Am Chem Soc. 2011 Oct 12; 133(40): 16251–16257. Published online 2011 Sep 5. doi: 10.1021/ja207066z

PMCID:: PMC3210546

Abstract Article PDF–1.4M

Select item 309230216.

Structure and Reaction Mechanism in the Heme Dioxygenases

Igor Efimov, Jaswir Basran, Sarah J. Thackray, Sandeep Handa, Christopher G. Mowat, Emma Lloyd Raven

Biochemistry. 2011 Apr 12; 50(14): 2717–2724. Published online 2011 Mar 1. doi: 10.1021/bi101732n

PMCID:: PMC3092302

Abstract Article PDF–2.7M

Select item 874824617.

Stemness and immune evasion conferred by the TDO2‐AHR pathway are associated with liver metastasis of colon cancer

Toshiaki Miyazaki, Suyoun Chung, Hiroaki Sakai, Hirokazu Ohata, Yuuki Obata, Daisuke Shiokawa, Yukihiro Mizoguchi, Takashi Kubo, Hitoshi Ichikawa, Hirokazu Taniguchi, Kazunori Aoki, Tomoyoshi Soga, Hitoshi Nakagama, Koji Okamoto

Cancer Sci. 2022 Jan; 113(1): 170–181. Published online 2021 Dec 2. doi: 10.1111/cas.15182