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Select item 108587331.

TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity

Tong Lu, Xiaojing Sun, Brian M. Necela, Hon-Chi Lee, Nadine Norton

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2024 Feb 10.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1; 1868(11): 166505. Published online 2022 Jul 23. doi: 10.1016/j.bbadis.2022.166505

PMCID:: PMC10858733

Abstract Article PDF–1.3M

Select item 106716812.

A Putative Role for TRPC6 in Immune-Mediated Kidney Injury

Daan C. ‘t Hart, Johan van der Vlag, Tom Nijenhuis

Int J Mol Sci. 2023 Nov; 24(22): 16419. Published online 2023 Nov 16. doi: 10.3390/ijms242216419

PMCID:: PMC10671681

Abstract Article PDF–1.4M

Select item 104499973.

An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis

Lilas Batool, Krithika Hariharan, Yao Xu, Mario Kaßmann, Dmitry Tsvetkov, Björn-Oliver Gohlke, Sylvia Kaden, Manfred Gossen, Bernd Nürnberg, Andreas Kurtz, Maik Gollasch

Cell Mol Life Sci. 2023 Sep; 80(9): 265. Published online 2023 Aug 24. doi: 10.1007/s00018-023-04901-w

PMCID:: PMC10449997

Abstract Article PDF–3.4M

Select item 79487464.

Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells

Isaac Jardin, Raquel Diez-Bello, Debora Falcon, Sandra Alvarado, Sergio Regodon, Gines M. Salido, Tarik Smani, Juan A. Rosado

J Biol Chem. 2021 Jan-Jun; 296: 100254. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015769

PMCID:: PMC7948746

Abstract Article PDF–6.3M

Select item 68140055.

Role of TRPC6 in progression of diabetic kidney disease

Alexander Staruschenko, Denisha Spires, Oleg Palygin

Curr Hypertens Rep. Author manuscript; available in PMC 2020 May 21.

Published in final edited form as: Curr Hypertens Rep. 2019 May 21; 21(7): 48. Published online 2019 May 21. doi: 10.1007/s11906-019-0960-9

PMCID:: PMC6814005

Abstract Article PDF–690K

Select item 61704816.

Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation

Xin Hou, Haitao Xiao, Yanhong Zhang, Xixi Zeng, Mengjun Huang, Xiaoyun Chen, Lutz Birnbaumer, Yanhong Liao

Cell Death Dis. 2018 Oct; 9(10): 1015. Published online 2018 Oct 3. doi: 10.1038/s41419-018-1052-5

PMCID:: PMC6170481

Abstract Article PDF–2.2M

Select item 57311277.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression

Henning Hagmann, Nicole Mangold, Markus M. Rinschen, Tim Koenig, Karl Kunzelmann, Bernhard Schermer, Thomas Benzing, Paul T. Brinkkoetter

FASEB J. 2018 Jan; 32(1): 208–219. Published online 2017 Sep 6. doi: 10.1096/fj.201700309R

PMCID:: PMC5731127

Abstract Article

Select item 55572918.

Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors

Eun Young Kim, Hila Roshanravan, Stuart E. Dryer

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Sep; 1863(9): 2342–2354. Published online 2017 Jun 16. doi: 10.1016/j.bbadis.2017.06.010

PMCID:: PMC5557291

Abstract Article PDF–1.5M

Select item 53417509.

Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion

Li-Li Yang, Bing-Chen Liu, Xiao-Yu Lu, Yan Yan, Yu-Jia Zhai, Qing Bao, Paul W. Doetsch, Xingming Deng, Tiffany L. Thai, Abdel A. Alli, Douglas C. Eaton, Bao-Zhong Shen, He-Ping Ma

Oncotarget. 2017 Jan 17; 8(3): 5123–5134. Published online 2016 Dec 20. doi: 10.18632/oncotarget.14034

PMCID:: PMC5341750

Abstract Article PDF–13M

Select item 532185210.

Significant contribution of TRPC6 channel-mediated Ca²⁺ influx to the pathogenesis of Crohn's disease fibrotic stenosis

Lin Hai Kurahara, Keizo Hiraishi, Miho Sumiyoshi, Mayumi Doi, Yaopeng Hu, Kunihiko Aoyagi, Yuwen Jian, Ryuji Inoue

J Smooth Muscle Res. 2016; 52: 78–92. Published online 2016 Nov 3. doi: 10.1540/jsmr.52.78

PMCID:: PMC5321852

Abstract Article PDF–3.3M

Select item 529220211.

Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca²⁺ Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing

Hiroya Takada, Jun Yonekawa, Masami Matsumoto, Kishio Furuya, Masahiro Sokabe

Biomed Res Int. 2017; 2017: 8701801. Published online 2017 Jan 22. doi: 10.1155/2017/8701801

PMCID:: PMC5292202

Abstract Article PDF–2.6M

Select item 507941612.

Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology

Rong Ma, Sarika Chaudhari, Weizu Li

Antioxid Redox Signal. 2016 Nov 1; 25(13): 732–748. Published online 2016 Nov 1. doi: 10.1089/ars.2016.6661

PMCID:: PMC5079416

Abstract Article PDF–545K

Select item 500463913.

TRPC6 G757D Loss-of-Function Mutation Associates with FSGS

Marc Riehle, Anja K. Büscher, Björn-Oliver Gohlke, Mario Kaßmann, Maria Kolatsi-Joannou, Jan H. Bräsen, Mato Nagel, Jan U. Becker, Paul Winyard, Peter F. Hoyer, Robert Preissner, Dietmar Krautwurst, Maik Gollasch, Stefanie Weber, Christian Harteneck

J Am Soc Nephrol. 2016 Sep; 27(9): 2771–2783. Published online 2016 Feb 18. doi: 10.1681/ASN.2015030318

PMCID:: PMC5004639

Abstract Article

Select item 480632014.

Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent

Liang Wen, Chao Liang, Enjiang Chen, Wei Chen, Feng Liang, Xiao Zhi, Tao Wei, Fei Xue, Guogang Li, Qi Yang, Weihua Gong, Xinhua Feng, Xueli Bai, Tingbo Liang

Sci Rep. 2016; 6: 23269. Published online 2016 Mar 24. doi: 10.1038/srep23269

PMCID:: PMC4806320

Abstract Article PDF–2.8M

Select item 477109415.

TRPC6 May Protect Renal Ischemia-Reperfusion Injury Through Inhibiting Necroptosis of Renal Tubular Epithelial Cells

BingBing Shen, Yue He, Shan Zhou, Hongwen Zhao, Mei Mei, Xiongfei Wu

Med Sci Monit. 2016; 22: 633–641. Published online 2016 Feb 25. doi: 10.12659/MSM.897353

PMCID:: PMC4771094

Abstract Article PDF–1.0M

Select item 444122416.

Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes

Xiao-Yu Lu, Bing-Chen Liu, Li-Hua Wang, Li-Li Yang, Qing Bao, Yu-Jia Zhai, Abdel A. Alli, Tiffany L. Thai, Douglas C. Eaton, Wei-Zhi Wang, He-Ping Ma

Biochim Biophys Acta. Author manuscript; available in PMC 2015 May 22.

Published in final edited form as: Biochim Biophys Acta. 2015 May; 1853(5): 965–974. Published online 2015 Jan 17. doi: 10.1016/j.bbamcr.2015.01.007

PMCID:: PMC4441224

Abstract Article PDF–1.9M

Select item 442755417.

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

Karina Griesi-Oliveira, Allan Acab, Abha R. Gupta, Daniele Yumi Sunaga, Thanathom Chailangkarn, Xavier Nicol, Yanelli Nunez, Michael F. Walker, John D. Murdoch, Stephan J. Sanders, Thomas V. Fernandez, Weizhen Ji, Richard P. Lifton, Estevão Vadasz, Alexander Dietrich, Dennis Pradhan, Hongjun Song, Guo-li Ming, Xiang Guoe, Gabriel Haddad, Maria C. N. Marchetto, Nicholas Spitzer, Maria Rita Passos-Bueno, Matthew W. State, Alysson R. Muotri

Mol Psychiatry. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mol Psychiatry. 2015 Nov; 20(11): 1350–1365. Published online 2014 Nov 11. doi: 10.1038/mp.2014.141

PMCID:: PMC4427554

Abstract Article PDF–1.9M

Select item 409651118.

TRPC6 Single Nucleotide Polymorphisms and Progression of Idiopathic Membranous Nephropathy

Julia M. Hofstra, Marieke J. H. Coenen, Mascha M. V. A. P. Schijvenaars, Jo H. M. Berden, Johan van der Vlag, Lies H. Hoefsloot, Nine V. A. M. Knoers, Jack F. M. Wetzels, Tom Nijenhuis

PLoS One. 2014; 9(7): e102065. Published online 2014 Jul 14. doi: 10.1371/journal.pone.0102065

PMCID:: PMC4096511

Abstract Article PDF–418K

Select item 373907819.

The role of TRPC6 in HGF-induced cell proliferation of human prostate cancer DU145 and PC3 cells

Yong Wang, Dan Yue, Kai Li, Yi-Li Liu, Chang-Shan Ren, Ping Wang

Asian J Androl. 2010 Nov; 12(6): 841–852. Published online 2010 Sep 13. doi: 10.1038/aja.2010.85

PMCID:: PMC3739078

Abstract Article PDF–2.0M

Select item 373500720.

Expression of TRPC6 in benign and malignant human prostate tissues

Dan Yue, Yong Wang, Jian-Ying Xiao, Ping Wang, Chang-Shan Ren

Asian J Androl. 2009 Sep; 11(5): 541–547. Published online 2009 Aug 24. doi: 10.1038/aja.2009.53

Correction in:: Asian J Androl. 2010 Jan; 12(1): 124.

PMCID:: PMC3735007

Abstract Article PDF–568K

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