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Select item 103560301.

Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II

Binh Y. Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu, Susanne S. Hille, Xiaojing Luo, Min Zi, Hongyuan Zhang, Antony Adamson, Fozia Z. Ahmed, Sam Butterworth, Elizabeth J. Cartwright, Oliver J. Müller, Kaomei Guan, Elizabeth M. Fitzgerald, Xin Wang

J Am Heart Assoc. 2023 Jun 20; 12(12): e028298. Published online 2023 Jun 15. doi: 10.1161/JAHA.122.028298

PMCID:: PMC10356030

Abstract Article PDF–5.4M

Select item 59852342.

Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight

Giuseppe Bruschetta, Sungho Jin, Jung Dae Kim, Sabrina Diano

Mol Metab. 2018 Apr; 10: 28–38. Published online 2018 Feb 8. doi: 10.1016/j.molmet.2018.02.003

PMCID:: PMC5985234

Abstract Article PDF–2.3M

Select item 38930423.

PROLYL CARBOXYPEPTIDASE mRNA EXPRESSION IN THE MOUSE BRAIN

Jin Kwon Jeong, Sabrina Diano

Brain Res. Author manuscript; available in PMC 2015 Jan 13.

Published in final edited form as: Brain Res. 2014 Jan 13; 1542: 85–92. Published online 2013 Oct 24. doi: 10.1016/j.brainres.2013.10.031

PMCID:: PMC3893042

Abstract Article PDF–3.2M

Select item 37576644.

Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice

Jin Kwon Jeong, Jung Dae Kim, Sabrina Diano

Mol Metab. 2013 Feb; 2(1): 23–30. Published online 2013 Jan 11. doi: 10.1016/j.molmet.2013.01.002

PMCID:: PMC3757664

Abstract Article PDF–1.5M

Select item 72864215.

Prolyl Oligopeptidase-Dependent Angiotensin II Conversion to Angiotensin-(1-7) in the circulation

Peter Serfozo, Jan Wysocki, Gvantca Gulua, Arndt Schulze, Minghao Ye, Pan Liu, Jing Jin, Michael Bader, Timo Myöhänen, J. Arturo García-Horsman, Daniel Batlle

Hypertension. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Hypertension. 2020 Jan; 75(1): 173–182. Published online 2019 Dec 2. doi: 10.1161/HYPERTENSIONAHA.119.14071

PMCID:: PMC7286421

Abstract Article PDF–1.2M

Select item 33781596.

Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity

Jin Kwon Jeong, Gyorgyi Szabo, Giuseppina Mattace Raso, Rosaria Meli, Sabrina Diano

Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12): E1502–E1510. Published online 2012 Mar 27. doi: 10.1152/ajpendo.00544.2011

PMCID:: PMC3378159

Abstract Article

Select item 32753927.

Prolyl Carboxypeptidase Regulates Energy Expenditure and the Thyroid Axis

Jin Kwon Jeong, Gyorgyi Szabo, Kaitlin Kelly, Sabrina Diano

Endocrinology. 2012 Feb; 153(2): 683–689. Published online 2011 Dec 27. doi: 10.1210/en.2011-1399

PMCID:: PMC3275392

Abstract Article

Select item 30833038.

Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

Gregory N. Adams, Gretchen A. LaRusch, Evi Stavrou, Yihua Zhou, Marvin T. Nieman, Gretta H. Jacobs, Yingjie Cui, Yuan Lu, Mukesh K. Jain, Fakhri Mahdi, Zia Shariat-Madar, Yoshio Okada, Louis G. D'Alecy, Alvin H. Schmaier

Blood. 2011 Apr 7; 117(14): 3929–3937. Prepublished online 2011 Feb 4. doi: 10.1182/blood-2010-11-318527

PMCID:: PMC3083303

Abstract Article

Select item 36516439.

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry

Nadja Grobe, Nathan M. Weir, Orly Leiva, Frank S. Ong, Kenneth E. Bernstein, Alvin H. Schmaier, Mariana Morris, Khalid M. Elased

Am J Physiol Cell Physiol. 2013 May 15; 304(10): C945–C953. Published online 2013 Feb 7. doi: 10.1152/ajpcell.00346.2012

PMCID:: PMC3651643

Abstract Article

Select item 271992510.

Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents

Nicholas Wallingford, Bertrand Perroud, Qian Gao, Anna Coppola, Erika Gyengesi, Zhong-Wu Liu, Xiao-Bing Gao, Adam Diament, Kari A. Haus, Zia Shariat-Madar, Fakhri Mahdi, Sharon L. Wardlaw, Alvin H. Schmaier, Craig H. Warden, Sabrina Diano

J Clin Invest. 2009 Aug 3; 119(8): 2291–2303. Published online 2009 Jul 20. doi: 10.1172/JCI37209

PMCID:: PMC2719925

Abstract Article PDF–2.4M

Select item 375034611.

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

Gregory N. Adams, Evi X. Stavrou, Chao Fang, Alona Merkulova, M. Amer Alaiti, Kohsuke Nakajima, Toshifumi Morooka, Sergei Merkulov, Gretchen A. LaRusch, Daniel I Simon, Mukesh K. Jain, Alvin H. Schmaier

Blood. 2013 Aug 22; 122(8): 1522–1531. Prepublished online 2013 Jun 6. doi: 10.1182/blood-2012-10-460360

PMCID:: PMC3750346

Abstract Article

Select item 1016525512.

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui

iScience. 2023 May 19; 26(5): 106670. Published online 2023 Apr 14. doi: 10.1016/j.isci.2023.106670

PMCID:: PMC10165255

Abstract Article PDF–8.2M

Select item 593256713.

Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation

Tatyana Danyukova, Khandsuren Ariunbat, Melanie Thelen, Nahal Brocke-Ahmadinejad, Sara E Mole, Stephan Storch

Hum Mol Genet. 2018 May 15; 27(10): 1711–1722. Published online 2018 Mar 5. doi: 10.1093/hmg/ddy076

PMCID:: PMC5932567

Abstract Article PDF–710K

Select item 497021314.

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart, Weikuan Gu

BMC Immunol. 2016; 17: 25. Published online 2016 Aug 2. doi: 10.1186/s12865-016-0163-y

PMCID:: PMC4970213

Abstract Article PDF–2.5M

Select item 18788515.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Jens Hansen, Thomas Floss, Petra Van Sloun, Ernst-Martin Füchtbauer, Franz Vauti, Hans-Hennig Arnold, Frank Schnütgen, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9918–9922. Published online 2003 Aug 6. doi: 10.1073/pnas.1633296100

PMCID:: PMC187885

Abstract Article PDF–287K

Select item 16551116.

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

Doug Stryke, Michiko Kawamoto, Conrad C. Huang, Susan J. Johns, Leslie A. King, Courtney A. Harper, Elaine C. Meng, Roy E. Lee, Alice Yee, Larry L'Italien, Pao-Tien Chuang, Stephen G. Young, William C. Skarnes, Patricia C. Babbitt, Thomas E. Ferrin

Nucleic Acids Res. 2003 Jan 1; 31(1): 278–281. doi: 10.1093/nar/gkg064

PMCID:: PMC165511

Abstract Article PDF–217K

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 28355419.

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands

Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100

Correction in:: Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.

PMCID:: PMC283554

Abstract Article PDF–481K

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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