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Select item 104541591.

Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease

Jung Oh Kim, Chang Soo Ryu, Jeong Yong Lee, Eun Ju Ko, Yong Hyun Ha, Jung Hoon Sung, Tae Sun Hwang, In Jai Kim, Nam Keun Kim

Int J Mol Sci. 2023 Aug; 24(16): 12591. Published online 2023 Aug 9. doi: 10.3390/ijms241612591

PMCID:: PMC10454159

Abstract Article PDF–758K

Select item 93883892.

Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita

Hemanth Tummala, Amanda Walne, Roberto Buccafusca, Jenna Alnajar, Anita Szabo, Peter Robinson, Allyn McConkie-Rosell, Meredith Wilson, Suzanne Crowley, Veronica Kinsler, Anna-Maria Ewins, Pradeepa M. Madapura, Manthan Patel, Nikolas Pontikos, Veryan Codd, Tom Vulliamy, Inderjeet Dokal

Am J Hum Genet. 2022 Aug 4; 109(8): 1472–1483. Published online 2022 Aug 5. doi: 10.1016/j.ajhg.2022.06.014

Correction in:: Am J Hum Genet. 2024 Jul 11; 111(7): 1494.

PMCID:: PMC9388389

Abstract Article PDF–2.3M

Select item 84083963.

Association between 5’-UTR and 3’-UTR Polymorphisms of the TYMS Gene and Breast Cancer in Kurdish Women of Iraq

Kazhal Shekh Mohamad

Asian Pac J Cancer Prev. 2021 May; 22(5): 1557–1560. doi: 10.31557/APJCP.2021.22.5.1557

PMCID:: PMC8408396

Abstract Article PDF–269K

Select item 82911724.

Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer

Si-Qi Dong, Tong-Min Wang, Jiang-Bo Zhang, Yong-Qiao He, Wen-Qiong Xue, Zi-Yi Wu, Da-Wei Yang, Lian-Jing Cao, Jing-Wen Huang, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Wei-Hua Jia

Cancer Res Treat. 2021 Jul; 53(3): 724–732. Published online 2020 Dec 2. doi: 10.4143/crt.2020.457

PMCID:: PMC8291172

Abstract Article PDF–1.2M

Select item 81597395.

The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens

Moh’d Khushman, Girijesh Kumar Patel, Anu Singh Maharjan, Gwendolyn A. McMillin, Cindy Nelson, Peter Hosein, Ajay P. Singh

Pharmacogenomics J. 2021; 21(3): 308–317. Published online 2021 Feb 19. doi: 10.1038/s41397-021-00210-2

PMCID:: PMC8159739

Abstract Article PDF–880K

Select item 80368176.

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase

Yong-Hwi Kang, Jin-Seok Lee, Nam-Hun Lee, Seung-Hyung Kim, Chang-Seob Seo, Chang-Gue Son

Molecules. 2021 Apr; 26(7): 1856. Published online 2021 Mar 25. doi: 10.3390/molecules26071856

PMCID:: PMC8036817

Abstract Article PDF–3.1M

Select item 80021317.

Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells

Chinatsu Kurasaka, Yoko Ogino, Akira Sato

Int J Mol Sci. 2021 Mar; 22(6): 2916. Published online 2021 Mar 13. doi: 10.3390/ijms22062916

PMCID:: PMC8002131

Abstract Article PDF–4.3M

Select item 73365058.

Identification of TYMS as a promoting factor of retroperitoneal liposarcoma progression: Bioinformatics analysis and biological evidence

Sha Zhang, Liang Yan, Can Cui, Zhen Wang, Jianhui Wu, Min Zhao, Bin Dong, Xiaoya Guan, Xiuyun Tian, Chunyi Hao

Oncol Rep. 2020 Aug; 44(2): 565–576. Published online 2020 Jun 5. doi: 10.3892/or.2020.7635

PMCID:: PMC7336505

Abstract Article PDF–1.5M

Select item 69401829.

TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer

Zhuo Fu, Yan Jiao, Yanqing Li, Bai Ji, Baoxing Jia, Bin Liu

Medicine (Baltimore) 2019 Dec; 98(51): e18487. Published online 2019 Dec 20. doi: 10.1097/MD.0000000000018487

PMCID:: PMC6940182

Abstract Article PDF–760K

Select item 688889710.

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers

Aarif Siddiqui, Paradesi Naidu Gollavilli, Annemarie Schwab, Maria Eleni Vazakidou, Pelin G. Ersan, Mallika Ramakrishnan, Dick Pluim, Si’Ana Coggins, Ozge Saatci, Laura Annaratone, Jan HM Schellens, Baek Kim, Irfan Ahmed Asangani, Suhail Ahmed Kabeer Rasheed, Caterina Marchiò, Ozgur Sahin, Paolo Ceppi

Cell Death Differ. 2019 Nov; 26(11): 2223–2236. Published online 2019 Feb 8. doi: 10.1038/s41418-019-0289-6

PMCID:: PMC6888897

Abstract Article PDF–3.2M

Select item 681815511.

Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase

Jeffrey P. Bonin, Paul J. Sapienza, Emily Wilkerson, Dennis Goldfarb, Li Wang, Laura Herring, Xian Chen, Michael B. Major, Andrew L. Lee

Biophys J. 2019 Sep 17; 117(6): 1074–1084. Published online 2019 Aug 22. doi: 10.1016/j.bpj.2019.08.015

Correction in:: Biophys J. 2021 Sep 21; 120(18): 4137.

PMCID:: PMC6818155

Abstract Article PDF–2.4M

Select item 668026312.

Thymidylate synthase expression in circulating tumor cells: A new tool to predict 5‐fluorouracil resistance in metastatic colorectal cancer patients

Emne Ali Abdallah, Marcello Ferretti Fanelli, Marcilei Eliza Cavicchioli Buim, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Virgílio Souza e Silva, Aldo Lourenço Abbade Dettino, Natalia Breve Mingues, Juliana Valim Romero, Luciana Menezes Mendonça Ocea, Bruna Maria Malagoli Rocha, Vanessa Silva Alves, Daniel Vilarim Araújo, Ludmilla Thomé Domingos Chinen

Int J Cancer. 2015 Sep 15; 137(6): 1397–1405. Published online 2015 Mar 11. doi: 10.1002/ijc.29495

PMCID:: PMC6680263

Abstract Article PDF–536K

Select item 662001313.

High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma

David B. Donner, Eric K. Nakakura, Alan P. Venook, Heinz-Josef Lenz, Wu Zhang, Jimee Hwang, Emily K. Bergsland, Meng Hsun Lin, Kan Toriguchi, Ricardo J. Antonia, Robert S. Warren

PLoS One. 2019; 14(7): e0219469. Published online 2019 Jul 10. doi: 10.1371/journal.pone.0219469

PMCID:: PMC6620013

Abstract Article PDF–985K

Select item 617504114.

Pharmacogenetic analysis of the UKMRC (Medical Research Council) MAGIC trial: association of polymorphisms with toxicity and survival in patients treated with perioperative epirubicin, cisplatin and 5-fluorouracil (ECF) chemotherapy

Elizabeth Smyth, Shenli Zhang, David Cunningham, Andrew Wotherspoon, Richie Soong, Clare Peckitt, Nicola Valeri, Matteo Fassan, Massimo Rugge, Alicia Okines, William Allum, Sally Stenning, Matthew Nankivell, Ruth Langley, Patrick Tan

Clin Cancer Res. Author manuscript; available in PMC 2018 Oct 8.

Published in final edited form as: Clin Cancer Res. 2017 Dec 15; 23(24): 7543–7549. Published online 2017 Oct 2. doi: 10.1158/1078-0432.CCR-16-3142