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Items: 1 to 20 of 71

1.
RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling
Ashapurna Sarma, Ambikai Gajan, Seongho Kim, Katherine Gurdziel, Guangzhao Mao, Pratima Nangia-Makker, Malathy P.V. Shekhar
Am J Pathol. 2021 Feb; 191(2): 368–384. doi: 10.1016/j.ajpath.2020.10.015
PMCID:
PMC7888193
AbstractArticlePDF–3.8M
2.
Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs
Matthew A. Sanders, Brittany Haynes, Pratima Nangia-Makker, Lisa A. Polin, Malathy P. Shekhar
J Biol Chem. 2017 Jun 23; 292(25): 10347–10363. Published online 2017 May 10. doi: 10.1074/jbc.M117.792192
PMCID:
PMC5481549
AbstractArticlePDF–4.9M
3.
Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer
Ranganatha R. Somasagara, Kaushlendra Tripathi, Sebastian M. Spencer, David W. Clark, Reagan Barnett, Lavanya Bachaboina, Jennifer Scalici, Rodney P. Rocconi, Gary A. Piazza, Komaraiah Palle
Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 Jan 15.
Published in final edited form as: Biochem Biophys Res Commun. 2016 Jan 15; 469(3): 449–455. Published online 2015 Dec 8. doi: 10.1016/j.bbrc.2015.11.134
PMCID:
PMC4715924
AbstractArticlePDF–1.1M
4.
A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia
Lisha Mou, Qiang Zhang, Ruiying Diao, Zhiming Cai, Yaoting Gui
Reprod Biol Endocrinol. 2015; 13: 79. Published online 2015 Jul 30. doi: 10.1186/s12958-015-0074-4
PMCID:
PMC4520152
AbstractArticlePDF–1.2M
5.
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men
Alexander N. Yatsenko, Andrew P. Georgiadis, Lata J. Murthy, Dolores J. Lamb, Martin M. Matzuk
Mol Hum Reprod. 2013 Jun; 19(6): 388–394. Published online 2013 Jan 31. doi: 10.1093/molehr/gat008
PMCID:
PMC3655768
AbstractArticlePDF–277K
6.
The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6.
R Schneider, C Eckerskorn, F Lottspeich, M Schweiger
EMBO J. 1990 May; 9(5): 1431–1435. doi: 10.1002/j.1460-2075.1990.tb08259.x
PMCID:
PMC551831
SummaryPage BrowsePDF–930K
7.
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism
Mengyuan Lyu, Jian Zhou, Yanbing Zhou, Weelic Chong, Wei Xu, Hongli Lai, Lu Niu, Yang Hai, Xiaojun Yao, Sheng Gong, Qinglan Wang, Yi Chen, Yili Wang, Liyu Chen, Zengwanggema, Jiongjiong Zeng, Chengdi Wang, Binwu Ying
Signal Transduct Target Ther. 2023; 8: 82. Published online 2023 Feb 24. doi: 10.1038/s41392-023-01346-2
PMCID:
PMC9958017
AbstractArticlePDF–3.6M
8.
Alternative Splicing of RAD6B and Not RAD6A Is Selectively Increased in Melanoma: Identification and Functional Characterization
Ambikai Gajan, Carly E. Martin, Seongho Kim, Milap Joshi, Sharon K. Michelhaugh, Ido Sloma, Sandeep Mittal, Steven Firestine, Malathy P. V. Shekhar
Cells. 2019 Nov; 8(11): 1375. Published online 2019 Nov 1. doi: 10.3390/cells8111375
PMCID:
PMC6912459
AbstractArticlePDF–1.9M
9.
RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence
Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. Shekhar
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1; 1866(1): 165561. Published online 2019 Oct 19. doi: 10.1016/j.bbadis.2019.165561
PMCID:
PMC6896319
AbstractArticlePDF–3.3M
10.
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance
Ranganatha R. Somasagara, Sebastian M. Spencer, Kaushlendra Tripathi, David W. Clark, Chinnadurai Mani, Luciana Madeira da Silva, Jennifer Scalici, Hend Kothayer, Andrew D. Westwell, Rodney P. Rocconi, Komaraiah Palle
Oncogene. Author manuscript; available in PMC 2018 Feb 14.
Published in final edited form as: Oncogene. 2017 Nov 30; 36(48): 6680–6690. Published online 2017 Aug 14. doi: 10.1038/onc.2017.279
PMCID:
PMC5709226
AbstractArticlePDF–1.3M
11.
Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin
Brigitte Gerard, Matthew A. Sanders, Daniel W. Visscher, Larry Tait, Malathy P.V. Shekhar
Biochim Biophys Acta. Author manuscript; available in PMC 2014 Feb 6.
Published in final edited form as: Biochim Biophys Acta. 2012 Oct; 1823(10): 1686–1696. Published online 2012 Jun 15. doi: 10.1016/j.bbamcr.2012.05.032
Correction in:
volume 1833 on page 1280
PMCID:
PMC3915360
AbstractArticlePDF–3.5M
12.
Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization
Matthew A. Sanders, Ghali Brahemi, Pratima Nangia-Makker, Vitaly Balan, Matteo Morelli, Hend Kothayer, Andrew D. Westwell, Malathy P.V. Shekhar
Mol Cancer Ther. Author manuscript; available in PMC 2013 Nov 26.
Published in final edited form as: Mol Cancer Ther. 2013 Apr; 12(4): 10.1158/1535-7163.MCT-12-0793. Published online 2013 Jan 21. doi: 10.1158/1535-7163.MCT-12-0793
PMCID:
PMC3840907
AbstractArticlePDF–1.7M
13.
Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells
Jung-Hoon Yoon, Satya Prakash, Louise Prakash
Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7799–7804. Published online 2012 Apr 30. doi: 10.1073/pnas.1204105109
PMCID:
PMC3356619
AbstractArticlePDF–179K
14.
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
Lucy Barnsby-Greer, Peter D. Mabbitt, Marc-Andre Dery, Daniel R. Squair, Nicola T. Wood, Frederic Lamoliatte, Sven M. Lange, Satpal Virdee
Nat Struct Mol Biol. 2024; 31(2): 351–363. Published online 2024 Jan 5. doi: 10.1038/s41594-023-01192-4
PMCID:
PMC10873205
AbstractArticlePDF–11M
15.
UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization
Xi Zeng, Wen Zheng, Yuting Sheng, Hongwei Ma
Bioengineered. 2022; 13(4): 8000–8012. Published online 2022 Mar 22. doi: 10.1080/21655979.2022.2048991
PMCID:
PMC9161992
AbstractArticlePDF–3.7M
16.
E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6
Richard G. Hibbert, Anding Huang, Rolf Boelens, Titia K. Sixma
Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14): 5590–5595. Published online 2011 Mar 21. doi: 10.1073/pnas.1017516108
PMCID:
PMC3078399
AbstractArticlePDF–4.1M
17.
Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway
Ihn Young Song, Komaraiah Palle, Aditi Gurkar, Satoshi Tateishi, Gary M. Kupfer, Cyrus Vaziri
J Biol Chem. 2010 Oct 8; 285(41): 31525–31536. Published online 2010 Jul 30. doi: 10.1074/jbc.M110.138206
PMCID:
PMC2951227
AbstractArticlePDF–2.8M
18.
Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens
Satoshi Tateishi, Yoshiyuki Sakuraba, Sadaharu Masuyama, Hirokazu Inoue, Masaru Yamaizumi
Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14): 7927–7932. doi: 10.1073/pnas.97.14.7927
PMCID:
PMC16647
AbstractArticlePDF–496K
19.
RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1
Su Chen, Chen Wang, Luxi Sun, Da-Liang Wang, Lu Chen, Zhuan Huang, Qi Yang, Jie Gao, Xi-Bin Yang, Jian-Feng Chang, Ping Chen, Li Lan, Zhiyong Mao, Fang-Lin Sun
Mol Cell Biol. 2015 Jan; 35(2): 406–416. Prepublished online 2014 Nov 10. Published online 2014 Dec 22. doi: 10.1128/MCB.01044-14
PMCID:
PMC4272427
AbstractArticlePDF–2.4M
20.
RAD6 Regulates the Dosage of p53 by a Combination of Transcriptional and Posttranscriptional Mechanisms
Su Chen, Da-Liang Wang, Yan Liu, Lei Zhao, Fang-Lin Sun
Mol Cell Biol. 2012 Jan; 32(2): 576–587. doi: 10.1128/MCB.05966-11
PMCID:
PMC3255784
AbstractArticlePDF–2.1M

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