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Select item 74313861.

Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p

Ke Hu, Xianhao Liu, Yi Li, Qinyang Li, Yijun Xu, Wei Zeng, Guocheng Zhong, Changhua Yu

Med Sci Monit. 2020; 26: e922253-1–e922253-12. Prepublished online 2020 Jun 9. Published online 2020 Aug 5. doi: 10.12659/MSM.922253

PMCID:: PMC7431386

Abstract Article PDF–1.4M

Select item 90340622.

Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

Life Sci Alliance. 2022 Aug; 5(8): e202101309. Published online 2022 Apr 22. doi: 10.26508/lsa.202101309

PMCID:: PMC9034062

Abstract Article PDF–2.3M

Select item 88975093.

Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C

Andrej Paluda, Adam J. Middleton, Claudia Rossig, Peter D. Mace, Catherine L. Day

Nat Commun. 2022; 13: 1181. Published online 2022 Mar 4. doi: 10.1038/s41467-022-28782-y

PMCID:: PMC8897509

Abstract Article PDF–2.7M

Select item 71906424.

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang

Nat Commun. 2020; 11: 2094. Published online 2020 Apr 29. doi: 10.1038/s41467-020-15783-y

PMCID:: PMC7190642

Abstract Article PDF–3.4M

Select item 69015125.

Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis

Young-Suk Yoo, Yeon-Ji Park, Ho-Soo Lee, Nguyen Thi Kim Oanh, Mi-Young Cho, June Heo, Eun-Seo Lee, Hyeseon Cho, Yong-Yea Park, Hyeseong Cho

Cell Death Dis. 2019 Dec; 10(12): 938. Published online 2019 Dec 9. doi: 10.1038/s41419-019-2175-z

PMCID:: PMC6901512

Abstract Article PDF–1.5M

Select item 67718226.

Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy

Dr. Xiaohui Zhao, Maite Mißun, Tobias Schneider, Franziska Müller, Joachim Lutz, Prof. Dr. Martin Scheffner, Prof. Dr. Andreas Marx, Prof. Dr. Michael Kovermann

Chembiochem. 2019 Jul 15; 20(14): 1772–1777. Published online 2019 Jun 24. doi: 10.1002/cbic.201900146

PMCID:: PMC6771822

Abstract Article PDF–790K

Select item 60505377.

Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase

Eilidh K. Leitch, Nagarajan Elumalai, Maria Fridén-Saxin, Göran Dahl, Paul Wan, Paul Clarkson, Eric Valeur, Garry Pairaudeau, Helen Boyd, Ali Tavassoli

Chem Sci. 2018 Jul 21; 9(27): 5957–5966. Published online 2018 Jun 26. doi: 10.1039/c8sc01186a

PMCID:: PMC6050537

Abstract Article PDF–667K

Select item 58776248.

Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1

Wesley O. Tucker, Andrew B. Kinghorn, Lewis A. Fraser, Yee-Wai Cheung, Julian A. Tanner

Int J Mol Sci. 2018 Mar; 19(3): 763. Published online 2018 Mar 7. doi: 10.3390/ijms19030763

PMCID:: PMC5877624

Abstract Article PDF–2.3M

Select item 47664139.

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity

Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Masahiko Satoh

Sci Rep. 2016; 6: 21968. Published online 2016 Feb 25. doi: 10.1038/srep21968

PMCID:: PMC4766413

Abstract Article PDF–2.2M

Select item 349797110.

Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase

Edna Matta-Camacho, Guennadi Kozlov, Marie Menade, Kalle Gehring

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1; 68(Pt 10): 1158–1163. Published online 2012 Sep 22. doi: 10.1107/S1744309112036937

PMCID:: PMC3497971

Abstract Article PDF–1021K

Select item 347326511.

HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

Angela M Sosin, Angelika M Burger, Aisha Siddiqi, Judith Abrams, Ramzi M Mohammad, Ayad M Al-Katib

J Hematol Oncol. 2012; 5: 57. Published online 2012 Sep 18. doi: 10.1186/1756-8722-5-57

PMCID:: PMC3473265

Abstract Article PDF–3.7M

Select item 335842112.

Protein Substrate Discrimination in the Quiescin-sulfhydryl Oxidase (QSOX) Family

Jennifer A. Codding, Benjamin A. Israel, Colin Thorpe

Biochemistry. Author manuscript; available in PMC 2013 May 22.

Published in final edited form as: Biochemistry. 2012 May 22; 51(20): 4226–4235. Published online 2012 May 14. doi: 10.1021/bi300394w

PMCID:: PMC3358421

Abstract Article PDF–2.0M

Select item 325113713.

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

Yoshihiro Kobashigawa, Akira Tomitaka, Hiroyuki Kumeta, Nobuo N. Noda, Masaya Yamaguchi, Fuyuhiko Inagaki

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20579-20584. Published online 2011 Dec 7. doi: 10.1073/pnas.1110712108

PMCID:: PMC3251137

Abstract Article PDF–2.0M

Select item 1121436414.

CircUBE2D2 regulates HMGB1 through miR-885-5p to promote ovarian cancer malignancy

RuiXue Yan, SaiTian Zeng, FangYuan Gao, LingLing Li, XiYun Xiao

Clinics (Sao Paulo) 2024 Jan-Dec; 79: 100391. Published online 2024 Jun 6. doi: 10.1016/j.clinsp.2024.100391

PMCID:: PMC11214364

Abstract Article PDF–3.2M

Select item 1040331615.

Structure of the human UBR5 E3 ubiquitin ligase

Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu, Efrat Finkin-Groner, Xiaojing Ma, Gang Lin, Huilin Li

Structure. Author manuscript; available in PMC 2023 Aug 4.

Published in final edited form as: Structure. 2023 May 4; 31(5): 541–552.e4. Published online 2023 Apr 10. doi: 10.1016/j.str.2023.03.010

PMCID:: PMC10403316

Abstract Article PDF–1.7M

Select item 1023410716.

The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function

William R. Critchley, Gina A. Smith, Ian C. Zachary, Michael A. Harrison, Sreenivasan Ponnambalam

J Cell Sci. 2023 May 15; 136(10): jcs260657. Published online 2023 May 25. doi: 10.1242/jcs.260657

PMCID:: PMC10234107

Abstract Article

Select item 1012525917.

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura

Nat Chem Biol. Author manuscript; available in PMC 2023 Apr 24.

Published in final edited form as: Nat Chem Biol. 2022 Apr; 18(4): 412–421. Published online 2022 Feb 24. doi: 10.1038/s41589-022-00971-2

PMCID:: PMC10125259

Abstract Article PDF–2.8M

Select item 984598818.

MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis

Cheng-Kai Wang, Tzu-Jou Chen, Grace Y.T. Tan, Fang-Pei Chang, Samyuktha Sridharan, Chen-Hsin Albert Yu, Yen-Hou Chang, Yi-Jen Chen, Li-Tzu Cheng, Wendy W. Hwang-Verslues

Cancer Res. 2023 Jan 18; 83(2): 251–263. Published online 2022 Nov 9. doi: 10.1158/0008-5472.CAN-22-1159