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Select item 72178641.

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny, Kristos I. Negrón Terón, Zhao-Qing Luo, Peter S. Brzovic, Rachel E. Klevit, Chittaranjan Das

Nat Commun. 2020; 11: 2365. Published online 2020 May 12. doi: 10.1038/s41467-020-16211-x

PMCID:: PMC7217864

Abstract Article PDF–2.6M

Select item 66399662.

Spatial UBE2N protein expression indicates genomic instability in colorectal cancers

Timo Gemoll, Elena Miroll, Oliver Klein, Annette Lischka, Murat Eravci, Christoph Thorns, Jens K. Habermann

BMC Cancer. 2019; 19: 710. Published online 2019 Jul 18. doi: 10.1186/s12885-019-5856-1

PMCID:: PMC6639966

Abstract Article PDF–611K

Select item 58337423.

The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer

Xu Zhang, Yan Feng, Xin-Yu Wang, Ya-Nan Zhang, Chun-Nv Yuan, Song-Fa Zhang, Yuan-Ming Shen, Yun-Feng Fu, Cai-Yun Zhou, Xiao Li, Xiao-Dong Cheng, Wei-Guo Lu, Xing Xie

Cell Death Dis. 2018 Feb; 9(2): 93. Published online 2018 Jan 24. doi: 10.1038/s41419-017-0137-x

PMCID:: PMC5833742

Abstract Article PDF–2.1M

Select item 39442684.

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

J Cheng, Y-H Fan, X Xu, H Zhang, J Dou, Y Tang, X Zhong, Y Rojas, Y Yu, Y Zhao, S A Vasudevan, H Zhang, J G Nuchtern, E S Kim, X Chen, F Lu, J Yang

Cell Death Dis. 2014 Feb; 5(2): e1079. Published online 2014 Feb 20. doi: 10.1038/cddis.2014.54

PMCID:: PMC3944268

Abstract Article PDF–3.6M

Select item 36360295.

Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition

Panhan Fu, Xiaoqing Zhang, Mengmeng Jin, Li Xu, Chong Wang, Zongping Xia, Yongqun Zhu

PLoS Pathog. 2013 Apr; 9(4): e1003322. Published online 2013 Apr 25. doi: 10.1371/journal.ppat.1003322

PMCID:: PMC3636029

Abstract Article PDF–1.2M

Select item 110752186.

UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells

Bo Yang, Weihua Chen, Tianyi Tao, Jun Zhang, Dehui Kong, Jidong Hao, Chao Yu, Guoqiang Liao, Hua Gong

Biol Direct. 2024; 19: 35. Published online 2024 May 7. doi: 10.1186/s13062-024-00469-y

PMCID:: PMC11075218

Abstract Article PDF–7.5M

Select item 72653027.

Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

Yong Wang, Qi Zhan, Xinlu Wang, Peipei Li, Songqing Liu, Guangxia Gao, Pu Gao

Nat Commun. 2020; 11: 2751. Published online 2020 Jun 2. doi: 10.1038/s41467-020-16587-w

PMCID:: PMC7265302

Abstract Article PDF–3.3M

Select item 67766658.

A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases

Leo Kiss, Jingwei Zeng, Claire F. Dickson, Donna L. Mallery, Ji-Chun Yang, Stephen H. McLaughlin, Andreas Boland, David Neuhaus, Leo C. James

Nat Commun. 2019; 10: 4502. Published online 2019 Oct 3. doi: 10.1038/s41467-019-12388-y

PMCID:: PMC6776665

Abstract Article PDF–5.6M

Select item 62946649.

Legionella pneumophila inhibits immune signaling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N

Ninghai Gan, Ernesto S. Nakayasu, Peter J. Hollenbeck, Zhao-Qing Luo

Nat Microbiol. Author manuscript; available in PMC 2019 May 12.

Published in final edited form as: Nat Microbiol. 2019 Jan; 4(1): 134–143. Published online 2018 Nov 12. doi: 10.1038/s41564-018-0282-8

PMCID:: PMC6294664

Abstract Article PDF–1.7M

Select item 588231010.

Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation

Zhaojia Wu, Heather Neufeld, Eminao Torlakovic, Wei Xiao

Oncotarget. 2018 Mar 23; 9(22): 15952–15967. Published online 2018 Mar 23. doi: 10.18632/oncotarget.24640

PMCID:: PMC5882310

Abstract Article PDF–8.0M

Select item 534673511.

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

Jianglin Zhang, Zhou Lei, Zunnan Huang, Xu Zhang, Youyou Zhou, Zhongling Luo, Weiqi Zeng, Juan Su, Cong Peng, Xiang Chen

Oncotarget. 2016 Nov 29; 7(48): 79557–79571. Published online 2016 Oct 24. doi: 10.18632/oncotarget.12836

PMCID:: PMC5346735

Abstract Article PDF–3.0M

Select item 305639312.

Ubiquitin in Motion: Structural studies of the E2~Ub conjugate

Jonathan N. Pruneda, Kate E. Stoll, Laura J. Bolton, Peter S. Brzovic, Rachel E. Klevit

Biochemistry. Author manuscript; available in PMC 2012 Mar 15.

Published in final edited form as: Biochemistry. 2011 Mar 15; 50(10): 1624–1633. Published online 2011 Feb 21. doi: 10.1021/bi101913m

PMCID:: PMC3056393

Abstract Article PDF–2.7M

Select item 220334513.

Structure, interactions, and dynamics of the RING domain from human TRAF6

Pascal Mercier, Michael J. Lewis, D. Duong Hau, Linda F. Saltibus, Wei Xiao, Leo Spyracopoulos

Protein Sci. 2007 Apr; 16(4): 602–614. doi: 10.1110/ps.062358007

PMCID:: PMC2203345

Abstract Article PDF–570K

Select item 1003127914.

The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Wei Dong, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Jing Feng, Bochu Wang

Acta Pharm Sin B. 2023 Mar; 13(3): 1071–1092. Published online 2022 Dec 12. doi: 10.1016/j.apsb.2022.12.006

PMCID:: PMC10031279

Abstract Article PDF–8.1M

Select item 863757515.

The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

Anaïs Wambecke, Mohammad Ahmad, Pierre‐Marie Morice, Bernard Lambert, Louis‐Bastien Weiswald, Mégane Vernon, Nicolas Vigneron, Edwige Abeilard, Emilie Brotin, Martin Figeac, Pascal Gauduchon, Laurent Poulain, Christophe Denoyelle, Matthieu Meryet‐Figuiere

Mol Oncol. 2021 Dec; 15(12): 3659–3678. Published online 2021 Jul 13. doi: 10.1002/1878-0261.13045

PMCID:: PMC8637575

Abstract Article PDF–4.0M

Select item 810411216.

Nonsegmented Negative-Sense RNA Viruses Utilize N⁶-Methyladenosine (m⁶A) as a Common Strategy To Evade Host Innate Immunity

Mijia Lu, Miaoge Xue, Hai-Tao Wang, Elizabeth L. Kairis, Sadeem Ahmad, Jiangbo Wei, Zijie Zhang, Qinzhe Liu, Yuexiu Zhang, Youling Gao, Dominique Garcin, Mark E. Peeples, Amit Sharma, Sun Hur, Chuan He, Jianrong Li

J Virol. 2021 May; 95(9): e01939-20. Prepublished online 2021 Feb 3. Published online 2021 Apr 12. doi: 10.1128/JVI.01939-20