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Select item 105879831.

UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma

Zheng Yang, Gujie Wu, Jianmei Zhao, Guanglin Shi, Juan Zhou, Xiaoyu Zhou

Cancer Med. 2023 Oct; 12(19): 19850–19865. Published online 2023 Sep 27. doi: 10.1002/cam4.6566

PMCID:: PMC10587983

Abstract Article PDF–12M

Select item 22630692.

hMMS2 serves a redundant role in human PCNA polyubiquitination

Jan Brun, Roland Chiu, Katherine Lockhart, Wei Xiao, Bradly G Wouters, Douglas A Gray

BMC Mol Biol. 2008; 9: 24. Published online 2008 Feb 19. doi: 10.1186/1471-2199-9-24

PMCID:: PMC2263069

Abstract Article PDF–818K

Select item 34066713.

Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13

Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Keiko Kubota, Rikako Miyamoto, Shinichiro Nakada, Shuya Fukai

J Biol Chem. 2012 Jul 27; 287(31): 25860–25868. Published online 2012 Jun 7. doi: 10.1074/jbc.M112.364752

PMCID:: PMC3406671

Abstract Article PDF–2.3M

Select item 31567254.

Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families

Mikko Vuorela, Katri Pylkäs, Robert Winqvist

BMC Med Genet. 2011; 12: 98. Published online 2011 Jul 21. doi: 10.1186/1471-2350-12-98

PMCID:: PMC3156725

Abstract Article PDF–204K

Select item 1215255.

Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells

Elena Sancho, Maya R. Vilá, Luis Sánchez-Pulido, Juan José Lozano, Rosanna Paciucci, Marga Nadal, Margaret Fox, Clare Harvey, Brenda Bercovich, Nourredine Loukili, Aaron Ciechanover, Stanley L. Lin, Ferran Sanz, Xavier Estivill, Alfonso Valencia, Timothy M. Thomson

Mol Cell Biol. 1998 Jan; 18(1): 576–589. doi: 10.1128/mcb.18.1.576

PMCID:: PMC121525

Abstract Article PDF–2.8M

Select item 95014386.

Unveiling the Essential Role of Arkadia’s Non-RING Elements in the Ubiquitination Process

Maria Birkou, Georgia N. Delegkou, Konstantinos D. Marousis, Nefeli Fragkaki, Tamara Toro, Vasso Episkopou, Georgios A. Spyroulias

Int J Mol Sci. 2022 Sep; 23(18): 10585. Published online 2022 Sep 13. doi: 10.3390/ijms231810585

PMCID:: PMC9501438

Abstract Article PDF–8.7M

Select item 79002067.

RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James

Nat Commun. 2021; 12: 1220. Published online 2021 Feb 22. doi: 10.1038/s41467-021-21443-6

PMCID:: PMC7900206

Abstract Article PDF–2.7M

Select item 45067358.

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting

Curtis D. Hodge, Ross A. Edwards, Craig J. Markin, Darin McDonald, Mary Pulvino, Michael S. Y. Huen, Jiyong Zhao, Leo Spyracopoulos, Michael J. Hendzel, J.N. Mark Glover

ACS Chem Biol. Author manuscript; available in PMC 2016 May 17.

Published in final edited form as: ACS Chem Biol. 2015 Jul 17; 10(7): 1718–1728. Published online 2015 May 1. doi: 10.1021/acschembio.5b00222

PMCID:: PMC4506735

Abstract Article PDF–1.7M

Select item 33906669.

Molecular Insights into the Function of RING Finger (RNF)-containing Proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent Ubiquitylation

Stephen J. Campbell, Ross A. Edwards, Charles C. Y. Leung, Dante Neculai, Curtis D. Hodge, Sirano Dhe-Paganon, J. N. Mark Glover

J Biol Chem. 2012 Jul 6; 287(28): 23900–23910. Published online 2012 May 15. doi: 10.1074/jbc.M112.359653

PMCID:: PMC3390666

Abstract Article PDF–2.4M

Select item 14779610.

The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.

W Xiao, S L Lin, S Broomfield, B L Chow, Y F Wei

Nucleic Acids Res. 1998 Sep 1; 26(17): 3908–3914. doi: 10.1093/nar/26.17.3908

PMCID:: PMC147796

Summary PDF–239K

Select item 452948911.

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

Emma Branigan, Anna Plechanovová, Ellis Jaffray, James H. Naismith, Ronald T. Hay

Nat Struct Mol Biol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Nat Struct Mol Biol. 2015 Aug; 22(8): 597–602. Published online 2015 Jul 6. doi: 10.1038/nsmb.3052

PMCID:: PMC4529489

Abstract Article PDF–1.6M

Select item 687447912.

Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases

Priyesh Mohanty, Rashmi Agrata, Batul Ismail Habibullah, Arun G S, Ranabir Das

eLife. 2019; 8: e49223. Published online 2019 Oct 22. doi: 10.7554/eLife.49223

PMCID:: PMC6874479

Abstract Article PDF–7.1M

Select item 590609513.

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James

eLife. 2018; 7: e32660. Published online 2018 Apr 18. doi: 10.7554/eLife.32660

PMCID:: PMC5906095

Abstract Article PDF–4.1M

Select item 380955314.

The Tomato Fni3 Lysine-63–Specific Ubiquitin-Conjugating Enzyme and Suv Ubiquitin E2 Variant Positively Regulate Plant Immunity

Ravi V. Mural, Yao Liu, Tracy R. Rosebrock, Jennifer J. Brady, Sadia Hamera, Richard A. Connor, Gregory B. Martin, Lirong Zeng

Plant Cell. 2013 Sep; 25(9): 3615–3631. Published online 2013 Sep 27. doi: 10.1105/tpc.113.117093

PMCID:: PMC3809553

Abstract Article PDF–1.2M

Select item 226882415.

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

Ildiko Unk, Ildikó Hajdú, Károly Fátyol, Jerard Hurwitz, Jung-Hoon Yoon, Louise Prakash, Satya Prakash, Lajos Haracska

Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10): 3768–3773. Published online 2008 Mar 3. doi: 10.1073/pnas.0800563105

PMCID:: PMC2268824

Abstract Article PDF–1.0M

Select item 183871416.

Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

Ildiko Unk, Ildikó Hajdú, Károly Fátyol, Barnabás Szakál, András Blastyák, Vladimir Bermudez, Jerard Hurwitz, Louise Prakash, Satya Prakash, Lajos Haracska

Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48): 18107–18112. Published online 2006 Nov 15. doi: 10.1073/pnas.0608595103

PMCID:: PMC1838714

Abstract Article PDF–640K

Select item 348822517.

En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs

Yuji Masuda, Miki Suzuki, Hidehiko Kawai, Asami Hishiki, Hiroshi Hashimoto, Chikahide Masutani, Takashi Hishida, Fumio Suzuki, Kenji Kamiya

Nucleic Acids Res. 2012 Nov; 40(20): 10394–10407. Published online 2012 Aug 13. doi: 10.1093/nar/gks763

PMCID:: PMC3488225

Abstract Article PDF–5.4M

Select item 217135618.

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A

Parker L. Andersen, Honglin Zhou, Landon Pastushok, Trevor Moraes, Sean McKenna, Barry Ziola, Michael J. Ellison, Vishva M. Dixit, Wei Xiao

J Cell Biol. 2005 Aug 29; 170(5): 745–755. doi: 10.1083/jcb.200502113

PMCID:: PMC2171356

Abstract Article PDF–2.1M

Select item 254701719.

Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly

Michael S. Y. Huen, Jun Huang, Jingsong Yuan, Masahiro Yamamoto, Shizuo Akira, Carolyn Ashley, Wei Xiao, Junjie Chen

Mol Cell Biol. 2008 Oct; 28(19): 6104–6112. Published online 2008 Aug 4. doi: 10.1128/MCB.00987-08

PMCID:: PMC2547017

Abstract Article PDF–3.9M

Select item 20448420.

A conserved catalytic residue in the ubiquitin-conjugating enzyme family

Pei-Ying Wu, Mary Hanlon, Michael Eddins, Colleen Tsui, Richard S. Rogers, Jane P. Jensen, Michael J. Matunis, Allan M. Weissman, Cynthia P. Wolberger, Cecile M. Pickart

EMBO J. 2003 Oct 1; 22(19): 5241–5250. doi: 10.1093/emboj/cdg501

Correction in:: EMBO J. 2004 Dec 8; 23(24): 4876.

PMCID:: PMC204484

Abstract Article PDF–324K

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PMC Links for Gene (Select 7336) (49)
PMC
MMADHC[gene] (386)
ClinVar
Homo sapiens transmembrane protein 230 (TMEM230), transcript variant 6, mRNA
Homo sapiens transmembrane protein 230 (TMEM230), transcript variant 6, mRNA
gi|1890256900|ref|NM_001330985.2|

Nucleotide
neural cell adhesion molecule L1-like protein isoform X1 [Homo sapiens]
neural cell adhesion molecule L1-like protein isoform X1 [Homo sapiens]
gi|767922155|ref|XP_011531594.1|

Protein

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