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Select item 107063001.

Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity

Katalin Gyurina, Mariia Yarmak, László Sasi-Szabó, Sarolta Molnár, Gábor Méhes, Tamás Röszer

Int J Mol Sci. 2023 Dec; 24(23): 16706. Published online 2023 Nov 24. doi: 10.3390/ijms242316706

PMCID:: PMC10706300

Abstract Article PDF–22M

Select item 104136602.

Structural basis of purine nucleotide inhibition of human uncoupling protein 1

Scott A. Jones, Prerana Gogoi, Jonathan J. Ruprecht, Martin S. King, Yang Lee, Thomas Zögg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M. Copeman, Camila A. Cotrim, Jan Steyaert, Paul G. Crichton, Vera Moiseenkova-Bell, Edmund R. S. Kunji

Sci Adv. 2023 Jun 2; 9(22): eadh4251. Published online 2023 May 31. doi: 10.1126/sciadv.adh4251

PMCID:: PMC10413660

Abstract Article PDF–1.1M

Select item 92655313.

Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model

Yukimasa Takeda, Ping Dai

Cells. 2022 Jul; 11(13): 2038. Published online 2022 Jun 27. doi: 10.3390/cells11132038

PMCID:: PMC9265531

Abstract Article PDF–6.6M

Select item 92431624.

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Riccardo Cavalieri, Marlou Klein Hazebroek, Camila A. Cotrim, Yang Lee, Edmund R.S. Kunji, Martin Jastroch, Susanne Keipert, Paul G. Crichton

Mol Metab. 2022 Aug; 62: 101526. Published online 2022 Jun 9. doi: 10.1016/j.molmet.2022.101526

PMCID:: PMC9243162

Abstract Article PDF–1.4M

Select item 90661085.

Mitochondrial Protein UCP1 Inhibits the Malignant Behaviors of Triple-negative Breast Cancer through Activation of Mitophagy and Pyroptosis

Jing Xia, Changbin Chu, Wanqing Li, Hong Chen, Wenhua Xie, Rui Cheng, Kai Hu, Xi Li

Int J Biol Sci. 2022; 18(7): 2949–2961. Published online 2022 Apr 18. doi: 10.7150/ijbs.68438

PMCID:: PMC9066108

Abstract Article PDF–3.2M

Select item 88003486.

UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients

Jinfa Huang, Guilian Wang, Kedan Liao, Ning Xie, Kaixian Deng

J Ovarian Res. 2022; 15: 16. Published online 2022 Jan 28. doi: 10.1186/s13048-022-00951-z

PMCID:: PMC8800348

Abstract Article PDF–2.2M

Select item 86550497.

Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans

Brian S. Finlin, Hasiyet Memetimin, Amy L. Confides, Beibei Zhu, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern

Sci Rep. 2021; 11: 23598. Published online 2021 Dec 8. doi: 10.1038/s41598-021-03014-3

PMCID:: PMC8655049

Abstract Article PDF–2.2M

Select item 81248698.

The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia

Alena A. Nikanorova, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin, Nyurgun N. Gotovtsev, Georgii P. Romanov, Aisen V. Solovyev, Sargylana S. Kuzmina, Nikolay N. Sazonov, Sardana A. Fedorova

Int J Mol Sci. 2021 May; 22(9): 4657. Published online 2021 Apr 28. doi: 10.3390/ijms22094657

PMCID:: PMC8124869

Abstract Article PDF–1.8M

Select item 72493959.

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov, Yulii V. Shidlovskii

Mol Med. 2020; 26: 51. Published online 2020 May 25. doi: 10.1186/s10020-020-00180-4

PMCID:: PMC7249395

Abstract Article PDF–1.3M

Select item 700641910.

Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population

Peiyao Jin, Zhiqiang Li, Xian Xu, Jiangnan He, Jianhua Chen, Xun Xu, Xuan Du, Xuelin Bai, Bo Zhang, Xiangui He, Lina Lu, Jianfeng Zhu, Yongyong Shi, Haidong Zou

BMC Med Genet. 2020; 21: 25. Published online 2020 Feb 6. doi: 10.1186/s12881-020-0956-y

PMCID:: PMC7006419

Abstract Article PDF–573K

Select item 677581711.

Increased UCP1 expression in the perirenal adipose tissue of patients with renal cell carcinoma

Xueqin Li, Gongcheng Wang, Juan Liu, Guoxian Ding

Oncol Rep. 2019 Nov; 42(5): 1972–1980. Published online 2019 Sep 10. doi: 10.3892/or.2019.7306

PMCID:: PMC6775817

Abstract Article PDF–736K

Select item 669206212.

Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes

D. Tews, T. Pula, J.B. Funcke, M. Jastroch, M. Keuper, K.M. Debatin, M. Wabitsch, P. Fischer-Posovszky

Redox Biol. 2019 Sep; 26: 101286. Published online 2019 Jul 27. doi: 10.1016/j.redox.2019.101286

PMCID:: PMC6692062

Abstract Article PDF–2.0M

Select item 653832413.

UCP1 expression–associated gene signatures of human epicardial adipose tissue

Kanta Chechi, Jinchu Vijay, Pierre Voisine, Patrick Mathieu, Yohan Bossé, Andre Tchernof, Elin Grundberg, Denis Richard

JCI Insight. 2019 Apr 18; 4(8): e123618. Published online 2019 Apr 18. doi: 10.1172/jci.insight.123618

PMCID:: PMC6538324

Abstract Article PDF–5.2M

Select item 624751214.

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study

Shahanas Chathoth, Mona H. Ismail, Chittibabu Vatte, Cyril Cyrus, Zhara Al Ali, Khandaker Ahtesham Ahmed, Sadananda Acharya, Aisha Mohammed Al Barqi, Amein Al Ali

BMC Med Genet. 2018; 19: 203. Published online 2018 Nov 20. doi: 10.1186/s12881-018-0715-5

PMCID:: PMC6247512

Abstract Article PDF–1.1M

Select item 568618315.

Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue

Kanta Chechi, Pierre Voisine, Patrick Mathieu, Mathieu Laplante, Sébastian Bonnet, Frédéric Picard, Philippe Joubert, Denis Richard

Sci Rep. 2017; 7: 15566. Published online 2017 Nov 14. doi: 10.1038/s41598-017-15501-7

PMCID:: PMC5686183

Abstract Article PDF–3.2M

Select item 546105816.

UCP1: a transporter for H⁺ and fatty acid anions

Ambre M. Bertholet, Yuriy Kirichok

Biochimie. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Biochimie. 2017 Mar; 134: 28–34. Published online 2016 Oct 27. doi: 10.1016/j.biochi.2016.10.013

PMCID:: PMC5461058

Abstract Article PDF–772K

Select item 541477017.

Thermogenic Activity of UCP1 in Human White Fat-Derived Beige Adipocytes

Stefano Bartesaghi, Stefan Hallen, Li Huang, Per-Arne Svensson, Remi A. Momo, Simonetta Wallin, Eva K. Carlsson, Anna Forslöw, Patrick Seale, Xiao-Rong Peng

Mol Endocrinol. 2015 Jan; 29(1): 130–139. Published online 2014 Nov 12. doi: 10.1210/me.2014-1295

PMCID:: PMC5414770

Abstract Article

Select item 539509018.

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism

Paul G. Crichton, Yang Lee, Edmund R.S. Kunji

Biochimie. Author manuscript; available in PMC 2017 Apr 18.

Published in final edited form as: Biochimie. 2017 Mar; 134: 35–50. Published online 2017 Jan 3. doi: 10.1016/j.biochi.2016.12.016

PMCID:: PMC5395090

Abstract Article PDF–3.5M

Select item 529035419.

Clozapine modifies the differentiation program of human adipocytes inducing browning

E Kristóf, Q-M Doan-Xuan, A K Sárvári, Á Klusóczki, P Fischer-Posovszky, M Wabitsch, Z Bacso, P Bai, Z Balajthy, L Fésüs

Transl Psychiatry. 2016 Nov; 6(11): e963. Published online 2016 Nov 29. doi: 10.1038/tp.2016.230

PMCID:: PMC5290354

Abstract Article PDF–3.5M

Select item 494938020.

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

Lynne E. Ramage, Murat Akyol, Alison M. Fletcher, John Forsythe, Mark Nixon, Roderick N. Carter, Edwin J.R. van Beek, Nicholas M. Morton, Brian R. Walker, Roland H. Stimson

Cell Metab. 2016 Jul 12; 24(1): 130–141. doi: 10.1016/j.cmet.2016.06.011