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Items: 1 to 20 of 96

1.
Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation
Le Thi My Le, Wonchull Kang, Ji-Yun Kim, Oanh Thi Tu Le, Sang Yoon Lee, Jin Kuk Yang
PLoS One. 2016; 11(9): e0163394. Published online 2016 Sep 29. doi: 10.1371/journal.pone.0163394
PMCID:
PMC5042407
AbstractArticlePDF–3.5M
2.
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative
Man Pan, Qingyun Zheng, Yuanyuan Yu, Huasong Ai, Yuan Xie, Xin Zeng, Chu Wang, Lei Liu, Minglei Zhao
Nat Commun. 2021; 12: 121. Published online 2021 Jan 5. doi: 10.1038/s41467-020-20359-x
PMCID:
PMC7785736
AbstractArticlePDF–2.0M
3.
Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species
Jingjing Yan, Meng Wang, Min Wang, Ying Dun, Liuyao Zhu, Zhigang Yi, Shuye Zhang
Virus Res. 2020 Jul 2; 283: 197974. Published online 2020 Apr 11. doi: 10.1016/j.virusres.2020.197974
PMCID:
PMC7151541
AbstractArticlePDF–3.9M
4.
Multisystem proteinopathy (MSP) mutations in VCP/p97 increase NPLOC4·UFD1L binding and substrate processing
Emily E. Blythe, Stephanie N. Gates, Raymond J. Deshaies, Andreas Martin
Structure. Author manuscript; available in PMC 2020 Dec 3.
Published in final edited form as: Structure. 2019 Dec 3; 27(12): 1820–1829.e4. Published online 2019 Oct 14. doi: 10.1016/j.str.2019.09.011
PMCID:
PMC6929323
AbstractArticlePDF–1.0M
5.
Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy
Emily E. Blythe, Kristine C. Olson, Vincent Chau, Raymond J. Deshaies
Proc Natl Acad Sci U S A. 2017 May 30; 114(22): E4380–E4388. Published online 2017 May 16. doi: 10.1073/pnas.1706205114
PMCID:
PMC5465906
AbstractArticlePDF–1.1M
6.
Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms
Vandana Shashi, Alan Francis, Stephen R Hooper, Peter G Kranz, Michael Zapadka, Kelly Schoch, Edward Ip, Neeraj Tandon, Timothy D Howard, Matcheri S Keshavan
Eur J Hum Genet. 2012 Oct; 20(10): 1051–1057. Published online 2012 Jun 27. doi: 10.1038/ejhg.2012.138
PMCID:
PMC3449066
AbstractArticlePDF–418K
7.
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response
LN Huiting, Y Samaha, GL Zhang, JE Roderick, B Li, NM Anderson, YW Wang, L Wang, FJF Laroche, JW Choi, CT Liu, MA Kelliher, H Feng
Leukemia. Author manuscript; available in PMC 2018 Oct 26.
Published in final edited form as: Leukemia. 2018 Nov; 32(11): 2339–2351. Published online 2018 Apr 25. doi: 10.1038/s41375-018-0141-x
PMCID:
PMC6202254
AbstractArticlePDF–1.4M
8.
Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control
Meifan Chen, Gustavo J. Gutierrez, Ze'ev A. Ronai
Proc Natl Acad Sci U S A. 2011 May 31; 108(22): 9119–9124. Published online 2011 May 13. doi: 10.1073/pnas.1100028108
PMCID:
PMC3107271
AbstractArticlePDF–1.1M
9.
The p97 ATPase Dislocates MHC Class I Heavy Chain in US2-expressing Cells via a Ufd1-Npl4-independent Mechanism
Nia Soetandyo, Yihong Ye
J Biol Chem. 2010 Oct 15; 285(42): 32352–32359. Published online 2010 Aug 11. doi: 10.1074/jbc.M110.131649
PMCID:
PMC2952236
AbstractArticlePDF–1.2M
10.
The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
Mike Blueggel, Alexander Kroening, Matthias Kracht, Johannes van den Boom, Matthias Dabisch, Anna Goehring, Farnusch Kaschani, Markus Kaiser, Peter Bayer, Hemmo Meyer, Christine Beuck
Nat Commun. 2023; 14: 3258. Published online 2023 Jun 5. doi: 10.1038/s41467-023-38604-4
PMCID:
PMC10241913
AbstractArticlePDF–3.0M
11.
K27‐linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Robert F Shearer, Dimitris Typas, Fabian Coscia, Sofie Schovsbo, Thomas Kruse, Andreas Mund, Niels Mailand
EMBO J. 2022 May; 41(9): e110145. Published online 2022 Mar 29. doi: 10.15252/embj.2021110145
PMCID:
PMC9058539
AbstractArticlePDF–2.9M
12.
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates
Thang Van Nguyen, Jing Li, Chin-Chun (Jean) Lu, Jennifer L. Mamrosh, Gang Lu, Brian E. Cathers, Raymond J. Deshaies
Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14): 3565–3571. Published online 2017 Mar 20. doi: 10.1073/pnas.1700949114
PMCID:
PMC5389304
AbstractArticlePDF–1.1M
13.
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation
Anne Riemer, Grzegorz Dobrynin, Alina Dressler, Sebastian Bremer, Aashish Soni, George Iliakis, Hemmo Meyer
Cell Cycle. 2014 Mar 15; 13(6): 919–927. Published online 2014 Jan 15. doi: 10.4161/cc.27779
PMCID:
PMC3984315
AbstractArticlePDF–7.1M
14.
NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97UFD1/NPL4 Complex
Shuai Liu, Hui Yang, Jian Zhao, Yu-Hang Zhang, Ai-Xin Song, Hong-Yu Hu
J Biol Chem. 2013 Oct 25; 288(43): 31339–31349. Published online 2013 Sep 9. doi: 10.1074/jbc.M113.484816
PMCID:
PMC3829446
AbstractArticlePDF–4.4M
15.
Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response
Tao Wang, Wangchao Xu, Meiling Qin, Yi Yang, Puhua Bao, Fuxiao Shen, Zhenlin Zhang, Jin Xu
J Biol Chem. 2016 Jul 1; 291(27): 14373–14384. Published online 2016 May 13. doi: 10.1074/jbc.M116.729343
PMCID:
PMC4933190
AbstractArticlePDF–2.9M
16.
Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD)
Jae-Jin Lee, Joon Kyu Park, Jaeho Jeong, Hyesung Jeon, Jong-Bok Yoon, Eunice EunKyeong Kim, Kong-Joo Lee
J Biol Chem. 2013 Mar 8; 288(10): 6998–7011. Published online 2013 Jan 4. doi: 10.1074/jbc.M112.417576
PMCID:
PMC3591610
AbstractArticlePDF–3.3M
17.
Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps
Javier G. Magadán, F. Javier Pérez-Victoria, Rachid Sougrat, Yihong Ye, Klaus Strebel, Juan S. Bonifacino
PLoS Pathog. 2010 Apr; 6(4): e1000869. Published online 2010 Apr 29. doi: 10.1371/journal.ppat.1000869
PMCID:
PMC2861688
AbstractArticlePDF–4.7M
18.
Inhibition of p97-dependent Protein Degradation by Eeyarestatin I
Qiuyan Wang, Lianyun Li, Yihong Ye
J Biol Chem. 2008 Mar 21; 283(12): 7445–7454. doi: 10.1074/jbc.M708347200
PMCID:
PMC2276333
AbstractArticlePDF–587K
19.
The p97-UFD1L-NPL4 Protein Complex Mediates Cytokine-Induced IκBα Proteolysis
Ju-Mei Li, Hongyu Wu, Wenzheng Zhang, Michael R. Blackburn, Jianping Jin
Mol Cell Biol. 2014 Feb; 34(3): 335–347. doi: 10.1128/MCB.01190-13
PMCID:
PMC3911508
AbstractArticlePDF–2.0M
20.
Imbalances in p97 co-factor interactions in human proteinopathy
Vanesa Fernández-Sáiz, Alexander Buchberger
EMBO Rep. 2010 Jun; 11(6): 479–485. Published online 2010 Apr 23. doi: 10.1038/embor.2010.49
PMCID:
PMC2892324
AbstractArticlePDF–849K

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