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Select item 112269741.

O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies

Ellie Karampini, Dearbhla Doherty, Petra E. Bürgisser, Massimiliano Garre, Ingmar Schoen, Stephanie Elliott, Ruben Bierings, James S. O’Donnell

Blood Adv. 2024 Jun 25; 8(12): 3254–3266. Published online 2024 Apr 23. doi: 10.1182/bloodadvances.2023012499

PMCID:: PMC11226974

Abstract Article PDF–6.5M

Select item 105028362.

Small Extracellular Vesicle‐Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma

Samuel Wan Ki Wong, Sze Keong Tey, Xiaowen Mao, Hiu Ling Fung, Zhi‐Jie Xiao, Danny Ka Ho Wong, Lung‐Yi Mak, Man‐Fung Yuen, Irene Oi‐Lin Ng, Jing Ping Yun, Yi Gao, Judy Wai Ping Yam

Adv Sci (Weinh) 2023 Sep; 10(26): 2302677. Published online 2023 Jun 30. doi: 10.1002/advs.202302677

PMCID:: PMC10502836

Abstract Article PDF–9.4M

Select item 101259113.

A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from patients with type 1 VWD

Robert Kloosterman, Matteo Zago-Schmitt, Julie Grabell, Lisa Thibeault, Patricia A. De Lima, Mackenzie Bowman, Kathrin Tyryshkin, Charles C. T. Hindmarch, Neil Renwick, Paula James

Blood Adv. 2023 Apr 25; 7(8): 1477–1487. Published online 2022 Sep 21. doi: 10.1182/bloodadvances.2022007884

PMCID:: PMC10125911

Abstract Article PDF–3.6M

Select item 100659204.

Hidden behind thromboinflammation: revealing the roles of von Willebrand factor in sickle cell disease pathophysiology

Eudorah F. Vital, Wilbur A. Lam

Curr Opin Hematol. 2023 May; 30(3): 86–92. Published online 2023 Jan 12. doi: 10.1097/MOH.0000000000000755

PMCID:: PMC10065920

Abstract Article PDF–1.1M

Select item 100486265.

Missense Variants of von Willebrand Factor in the Background of COVID-19 Associated Coagulopathy

Zsuzsanna Elek, Eszter Losoncz, Katalin Maricza, Zoltán Fülep, Zsófia Bánlaki, Réka Kovács-Nagy, Gergely Keszler, Zsolt Rónai

Genes (Basel) 2023 Mar; 14(3): 617. Published online 2023 Feb 28. doi: 10.3390/genes14030617

PMCID:: PMC10048626

Abstract Article PDF–1.1M

Select item 100238336.

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Emily R. Legan, Yi Liu, Nicholas A. Arce, Ernest T. Parker, Pete Lollar, X. Frank Zhang, Renhao Li

Blood. 2023 Mar 9; 141(10): 1221–1232. Published online 2022 Dec 30. doi: 10.1182/blood.2022017239

PMCID:: PMC10023833

Abstract Article

Select item 97982477.

Structural hierarchy of mechanical extensibility in human von Willebrand factor multimers

Mária Csilla Csányi, Pál Salamon, Tímea Feller, Tamás Bozó, Jolán Hársfalvi, Miklós S. Z. Kellermayer

Protein Sci. 2023 Jan; 32(1): e4535. Published online 2023 Jan 1. doi: 10.1002/pro.4535

PMCID:: PMC9798247

Abstract Article PDF–6.6M

Select item 95070118.

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange

Jacob R. Anderson, Jing Li, Timothy A. Springer, Alan Brown

Blood. 2022 Sep 22; 140(12): 1419–1430. doi: 10.1182/blood.2022016467

PMCID:: PMC9507011

Abstract Article

Select item 93037089.

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients

Maria Teresa Pagliari, Luciano Baronciani, Chiara Cordiglieri, Paola Colpani, Giovanna Cozzi, Simona M. Siboni, Flora Peyvandi

Haemophilia. 2022 Mar; 28(2): 292–300. Published online 2022 Jan 22. doi: 10.1111/hae.14494

PMCID:: PMC9303708

Abstract Article PDF–4.9M

Select item 894529510.

Multifaceted pathomolecular mechanism of a VWF large deletion involved in the pathogenesis of severe VWD

Hamideh Yadegari, Muhammad Ahmer Jamil, Jens Müller, Natascha Marquardt, Orla Rawley, Ulrich Budde, Osman El-Maarri, David Lillicrap, Johannes Oldenburg

Blood Adv. 2022 Feb 8; 6(3): 1038–1053. Published online 2022 Feb 7. doi: 10.1182/bloodadvances.2021005895

PMCID:: PMC8945295

Abstract Article PDF–3.5M

Select item 882839711.

Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics

Volker Huck, Po-Chia Chen, Emma-Ruoqi Xu, Alexander Tischer, Ulrike Klemm, Camilo Aponte-Santamaría, Christian Mess, Tobias Obser, Fabian Kutzki, Gesa König, Cécile V. Denis, Frauke Gräter, Matthias Wilmanns, Matthew Auton, Stefan W. Schneider, Reinhard Schneppenheim, Janosch Hennig, Maria A. Brehm

Thromb Haemost. 2022 Feb; 122(2): 226–239. Published online 2020 Dec 31. doi: 10.1055/a-1344-4405

PMCID:: PMC8828397

Abstract Article PDF–839K

Select item 870608912.

A Deep Exon Cryptic Splice Site Promotes Aberrant Intron Retention in a Von Willebrand Disease Patient

John G. Conboy

Int J Mol Sci. 2021 Dec; 22(24): 13248. Published online 2021 Dec 9. doi: 10.3390/ijms222413248

PMCID:: PMC8706089

Abstract Article PDF–1.8M

Select item 866206913.

Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association

Hongxia Fu, Yan Jiang, Wesley P. Wong, Timothy A. Springer

Blood. 2021 Dec 9; 138(23): 2425–2434. doi: 10.1182/blood.2021012595

PMCID:: PMC8662069

Abstract Article

Select item 843298014.

Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19

Shalki Choudhary, Kajal Sharma, Pankaj Kumar Singh

Chem Biol Interact. 2021 Oct 1; 348: 109657. Published online 2021 Sep 10. doi: 10.1016/j.cbi.2021.109657

PMCID:: PMC8432980

Abstract Article PDF–2.2M

Select item 835190015.

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene

Brooke Sadler, Pamela A. Christopherson, Gabe Haller, Robert R. Montgomery, Jorge Di Paola

Blood. 2021 Jun 10; 137(23): 3277–3283. Prepublished online 2021 Feb 8. doi: 10.1182/blood.2020009999

Correction in:: Blood. 2022 Sep 15; 140(11): 1327.

PMCID:: PMC8351900

Abstract Article

Select item 813572216.

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

Zhen W Mei, Xander M R van Wijk, Huy P Pham, Maximo J Marin

J Appl Lab Med. 2021 Apr 30 : jfab042. Published online 2021 Apr 30. doi: 10.1093/jalm/jfab042

PMCID:: PMC8135722

Abstract PDF–684K

Select item 806027817.

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Nicholas A. Arce, Wenpeng Cao, Alexander K. Brown, Emily R. Legan, Moriah S. Wilson, Emma-Ruoqi Xu, Michael C. Berndt, Jonas Emsley, X. Frank Zhang, Renhao Li

Nat Commun. 2021; 12: 2360. Published online 2021 Apr 21. doi: 10.1038/s41467-021-22634-x

PMCID:: PMC8060278

Abstract Article PDF–2.3M

Select item 793376518.

Disulfide exchange in multimerization of von Willebrand factor and gel-forming mucins

Xianchi Dong, Timothy A. Springer

Blood. 2021 Mar 4; 137(9): 1263–1267. Prepublished online 2020 Sep 22. doi: 10.1182/blood.2020005989

PMCID:: PMC7933765

Article

Select item 786195919.

Pathological Features of Ruptured Coronary Plaque and Thrombus Interfaces: Fibrin and von Willebrand Factor as Platelet Scaffolds on Rupture Sites

Atsushi Yamashita, Kensaku Nishihira, Toshihiro Gi, Kazunari Maekawa, Kinta Hatakeyama, Saki Horiuchi, Kei Wada, Yoshisato Shibata, Yujiro Asada

Thromb Haemost. 2021 Feb; 121(2): 234–241. Published online 2020 Sep 13. doi: 10.1055/s-0040-1716539

PMCID:: PMC7861959

Abstract Article PDF–525K

Select item 780955320.

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

Aurélien Philippe, Richard Chocron, Nicolas Gendron, Olivier Bory, Agathe Beauvais, Nicolas Peron, Lina Khider, Coralie L. Guerin, Guillaume Goudot, Françoise Levasseur, Christophe Peronino, Jerome Duchemin, Julie Brichet, Elise Sourdeau, Florence Desvard, Sébastien Bertil, Frédéric Pene, Cherifa Cheurfa, Tali-Anne Szwebel, Benjamin Planquette, Nadia Rivet, Georges Jourdi, Caroline Hauw-Berlemont, Bertrand Hermann, Pascale Gaussem, Tristan Mirault, Benjamin Terrier, Olivier Sanchez, Jean-Luc Diehl, Michaela Fontenay, David M. Smadja

Angiogenesis. 2021; 24(3): 505–517. Published online 2021 Jan 15. doi: 10.1007/s10456-020-09762-6

PMCID:: PMC7809553

Abstract Article PDF–1.8M

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